Cidofovir

Catalog No.S1516 Synonyms: HPMPC

Cidofovir Chemical Structure

Molecular Weight(MW): 279.19

Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.

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2 Customer Reviews

  • The copy numbers of the intracellular viral DNA were directly extracted from cells and were quantified by qPCR using primers specific for the KSHV ORF73 gene. Then each sample was normalized to the amount of the GAPDH gene (C), CDV (20 µM) was used as a positive control. CDV:Cidofovir.

    Viruses 2015, 7, 2268-2287. . Cidofovir purchased from Selleck.

    Triptolide reduces lytic and latent replication of KSHV in BCBL-1 cells. Uninduced and induced BCBL-1 cells were treated with vehicle control or indicated concentrations of triptolide for 48 h. The whole cell supernatants, genomic DNA and lysates were prepared. (A) The copy numbers of the intracellular viral DNA were quantified by qRT-PCR, each sample was normalized to the amount of the GAPDH gene. *p<0.05, compared to control.

    Int J Oncol, 2016, 48(4):1519-30. . Cidofovir purchased from Selleck.

Purity & Quality Control

Choose Selective DNA/RNA Synthesis Inhibitors

Biological Activity

Description Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.
In vitro

Cidofovir inhibits human cytomegalovirus (HCMV) infection in cultured cells. Cidofovir is inhibitory to CMV plaque formation even when added to the cells at 48 hr post infection with IC50 of 0.9 μg/mL for Davis and 1.6 μg/mL for AD-169 strains,respectively. [1] Cidofovir also inhibits herpes simplex virus infection. In addition, Cidofovir blocks cell fusion induced by HSV-1 in monkey kidney cells and blocks the expression of HSV-l-specific proteins and the synthesis of viral DNA. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEL cells NFrRWWlHfW6ldHnvckBie3OjeR?= NGX6PXNEd22yb4Xu[EB4[XNidHXzeIVlKG[xcjDhcpRqNX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHNXNTFqS1;TLUBqdiCKRVygZ4VtdHNuIFXDOVA:OC53NzFOwG0> NGLDdXgyPDZ2M{OyPC=>
MRC-5 cells NEfRRo5HfW6ldHnvckBie3OjeR?= NG\z[IlKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5Qh[3m2b4DheIhq[yCnZn\lZ5Qhd2ZiSGPWMVIpTSBzOUSpJIlvKE2UQz21JINmdGy|LDDJR|UxRTFyIN88US=> NHzI[Xc5PjN{NEO5
NHDF cells M{mzWWZ2dmO2aX;uJIF{e2G7 NGPTVYFKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhemWybHnjZZRqd25ib3[gTGNOXiCrbjDOTGRHKGOnbHzzMEBKSzVyPUCuOUDPxE1? MnHSPFY{OjR|OR?=
HFF cells NEPpWmNHfW6ldHnvckBie3OjeR?= MXfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDWZYNkcW6rYTD2bZJ2eyCFb4Dlcohi\2WwIHnuJGhHTiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ5l1d3CjdHjv[4VvcWOrdImsJGVEPTB;Mz6yJO69VQ>? NUDNelEzOTZ4MEOzOVE>
HFF cells MoL2SpVv[3Srb36gZZN{[Xl? NI\KTGxCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEd3eyb4igeolzfXNiQoLp[4h1d25iaX6gTGZHKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDjfZRweGG2aH;n[Y5q[2m2eTygSWM2OD15LkGg{txO NWTCWo5tOTZ4MEOzOVE>
HFF cells NGHwU3pHfW6ldHnvckBie3OjeR?= NWL5b|M1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhfmGlY3nubYEhfmm{dYOgR49x\W6qYXflckBu\WG|dYLl[EBieyCleYTvdIF1cG:pZX7pZ4l1gSCrbjDISmYh[2WubIOsJGVEPTB;Nj65JO69VQ>? NFzoZ3kyPjd{Mk[1Oy=>
bone marrow cells MYnDfZRwfG:6aXPpeJkh[XO|YYm= MlO4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gZo9v\SCvYYLyc5ch[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDjc4xwdnliZn;ycYlv\yC3bnn0JI9nKGe{YX71cI9kgXSnL33hZ5JweGijZ3WsJGlEPTB;MUCg{txO MXuxOlgyPDV2NR?=
HFF cells MWTGeY5kfGmxbjDhd5NigQ>? NYHDbJg6SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gR21XKFR{MkSxJIlvKEiIRjDj[YxteyCkeTDTSWFRKGG|c3H5MEBKSzVyPUCuN{DPxE1? M4nkWVE4ODR|MUK4
MRC5 cells MX7GeY5kfGmxbjDhd5NigQ>? MoPJRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTJVu[W5iQ13WJHRwf26nIHnuJG1TSzViY3XscJMh[nliUGLBMEBKSzVyPUCuN{DPxE1? NGryT4syPzB2M{GyPC=>
UC1B cells MoPBSpVv[3Srb36gZZN{[Xl? MoPiRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgUZVzcW6nIIDvcJlwdWG4aYL1d{BOVi:URFWgWI9zd262bzDpckBud3W|ZTDVR|FDKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6NCCHQ{WwQVE{KM7:TR?= NWTpc4x[OTd2MkCyNVQ>
african green monkey Vero cells NFrjV2tHfW6ldHnvckBie3OjeR?= NWniclNDSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGW{cHXzJJNqdXCuZYigeolzfXNiMTDGJIlv\mWldHXkJIlvKGGocnnjZY4h\3KnZX6gcY9vc2W7IG\ldo8h[2WubIOgZZN{\XO|ZXSgZZMheGyjcYXlJJJm\HWldHnvckBi\nSncjCzOkB1dyB2ODDodpMtKEWFNUC9NVQvPCEQvF2= NEe3S5QyPzR|OEC2NS=>
HEL cells NInHco1HfW6ldHnvckBie3OjeR?= MX6zJIRigXN? NU\h[3MySW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDBSFE3QSCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkh[W[2ZYKgN{Bl[Xm|LDDFR|UxRTBwNEGg{txO M3jINlE4QTZzOEWx
HEL cells NYLscHRGTnWwY4Tpc44h[XO|YYm= MX2zJIRigXN? NIrEfpFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFTheol{KGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBi\nSncjCzJIRigXNuIFXDOVA:OC52MTFOwG0> NXrUfZBNOTd7NkG4OVE>
HFF cells NEfZVmVHfW6ldHnvckBie3OjeR?= Mn3uRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFPNWkBVOjJzMTDpcoZm[3SnZDDpckBJTkZiY3XscJMh[nliU1XBVEBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVAvOjJizszN MYOxO|cxQTR4OB?=
HEL cells NYOxXZlOTnWwY4Tpc44h[XO|YYm= Ml\pRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sg[4Fv[2mlbH;2bZIuemW|aYP0ZY51KEiFTW[gRWQyPjliY3zvcoUhPCCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImsJGVEPTB;MD63OEDPxE1? M{nITlE6OjJ4MUSw
HEL cells MmHXSpVv[3Srb36gZZN{[Xl? M{f4[GFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiRHH2bZMhcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5JIFnfGW{IEeg[IF6eyCyb4P0bY5n\WO2aX;uMEBGSzVyPUCuOUDPxE1? NUfY[5hHOTl{Mk[xOFA>
HEL cells M1;oV2Z2dmO2aX;uJIF{e2G7 M2Owe2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiQVSxOlkhcW6oZXP0[YQhcW5iaIXtZY4hUEWOIHPlcIx{KGG|c3Xzd4VlKGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlaYT5JIFnfGW{IEeg[IF6eyCyb4P0bY5n\WO2aX;uMEBGSzVyPUCuN{DPxE1? NFTJN5gyQTJ{NkG0NC=>
HEL cells M{m3XmZ2dmO2aX;uJIF{e2G7 M{XMZmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIZwe2Ojcn7leE1z\XOrc4ThcpQhUEOPVjDBSFE3QSClbH;u[UBEKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygTWM2OD1yLkC0OUDPxE1? MUSxPVIzPjF2MB?=
HFF MXLQdo9tcW[ncnH0bY9vKGG|c3H5 NXS0c2tbOyCmYYnz NG[zOVhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGhHTiCjZoTldkA{KGSjeYOgZpkh[2:3bITldkBkd3WwdHXyJIF{e2G7LDDFR|UxRTFwOTFOwG0> MlLWNVkxOjl|MkK=
HeLaS3 cells NVrCU25vTnWwY4Tpc44h[XO|YYm= M2\rdlMuPSCmYYnz NYrpRYZtSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhXmGlY3nubYEhfmm{dYOgTWhFNUpiQWTDR{BXWi1zNU[gbY5n\WO2ZXSgbY4hUGWOYWOzJINmdGy|IHHmeIVzKDNidH:gOUBl[Xm|IHL5JJBt[XG3ZTDhd5NigSxiRVO1NF0yQC55NDFOwG0> MoO3NVg5PTJ{N{G=
HSB2 cells MWLGeY5kfGmxbjDhd5NigQ>? M17XRVch\GG7cx?= NWXQZ|dKSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gbIVzeGW|dnnyeZMhPiCJUzDpcoZm[3SnZDDpckBpfW2jbjDIV2IzKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwII\pdoFtKESQQTDhZ4N2dXWuYYTpc44h[W[2ZYKgO{Bl[Xm|LDDFR|UxRTJwNzFOwG0> MlPnNVk4PzB{N{S=
A549 cells MknsSpVv[3Srb36gZZN{[Xl? M3rkd2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHHk[Y5wfmm{dYOgeJlx\SBzMYCgd4xw[mm2c3vpJIlv\mWldHXkJIlvKEF3NEmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCGTlGgdoVxdGmlYYTpc44h[nliUWDDVkBie3OjeTygSWM2OD1zNj61JO69VQ>? M2Pj[FIxPTh3MUGy
HFF cells MWXGeY5kfGmxbjDhd5NigQ>? MmXJRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR494eG:6II\pdpV{KCiEcnnnbJRwdiCUZXSpJIlv\mWldHXkJIlvKGi3bXHuJGhHTiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolz[WxvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCkeTDu[ZV1emGuIILl[EB2eHSja3WgZZN{[XluIFXDOVA:Pi55IN88US=> NVvvU241OjF|N{[0Nlk>

