Catalog No.S1516 Synonyms: HPMPC
Molecular Weight(MW): 279.19
Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.
2 Customer Reviews
The copy numbers of the intracellular viral DNA were directly extracted from cells and were quantified by qPCR using primers specific for the KSHV ORF73 gene. Then each sample was normalized to the amount of the GAPDH gene (C), CDV (20 µM) was used as a positive control. CDV:Cidofovir.
Viruses 2015, 7, 2268-2287. . Cidofovir purchased from Selleck.
Triptolide reduces lytic and latent replication of KSHV in BCBL-1 cells. Uninduced and induced BCBL-1 cells were treated with vehicle control or indicated concentrations of triptolide for 48 h. The whole cell supernatants, genomic DNA and lysates were prepared. (A) The copy numbers of the intracellular viral DNA were quantified by qRT-PCR, each sample was normalized to the amount of the GAPDH gene. *p<0.05, compared to control.
Int J Oncol, 2016, 48(4):1519-30. . Cidofovir purchased from Selleck.
Purity & Quality Control
Choose Selective DNA/RNA Synthesis Inhibitors
|Description||Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.|
Cidofovir inhibits human cytomegalovirus (HCMV) infection in cultured cells. Cidofovir is inhibitory to CMV plaque formation even when added to the cells at 48 hr post infection with IC50 of 0.9 μg/mL for Davis and 1.6 μg/mL for AD-169 strains,respectively.  Cidofovir also inhibits herpes simplex virus infection. In addition, Cidofovir blocks cell fusion induced by HSV-1 in monkey kidney cells and blocks the expression of HSV-l-specific proteins and the synthesis of viral DNA. 
|In vivo||Cidofovir (5 mg/kg/day) subcutaneously for 5 days significantly reduces average virus infectivity titer in blood, spleen, lung and salivary gland in infected guinea pigs. Cidofovir significantly reduces lymphocytosis and average tissue indexe of spleen in infected animals. . Cidofovir suppresses all manifestations (skin lesions, paralysis of the hind legs, and mortality) of hairless mice infected intracutaneously with HSV-1 or HSV-2. The most remarkable feature of Cidofovir is that a single administration of the compound, even as late as 4 days after infection, conferees significant protection against HSV-1 or HSV-2 infection.  Cidofovir inhibits growth of the highly aggressive melanoma tumor arising from mouse melanoma B16 cells grafted subcutaneously in C57B16/J mice. |
-  Snoeck R, et al, Antimicrob Agents Chemother, 1988, 32(12), 1839-1844.
-  Li SB, et al. Antiviral Res, 1990, 13(5), 237-252.
-  Chatterjee S, et al. Antiviral Res., 1992, 19(3), 181-192.
|In vitro||Water||12 mg/mL (42.98 mM)|
|DMSO||2 mg/mL (7.16 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT01610765||Withdrawn||Drug: Novel Antiviral Drug|Drug: Placebo||Herpes Simplex Virus||University of Alabama at Birmingham||January 2016||Phase 1|Phase 2|
|NCT01816646||Completed||Drug: Cidofovir|Drug: Probenecid||Blood And Marrow Transplantation||M.D. Anderson Cancer Center|Gilead Sciences||September 2013||Phase 1|
|NCT00780182||Completed||Drug: CMX001||Healthy||Chimerix|National Institutes of Health (NIH)||October 2008||Phase 1|
|NCT00138424||Terminated||Drug: Cidofovir|Drug: Placebo||BK Virus (Nephropathy)||National Institute of Allergy and Infectious Diseases (NIAID)||May 2006||Phase 1|Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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