Cidofovir

Catalog No.S1516 Synonyms: HPMPC

Cidofovir Chemical Structure

Molecular Weight(MW): 279.19

Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.

Size Price Stock Quantity  
USD 97 In stock
USD 270 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Cited by 5 Publications

2 Customer Reviews

  • The copy numbers of the intracellular viral DNA were directly extracted from cells and were quantified by qPCR using primers specific for the KSHV ORF73 gene. Then each sample was normalized to the amount of the GAPDH gene (C), CDV (20 µM) was used as a positive control. CDV:Cidofovir.

    Viruses 2015, 7, 2268-2287. . Cidofovir purchased from Selleck.

    Triptolide reduces lytic and latent replication of KSHV in BCBL-1 cells. Uninduced and induced BCBL-1 cells were treated with vehicle control or indicated concentrations of triptolide for 48 h. The whole cell supernatants, genomic DNA and lysates were prepared. (A) The copy numbers of the intracellular viral DNA were quantified by qRT-PCR, each sample was normalized to the amount of the GAPDH gene. *p<0.05, compared to control.

    Int J Oncol, 2016, 48(4):1519-30. . Cidofovir purchased from Selleck.

Purity & Quality Control

Choose Selective DNA/RNA Synthesis Inhibitors

Biological Activity

Description Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.
In vitro

Cidofovir inhibits human cytomegalovirus (HCMV) infection in cultured cells. Cidofovir is inhibitory to CMV plaque formation even when added to the cells at 48 hr post infection with IC50 of 0.9 μg/mL for Davis and 1.6 μg/mL for AD-169 strains,respectively. [1] Cidofovir also inhibits herpes simplex virus infection. In addition, Cidofovir blocks cell fusion induced by HSV-1 in monkey kidney cells and blocks the expression of HSV-l-specific proteins and the synthesis of viral DNA. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEL cells M{DMO2Z2dmO2aX;uJIF{e2G7 NYK3[ZZFS2:vcH;1coQhf2G|IITld5Rm\CCob4KgZY51cS24aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhUXi1zKFvPV{khcW5iSFXMJINmdGy|LDDFR|UxRTBwNUeg{txO NFr4Z44yPDZ2M{OyPC=>
MRC-5 cells NHrLblVHfW6ldHnvckBie3OjeR?= MkGxTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JIN6fG:yYYTobYMh\W[oZXP0JI9nKEiVVj2yLGUhOTl2KTDpckBOWkNvNTDj[YxteyxiSVO1NF0yOCEQvF2= NIDWT5o5PjN{NEO5
NHDF cells NH\oS5RHfW6ldHnvckBie3OjeR?= M1HOZ2lvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBz\XCuaXPheIlwdiCxZjDIR21XKGmwIF7ISGYh[2WubIOsJGlEPTB;MD61JO69VQ>? MoHUPFY{OjR|OR?=
HFF cells NFTHc|dHfW6ldHnvckBie3OjeR?= M{LnWmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JHZi[2OrbnnhJJZqenW|IFPvdIVvcGGpZX6gbY4hUE[IIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBkgXSxcHH0bI9o\W6rY3n0fUwhTUN3ME2zMlIh|ryP MknDNVY3ODN|NUG=
HFF cells NXi0N|JUTnWwY4Tpc44h[XO|YYm= MV3BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDc5dxd3hidnnyeZMhSnKrZ3j0c44hcW5iSF\GJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCleYTvdIF1cG:pZX7pZ4l1gSxiRVO1NF04NjFizszN NIexR3QyPjZyM{O1NS=>
HFF cells MkCzSpVv[3Srb36gZZN{[Xl? M1LLdGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JJZi[2OrbnnhJJZqenW|IFPvdIVvcGGpZX6gcYVie3W{ZXSgZZMh[3m2b4DheIhw\2WwaXPpeJkhcW5iSF\GJINmdGy|LDDFR|UxRTZwOTFOwG0> M1f2NFE3PzJ{NkW3
bone marrow cells MUXDfZRwfG:6aXPpeJkh[XO|YYm= NXjHWnV7S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4h[m:wZTDtZZJzd3diY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBkd2yxbomg[o9zdWmwZzD1col1KG:oIHfyZY52dG:leYTlM41i[3KxcHjh[4UtKEmFNUC9NVAh|ryP NHHsSGQyPjhzNEW0OS=>
HFF cells MkizSpVv[3Srb36gZZN{[Xl? M{HWZ2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIFPNWkBVOjJ2MTDpckBJTkZiY3XscJMh[nliU1XBVEBie3OjeTygTWM2OD1yLkOg{txO MYOxO|A1OzF{OB?=
MRC5 cells NEXnOFJHfW6ldHnvckBie3OjeR?= MWLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIeY1idiCFTW[gWI94dmViaX6gUXJEPSClZXzsd{BjgSCSUlGsJGlEPTB;MD6zJO69VQ>? NWGyPFViOTdyNEOxNlg>
UC1B cells NXnRT2pDTnWwY4Tpc44h[XO|YYm= MmrDRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgUZVzcW6nIIDvcJlwdWG4aYL1d{BOVi:URFWgWI9zd262bzDpckBud3W|ZTDVR|FDKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6NCCHQ{WwQVE{KM7:TR?= Mo\ZNVc1OjB{MUS=
african green monkey Vero cells M1nEVWZ2dmO2aX;uJIF{e2G7 M1TGVWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDzbY1xdGW6II\pdpV{KDFiRjDpcoZm[3SnZDDpckBi\nKrY3HuJIdz\WWwIH3vcotmgSCYZYLvJINmdGy|IHHzd4V{e2WmIHHzJJBt[XG3ZTDy[YR2[3Srb36gZYZ1\XJiM{[geI8hPDhiaILzMEBGSzVyPUG0MlQh|ryP MV6xO|Q{QDB4MR?=
HEL cells M2H5bmZ2dmO2aX;uJIF{e2G7 M1m5[lMh\GG7cx?= M1zjS2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiQVSxOlkhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIFnfGW{IEOg[IF6eyxiRVO1NF0xNjRzIN88US=> M{fLSFE4QTZzOEWx
HEL cells NV;RVJp{TnWwY4Tpc44h[XO|YYm= NEHPeIM{KGSjeYO= M4D0WmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEVVZiRHH2bZMhcW6oZXP0[YQhcW5iSFXMJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIFnfGW{IEOg[IF6eyxiRVO1NF0xNjRzIN88US=> M1TLZVE4QTZzOEWx
HFF cells Ml6xSpVv[3Srb36gZZN{[Xl? MoXFRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR5l1d22nZ3Hsc5ZqenW|IFPNWkBVOjJzMTDpcoZm[3SnZDDpckBJTkZiY3XscJMh[nliU1XBVEBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVAvOjJizszN M4XhdFE4PzB7NE[4
HEL cells MofMSpVv[3Srb36gZZN{[Xl? NHm4enhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBo[W6laXPsc5Zqei2{ZYPpd5RidnRiSFPNWkBCTDF4OTDjcI9v\SB2IHnu[oVkfGWmIHnuJGhGVCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUwhTUN3ME2wMlc1KM7:TR?= NUnpeow2OTl{Mk[xOFA>
HEL cells NYjxSFZnTnWwY4Tpc44h[XO|YYm= MkmzRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCGYY\pd{Bqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImgZYZ1\XJiNzDkZZl{KHCxc4TpcoZm[3Srb36sJGVEPTB;MD61JO69VQ>? NEXHdFcyQTJ{NkG0NC=>
HEL cells M1zEeGZ2dmO2aX;uJIF{e2G7 MknrRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNOXiCDREG2PUBqdm[nY4Tl[EBqdiCqdX3hckBJTUxiY3XscJMh[XO|ZYPz[YQhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImgZYZ1\XJiNzDkZZl{KHCxc4TpcoZm[3Srb36sJGVEPTB;MD6zJO69VQ>? Ml:0NVkzOjZzNEC=
HEL cells MkLjSpVv[3Srb36gZZN{[Xl? M2TjOGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIZwe2Ojcn7leE1z\XOrc4ThcpQhUEOPVjDBSFE3QSClbH;u[UBEKGmwZnXjeIVlKGmwIFjFUEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[2m2eTygTWM2OD1yLkC0OUDPxE1? NVHpbXR4OTl{Mk[xOFA>
HFF NGLvWYZRem:uaX\ldoF1cW:wIHHzd4F6 NGToNFE{KGSjeYO= MYnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFjGSkBi\nSncjCzJIRigXNiYomgZ492dHSncjDjc5VvfGW{IHHzd4F6NCCHQ{WwQVEvQSEQvF2= MYGxPVAzQTN{Mh?=
HeLaS3 cells NXe2Z|ZyTnWwY4Tpc44h[XO|YYm= NGHk[FA{NTViZHH5dy=> NWW2WI1{SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhXmGlY3nubYEhfmm{dYOgTWhFNUpiQWTDR{BXWi1zNU[gbY5n\WO2ZXSgbY4hUGWOYWOzJINmdGy|IHHmeIVzKDNidH:gOUBl[Xm|IHL5JJBt[XG3ZTDhd5NigSxiRVO1NF0yQC55NDFOwG0> MUOxPFg2OjJ5MR?=
HSB2 cells M4i2WmZ2dmO2aX;uJIF{e2G7 MnzpO{Bl[Xm| NY\re5Q3SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gbIVzeGW|dnnyeZMhPiCJUzDpcoZm[3SnZDDpckBpfW2jbjDIV2IzKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwII\pdoFtKESQQTDhZ4N2dXWuYYTpc44h[W[2ZYKgO{Bl[Xm|LDDFR|UxRTJwNzFOwG0> MUexPVc4ODJ5NB?=
A549 cells M4nKPGZ2dmO2aX;uJIF{e2G7 NXPCTlNSSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZYRmdm:4aYL1d{B1gXCnIEGxdEB{dG:kaYTzb4khcW6oZXP0[YQhcW5iQUW0PUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFTORUBz\XCuaXPheIlwdiCkeTDRVGNTKGG|c3H5MEBGSzVyPUG2MlUh|ryP NEjhRYszODV6NUGxNi=>
HFF cells NIHve2ZHfW6ldHnvckBie3OjeR?= MmjRRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR494eG:6II\pdpV{KCiEcnnnbJRwdiCUZXSpJIlv\mWldHXkJIlvKGi3bXHuJGhHTiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolz[WxvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCkeTDu[ZV1emGuIILl[EB2eHSja3WgZZN{[XluIFXDOVA:Pi55IN88US=> NGm5bmUzOTN5NkSyPS=>

... Click to View More Cell Line Experimental Data

In vivo Cidofovir (5 mg/kg/day) subcutaneously for 5 days significantly reduces average virus infectivity titer in blood, spleen, lung and salivary gland in infected guinea pigs. Cidofovir significantly reduces lymphocytosis and average tissue indexe of spleen in infected animals. [2]. Cidofovir suppresses all manifestations (skin lesions, paralysis of the hind legs, and mortality) of hairless mice infected intracutaneously with HSV-1 or HSV-2. The most remarkable feature of Cidofovir is that a single administration of the compound, even as late as 4 days after infection, conferees significant protection against HSV-1 or HSV-2 infection. [4] Cidofovir inhibits growth of the highly aggressive melanoma tumor arising from mouse melanoma B16 cells grafted subcutaneously in C57B16/J mice. [5]

Protocol

Solubility (25°C)

In vitro Water 12 mg/mL (42.98 mM)
DMSO 2 mg/mL (7.16 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 279.19
Formula

C8H14N3O6P

CAS No. 113852-37-2
Storage powder
in solvent
Synonyms HPMPC

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01610765 Withdrawn Drug: Novel Antiviral Drug|Drug: Placebo Herpes Simplex Virus University of Alabama at Birmingham January 2016 Phase 1|Phase 2
NCT01816646 Completed Drug: Cidofovir|Drug: Probenecid Blood And Marrow Transplantation M.D. Anderson Cancer Center|Gilead Sciences September 2013 Phase 1
NCT00780182 Completed Drug: CMX001 Healthy Chimerix|National Institutes of Health (NIH) October 2008 Phase 1
NCT00138424 Terminated Drug: Cidofovir|Drug: Placebo BK Virus (Nephropathy) National Institute of Allergy and Infectious Diseases (NIAID) May 2006 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

DNA/RNA Synthesis Signaling Pathway Map

Related DNA/RNA Synthesis Products

Tags: buy Cidofovir | Cidofovir supplier | purchase Cidofovir | Cidofovir cost | Cidofovir manufacturer | order Cidofovir | Cidofovir distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID