Cidofovir

For research use only.

Catalog No.S1516 Synonyms: HPMPC

8 publications

Cidofovir Chemical Structure

CAS No. 113852-37-2

Cidofovir (HPMPC) suppresses virus replication by selective inhibition of viral DNA synthesis.

Selleck's Cidofovir has been cited by 8 publications

2 Customer Reviews

  • The copy numbers of the intracellular viral DNA were directly extracted from cells and were quantified by qPCR using primers specific for the KSHV ORF73 gene. Then each sample was normalized to the amount of the GAPDH gene (C), CDV (20 µM) was used as a positive control. CDV:Cidofovir.

    Viruses 2015, 7, 2268-2287. . Cidofovir purchased from Selleck.

    Triptolide reduces lytic and latent replication of KSHV in BCBL-1 cells. Uninduced and induced BCBL-1 cells were treated with vehicle control or indicated concentrations of triptolide for 48 h. The whole cell supernatants, genomic DNA and lysates were prepared. (A) The copy numbers of the intracellular viral DNA were quantified by qRT-PCR, each sample was normalized to the amount of the GAPDH gene. *p<0.05, compared to control.

    Int J Oncol, 2016, 48(4):1519-30. . Cidofovir purchased from Selleck.

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Biological Activity

Description Cidofovir (HPMPC) suppresses virus replication by selective inhibition of viral DNA synthesis.
In vitro

Cidofovir inhibits human cytomegalovirus (HCMV) infection in cultured cells. Cidofovir is inhibitory to CMV plaque formation even when added to the cells at 48 hr post infection with IC50 of 0.9 μg/mL for Davis and 1.6 μg/mL for AD-169 strains,respectively. [1] Cidofovir also inhibits herpes simplex virus infection. In addition, Cidofovir blocks cell fusion induced by HSV-1 in monkey kidney cells and blocks the expression of HSV-l-specific proteins and the synthesis of viral DNA. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEL cells MVXGeY5kfGmxbjDhd5NigQ>? NXvrUJZ1S2:vcH;1coQhf2G|IITld5Rm\CCob4KgZY51cS24aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXi1zKFvPV{khcW5iSFXMJINmdGy|LDDFR|UxRTBwNUeg{txO M3HJPVE1PjR|M{K4
MRC-5 cells NHv4NW1HfW6ldHnvckBie3OjeR?= M3LmUGlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBkgXSxcHH0bIlkKGWoZnXjeEBw\iCKU2[tNkhGKDF7NDmgbY4hVVKFLUWgZ4VtdHNuIFnDOVA:OTBizszN NH;1dIg5PjN{NEO5
NHDF cells M2jaSWZ2dmO2aX;uJIF{e2G7 MonzTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JJJmeGyrY3H0bY9vKG:oIFjDUXYhcW5iTljESkBk\WyuczygTWM2OD1yLkWg{txO MYi4OlMzPDN7
HFF cells MWrGeY5kfGmxbjDhd5NigQ>? MkW5RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgWoFk[2mwaXGgeolzfXNiQ3;w[Y5p[WenbjDpckBJTkZiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJIN6fG:yYYToc4dmdmmlaYT5MEBGSzVyPUOuNkDPxE1? M{DhclE3PjB|M{Wx
HFF cells M2PH[2Z2dmO2aX;uJIF{e2G7 MV;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDc5dxd3hidnnyeZMhSnKrZ3j0c44hcW5iSF\GJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCleYTvdIF1cG:pZX7pZ4l1gSxiRVO1NF04NjFizszN MVWxOlYxOzN3MR?=
HFF cells M4LQbmZ2dmO2aX;uJIF{e2G7 MlfrRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgeoFk[2mwaXGgeolzfXNiQ3;w[Y5p[WenbjDt[YF{fXKnZDDhd{BkgXSxcHH0bI9o\W6rY3n0fUBqdiCKRl[gZ4VtdHNuIFXDOVA:Pi57IN88US=> NUXvSXZiOTZ5MkK2OVc>
bone marrow cells NX2xXVl7S3m2b4TvfIlkcXS7IHHzd4F6 MmjyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gZo9v\SCvYYLyc5ch[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDjc4xwdnliZn;ycYlv\yC3bnn0JI9nKGe{YX71cI9kgXSnL33hZ5JweGijZ3WsJGlEPTB;MUCg{txO MYWxOlgyPDV2NR?=
HFF cells M4racmZ2dmO2aX;uJIF{e2G7 NVu2VHRESW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gR21XKFR{MkSxJIlvKEiIRjDj[YxteyCkeTDTSWFRKGG|c3H5MEBKSzVyPUCuN{DPxE1? MkXXNVcxPDNzMki=
MRC5 cells NWnvOoNjTnWwY4Tpc44h[XO|YYm= NWDnXFFkSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gR21XKFSxd37lJIlvKE2UQ{WgZ4VtdHNiYomgVHJCNCCLQ{WwQVAvOyEQvF2= NEHidnYyPzB2M{GyPC=>
UC1B cells NF21NXJHfW6ldHnvckBie3OjeR?= NYWxXpQ3SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhVXW{aX7lJJBwdHmxbXH2bZJ2eyCPTj;SSGUhXG:{b370c{BqdiCvb4Xz[UBWSzGEIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7LDDFR|UxRTF|IN88US=> NIPjSFEyPzR{MEKxOC=>
african green monkey Vero cells NFjMT3dHfW6ldHnvckBie3OjeR?= M4jre2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDFiRjDpcoZm[3SnZDDpckBi\nKrY3HuJIdz\WWwIH3vcotmgSCYZYLvJINmdGy|IHHzd4V{e2WmIHHzJJBt[XG3ZTDy[YR2[3Srb36gZYZ1\XJiM{[geI8hPDhiaILzMEBGSzVyPUG0MlQh|ryP NVf2UYl6OTd2M{iwOlE>
HEL cells M3\0NWZ2dmO2aX;uJIF{e2G7 NFv2WHM{KGSjeYO= NVTpOoJbSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOPVjDBSFE3QSCrbn\lZ5Rm\CCrbjDISWwh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkh[W[2ZYKgN{Bl[Xm|LDDFR|UxRTBwNEGg{txO M1uxO|E4QTZzOEWx
HEL cells MmTJSpVv[3Srb36gZZN{[Xl? M3;WVFMh\GG7cx?= MlLuRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCGYY\pd{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgZYZ1\XJiMzDkZZl{NCCHQ{WwQVAvPDFizszN M3rRelE4QTZzOEWx
HFF cells MW\GeY5kfGmxbjDhd5NigQ>? M2DmW2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGN6fG:vZXfhcI93cXK3czDDUXYhXDJ{MUGgbY5n\WO2ZXSgbY4hUE[IIHPlcIx{KGK7IGPFRXAhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjJ{IN88US=> MVuxO|cxQTR4OB?=
HEL cells MXPGeY5kfGmxbjDhd5NigQ>? NIe0OI1CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBo[W6laXPsc5Zqei2{ZYPpd5RidnRiSFPNWkBCTDF4OTDjcI9v\SB2IHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUwhTUN3ME2wMlc1KM7:TR?= M2e5WVE6OjJ4MUSw
HEL cells M{\iVWZ2dmO2aX;uJIF{e2G7 MXHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIR21XKESjdnnzJIlv\mWldHXkJIlvKGi3bXHuJGhGVCClZXzsd{Bie3Onc4Pl[EBqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTDh[pRmeiB5IHThfZMheG:|dHnu[oVkfGmxbjygSWM2OD1yLkWg{txO NVG0XHdNOTl{Mk[xOFA>
HEL cells MVjGeY5kfGmxbjDhd5NigQ>? NGXqTmZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS02YIFHENVY6KGmwZnXjeIVlKGmwIHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUBi\nSncjC3JIRigXNicH;zeIlv\mWldHnvckwhTUN3ME2wMlMh|ryP NXzYVXFJOTl{Mk[xOFA>
HEL cells MXvGeY5kfGmxbjDhd5NigQ>? MUPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDmc5Nk[XKwZYStdoV{cXO2YX70JGhEVVZiQVSxOlkh[2yxbnWgR{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYNqfHluIFnDOVA:OC5yNEWg{txO MlLWNVkzOjZzNEC=
HFF NXjFVFNuWHKxbHnm[ZJifGmxbjDhd5NigQ>? M3fUSlMh\GG7cx?= M{jsZmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgTGZHKGGodHXyJFMh\GG7czDifUBkd3WudHXyJINwfW62ZYKgZZN{[XluIFXDOVA:OS57IN88US=> M1HweVE6ODJ7M{Ky
HeLaS3 cells MXPGeY5kfGmxbjDhd5NigQ>? NHrQWJU{NTViZHH5dy=> NWTTfWk4SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhXmGlY3nubYEhfmm{dYOgTWhFNUpiQWTDR{BXWi1zNU[gbY5n\WO2ZXSgbY4hUGWOYWOzJINmdGy|IHHmeIVzKDNidH:gOUBl[Xm|IHL5JJBt[XG3ZTDhd5NigSxiRVO1NF0yQC55NDFOwG0> NIHRUXQyQDh3MkK3NS=>
HSB2 cells MXzGeY5kfGmxbjDhd5NigQ>? M1XYS|ch\GG7cx?= MV\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCqZYLw[ZN3cXK3czC2JGdUKGmwZnXjeIVlKGmwIHj1cYFvKEiVQkKgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hfmm{YXygSG5CKGGlY4XteYxifGmxbjDh[pRmeiB5IHThfZMtKEWFNUC9Nk44KM7:TR?= NVnqXGhLOTl5N{CyO|Q>
A549 cells M2XIbmZ2dmO2aX;uJIF{e2G7 MX\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCjZHXuc5ZqenW|IIT5dIUhOTGyIIPsc4JqfHOtaTDpcoZm[3SnZDDpckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhTE6DIILldIxq[2G2aX;uJIJ6KFGSQ2KgZZN{[XluIFXDOVA:OTZwNTFOwG0> MlX2NlA2QDVzMUK=
HFF cells M2Hlc2Z2dmO2aX;uJIF{e2G7 NGrMfZBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEd3eyb4igeolzfXNiKFLybYdpfG:wIGLl[EkhcW6oZXP0[YQhcW5iaIXtZY4hUE[IIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB3cXKjbD3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IHL5JI5mfXS{YXygdoVlKHWydHHr[UBie3OjeTygSWM2OD14Lkeg{txO NYr0[4pZOjF|N{[0Nlk>

