Clonidine HCl

For research use only.

Catalog No.S2458

Clonidine HCl  Chemical Structure

CAS No. 4205-91-8

Clonidine HCl is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 130 In stock
USD 97 In stock
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Biological Activity

Description Clonidine HCl is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.
α2-adrenergic receptor [1]



Solubility (25°C)

In vitro DMSO 53 mg/mL (198.87 mM)
Water 53 mg/mL (198.87 mM)
Ethanol 53 mg/mL (198.87 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 266.5


CAS No. 4205-91-8
Storage powder
in solvent
Synonyms N/A
Smiles C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl.Cl

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03537612 Suspended Drug: Clonidine|Other: Morphine Scoliosis Dr. Jean A. Ouellet MD FRCSC|Shriners Hospitals for Children June 22 2018 Phase 3
NCT03177980 Recruiting Drug: Fentanyl|Drug: Fentanyl and clonidine Asphyxia Neonatorum Region Skane|Lund University|Karolinska Institutet|Helsinki University Central Hospital|Great Ormond Street Hospital for Children NHS Foundation Trust|Örebro University Sweden|The Swedish Research Council|University of Colorado Denver|University of Tartu April 24 2017 --
NCT02466373 Completed Drug: Clonidine (Catapresan®) 0150 mg/ml ampoule 1 ml Delirium|Critical Illness Deventer Ziekenhuis December 2016 Phase 3
NCT02851303 Unknown status Drug: Morphine|Drug: Methadone Neonatal Abstinence Syndrome University of New Mexico October 2016 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Adrenergic Receptor Signaling Pathway Map

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