... Click to View More Cell Line Experimental Data

In vivo Cidofovir (5 mg/kg/day) subcutaneously for 5 days significantly reduces average virus infectivity titer in blood, spleen, lung and salivary gland in infected guinea pigs. Cidofovir significantly reduces lymphocytosis and average tissue indexe of spleen in infected animals. [2]. Cidofovir suppresses all manifestations (skin lesions, paralysis of the hind legs, and mortality) of hairless mice infected intracutaneously with HSV-1 or HSV-2. The most remarkable feature of Cidofovir is that a single administration of the compound, even as late as 4 days after infection, conferees significant protection against HSV-1 or HSV-2 infection. [4] Cidofovir inhibits growth of the highly aggressive melanoma tumor arising from mouse melanoma B16 cells grafted subcutaneously in C57B16/J mice. [5]

Protocol

Solubility (25°C)

In vitro Water 12 mg/mL (42.98 mM)
DMSO 2 mg/mL (7.16 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 279.19
Formula

C8H14N3O6P

CAS No. 113852-37-2
Storage powder
in solvent
Synonyms HPMPC

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03532035 Not yet recruiting Adenovirus Chimerix August 30 2018 Phase 2
NCT02931539 Recruiting Cytomegalovirus (CMV) Shire December 29 2016 Phase 3
NCT02567149 Withdrawn Warts University of Minnesota - Clinical and Translational Science Institute June 2016 Phase 2
NCT02555800 Unknown status Recurrent Respiratory Papillomatosis Centro de Investigación en. Enfermedades Infecciosas Mexico December 2014 Phase 2
NCT01816646 Completed Blood And Marrow Transplantation M.D. Anderson Cancer Center|Gilead Sciences September 2013 Phase 1
NCT01946009 Completed HIV Fundacion SEIMC-GESIDA September 2013 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID