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Cidofovir
Catalog No.S1516 Synonyms: HPMPC
For research use only.
Cidofovir (HPMPC) suppresses virus replication by selective inhibition of viral DNA synthesis.
CAS No. 113852-37-2
Selleck's Cidofovir has been cited by 8 Publications
2 Customer Reviews
Purity & Quality Control
Choose Selective DNA/RNA Synthesis Inhibitors
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Biological Activity
| Description | Cidofovir (HPMPC) suppresses virus replication by selective inhibition of viral DNA synthesis. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| In vitro |
Cidofovir inhibits human cytomegalovirus (HCMV) infection in cultured cells. Cidofovir is inhibitory to CMV plaque formation even when added to the cells at 48 hr post infection with IC50 of 0.9 μg/mL for Davis and 1.6 μg/mL for AD-169 strains,respectively. [1] Cidofovir also inhibits herpes simplex virus infection. In addition, Cidofovir blocks cell fusion induced by HSV-1 in monkey kidney cells and blocks the expression of HSV-l-specific proteins and the synthesis of viral DNA. [3] |
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| Cell Data |
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| In vivo | Cidofovir (5 mg/kg/day) subcutaneously for 5 days significantly reduces average virus infectivity titer in blood, spleen, lung and salivary gland in infected guinea pigs. Cidofovir significantly reduces lymphocytosis and average tissue indexe of spleen in infected animals. [2]. Cidofovir suppresses all manifestations (skin lesions, paralysis of the hind legs, and mortality) of hairless mice infected intracutaneously with HSV-1 or HSV-2. The most remarkable feature of Cidofovir is that a single administration of the compound, even as late as 4 days after infection, conferees significant protection against HSV-1 or HSV-2 infection. [4] Cidofovir inhibits growth of the highly aggressive melanoma tumor arising from mouse melanoma B16 cells grafted subcutaneously in C57B16/J mice. [5] |
Protocol (from reference)
| References |
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Solubility (25°C)
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In vitro |
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Chemical Information
| Molecular Weight | 279.19 | ||
|---|---|---|---|
| Formula | C8H14N3O6P |
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| CAS No. | 113852-37-2 | ||
| Storage | 3 years | -20°C | powder |
| 2 years | -80°C | in solvent | |
| Smiles | C1=CN(C(=O)N=C1N)CC(CO)OCP(=O)(O)O | ||
In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.
Clinical Trial Information
| NCT Number | Recruitment | Interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|---|
| NCT04542252 | Completed | Drug: SyB V-1901|Drug: Cyclosporine | Drug Drug Interaction | SymBio Pharmaceuticals | November 9 2020 | Phase 1 |
| NCT01610765 | Withdrawn | Drug: Novel Antiviral Drug|Drug: Placebo | Herpes Simplex Virus | University of Alabama at Birmingham | January 2016 | Phase 1|Phase 2 |
| NCT01816646 | Completed | Drug: Cidofovir|Drug: Probenecid | Blood And Marrow Transplantation | M.D. Anderson Cancer Center|Gilead Sciences | September 2013 | Phase 1 |
| NCT00780182 | Completed | Drug: CMX001 | Healthy | Chimerix|National Institutes of Health (NIH) | October 2008 | Phase 1 |
(data from https://clinicaltrials.gov, updated on 2022-08-01)
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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