Cerdulatinib (PRT062070)

Catalog No.S3566 Synonyms: PRT2070

For research use only.

Cerdulatinib (PRT062070, PRT2070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19 other tested kinases with IC50 less than 200 nM.

Cerdulatinib (PRT062070) Chemical Structure

CAS No. 1198300-79-6

Purity & Quality Control

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Biological Activity

Description Cerdulatinib (PRT062070, PRT2070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19 other tested kinases with IC50 less than 200 nM.
Targets
JAK2 [1]
(Cell-free assay)
JAK3 [1]
(Cell-free assay)
JAK1 [1]
(Cell-free assay)
6 nM 8 nM 12 nM

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 89 mg/mL
(199.75 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 445.54
Formula

C20H27N7O3S

CAS No. 1198300-79-6
Storage 3 years -20°C powder
2 years -80°C in solvent

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04103060 Completed Drug: Cerdulatinib 0.37% gel|Drug: Vehicle gel Vitiligo Dermavant Sciences GmbH|Dermavant Sciences Inc. September 27 2019 Phase 2
NCT01994382 Completed Drug: Cerdulatinib (PRT062070) Follicular Lymphoma (FL/Indolent NHL)|Aggressive NHL (a NHL)|Chronic Lymphocytic Leukemia (CLL) / Small Lymphocytic Lymphoma (SLL)|T-cell Lymphoma (PTCL and CTCL)|B-cell Non Hodgkin Lymphoma (NHL) Portola Pharmaceuticals|Alexion Pharmaceuticals August 31 2013 Phase 1|Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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