... Click to View More Cell Line Experimental Data

In vivo Cidofovir (5 mg/kg/day) subcutaneously for 5 days significantly reduces average virus infectivity titer in blood, spleen, lung and salivary gland in infected guinea pigs. Cidofovir significantly reduces lymphocytosis and average tissue indexe of spleen in infected animals. [2]. Cidofovir suppresses all manifestations (skin lesions, paralysis of the hind legs, and mortality) of hairless mice infected intracutaneously with HSV-1 or HSV-2. The most remarkable feature of Cidofovir is that a single administration of the compound, even as late as 4 days after infection, conferees significant protection against HSV-1 or HSV-2 infection. [4] Cidofovir inhibits growth of the highly aggressive melanoma tumor arising from mouse melanoma B16 cells grafted subcutaneously in C57B16/J mice. [5]

Protocol

Solubility (25°C)

In vitro Water 12 mg/mL (42.98 mM)
DMSO 2 mg/mL (7.16 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 279.19
Formula

C8H14N3O6P

CAS No. 113852-37-2
Storage powder
in solvent
Synonyms HPMPC
Smiles C1=CN(C(=O)N=C1N)CC(CO)OCP(=O)(O)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04542252 Completed Drug: SyB V-1901|Drug: Cyclosporine Drug Drug Interaction SymBio Pharmaceuticals November 9 2020 Phase 1
NCT01610765 Withdrawn Drug: Novel Antiviral Drug|Drug: Placebo Herpes Simplex Virus University of Alabama at Birmingham January 2016 Phase 1|Phase 2
NCT01816646 Completed Drug: Cidofovir|Drug: Probenecid Blood And Marrow Transplantation M.D. Anderson Cancer Center|Gilead Sciences September 2013 Phase 1
NCT00780182 Completed Drug: CMX001 Healthy Chimerix|National Institutes of Health (NIH) October 2008 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID