Clomifene citrate

For research use only.

Catalog No.S2561 Synonyms: NSC 35770

6 publications

Clomifene citrate  Chemical Structure

CAS No. 50-41-9

Clomifene Citrate (NSC 35770) is a selective estrogen receptor modulator, used in the treatment of ovulation induction.

Size Price Stock Quantity  
10mM (1mL in DMSO) GBP 106 In stock
GBP 79 In stock
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Selleck's Clomifene citrate has been cited by 6 publications

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  • (a) Inhibitory activities of IDH1R132H enzyme lead to decreased production of D-2HG in IDH1R132H mutant HT1080 cells after treatment with clomifene for 48 h, and D-2HG was measured by LC/MS method. (b) HT1080 cells were treated for 24 h in the different concentrations of clomifene and then processed for FACS by using Annexin V/propidium iodide staining. (c) Treatment of clomifene significantly reduced methylation levels of histone lysine residues in HT1080 cells. All data are the average of results from triplicate experiments.

    Oncotarget, 2017, 8(27):44255-44265. Clomifene citrate purchased from Selleck.

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Biological Activity

Description Clomifene Citrate (NSC 35770) is a selective estrogen receptor modulator, used in the treatment of ovulation induction.
Estrogen receptor [1]
In vitro

Clomifene competes with [3H]-QNB and [3H]-nitrendipine for their binding to the receptor in the membrane fractions from the urinary bladder and myometrium. [1] Clomifene inhibits estrogen receptors in the hypothalamus, inhibiting negative feedback of estrogen on gonadotropinrelease, leading to up-regulation of the hypothalamic–pituitary–gonadal axis. Clomifene is a mixture of two geometric isomers, enclomifene (E-clomifene) and zuclomifene (Z-clomifene). [2]

In vivo Clomiphene citrate treatment significantly increases the chance of homosexuality and effeminized behavior in male mice. [3]


Solubility (25°C)

In vitro DMSO 120 mg/mL (200.64 mM)
Ethanol 11 mg/mL (18.39 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 598.08


CAS No. 50-41-9
Storage powder
in solvent
Synonyms NSC 35770
Smiles CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O

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Estrogen/progestogen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID