Curcumin

For research use only.

Catalog No.S1848 Synonyms: Diferuloylmethane, Natural Yellow 3, Turmeric yellow

34 publications

Curcumin Chemical Structure

CAS No. 458-37-7

Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase(IC50~25 μM)and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.

Selleck's Curcumin has been cited by 34 publications

Purity & Quality Control

Choose Selective Histone Acetyltransferase Inhibitors

Biological Activity

Description Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase(IC50~25 μM)and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.
Targets
Nrf2 [1]
(Cell-free assay)
Ferroptosis [9]
()
HDAC [7]
(Cell-free assay)
NF-κB [8]
(Cell-free assay)
p300 [6]
(Cell-free assay)
~25 μM
In vitro

Curcumin induces the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal-regulated kinase 1/2 signaling. Curcumin inhibits cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and downregulation of cyclin D1[2]. Curcumin induces endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells[3].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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DU145 NHHNZmVEgXSxdH;4bYNqfHliYYPzZZk> M3e0UVQ5KGi{cx?= M3TlTmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOzMlEzKM7:TT6= NUTJVpdqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxO|Q5OTZpPkK5NVc1QDF4PD;hQi=>
HepG2 NIHDbmFHfW6ldHnvckBie3OjeR?= MYK1JIhzew>? M1LlUWFkfGm4YYTpc44hd2ZiToLmNkApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA2KGi{czDifUBCWkVvZILpeoVvKGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OCB;IEKxJO69VS5? NGXDe2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUKyN|ExOCd-MkmyNlMyODB:L3G+
BGC823 NIi5XphEgXSxdH;4bYNqfHliYYPzZZk> Ml3rO|IhcHK| NUD4ZW1CS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSkeFOEKzJINmdGy|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF7LkWg{txONg>? MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ6OEm0Okc,Ojl{OEi5OFY9N2F-
NCI-H460 NFu5OFlEgXSxdH;4bYNqfHliYYPzZZk> MVi3NkBpenN? MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOR2kuUDR4MDDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzOC5|IN88UU4> Mly1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl{OEi5OFYoRjJ7Mki4PVQ3RC:jPh?=
SGC7901 NHXqb2xEgXSxdH;4bYNqfHliYYPzZZk> Ml\iO|IhcHK| NFH0cYpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUT0N5OUCxJINmdGy|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ4LkKg{txONg>? MoXPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl{OEi5OFYoRjJ7Mki4PVQ3RC:jPh?=
NCI-H460 NFj6WnVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGj2V5Y2KHSxIEGwJJVO NHyx[VUzPCC2bzC3NkBpenN? MYrHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDOR2kuUDR4MDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZZQhPSC2bzCxNEB2VSCrbnP1ZoF1\WRiZn;yJFI1KHSxIEeyJIhzeyCkeTDNWHQh[XO|YYm= MmC0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl{OEi5OFYoRjJ7Mki4PVQ3RC:jPh?=
NCI-H460 MmrNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIDlWIIzOCC3TR?= M2m2ZlE5KGi{cx?= M3jieGFvfGlvZ4Lve5RpKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUmNKNUh2NkCgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOxbH;ufUBnd3KvYYTpc44h[XRiMkCgeW0h[W[2ZYKgNVghcHK|IHL5JINzgXO2YXygeolwdGW2LXLhd4VlKGOxbH;ufUBnd3KvaX7nJIF{e2G7 MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ6OEm0Okc,Ojl{OEi5OFY9N2F-
NCI-H460 MY\BcpRqdWmpcnH0c5J6KGG|c3H5 NE\tNYkzOCC3TR?= MUO0PEBpenN? MUfBcpRqNW2rZ4LheI9zgSCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KNE[wJINmdGy|IHH0JFIxKHWPIHnuZ5Vj[XSnZDDmc5IhPDhiaILzJIJ6KHexdX7kJIhm[WyrbnegZZN{[Xl? NXvycZJLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyPFg6PDZpPkK5Nlg5QTR4PD;hQi=>
NCI-H460 M3[xbWFxd3C2b4Ppd{Bie3OjeR?= M1;re|E2KG2pL3vn NVq4OoxCOTViZHH5dy=> NF36SFRKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJJR2dW:{IH;mJIh2dWGwIF7DTU1JPDZyIHPlcIx{KHinbn;ndoFnfGWmIHnuJGJCVEJxQzDueUBvfWSnIH3veZNmKGG|c3Xzd4VlKGG|IHTve45z\We3bHH0bY9vKG:oIHLjcFIh\XiycnXzd4lwdiCjdDCxOUBu\y:tZzygbZAh[WSvaX7pd5RmemWmIHX2[ZJ6\GG7IH\vdkAyPSCmYYnzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?= NVfsU|JxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyPFg6PDZpPkK5Nlg5QTR4PD;hQi=>
HepG2 MnPvR5l1d3SxeHnjbZR6KGG|c3H5 MWSyOEBpenN? Mm\ER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMz63PEDPxE1w MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR{MUW2PEc,Ojl2MkG1Olg9N2F-
THP1 M4TSdWN6fG:2b4jpZ4l1gSCjc4PhfS=> NXHwRo5IOjRiaILz MmXiR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWGhROSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ{LkW0JO69VS5? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR{MUW2PEc,Ojl2MkG1Olg9N2F-
K562 M{HyUmN6fG:2b4jpZ4l1gSCjc4PhfS=> MlvtNlQhcHK| MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjNwMUKg{txONg>? M3vq[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEKxOVY5Lz5{OUSyNVU3QDxxYU6=
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HeLa MVjDfZRwfG:6aXPpeJkh[XO|YYm= NGrlNnQzPCCqcoO= MXPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOzFwOEmg{txONg>? M1:wRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEKxOVY5Lz5{OUSyNVU3QDxxYU6=
NCI-H460 NGX4RpNEgXSxdH;4bYNqfHliYYPzZZk> M1fOTlQ5KGi{cx?= NULxOZhFS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLVi0OlAh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyPy5zMTFOwG0v M1LE[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEK5PFM1Lz5{OUSyPVg{PDxxYU6=
PC3 NW\yc|A{S3m2b4TvfIlkcXS7IHHzd4F6 MmL1OFghcHK| NXXEd5pxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN|IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUiuOlUh|ryPLh?= MlHHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2Mkm4N|QoRjJ7NEK5PFM1RC:jPh?=
DU145 M{S1eWN6fG:2b4jpZ4l1gSCjc4PhfS=> NF\y[oU1QCCqcoO= M37qSmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{OuNVUh|ryPLh?= NXrH[lc6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0Nlk5OzRpPkK5OFI6QDN2PD;hQi=>
MCF7 NILTS5pEgXSxdH;4bYNqfHliYYPzZZk> Mn\VOEBpenN? NETGV|hEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KHC{ZXnuZ5Vj[XSnZDDmc5IhPCCqcoOg[o9tdG:5ZXSgZpkhcW6ldXLheIlwdiCrbjDjc41xd3WwZDDmdoVmKG2nZHnhJIZweiB{NDDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkKuNUDPxE1w MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZyNUiwPEc,Ojl4MEW4NFg9N2F-
WRL68 M17JPWN6fG:2b4jpZ4l1gSCjc4PhfS=> NX3n[YVPPCCqcoO= MXzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDXVmw3QCClZXzsd{BxemWrbnP1ZoF1\WRiZn;yJFQhcHK|IH\vcIxwf2WmIHL5JIlv[3WkYYTpc44hcW5iY3;tdI92dmRiZoLl[UBu\WSrYTDmc5IhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ5Lkig{txONg>? NHXROmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[wOVgxQCd-Mkm2NFU5ODh:L3G+
A549 Mkf3R5l1d3SxeHnjbZR6KGG|c3H5 MV:0JIhzew>? MmLUR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{BxemWrbnP1ZoF1\WRiZn;yJFQhcHK|IH\vcIxwf2WmIHL5JIlv[3WkYYTpc44hcW5iY3;tdI92dmRiZoLl[UBu\WSrYTDmc5IhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDR|Lkmg{txONg>? NEPySo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[wOVgxQCd-Mkm2NFU5ODh:L3G+
NCI-H1975 NYfxcpZUS3m2b4TvfIlkcXS7IHHzd4F6 M3HlNlczKGi{cx?= MknVR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmNKNUhzOUe1JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNU41KM7:TT6= NV;oXm9zRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2OVUxQDNpPkK5OlU2ODh|PD;hQi=>
A549 MUTDfZRwfG:6aXPpeJkh[XO|YYm= NV\wTZN[PzJiaILz NYr4V|RYS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IE[uPEDPxE1w NG\kZm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[1OVA5Oyd-Mkm2OVUxQDN:L3G+
HL7702 MoDaR5l1d3SxeHnjbZR6KGG|c3H5 M4G3WFczKGi{cx?= MV3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUFc4ODJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB5LkKg{txONg>? NFnQSG49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[1OVA5Oyd-Mkm2OVUxQDN:L3G+
H460 Ml3pR5l1d3SxeHnjbZR6KGG|c3H5 M3vxOVczKGi{cx?= M{jJT2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGg1PjBiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB6LkWg{txONg>? M3fuc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkW1NFg{Lz5{OU[1OVA5OzxxYU6=
NCI-H1650 NIDzTVNEgXSxdH;4bYNqfHliYYPzZZk> M{nJflczKGi{cx?= MWnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOR2kuUDF4NUCgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyNE42KM7:TT6= MlHMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4NUWwPFMoRjJ7NkW1NFg{RC:jPh?=
HepG2 MYDDfZRwfG:6aXPpeJkh[XO|YYm= NVTXVZJ{OjRiaILz M3fHUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB{NDDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUCg{txONg>? M1G4OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7N{m4PFI4Lz5{OUe5PFgzPzxxYU6=
HCT116 MXTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MUS3NkBpenN? NVn5NopHSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFExNjlzIN88UU4> MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTh6NkCyNUc,Ojl6OE[wNlE9N2F-
HepG2 MYPDfZRwfG:6aXPpeJkh[XO|YYm= NUf0[4g2OjRiaILz MXjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF4LkCxJO69VS5? M3XMWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OUC5N|M5Lz5{OUmwPVM{QDxxYU6=
SMMC7721 NHqyeYJEgXSxdH;4bYNqfHliYYPzZZk> NELKbWkzPCCqcoO= Moj3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV21OSzd5MkGgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxPU41PyEQvF2u MnjrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl7MEmzN|goRjJ7OUC5N|M5RC:jPh?=
QGY7703 MUXDfZRwfG:6aXPpeJkh[XO|YYm= NV;TcWF7OjRiaILz M1mycmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHFIYTd5MEOgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyNU41PCEQvF2u NH7lRWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUmwPVM{QCd-Mkm5NFk{Ozh:L3G+
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LNCAP NV3GNmtJSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NIrPbo5CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIFv\HKxZ3XuMZNmdnOrdHn2[UBpfW2jbjDMUmNCWCClZXzsd{whUUN3MDC9JFIh|ryPLh?= M3LQdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUKxNlE1Lz5|MEGyNVIyPDxxYU6=
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HT1080 MkfvR5l1d3SxeHnjbZR6KGG|c3H5 MWW3NkBpenN? MXHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWFExQDBiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE{NjFizszNMi=> NWj5UmJ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxN|g5ODNpPkOwNVM5QDB|PD;hQi=>
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HHL5 MlzWR5l1d3SxeHnjbZR6KGG|c3H5 M2PDbVI1KGi{cx?= MlHkR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGhNPSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjRwMUmg{txONg>? MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd5MU[wOUc,OzB5N{G2NFU9N2F-
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BGC823 Mn3uR5l1d3SxeHnjbZR6KGG|c3H5 MXrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCS2M5OjNiY3XscJMtKEmFNUCgQUAyPy53IN88UU4> M1i2[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK5OFU2Lz5|MUGyPVQ2PTxxYU6=
BxPC3 MXfDfZRwfG:6aXPpeJkh[XO|YYm= Ml\FR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRphRSzNiY3XscJMtKEmFNUCgQUAyQC5{NTFOwG0v Mnz3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
HT-29 NVrlfXpwS3m2b4TvfIlkcXS7IHHzd4F6 NWLCUllkS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRvMkmgR4VtdHNuIFnDOVAhRSBzOD63OEDPxE1w MnTOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
H1299 NH3F[m9EgXSxdH;4bYNqfHliYYPzZZk> MkPGR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTFEzQTliY3XscJMtKEmFNUCgQUAyQC57MzFOwG0v MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{OUS1OUc,OzFzMkm0OVU9N2F-
PC3 MlLrR5l1d3SxeHnjbZR6KGG|c3H5 NWfIcnE6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN|IHPlcIx{NCCLQ{WwJF0hOTlwOUig{txONg>? NWXBV|RyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlk1PTVpPkOxNVI6PDV3PD;hQi=>
EAhy926 NWe2fIczS3m2b4TvfIlkcXS7IHHzd4F6 NIqyWWE4OiCqcoO= M4LFVGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGVCcHl7Mk[gR4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJyIN88UU4> NGDpboc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
HepG2 NVLzSZNYS3m2b4TvfIlkcXS7IHHzd4F6 NXHPOJREPzJiaILz Mnv2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiQ3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFIxNjNizszNMi=> NXTmWGdJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlk1PTVpPkOxNVI6PDV3PD;hQi=>
AGS NWn4blg6S3m2b4TvfIlkcXS7IHHzd4F6 NYLPOpVJS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSUeVIFPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKwMlc3KM7:TT6= MkPTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
PC3 M{f4T2FvfGmlYX7j[ZIh[XO|YYm= NYjLVWJYSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJHBEOyClZXzsd{whUUN3MDC9JFIxNjlizszNMi=> NEPQcGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
MGC803 NX;YUplrS3m2b4TvfIlkcXS7IHHzd4F6 Mk\kR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWdEQDB|IHPlcIx{NCCLQ{WwJF0hOjFwMjFOwG0v M1TTRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK5OFU2Lz5|MUGyPVQ2PTxxYU6=
CHOK1 MXnDfZRwfG:6aXPpeJkh[XO|YYm= M2HBc|czKGi{cx?= Mn;kR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR2hQUzFiQ3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFIyNjNizszNMi=> Mn3jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
Hep2 MYTDfZRwfG:6aXPpeJkh[XO|YYm= M{nvNWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeDJiQ3XscJMtKEmFNUCgQUAzOS5|NzFOwG0v MlTFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
MCF7 MVnDfZRwfG:6aXPpeJkh[XO|YYm= NYWzPW1tS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyxiSVO1NEA:KDJ{LkWg{txONg>? NF\yXFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
SGC7901 M1:1PGN6fG:2b4jpZ4l1gSCjc4PhfS=> MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTS2M4QTBzIHPlcIx{NCCLQ{WwJF0hOjJwNTFOwG0v MojpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
HT-29 NYHnSFl6S3m2b4TvfIlkcXS7IHHzd4F6 M17DcVczKGi{cx?= MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWE0zQSCFZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlMvPCEQvF2u M3zOWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK5OFU2Lz5|MUGyPVQ2PTxxYU6=
A549 NUDtO5lDS3m2b4TvfIlkcXS7IHHzd4F6 NVz0foJyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDD[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyOU4{OyEQvF2u NF[zRVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
MDA-MB-231 M2fz[WN6fG:2b4jpZ4l1gSCjc4PhfS=> NXryVpo4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{whUUN3MDC9JFI3NjVizszNMi=> MoToQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
A549 MmK4R5l1d3SxeHnjbZR6KGG|c3H5 NV75VGtmOjRidH:gOFghcHK| MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KEOnbHzzJIFnfGW{IEK0JJRwKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{ODFOwG0v MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{OUS1OUc,OzFzMkm0OVU9N2F-
Caco2 MojxR5l1d3SxeHnjbZR6KGG|c3H5 NVrXSFV7PzJiaILz NIfnXnZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBE[WOxMjDD[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjhizszNMi=> MljGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
GES-1 MWPDfZRwfG:6aXPpeJkh[XO|YYm= MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDHSXMuOSClZXzsd{whUUN3MDC9JFI6NjFizszNMi=> M2L0WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK5OFU2Lz5|MUGyPVQ2PTxxYU6=
DU145 M3\zZWFvfGmlYX7j[ZIh[XO|YYm= NWnod4dWSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{NCCLQ{WwJF0hOzFwNzFOwG0v Mnn1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
MDCK2 NVLtdolES3m2b4TvfIlkcXS7IHHzd4F6 NVX4eI4zOTVibXnudy=> NXLtRY5OS3m2b4TvfIlkcXS7IHHnZYlve3RibXn0c5hidnS{b37lJJJme2m|dHHueEBpfW2jbjDNSGNMOiClZXzsd{BmgHC{ZYPzbY5oKEKFUmCgZYZ1\XJiMUWgcYlveyCkeTDmcJVwemW|Y3XuZ4Uh[XO|YYmsJGlEPTBiPTCzNkDPxE1w MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{OUS1OUc,OzFzMkm0OVU9N2F-
HL-7702 NF3QN41EgXSxdH;4bYNqfHliYYPzZZk> M13SXmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhNNTd5MEKgZ4VtdHNuIFnDOVAhRSB|Mj6zN{DPxE1w NF3kbok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
K562 M3\1NmN6fG:2b4jpZ4l1gSCjc4PhfS=> MofYNlQhfG9iNEigbJJ{ M2LGdGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiQ3XscJMh[W[2ZYKgNlQhfG9iNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEO2JO69VS5? M2iybFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK5OFU2Lz5|MUGyPVQ2PTxxYU6=
HepG2 MXrDfZRwfG:6aXPpeJkh[XO|YYm= MmfCR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiQ3XscJMtKEmFNUCgQUA{Pi55NzFOwG0v NXHtcYxkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlk1PTVpPkOxNVI6PDV3PD;hQi=>
GBM1 NUfFTVNsS3m2b4TvfIlkcXS7IHHzd4F6 MmPROFghcHK| Mn3oR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gS2JOOSCFZXzsd{A1QCCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwJF0hOzlwNkWg{txONg>? NHW0N3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
PC12 Mk\PR5l1d3SxeHnjbZR6KGG|c3H5 M{fPcFI1KGi{cx?= NWWxOm9wS3m2b4TvfIlkcXS7IHHnZYlve3RicnH0JHBEOTJiY3XscJMhdWWjc4Xy[YQh[W[2ZYKgNlQhcHK|IHL5JHdUXDhxUF3TJIF{e2G7LDDDR|UxKD1iNEKg{txONg>? MmTIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF{NkK1OVkoRjNzMk[yOVU6RC:jPh?=
HCT116 MkDlRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MnnrO|IhcHK| MnLqRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFExNjVizszNMi=> MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTN{NkK0NUc,OzF|Mk[yOFE9N2F-
HeLa M1yyO2N6fG:2b4jpZ4l1gSCjc4PhfS=> M2jyd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMtKEmFNUCgQUA5NjJizszNMi=> NGfMRWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUOzOlMyOCd-M{GzN|Y{OTB:L3G+
B16 M3rDSGN6fG:2b4jpZ4l1gSCjc4PhfS=> M1XqdGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGIyPiClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB6LkWg{txONg>? MnSxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF|M{[zNVAoRjNzM{O2N|ExRC:jPh?=
HT1080 NFnTcGRHfW6ldHnvckBie3OjeR?= Mn2xSIVkemWjc3WgbY4hXVCDIHX4dJJme3Orb36gbY4hcHWvYX6gTHQyODhyIHPlcIx{NCCLQ{WwJF0hOTBizszNMi=> MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTN|NkOxNEc,OzF|M{[zNVA9N2F-
Hep3B M375fWN6fG:2b4jpZ4l1gSCjc4PhfS=> MlLhR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxO0JiY3XscJMtKEmFNUCgQUAyOCEQvF2u MluwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF|M{[zNVAoRjNzM{O2N|ExRC:jPh?=
BT474 NVXpd2RmS3m2b4TvfIlkcXS7IHHzd4F6 M{THWGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJVPDd2IHPlcIx{NCCLQ{WwJF0hOTFizszNMi=> M1[zW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzM{O2N|ExLz5|MUOzOlMyODxxYU6=
T47D NWPlPHpnS3m2b4TvfIlkcXS7IHHzd4F6 NEHqWoNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBVPDeGIHPlcIx{NCCLQ{WwJF0hOTFizszNMi=> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTN|NkOxNEc,OzF|M{[zNVA9N2F-
HaCaT NXPwOIF4S3m2b4TvfIlkcXS7IHHzd4F6 M1\G[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhiS2GWIHPlcIx{NCCLQ{WwJF0hOTNizszNMi=> NWHDO|N1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GzN|Y{OTBpPkOxN|M3OzFyPD;hQi=>
KM12 NWrxUXNiS3m2b4TvfIlkcXS7IHHzd4F6 MnfkOEBpenN? NH64[odEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMVTF{IHPlcIx{KGGodHXyJFQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE3KM7:TT6= MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTN|NkOxNEc,OzF|M{[zNVA9N2F-
HPL1D NFzNenVEgXSxdH;4bYNqfHliYYPzZZk> M3m4ZmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhRVDGGIHPlcIx{NCCLQ{WwJF0hOTZizszNMi=> MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTN|NkOxNEc,OzF|M{[zNVA9N2F-
SW480 MV;DfZRwfG:6aXPpeJkh[XO|YYm= NEnBT2c1KGi{cx?= M4LndWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNYPDhyIHPlcIx{KGGodHXyJFQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE4Njl2IN88UU4> NGTEZ2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUOzOlMyOCd-M{GzN|Y{OTB:L3G+
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... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-IRE1α / IREα ; 

PubMed: 29901626     


Curcumin increases the phosphorylation of IRE1α in BCPAP cells. The protein levels of phosphorylated IRE1α and total IRE1α were detected by western blot analysis. β-actin was used as a loading control. 

HDAC1/ HDAC2 ; 

PubMed: 31196210     


Curcumin-induced suppression of HDCA1 and HDCA2 proteins in H157 and H1299 cells.

p-STAT3 / STAT3 ; 

PubMed: 23874455     


Dose-dependent inhibition of STAT3 phosphorylation by curcumin. SiHa cells treated with indicated concentration of curcumin for 24 h were tested for expression of phospho-STAT3 by immunoblotting. Subsequently the blots were stripped and reprobed with STAT3 and β-actin. 

29901626 31196210 23874455
Immunofluorescence
β-catenin ; 

PubMed: 22523587     


C4-2 cells were cultured on glass coverslips overnight in 12 well plates. The cells were treated with DMSO (upper panel) or curcumin (20 µM) (lower panel) for 1 h, washed, fixed and immunostained for β-catenin (red) and counter-stained with DAPI (blue). Higher β-catenin staining was observed on the cell surface at 1 h of curcumin treatment, compared to DMSO control treated cells. Original Magnifications 600×.

PKD1; 

PubMed: 22523587     


Effect of curcumin treatment on the cellular localization of β-catenin and PKD1. C4-2 cells treated with curcumin (20 µM) or DMSO for 24 h were immunostained for β-catenin (green) or PKD1 (red) and counter-stained with DAPI (blue). Curcumin treated cells showed lower cytoplasmic and higher membrane β-catenin staining compared to control cells. In addition, while PKD1 was predominantly localized in the cytoplasm in control cells, curcumin treated cells exhibited staining primarily on the cell membrane and in the nucleus (white arrows), with faint cytoplasmic staining. Original Magnifications 600× with 2× zoom. 

EGFR / LC3 ; 

PubMed: 31196210     


H157 and H1299 cells were treated with gefitinib, or curcumin alone, or gefitinib plus curcumin at indicated concentration for 48 h and then were fixed with methanol, immunostained with anti-EGFR (green), anti-LC3 (red), and DAPI (blue), and analyzed by confocal microscopy to determine the intracellular locations of EGFR and LC3.

22523587 31196210
Growth inhibition assay
Cell proliferation ; 

PubMed: 22523587     


Effect of curcumin on proliferation of various prostate cancer cell lines. LNCaP, C4-2, DU145 and PC3 cell were treated with curcumin or vehicle control DMSO for 48 h and cell proliferation was determined using MTS assay. The percent cell proliferation was calculated by normalizing the proliferation of curcumin treated cells with proliferation of control treated cells. Concentration dependent inhibition in cell proliferation was observed with curcumin treatment. Mean ± SE; n = 3; *p<0.05.

Cell viability; 

PubMed: 19809577     


Triple negative MDA468, HCC1806, and HCC1937, and ER+/HER2-over-expressing BT474, HER2-over-expressing SKBR3, ER+ MCF7, and non-transformed MCF12A cells were treated with 5, 10, or 20 μM curcumin for 72 h. Control cells were treated with ethanol corresponding to the highest dose of curcumin, since curcumin is dissolved in ethanol. Surviving cells were counted by trypan blue exclusion. For each treatment group, cell viability is shown as a percentage of the ethanol control group per line. Experiments were done in duplicate or triplicate at least twice. Error bars represent standard deviation between replicates. In comparison to MCF12A non-transformed mammary epithelial cells, curcumin inhibited viability of all cancer lines (**p < 0.005 at 10 μM and 20 μM).

22523587 19809577
In vivo

Chronic treatment with curcumin significantly reverses the CMS-induced behavioral abnormalities in stressed rats. Additionally, curcumin effectively inhibits cytokine gene expression at both the mRNA and the protein level and reduces the activation of NF-κB[4].

Protocol

Cell Research:

[5]

- Collapse
  • Cell lines: murine melanoma cell subline(B16-R)
  • Concentrations: 0-100 μM
  • Incubation Time: 24-48 h
  • Method:

    1×104 B16-R cells are cultivated as monolayer culture for 12 hr. They were then incubated in 200 μL of RPMI, 10% FBS containing curcumin at final concentrations from 1–100 μM in 96-multiwell plates for 24-48 hr. After these incubations, cells are washed twice in PBS and 500 μl of fresh culture medium containing MTT (0.3 mg/mL) are added for colorimetric assay.


    (Only for Reference)
Animal Research:

[5]

- Collapse
  • Animal Models: Female B6D2F1 mice (6-8 weeks old)
  • Dosages: 25 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 73 mg/mL (198.16 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5%DMSO+10%PEG300+5%Tween80+80%ddH2O
For best results, use promptly after mixing.
4mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 368.38
Formula

C21H20O6

CAS No. 458-37-7
Storage powder
in solvent
Synonyms Diferuloylmethane, Natural Yellow 3, Turmeric yellow
Smiles COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04458116 Not yet recruiting Dietary Supplement: Curcumin Coronary Artery Disease|Oxidative Stress|Inflammation Universidade Federal Fluminense March 10 2022 Not Applicable
NCT04731844 Not yet recruiting Drug: Curcumin plus Piperine Prostate Cancer|Multiple Myeloma|Smoldering Multiple Myeloma (SMM)|Monoclonal Gammopathy of Undetermined Significance University of Rochester September 1 2021 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Histone Acetyltransferase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID