Cidofovir

Catalog No.S1516 Synonyms: HPMPC

For research use only.

Cidofovir (HPMPC) suppresses virus replication by selective inhibition of viral DNA synthesis.

Cidofovir Chemical Structure

CAS No. 113852-37-2

Selleck's Cidofovir has been cited by 8 Publications

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Biological Activity

Description Cidofovir (HPMPC) suppresses virus replication by selective inhibition of viral DNA synthesis.
In vitro

Cidofovir inhibits human cytomegalovirus (HCMV) infection in cultured cells. Cidofovir is inhibitory to CMV plaque formation even when added to the cells at 48 hr post infection with IC50 of 0.9 μg/mL for Davis and 1.6 μg/mL for AD-169 strains,respectively. [1] Cidofovir also inhibits herpes simplex virus infection. In addition, Cidofovir blocks cell fusion induced by HSV-1 in monkey kidney cells and blocks the expression of HSV-l-specific proteins and the synthesis of viral DNA. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEL cells MmL2SpVv[3Srb36gZZN{[Xl? MojWR49ueG:3bnSge4F{KHSnc4Tl[EBnd3JiYX70bU13cXKjbDDhZ5Rqfmm2eTDh[4FqdnO2IFjTWk0yMEuRUzmgbY4hUEWOIHPlcIx{NCCHQ{WwQVAvPTdizszN MlH6NVQ3PDN|Mki=
MRC-5 cells NXLxbXNtTnWwY4Tpc44h[XO|YYm= M4i0UmlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBkgXSxcHH0bIlkKGWoZnXjeEBw\iCKU2[tNkhGKDF7NDmgbY4hVVKFLUWgZ4VtdHNuIFnDOVA:OTBizszN NUTLeWxyQDZ|MkSzPS=>
NHDF cells M3LDRWZ2dmO2aX;uJIF{e2G7 MYPJcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgdoVxdGmlYYTpc44hd2ZiSFPNWkBqdiCQSFTGJINmdGy|LDDJR|UxRTBwNTFOwG0> NYe3T4RkQDZ|MkSzPS=>
HFF cells NU\CZnkzTnWwY4Tpc44h[XO|YYm= NIfEZ|JCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBX[WOlaX7pZUB3cXK3czDDc5BmdmijZ3XuJIlvKEiIRjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[3m2b4DheIhw\2WwaXPpeJktKEWFNUC9N{4zKM7:TR?= NVfiN4toOTZ4MEOzOVE>
HFF cells MUHGeY5kfGmxbjDhd5NigQ>? MVPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDc5dxd3hidnnyeZMhSnKrZ3j0c44hcW5iSF\GJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCleYTvdIF1cG:pZX7pZ4l1gSxiRVO1NF04NjFizszN MY[xOlYxOzN3MR?=
HFF cells MoK0SpVv[3Srb36gZZN{[Xl? M2XSc2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJZi[2OrbnnhJJZqenW|IFPvdIVvcGGpZX6gcYVie3W{ZXSgZZMh[3m2b4DheIhw\2WwaXPpeJkhcW5iSF\GJINmdGy|LDDFR|UxRTZwOTFOwG0> M2\CZVE3PzJ{NkW3
bone marrow cells M4HYZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> Ml7oR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gZo9v\SCvYYLyc5ch[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDjc4xwdnliZn;ycYlv\yC3bnn0JI9nKGe{YX71cI9kgXSnL33hZ5JweGijZ3WsJGlEPTB;MUCg{txO MkHLNVY5OTR3NEW=
HFF cells Ml;tSpVv[3Srb36gZZN{[Xl? MnzCRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iQ13WJHQzOjRzIHnuJGhHTiClZXzsd{BjgSCVRVHQJIF{e2G7LDDJR|UxRTBwMzFOwG0> MkLONVcxPDNzMki=
MRC5 cells MYTGeY5kfGmxbjDhd5NigQ>? MoDLRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iQ13WJHRwf26nIHnuJG1TSzViY3XscJMh[nliUGLBMEBKSzVyPUCuN{DPxE1? NFjheoUyPzB2M{GyPC=>
UC1B cells NUD6XoNnTnWwY4Tpc44h[XO|YYm= Ml7uRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgUZVzcW6nIIDvcJlwdWG4aYL1d{BOVi:URFWgWI9zd262bzDpckBud3W|ZTDVR|FDKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6NCCHQ{WwQVE{KM7:TR?= NU\RUYVlOTd2MkCyNVQ>
african green monkey Vero cells NGHET45HfW6ldHnvckBie3OjeR?= MnW3RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVzeGW|IIPpcZBt\XhidnnyeZMhOSCIIHnu[oVkfGWmIHnuJIFnemmlYX6g[5Jm\W5ibX;ub4V6KF[ncn:gZ4VtdHNiYYPz[ZN{\WRiYYOgdIxieXWnIILl[JVkfGmxbjDh[pRmeiB|NjD0c{A1QCCqcoOsJGVEPTB;MUSuOEDPxE1? NU\lTWFMOTd2M{iwOlE>
HEL cells MnPwSpVv[3Srb36gZZN{[Xl? MUCzJIRigXN? NInYXJlCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFHENVY6KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBi\nSncjCzJIRigXNuIFXDOVA:OC52MTFOwG0> MnnoNVc6PjF6NUG=
HEL cells NGjCR2hHfW6ldHnvckBie3OjeR?= MUizJIRigXN? M2XiR2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIFnfGW{IEOg[IF6eyxiRVO1NF0xNjRzIN88US=> NXzlbXR{OTd7NkG4OVE>
HFF cells NILOSZlHfW6ldHnvckBie3OjeR?= M3\ZXGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDDUXYhXDJ{MUGgbY5n\WO2ZXSgbY4hUE[IIHPlcIx{KGK7IGPFRXAhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjJ{IN88US=> NVrPdowyOTd5MEm0Olg>
HEL cells NHTUdW1HfW6ldHnvckBie3OjeR?= M{HMTGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIdidmOrY3zveolzNXKnc3nzeIFvfCCKQ13WJGFFOTZ7IHPsc45mKDRiaX7m[YN1\WRiaX6gTGVNKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5MEBGSzVyPUCuO|Qh|ryP NVnoRYhlOTl{Mk[xOFA>
HEL cells NI\xXG1HfW6ldHnvckBie3OjeR?= MWHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKESjdnnzJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTDh[pRmeiB5IHThfZMheG:|dHnu[oVkfGmxbjygSWM2OD1yLkWg{txO MlqzNVkzOjZzNEC=
HEL cells NWfHXFRITnWwY4Tpc44h[XO|YYm= M{C2XGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiQVSxOlkhcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5JIFnfGW{IEeg[IF6eyCyb4P0bY5n\WO2aX;uMEBGSzVyPUCuN{DPxE1? Mk\INVkzOjZzNEC=
HEL cells NXS5V|RWTnWwY4Tpc44h[XO|YYm= M{HNbWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIZwe2Ojcn7leE1z\XOrc4ThcpQhUEOPVjDBSFE3QSClbH;u[UBEKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygTWM2OD1yLkC0OUDPxE1? NGrEW2EyQTJ{NkG0NC=>
HFF NXG2TGZYWHKxbHnm[ZJifGmxbjDhd5NigQ>? NUDaeGdPOyCmYYnz NF7LNG5CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGhHTiCjZoTldkA{KGSjeYOgZpkh[2:3bITldkBkd3WwdHXyJIF{e2G7LDDFR|UxRTFwOTFOwG0> NXjWeJZ4OTlyMkmzNlI>
HeLaS3 cells M4HMcWZ2dmO2aX;uJIF{e2G7 NXnBNoJMOy13IHThfZM> NG\ieZpCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBX[WOlaX7pZUB3cXK3czDJTGQuUiCDVFPDJHZTNTF3NjDpcoZm[3SnZDDpckBJ\UyjU{OgZ4VtdHNiYX\0[ZIhOyC2bzC1JIRigXNiYomgdIxieXWnIHHzd4F6NCCHQ{WwQVE5Njd2IN88US=> MkTENVg5PTJ{N{G=
HSB2 cells MVPGeY5kfGmxbjDhd5NigQ>? MYW3JIRigXN? M3;BUmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHjldpBme3[rcoXzJFYhT1NiaX7m[YN1\WRiaX6gbJVu[W5iSGPCNkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiC4aYLhcEBFVkFiYXPjeY12dGG2aX;uJIFnfGW{IEeg[IF6eyxiRVO1NF0zNjdizszN NV\ydXNQOTl5N{CyO|Q>
A549 cells MkfsSpVv[3Srb36gZZN{[Xl? M1nZXWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHHk[Y5wfmm{dYOgeJlx\SBzMYCgd4xw[mm2c3vpJIlv\mWldHXkJIlvKEF3NEmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCGTlGgdoVxdGmlYYTpc44h[nliUWDDVkBie3OjeTygSWM2OD1zNj61JO69VQ>? MnnhNlA2QDVzMUK=
HFF cells M1jSRmZ2dmO2aX;uJIF{e2G7 MVrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDc5dxd3hidnnyeZMhMEK{aXfoeI9vKFKnZDmgbY5n\WO2ZXSgbY4hcHWvYX6gTGZHKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJidC2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGK7IH7leZRz[WxicnXkJJVxfGGtZTDhd5NigSxiRVO1NF03NjdizszN MlO2NlE{PzZ2Mkm=
In vivo Cidofovir (5 mg/kg/day) subcutaneously for 5 days significantly reduces average virus infectivity titer in blood, spleen, lung and salivary gland in infected guinea pigs. Cidofovir significantly reduces lymphocytosis and average tissue indexe of spleen in infected animals. [2]. Cidofovir suppresses all manifestations (skin lesions, paralysis of the hind legs, and mortality) of hairless mice infected intracutaneously with HSV-1 or HSV-2. The most remarkable feature of Cidofovir is that a single administration of the compound, even as late as 4 days after infection, conferees significant protection against HSV-1 or HSV-2 infection. [4] Cidofovir inhibits growth of the highly aggressive melanoma tumor arising from mouse melanoma B16 cells grafted subcutaneously in C57B16/J mice. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 279.19
Formula

C8H14N3O6P

CAS No. 113852-37-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CN(C(=O)N=C1N)CC(CO)OCP(=O)(O)O

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04542252 Completed Drug: SyB V-1901|Drug: Cyclosporine Drug Drug Interaction SymBio Pharmaceuticals November 9 2020 Phase 1
NCT01610765 Withdrawn Drug: Novel Antiviral Drug|Drug: Placebo Herpes Simplex Virus University of Alabama at Birmingham January 2016 Phase 1|Phase 2
NCT01816646 Completed Drug: Cidofovir|Drug: Probenecid Blood And Marrow Transplantation M.D. Anderson Cancer Center|Gilead Sciences September 2013 Phase 1
NCT00780182 Completed Drug: CMX001 Healthy Chimerix|National Institutes of Health (NIH) October 2008 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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