Cediranib Maleate

Catalog No.S5242 Synonyms: AZD-2171 maleate

Cediranib Maleate Chemical Structure

Molecular Weight(MW): 566.58

Cediranib Maleate is the maleate salt of Cediranib, which is a potent inhibitor of VEGFR with IC50 of <1 nM and also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM.

Availability

The item is temporarily out of stock. Please leave your email address and we will inform you when we have it in stock.

Just click the ‘Arrival Notice’ and leave your email address to get 10% off.

Arrival Notice

Purity & Quality Control

Choose Selective VEGFR Inhibitors

Biological Activity

Description Cediranib Maleate is the maleate salt of Cediranib, which is a potent inhibitor of VEGFR with IC50 of <1 nM and also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM.
Targets
VEGFR2/KDR [2]
(HUVECs)
c-Kit [2]
(HUVECs)
c-Kit [2]
(HUVECs)
VEGFR3/FLT4 [2]
(HUVECs)
VEGFR1/FLT1 [2]
(HUVECs)
0.5 nM 2 nM 2 nM <=3 nM 5 nM
In vitro

In recombinant kinase assays, cediranib inhibits VEGFR-1 kinase activity (IC50 = 5 nmol/L) within a similar concentration range to VEGFR-2 and VEGFR-3 (IC50 values of <0.1 and ≤3 nmol/L). It shows selectivity against other kinases. Cediranib has similar potency against c-Kit when compared with VEGFR-2 in phosphorylation assays but less potency against PDGFR-α and PDGFR-β, particularly in a PDGF-AA/PDGFR-α–driven tumor cell proliferation assay. Cediranib is inactive against wild-type Flt-3 (IC50 value >1 μmol/L) and had marginal activity versus FGFR-1 and -4 (IC50 values of 0.35 and 2.17 μmol/L, respectively)[1].

In vivo Phosphorylation of wild-type c-Kit in NCI-H526 tumor xenografts was reduced markedly following oral administration of cediranib (≥1.5 mg/kg/d) to tumor-bearing nude mice[1].

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (176.49 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 566.58
Formula

C25H27FN4O3.C4H4O4

CAS No. 857036-77-2
Storage powder
in solvent
Synonyms AZD-2171 maleate

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03660826 Suspended Endometrial Undifferentiated Carcinoma|Endometrioid Adenocarcinoma|Recurrent Endometrial Serous Adenocarcinoma|Recurrent Uterine Corpus Carcinoma|Stage IV Uterine Corpus Cancer AJCC v7|Stage IVA Uterine Corpus Cancer AJCC v7|Stage IVB Uterine Corpus Cancer AJCC v7 National Cancer Institute (NCI) September 4 2018 Phase 2
NCT03660826 Suspended Endometrial Undifferentiated Carcinoma|Endometrioid Adenocarcinoma|Recurrent Endometrial Serous Adenocarcinoma|Recurrent Uterine Corpus Carcinoma|Stage IV Uterine Corpus Cancer AJCC v7|Stage IVA Uterine Corpus Cancer AJCC v7|Stage IVB Uterine Corpus Cancer AJCC v7 National Cancer Institute (NCI) September 4 2018 Phase 2
NCT02974621 Active not recruiting Recurrent Glioblastoma National Cancer Institute (NCI) September 15 2017 Phase 2
NCT02974621 Active not recruiting Recurrent Glioblastoma National Cancer Institute (NCI) September 15 2017 Phase 2
NCT02899728 Suspended Extensive Stage Lung Small Cell Carcinoma National Cancer Institute (NCI) April 7 2017 Phase 2
NCT02899728 Suspended Extensive Stage Lung Small Cell Carcinoma National Cancer Institute (NCI) April 7 2017 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

VEGFR Signaling Pathway Map

Related VEGFR Products0

Tags: buy Cediranib Maleate | Cediranib Maleate supplier | purchase Cediranib Maleate | Cediranib Maleate cost | Cediranib Maleate manufacturer | order Cediranib Maleate | Cediranib Maleate distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID