Curcumin

Catalog No.S1848 Synonyms: Diferuloylmethane, Natural Yellow 3, Turmeric yellow

For research use only.

Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase(IC50~25 μM)and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.

Curcumin Chemical Structure

CAS No. 458-37-7

Selleck's Curcumin has been cited by 39 publications

Purity & Quality Control

Choose Selective Histone Acetyltransferase Inhibitors

Biological Activity

Description Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase(IC50~25 μM)and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.
Targets
Nrf2 [1]
(Cell-free assay)
Ferroptosis [9] HDAC [7]
(Cell-free assay)
NF-κB [8]
(Cell-free assay)
p300 [6]
(Cell-free assay)
~25 μM
In vitro

Curcumin induces the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal-regulated kinase 1/2 signaling. Curcumin inhibits cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and downregulation of cyclin D1[2]. Curcumin induces endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells[3].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
U87 NXrjNJRVS2WubDD2bYFjcWyrdImgZZN{[Xl? MkDHNEwhOTBuIEKwMEA{OCxiNECsJIFv\CB3MDFCuW0wVA>? NGLjSnUzPCCqb4Xydy=> MVXBeEBkd26lZX70doF1cW:wczDobYdp\XJidHjhckAzOCEEtV2vUEwh[2WubDD2bYFjcWyrdHnld{B{fGWncHz5JIRm[2yrbnXk NX\kTIpCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GwOlI2OjdpPkOxNFYzPTJ5PD;hQi=>
HEL cells MUnD[YxtKH[rYXLpcIl1gSCjc4PhfS=> M13lTFAuOzBiwsXtc4wwVA>? M2XsOVI1NzR6wrDoc5Vzew>? NV3sSWV3XGinII\pZYJqdGm2eTDv[kB1cGViSFXMJINmdGy|IHX4dI9{\WRidH:gZ5Vz[3WvaX6ge4F{KHOrZ37p[olk[W62bImgcI94\XJiY3;tdIFz\WRidH:gZ49vfHKxbDDj[YxteyCndnXuJIF1KGyxdzDjc45k\W62cnH0bY9vey5? MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTB|M{KwPUc,OzFyM{OyNFk9N2F-
Raw246.7 M1rJbmNmdGxidnnhZoltcXS7IHHzd4F6 NInXVJkyNCB3LDCxNEwhPTBuIEGwNEwhOjByLDDhcoQhPTByIHevcWw> NWjrfo9KRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GwNFc4ODFpPkOxNFA4PzBzPD;hQi=>
RT112 M2jzNmNmdGxidnnhZoltcXS7IHHzd4F6 NWPUU4R3OC5zIH;yJFAvPCEQvHevcYw> NH;GOVkzPCxiNEisJIFv\CB5MjDo MX;DeZJkfW2rbjDhcI9v\SxiYXTk[YQh[XRiYTDjc45k\W62cnH0bY9vKG[{b32gNE4yKHSxIECuOEDPxGdxbXysJIRq\CCwb4SgZYx1\XJiY3XscEBoem:5dHigc4YhWlRzMUKgZ4VtdHNuIIPsbYdpfGy7IILl[JVk\WRiVV3VR|Mh[2WubDDndo94fGhiYYSgNE41KM7:Zz;tcEwh[W6mIH;ucJkhdW:mZYLheIVtgSC|dYDwdoV{e2WmIHfyc5d1cCCxZjDUR2NUXVBiYYSgNE4zKGGwZDCwMlQh|rypL33sMEBm[WOqIHPvcZBiemWmIITvJJJme3CnY4TpeoUh[2:wdILvcJM> MkizQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB7OESyO|goRjNyOUi0Nlc5RC:jPh?=
UMUC3 NVr4fYlFS2WubDD2bYFjcWyrdImgZZN{[Xl? NFzmNHUxNjFib4KgNE41yqEQvHevcYw> NVvQepplOjRuIES4MEBidmRiN{OgbC=> Mn71R5Vz[3WvaX6gZYxwdmVuIHHk[IVlKGG2IHGgZ49v[2WwdILheIlwdiCocn;tJFAvOSC2bzCwMlQh|rypL33sMEBlcWRibn;0JIFtfGW{IHPlcIwh\3Kxd4ToJI9nKFKWMUGyJINmdGy|LDDzcIlocHSueTDy[YR2[2WmIGXNWWM{KGOnbHyg[5Jwf3SqIHH0JFAvPCEQvHevcYwtKGGwZDDvcox6KG2xZHXyZZRmdHlic4XwdJJme3OnZDDndo94fGhib3[gWGNEW1WSIHH0JFAvOiCjbnSgNE42KM7:Zz;tcEwh\WGlaDDjc41x[XKnZDD0c{Bz\XOyZXP0bZZmKGOxboTyc4x{ MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODl6NEK3PEc,OzB7OESyO|g9N2F-
TCCSUP NUTqcIJkS2WubDD2bYFjcWyrdImgZZN{[Xl? MYWwMlEhd3JiMD60xsDPxGdxbXy= M1vvZlI1NCB2ODygZY5lKDd2IHi= NHHDVVNEfXKldX3pckBidG:wZTygZYRl\WRiYYSgZUBkd26lZX70doF1cW:wIH\yc40hOC5zIITvJFAvPCEQvHevcYwtKGSrZDDuc5Qh[Wy2ZYKgZ4VtdCCpcn;3eIghd2ZiUmSxNVIh[2WubIOsJJNtcWeqdHz5JJJm\HWlZXSgWW1WSzNiY3XscEBoem:5dHigZZQhOC52IN88[{9udCxiYX7kJI9vdHlibX;k[ZJifGWueTDzeZBxemW|c3XkJIdzd3e2aDDv[kBVS0OVVWCgZZQhOC5{IHHu[EAxNjZizsznM41tNCCnYXPoJINwdXCjcnXkJJRwKHKnc4DlZ5RqfmViY3;ueJJwdHN? NGfWZZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEm4OFI4QCd-M{C5PFQzPzh:L3G+
KBM5 MorxRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NH\TOIs4OiCqcoO= MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEuETUWgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNwOESg{txONg>? MlrCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{OECwOlkoRjJ2MkiwNFY6RC:jPh?=
Jurkat Ml;GRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NUjyWINJPzJiaILz M1j6e2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSoXyb4F1KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0MlI6KM7:TT6= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ6MEC2PUc,OjR{OECwOlk9N2F-
U266 NFX6W|RCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MVu3NkBpenN? NVnvd|lQSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVNlY3KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC3MlU4KM7:TT6= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ6MEC2PUc,OjR{OECwOlk9N2F-
A549 NW[wNI5OSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MWi3NkBpenN? MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF5LkOg{txONg>? NUfudXMzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyPFAxPjlpPkK0NlgxODZ7PD;hQi=>
MCF7 M3vUOmN6fG:2b4jpZ4l1gSCjc4PhfS=> MlLyNlQhcHK| MkP6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|IvOiEQvF2u MlPnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzN{S1OVUoRjJ4MUe0OVU2RC:jPh?=
SKOV3 MWHDfZRwfG:6aXPpeJkh[XO|YYm= NVK3dmQ3OjRiaILz M{LEWGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMV1Z|IHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1Oy54MzFOwG0v NEGxPZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkG3OFU2PSd-Mk[xO|Q2PTV:L3G+
CT26 NF3iUotEgXSxdH;4bYNqfHliYYPzZZk> NEjDcI84OiCqcoO= M17hTGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGNVOjZiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIIDyc4xq\mW{YYTpc44hcW6ldXLheIVlKG[xcjC3NkBpenNiYomgUXRUKGG|c3H5MEBKSzVyIE2gO{44KM7:TT6= NIjJVGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOxPFA2Pyd-Mk[zNVgxPTd:L3G+
SW620 MWnDfZRwfG:6aXPpeJkh[XO|YYm= M170XFczKGi{cx?= MXXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTW|YzOCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxicILvcIln\XKjdHnvckBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHMh[XO|YYmsJGlEPTBiPTCxNk42OiEQvF2u MorrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|MUiwOVcoRjJ4M{G4NFU4RC:jPh?=
SGC7901 NHXnV|NEgXSxdH;4bYNqfHliYYPzZZk> NGi4UZA4OiCqcoO= M4\GfmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNISzd7MEGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25iaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwJF0hOjRwNEGg{txONg>? Ml71QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|MUiwOVcoRjJ4M{G4NFU4RC:jPh?=
GES-1 NX\JRXBLS3m2b4TvfIlkcXS7IHHzd4F6 NXfOPIdrPzJiaILz NV;QS3dNS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hT0WVLUGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25iaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwJF0hOjdwOEmg{txONg>? MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjNzOEC1O{c,OjZ|MUiwOVc9N2F-
MGC803 NYK1UJllS3m2b4TvfIlkcXS7IHHzd4F6 MmC4O|IhcHK| MorUR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWdEQDB|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JG1VWyCjc4PhfUwhUUN3MDC9JFMyNjN7IN88UU4> MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjNzOEC1O{c,OjZ|MUiwOVc9N2F-
Caco2 NH73VHdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NHvXTohCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPhZ48zKGOnbHzzMEBKSzVyIE2gNVAvOyEQvF2u NHXyN4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkWzPVYzPid-Mk[1N|k3OjZ:L3G+
U2OS MXnDfZRwfG:6aXPpeJkh[XO|YYm= MX20PEBpenN? Ml7iR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWVJQWyClZXzsd{BmgHC{ZYPzbY5oKHerbHSteJlx\SCyNUOgZYZ1\XJiNEigbJJ{KGK7IHPyfZN1[WxidnnvcIV1NXO2YXnubY5oKGKjc3XkJJNx\WO2cn;wbI91d22ndILpZ{Bie3OjeTygSWM2OCB;IEKyMlgh|ryPLh?= M2\QNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkC2NlQ3Lz5{Nk[wOlI1PjxxYU6=
Saos2 NXPvW|RrS3m2b4TvfIlkcXS7IHHzd4F6 MWm0PEBpenN? M3f0ZmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNid3N{IHPlcIx{KGW6cILld5NqdmdicEWzJI12fGGwdDDh[pRmeiB2ODDodpMh[nliY4L5d5RidCC4aX;s[ZQue3SjaX7pcoch[mG|ZXSgd5Bm[3S{b4Doc5RwdWW2cnnjJIF{e2G7LDDFR|UxKD1iMkiuNUDPxE1w MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjZyNkK0Okc,OjZ4ME[yOFY9N2F-
U2OS NIO2OmVEgXSxdH;4bYNqfHliYYPzZZk> M3n6blI1KGi{cx?= MULDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVNm9UKGOnbHzzJIV5eHKnc4Ppcochf2muZD30fZBmKHB3MzDh[pRmeiB{NDDodpMh[nliY4L5d5RidCC4aX;s[ZQue3SjaX7pcoch[mG|ZXSgd5Bm[3S{b4Doc5RwdWW2cnnjJIF{e2G7LDDFR|UxKD1iM{SuOEDPxE1w NFTGTIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[wOlI1Pid-Mk[2NFYzPDZ:L3G+
Saos2 MXzDfZRwfG:6aXPpeJkh[XO|YYm= M2riOFI1KGi{cx?= M2fCSWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNid3N{IHPlcIx{KGW6cILld5NqdmdicEWzJI12fGGwdDDh[pRmeiB{NDDodpMh[nliY4L5d5RidCC4aX;s[ZQue3SjaX7pcoch[mG|ZXSgd5Bm[3S{b4Doc5RwdWW2cnnjJIF{e2G7LDDFR|UxKD1iNEiuOkDPxE1w NH;FeoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[wOlI1Pid-Mk[2NFYzPDZ:L3G+
T98G MkL5RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MXmyOEBpenN? MYHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFR7OFegZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KEWcLWTvfEBie3OjeTygTWM2OCB;IEGwJO69VS5? MnfDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4M{GzNVgoRjJ4NkOxN|E5RC:jPh?=
T98G M1X2eWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M{f0WlczKGi{cx?= NELrT2FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGS5PGch[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK1JO69VS5? Ml\oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4M{GzNVgoRjJ4NkOxN|E5RC:jPh?=
T67 MVzO[ZVzd3C{b4TlZ5RqfmViYYPzZZk> NIPHVYtP\XW{b4Dyc5Rm[3SrdnWg[YZn\WO2IHnuJIh2dWGwIGS2O{Bk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCQUV:xJIFkfGm4aYT5JJV{cW6pIFTDTXAh[XNic4Xid5Rz[XSn MmPxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4OU[yOVIoRjJ4Nkm2NlUzRC:jPh?=
SH-SY5Y NXzMOmExSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MkS2OFghcHK| MYPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOKLWPZOXkh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{NCCLQ{WwJF0hOTZwMTFOwG0v M124W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4N{C1NVQ1Lz5{NkewOVE1PDxxYU6=
HeLa M1HScmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M1G0dFQ5KGi{cx?= NHTNcW1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjlUIEh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{NCCLQ{WwJF0hOjFwODFOwG0v M4LMRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4N{C1NVQ1Lz5{NkewOVE1PDxxYU6=
HeLa M3[4fWNmdGxiY4njcIUh[XO|YYm= NVjiNJNWOTZiaILz M3m1[WNmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJGhmVGFiY3XscJMh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEdzIIDoZZNmKGG2IFnDOVAhfG9iMjD0bY1meyCLQ{WwJIFnfGW{IEG2JIhzeyCkeTDGRWNUKGGwYXz5d4l{ MlO5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5MEWxOFQoRjJ4N{C1NVQ1RC:jPh?=
HuH7 MVPDfZRwfG:6aXPpeJkh[XO|YYm= NUjsNIFTPDhiaILz NX6wOJZwS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUHWKNzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPDhizszNMi=> Ml\BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5OEOxO|koRjJ4N{izNVc6RC:jPh?=
HeLa NIDFS4hCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NVz1TI41OyCmYYnz MnvGRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZVzhJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEB3cWGkaXzpeJkh[W[2ZYKgN{Bl[Xm|IHL5JHdUXC1zIHHzd4F6NCCLQ{WwJF0hOTJwMUGg{txONg>? M2fBc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OEK3NVYyLz5{NkiyO|E3OTxxYU6=
LNCAP MUTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M{fBcFMh\GG7cx?= NFLFZmhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzOR2FRKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCC4aXHibYxqfHliYX\0[ZIhOyCmYYnzJIJ6KFeVVD2xJIF{e2G7LDDJR|UxKD1iMUOuOlEh|ryPLh?= NFrR[XQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkiyO|E3OSd-Mk[4NlcyPjF:L3G+
PC3 MX;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NH7jZ2o{KGSjeYO= MVfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCFMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygeoli[mmuaYT5JIFnfGW{IEOg[IF6eyCkeTDXV3QuOSCjc4PhfUwhUUN3MDC9JFI2NjR|IN88UU4> M13FWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OEK3NVYyLz5{NkiyO|E3OTxxYU6=
DU145 M1TtV2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NFvO[4g{KGSjeYO= NYPL[o9wSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxidnnhZoltcXS7IHHmeIVzKDNiZHH5d{BjgSCZU2StNUBie3OjeTygTWM2OCB;IEK2MlI{KM7:TT6= MmTZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ6MkexOlEoRjJ4OEK3NVYyRC:jPh?=
RAW264.7 MnfpRY51cWmwZnzhcY1ifG:{eTDhd5NigQ>? M3\pbFI1KGi{cx?= NHW4NYdCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgcol1emmlIH;4bYRmKHC{b3T1Z5Rqd25iYX\0[ZIhOjRiaILzJIJ6KEe{aXXzd{Bie3OjeTygTWM2OCB;IEG5MlEh|ryPLh?= M1LZSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OESxNVY5Lz5{Nki0NVE3QDxxYU6=
BV2 Ml7xSpVv[3Srb36gZZN{[Xl? M4HFWlI1KGi{cx?= M2LSVmlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgUm8heHKxZIXjeIlwdiCrbjDtc5V{\SCEVkKgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKG6rdILpeIUhdGW4ZXygdJJmfHKnYYTl[EBnd3JiMkSgbJJ{KGKnZn;y[UBNWFNidILlZZRu\W62IH\vdkBi\GSrdHnvcoFtKDJ2IHjyd{BjgSCJcnnld5MhemWjY4Tpc44hdWW2aH;kMEBKSzVyIE2gNE42OiEQvF2u MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjh3OUe3Okc,OjZ6NUm3O|Y9N2F-
HepG2 M2e4U2N6fG:2b4jpZ4l1gSCjc4PhfS=> MUnDfZRwfG:6aXPpeJkh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2LkSzJO69VS5? MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjh5M{SxOEc,OjZ6N{O0NVQ9N2F-
A549 NXu5Z3FQS3m2b4TvfIlkcXS7IHHzd4F6 MV7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ|LkW0JO69VS5? Ml;VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ6N{O0NVQoRjJ4OEezOFE1RC:jPh?=
MCF7 NWX6cVdqS3m2b4TvfIlkcXS7IHHzd4F6 NX7nUWFDS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0Ok4zPSEQvF2u MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjh5M{SxOEc,OjZ6N{O0NVQ9N2F-
SKOV3 NVvkZW1CS3m2b4TvfIlkcXS7IHHzd4F6 NG[4VWZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0:YMzDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0PU45PSEQvF2u MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjh5M{SxOEc,OjZ6N{O0NVQ9N2F-
A549/CDDP Mn[xRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NHrjXVY4OiCqcoO= MVTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmvR2RFWCClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|IvOzlizszNMi=> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjh7MUC5PUc,OjZ6OUGwPVk9N2F-
A549 NWjxXGJJSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MYq3NkBpenN? MX3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDN6LkGyJO69VS5? NG[xTXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nki5NVA6QSd-Mk[4PVExQTl:L3G+
A549/CDDP MVHGeY5kfGmxbjDhd5NigQ>? MkD1TY5pcWKrdHnvckBw\iC2aHnvdoVld3irbjDy[YR2[3Sjc3WgbY4hcHWvYX6gRVU1QS:FRFTQJINmdGy|IHL5JGRVVkJiZInlJIJie2WmIH3pZ5JweGyjdHWgd5Bm[3S{b4Doc5RwdWW2comsJGlEPTBiPTCzPU41OiEQvF2u MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjh7MUC5PUc,OjZ6OUGwPVk9N2F-
A549 MYDGeY5kfGmxbjDhd5NigQ>? M1;ZRWlvcGmkaYTpc44hd2ZidHjpc5Jm\G:6aX6gdoVlfWO2YYPlJIlvKGi3bXHuJGE2PDliY3XscJMh[nliRGTORkBlgWViYnHz[YQhdWmlcn;wcIF1\SC|cHXjeJJweGixdH;t[ZRzgSxiSVO1NEA:KDRyLkW2JO69VS5? NIXX[HM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nki5NVA6QSd-Mk[4PVExQTl:L3G+
A549 NUjyWFZvSXCxcITvd4l{KGG|c3H5 MXOyMlEhfG9iND6yJJVO NVy0XI4xOjRiaILz NHvUVoxKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIFG1OFkh[2WubIOgZZQhOi5zIITvJFQvOiC3TTDh[pRmeiB{NDDodpMh[nliYX7u[ZhqdiCYLV\JWGMweHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{1j[XOnZDDmcI94KGO7dH;t[ZRzgQ>? MmLlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ6OUGwPVkoRjJ4OEmxNFk6RC:jPh?=
A549/CDDP MkPKRZBweHSxc3nzJIF{e2G7 M2\uV|AvPiC2bzCxMlIhfU1? M1vlfFI1KGi{cx?= NW\nfZk3UW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDBOVQ6N0OGRGCgZ4VtdHNiYYSgNE43KHSxIEGuNkB2VSCjZoTldkAzPCCqcoOgZpkh[W6wZYjpckBXNU[LVFOvdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZz3iZZNm\CCobH;3JIN6fG:vZYTyfS=> MorIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ6OUGwPVkoRjJ4OEmxNFk6RC:jPh?=
bone marrow NInGXlFHfW6ldHnvckBie3OjeR?= NILjRmo1QCCqcoO= MnW2TY5pcWKrdHnvckBw\iCUQV7LUE1qdmS3Y3XkJI9{fGWxY3zhd5Qh\GmoZnXy[Y51cWG2aX;uJIlvKEmFUjDtc5V{\SCkb37lJI1ienKxdzDj[YxteyCjZoTldkA1QCCqcoOgZpkhXFKDUDDhd5NigSxiSVO1NEA:KDdwNTFOwG0v NFzFc|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkmyN|Y6Pid-Mk[5NlM3QTZ:L3G+
U937 MlyzSpVv[3Srb36gZZN{[Xl? NX32XpAyOTdidH:gNlAhcHK| NIPa[nhKdmirYnn0bY9vKG:oIFzQV{9KTk5vZ3HtcYEucW6mdXPl[EBRT0V{IIDyc4R2[3Srb36gbY4hWE2DLYTy[YF1\WRiaIXtZY4hXTl|NzDj[YxteyCjZoTldkAyPyC2bzCyNEBpenNiYomg[Y57gW2nIHntcZVvd2G|c3H5MEBKSzVyIE2gNU45QCEQvF2u NFjDZnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C0NFY2QSd-MkewOFA3PTl:L3G+
RAW264.7 Mn;kSpVv[3Srb36gZZN{[Xl? M2riUlE4KHSxIEKwJIhzew>? Ml7pTY5pcWKrdHnvckBw\iCOUGOvTWZPNWejbX3hMYlv\HWlZXSgVGdGOiCycn;keYN1cW:wIHnuJI1wfXOnIGLBW|I3PC55IHPlcIx{KGGodHXyJFE4KHSxIEKwJIhzeyCkeTDlcpp6dWViaX3teY5w[XO|YYmsJGlEPTBiPTCxOU46PSEQvF2u M3TCb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MESwOlU6Lz5{N{C0NFY2QTxxYU6=
BV2 NY\X[VNLSW62aXnu[oxidW2jdH;yfUBie3OjeR?= M2TZc|I1KGi{cx?= NIjDTGZCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKG2xdYPlJGJXOiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGxRWy2rbnT1Z4VlKG6rdILpZ{BwgGmmZTDwdo9lfWO2aX;uJIFnfGW{IEK0JIhzeyCkeTDHdolme3NiYYPzZZktKEmFNUCgQUA1Njd5IN88UU4> M2L5blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MkK4NlI4Lz5{N{KyPFIzPzxxYU6=
SH-SY5Y M{K0UW5mfXKxcILveIVkfGm4ZTDhd5NigQ>? NUTLUVVxOjRiaILz M2fDdW5mfXKxcILveIVkfGm4ZTDhZ5Rqfmm2eTDpckBpfW2jbjDTTE1UYTW\IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckA3NU:KRFGtbY5lfWOnZDDj[YxtKGSnYYToJI1m[XO3cnXkJIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO|YYmsJGVEPTBiPTC2MlIh|ryPLh?= NVzkcoVMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke0NlA6OTlpPkK3OFIxQTF7PD;hQi=>
PC3 NEL6dXNEgXSxdH;4bYNqfHliYYPzZZk> NFqxW3MzPCCqcoO= NWixWlYzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN|IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|OTFOwG0v M1j1TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NEm2NlEzLz5{N{S5OlIyOjxxYU6=
DU145 M{XYdmN6fG:2b4jpZ4l1gSCjc4PhfS=> MmTTNlQhcHK| MojUR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSHUyPDViY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDRzIN88UU4> MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzR7NkKxNkc,Ojd2OU[yNVI9N2F-
4T1 MWPDfZRwfG:6aXPpeJkh[XO|YYm= MXmyOEBpenN? NI\EfHVEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UA1XDFiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDR7LkSg{txONg>? MnvzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd2OU[yNVIoRjJ5NEm2NlEzRC:jPh?=
T47D M4\uOWN6fG:2b4jpZ4l1gSCjc4PhfS=> NXrw[G9oOjRiaILz M2\2N2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHQ1P0RiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|MDFOwG0v MmXUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3MUe4NFYoRjJ5NUG3PFA3RC:jPh?=
CHOK1 NXvoVWljT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnnTO|IhcHK| NFP4XZRIem:5dHigbY5pcWKrdHnvckBw\iCFSF;LNUBk\WyuczDhd5Nme3OnZDDhd{BucXSxY3jvcoRzcWGuIHHjeIl3cXS7IH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB5LkWg{txONg>? MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV{MUW4PUc,Ojd3MkG1PFk9N2F-
LNCAP MmezRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M3:1TlMh\GG7cx?= MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEyQQ1HQJINmdGy|IHHmeIVzKDNiZHH5d{BjgSCZU2Sgc5IhfHK7cHHuJIJtfWViYYPzZZktKEmFNUCgQUAyOy54MTFOwG0v MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV2M{O5NUc,Ojd3NEOzPVE9N2F-
PC3 M{HYRWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NXXnRVI2OyCmYYnz MnHURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KFeVVDDvdkB1enmyYX6gZox2\SCjc4PhfUwhUUN3MDC9JFI2NjR|IN88UU4> M3rMXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUSzN|kyLz5{N{W0N|M6OTxxYU6=
DU145 MnjiRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NGm3T5o{KGSjeYO= NX\IbI4xSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bi\nSncjCzJIRigXNiYomgW3NVKG:{IITyfZBidiCkbIXlJIF{e2G7LDDJR|UxKD1iMk[uNlMh|ryPLh?= Mo\YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3NEOzPVEoRjJ5NUSzN|kyRC:jPh?=
BV2 MXjGeY5kfGmxbjDhd5NigQ>? NHOxVZYyKGi{ MnnXTY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDubZRzcWNib4jp[IUheHKxZIXjeIlwdiCrbjDtc5V{\SCEVkKgZ4VtdHNicILleJJm[XSnZDDmc5IhOSCqcjDi[YZwemViTGDTJJN1cW23bHH0bY9vKG2nYYP1doVlKGGodHXyJFI1KGi{czDifUBIemmnc4OgZZN{[XluIFnDOVAhRSBzLkSyJO69VS5? M1u0cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUmyNVM2Lz5{N{W5NlE{PTxxYU6=
BV2 MXvGeY5kfGmxbjDhd5NigQ>? M2\1[lEhcHJ? NUjFO|R1UW6qaXLpeIlwdiCxZjDTdoMhcW5ibX;1d4UhSlZ{IHPlcIx{KGG|c3Xzd4VlKGG|IIP1dJBz\XO|aX;uJI9nKEySUz3pcoR2[2WmIF7PJJJmdGWjc3WgdJJmcW6ldXLheIVlKG[xcjCxJIhzKG[xbHzve4VlKGK7IFzQV{Bi\GSrdHnvckBu\WG|dYLl[EBi\nSncjCyOEBpenNiYomgS5Jq\XO|IHHzd4F6NCCLQ{WwJF0hOi5{IN88UU4> NUGyUWo{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2NVc5ODNpPkK3OlE4QDB|PD;hQi=>
A549 MUXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NUTGe|JYPDhiaILz M2nZWGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUWuNFYh|ryPLh?= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzhzNkK2O{c,Ojd6MU[yOlc9N2F-
MDA-MB-231 MVvBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NEHNXJY1QCCqcoO= NVu4dI1nSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{ND61OEDPxE1w MoTHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd6MU[yOlcoRjJ5OEG2NlY4RC:jPh?=
DU145 NGXLO|FCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M{LrPVQ5KGi{cx?= NVzVSZlsSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOFQvPzFizszNMi=> MmfSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd6MU[yOlcoRjJ5OEG2NlY4RC:jPh?=
EAhy926 M4jO[mN6fG:2b4jpZ4l1gSCjc4PhfS=> MYS0PEBpenN? NWDKWpFrS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTUGqeUmyOkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlQvPiEQvF2u NWrrXmJ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4OFMyOTNpPkK3PFQ{OTF|PD;hQi=>
Caco2 Mke2R5l1d3SxeHnjbZR6KGG|c3H5 Moq4OFghcHK| NEjneoNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBE[WOxMjDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{iuN{DPxE1w NIqyXG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{i0N|EyOyd-Mke4OFMyOTN:L3G+
CHOK1 MX\DfZRwfG:6aXPpeJkh[XO|YYm= MnnIOFghcHK| NHv2VYZEgXSxdH;4bYNqfHliYXfhbY5{fCCFSF;LNUBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOFIh|ryPLh?= NWrkfHN7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4OFMyOTNpPkK3PFQ{OTF|PD;hQi=>
SH-SY5Y M{jSVmZ2dmO2aX;uJIF{e2G7 NVzkUXE{OSC2bzC1JJVO NGjvS28zPCCqcoO= NYrCW49lSW62aX;4bYRidnRiYXP0bZZqfHliYXfhbY5{fCC2LVLIVE1qdmS3Y3XkJI95cWSjdHn2[UB{fHKnc4OgbY4hcHWvYX6gV2guW1l3WTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKFKRUzDwdo9lfWO2aX;uJIF1KDFidH:gOUB2VSCjZoTldkAzPCCqcoOgZpkhTEOISD3ERUBxem:kZTDiZZNm\CCobH;3JIN6fG:vZYTybYMh[W6jbInzbZM> NV63O3BWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4OVYzOzZpPkK3PFU3OjN4PD;hQi=>
NCI-H1650 M2DxemN6fG:2b4jpZ4l1gSCjc4PhfS=> M4PMOFczKGi{cx?= Mk\0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmNKNUhzNkWwJINmdGy|IH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{MD63JO69VS5? M{C1NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OEi2OVQ5Lz5{N{i4OlU1QDxxYU6=
LLC M17CTWN6fG:2b4jpZ4l1gSCjc4PhfS=> NU\nO2hFPzJiaILz Mm\kR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgUGxEKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyOE44KM7:TT6= MonsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd6OE[1OFgoRjJ5OEi2OVQ5RC:jPh?=
A549 MnrPR5l1d3SxeHnjbZR6KGG|c3H5 MVq3NkBpenN? MmPaR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bu\WG|dYLl[EBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlcvQCEQvF2u MnG2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd6OE[1OFgoRjJ5OEi2OVQ5RC:jPh?=
K562 M{P6RWZ2dmO2aX;uJIF{e2G7 NX60[VJbPDhiaILz NF74enJKdmirYnn0bY9vKG:oIGCt[5AhcW5iZH;4c5J2[mmlaX6gdoV{cXO2YX70JIh2dWGwIFu1OlIh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KG2nYYP1doVlKGGodHXyJFQ5KGi{czDifUBRemW|dH:gZox2\SCjc4PhfUwhT0l3MDC9JFE6NjZ5IN88UU4> NHi2SnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{mwPFc2Pid-Mke5NFg4PTZ:L3G+
K562 M3;Fe2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NYrYTm5JPDhiaILz NGjoUY1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgcYVie3W{ZXSgZYZ1\XJiNEigbJJ{KGK7IGDy[ZN1dyCkbIXlJIF{e2G7LDDHTVUxKD1iMkGuOlch|ryPLh?= NFPYT4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{mwPFc2Pid-Mke5NFg4PTZ:L3G+
H460 MX;GeY5kfGmxbjDhd5NigQ>? MYm0PEBpenN? NX:0SZBpUW6qaXLpeIlwdiCxZjDQMYdxKGmwIHTyeYchemW|aYP0ZY51KGi3bXHuJGg1PjBiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IH3lZZN2emWmIHHmeIVzKDR6IHjyd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGG|c3H5MEBIUTVyIE2gNlYh|ryPLh?= MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzlyOEe1Okc,Ojd7MEi3OVY9N2F-
NCI-H460 NIHjSXpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MX20PEBpenN? MYnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3IOFYxKGOnbHzzJI1m[XO3cnXkJIFnfGW{IES4JIhzeyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6NCCJSUWwJF0hOjdwMzFOwG0v M4jNWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUC4O|U3Lz5{N{mwPFc2PjxxYU6=
K562 MWTGeY5kfGmxbjDhd5NigQ>? NGH3T5UzOCC2bzCzNEB2VQ>? NInKeVE1QCCqcoO= NUXaRXVGTG:5bjDy[Yd2dGG2aX;uJI9nKHBvZ4Cg[ZhxemW|c3nvckBqdiCmb4jvdpVjcWOrbjDy[ZNqe3SjboSgbJVu[W5iS{W2NkBk\WyuczDheEAzOCC2bzCzNEB2VSCvZXHzeZJm\CCjZoTldkA1QCCqcoOgZpkhX2W|dHXyckBjdG:2IH3leIhw\A>? NH\6b2U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{mwPFc2Pid-Mke5NFg4PTZ:L3G+
K562 MmjRR4VtdCCleXPs[UBie3OjeR?= MUmyNEB2VQ>? M{\PVFQ5KGi{cx?= MV7D[YxtKGO7Y3zlJIFzemW|dDDpckBld3ixcoXibYNqdiC{ZYPpd5RidnRiaIXtZY4hUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBIOC:JMTDwbIF{\SCjdDCyNEB2VSCvZXHzeZJm\CCjZoTldkA1QCCqcoOgZpkheHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{Bj[XOnZDDmcI94KGO7dH;t[ZRzgQ>? M1\hdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUC4O|U3Lz5{N{mwPFc2PjxxYU6=
K562 MX7D[YxtKGO7Y3zlJIF{e2G7 M3u4OlIxKHWP MUK0PEBpenN? NUDuTYhpS2WubDDjfYNt\SCjcoLld5QhcW5iZH;4c5J2[mmlaX6gdoV{cXO2YX70JIh2dWGwIFu1OlIh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iR{KvUUBxcGG|ZTDheEAzOCC3TTDt[YF{fXKnZDDh[pRmeiB2ODDodpMh[nlicILvdIllcXWvIHnv[Ill\SC|dHHpcolv\yCkYYPl[EBndG:5IHP5eI9u\XS{eR?= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzlyOEe1Okc,Ojd7MEi3OVY9N2F-
K562 NEXDdmxHfW6ldHnvckBie3OjeR?= MofJNlAhfG9iNECgeW0> M4XUTlQ5KGi{cx?= NGWySHpWeCC{ZXf1cIF1cW:wIH;mJJA2OyCneIDy[ZN{cW:wIHnuJIRwgG:{dXLpZ4lvKHKnc3nzeIFvfCCqdX3hckBMPTZ{IHPlcIx{KGG2IEKwJJRwKDRyIIXNJI1m[XO3cnXkJIFnfGW{IES4JIhzeyCkeTDX[ZN1\XKwIHLsc5QhdWW2aH;k MlL0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7MEi3OVYoRjJ5OUC4O|U3RC:jPh?=
K562 NUS3NmZDS2WubDDjfYNt\SCjc4PhfS=> M4TpdFIxKHWP MoTPOFghcHK| MWTD[YxtKGO7Y3zlJIFzemW|dDDpckBld3ixcoXibYNqdiC{ZYPpd5RidnRiaIXtZY4hUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBUKHCqYYPlJIF1KDJyIIXNJI1m[XO3cnXkJIFnfGW{IES4JIhzeyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pIHLhd4VlKG[ub4egZ5l1d22ndIL5 NFnaOVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{mwPFc2Pid-Mke5NFg4PTZ:L3G+
K562 NHjJVVBE\WyuIHP5Z4xmKGG|c3H5 M3HjTlMxKHSxIESwJJVO NWHJVZBWPDhiaILz MXXD[YxtKGO7Y3zlJIFzemW|dDDpckBld3ixcoXibYNqdiC{ZYPpd5RidnRiaIXtZY4hUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDhZ4N2dXWuYYTpc44h[XRiR{CvS|EheGijc3WgZZQhOzBidH:gOFAhfU1ibXXhd5Vz\WRiYX\0[ZIhPDhiaILzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcoch[mG|ZXSg[oxwfyCleYTvcYV1enl? NIXDenc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{mwPFc2Pid-Mke5NFg4PTZ:L3G+
K562 Mn7DR4VtdCCleXPs[UBie3OjeR?= M3GzVlMxKHSxIESwJJVO NWPJZmN7PDhiaILz Mm\RR4VtdCCleXPs[UBienKnc4SgbY4h\G:6b4L1ZolkcW5icnXzbZN1[W62IHj1cYFvKEt3NkKgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hTzJxTTDwbIF{\SCjdDCzNEB1dyB2MDD1UUBu\WG|dYLl[EBi\nSncjC0PEBpenNiYomgdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZzDiZZNm\CCobH;3JIN6fG:vZYTyfS=> NWPjOXU{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5NFg4PTZpPkK3PVA5PzV4PD;hQi=>
K562 M{XvfWZ2dmO2aX;uJIF{e2G7 MnnDNlAhfG9iNECgeW0> MmDzOFghcHK| NWC2ZWoyTG:5bjDy[Yd2dGG2aX;uJI9nKGO7Y3zpckBDOSCneIDy[ZN{cW:wIHnuJIRwgG:{dXLpZ4lvKHKnc3nzeIFvfCCqdX3hckBMPTZ{IHPlcIx{KGG2IEKwJJRwKDRyIIXNJI1m[XO3cnXkJIFnfGW{IES4JIhzeyCkeTDX[ZN1\XKwIHLsc5QhdWW2aH;k MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzlyOEe1Okc,Ojd7MEi3OVY9N2F-
K562 MV3BdI9xfG:|aYOgZZN{[Xl? M{fQZVIxKHSxIESwJJVO MmPPOFghcHK| MoH4TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDkc5hwenWkaXPpckBz\XOrc4ThcpQhcHWvYX6gT|U3OiClZXzsd{Bl\WO{ZXHz[UBqdiCycn:tZ4F{eGG|ZTCzJIxmfmWuIHH0JFIxKHSxIESwJJVOKG2nYYP1doVlKGGodHXyJFQ5KGi{czDifUBY\XO2ZYLuJIJtd3RibXX0bI9l NEHjfpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{mwPFc2Pid-Mke5NFg4PTZ:L3G+
K562 NGHmPJVCeG:ydH;zbZMh[XO|YYm= NXzqR5VFOjBidH:gOFAhfU1? Mnu1OFghcHK| MU\JcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHTvfI9zfWKrY3nuJJJme2m|dHHueEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIGDBVnAuOSClbHXheoFo\SCjdDCyNEB1dyB2MDD1UUBu\WG|dYLl[EBi\nSncjC0PEBpenNiYomgW4V{fGW{bjDicI91KG2ndHjv[C=> MnPDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7MEi3OVYoRjJ5OUC4O|U3RC:jPh?=
Raji NVjtfY1sTnWwY4Tpc44h[XO|YYm= NIq0TYY1QCCqcoO= NEn0S4xKdmirYnn0bY9vKG:oIGTQRU1qdmS3Y3XkJGVDXi2nYYLsfUBidnSrZ3XuJIFkfGm4YYTpc44hcW5iaIXtZY4hWmGsaTDj[YxteyCjZoTldkA1QCCqcoOgZpkhcW6maYLlZ5QhcW2vdX7v[ox2d3Knc3PlcoNmKG2ndHjv[EwhUUN3MDC9JFEzNjFizszNMi=> Mo\jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7M{O4PVYoRjJ5OUOzPFk3RC:jPh?=
BV2 NVW5c|YyTnWwY4Tpc44h[XO|YYm= NIrMR4YzPCCqcoO= M3G1RmlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgcol1emmlIH;4bYRmKHC{b3T1Z5Rqd25iaX6gcY92e2ViQm[yJINmdGy|IIDy[ZRz\WG2ZXSg[o9zKDJ2IHjyd{Bnd2yub4fl[EBjgSCOUGOtd5RqdXWuYYTpc44h[W[2ZYKgNlQhcHK|IHL5JGdzcWW|czDhd5NigSxiSVO1NEA:KDJwM{[g{txONg>? NUHSdFRpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwN|I4PTlpPkK4NFMzPzV7PD;hQi=>
PC3 NFj3ZZpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NFK4Om81QCCqcoO= M2q5ZmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMj6yNkDPxE1w Mke0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyM{izNlMoRjJ6MEO4N|I{RC:jPh?=
MDA-MB-231 NEHBepFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MXm0PEBpenN? NF;kdHNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF3LkixJO69VS5? NV\LcXN6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwN|g{OjNpPkK4NFM5OzJ|PD;hQi=>
BT549 Mk\MRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M4rONFQ5KGi{cx?= Mm\LRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCEVEW0PUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkSuPVMh|ryPLh?= NYPKOFFURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwN|g{OjNpPkK4NFM5OzJ|PD;hQi=>
HeLa M1;zNWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MXi0PEBpenN? M2rSOGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXMZUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkWuOFEh|ryPLh?= NEKwdlY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OECzPFMzOyd-MkiwN|g{OjN:L3G+
DU145 NEnaOHRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MkDzOFghcHK| NX3HSJlGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlgvPDFizszNMi=> MlzjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyM{izNlMoRjJ6MEO4N|I{RC:jPh?=
BV2 MWXGeY5kfGmxbjDhd5NigQ>? NX7HeoJwOzBibXnudy=> M1rNUWlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgcol1emmlIH;4bYRmKHC{b3T1Z5Rqd25iaX6gcY92e2ViQm[yJINmdGy|IIDy[ZRz\WG2ZXSg[o9zKDNyIH3pcpMh\m:ubH;3[YQh[nliTGDTMZN1cW23bHH0bY9vKGGodHXyJFI1KGi{czDifUBIemmnc4OgZZN{[XluIFnDOVAhRSB2LkWg{txONg>? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB3NUKxNEc,OjhyNUWyNVA9N2F-
THP1 NYHBRY9oTnWwY4Tpc44h[XO|YYm= MlzCNUBpeg>? NHvnRpFKdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJJRqe3O3ZTDmZYN1d3JicILvZ49i\3WuYX70JIFkfGm4aYT5JIlvKGi3bXHuJHRJWDFiY3XscJMheHKnaX7jeYJifGWmIH\vdkAyKGi{IH\vcIxwf2WmIHL5JGxRWyCjZHTpeIlwdiCvZXHzeZJm\CCjZoTldkA2KGi{czD1d4lv\yCoYXP0c5IhOTCjIHPodo9ud2enbnnjJJN2[nO2cnH0[UBqdiCycnXz[Y5k\SCxZjDwdo91cHKxbXLpckBkd22ybHX4MEBKSzVyIE2gNE4xOTNzNjFOwG0v MoLTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzMEm3PFgoRjJ6MUC5O|g5RC:jPh?=
RAW264.7 NWjtOohRSW62aXnu[oxidW2jdH;yfUBie3OjeR?= MoTDNlAhfU1? M3PTXmFvfGlvaX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgTWwuPiCycn;keYN1cW:wIHH0JFIxKHWPIHL5JGVNUVOD M2HvZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6Mki0PFA3Lz5{OEK4OFgxPjxxYU6=
RAW264.7 MVnBcpRqcW6obHHtcYF1d3K7IHHzd4F6 MkDpNlAhfU1? NInISJdCdnSrLXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJHRPTmGucHjhJJBzd2S3Y4Tpc44h[XRiMkCgeW0h[nliRVzJV2E> NFnJZ5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK4OFgxPid-MkiyPFQ5ODZ:L3G+
PC12 NVi2VZdGVmW3cn;wdo91\WO2aY\lJIF{e2G7 NEDPWHAxNjFidH:gNVAhfU1? NIjGUGwzPCCqcoO= M1\xfW5mfXKxcILveIVkfGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFiyNFIucW6mdXPl[EB1d3irY3n0fUBqdiC{YYSgVGMyOiClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDj[YxtKH[rYXLpcIl1gSCjdDCwMlEhfG9iMUCgeW0h[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfS=> NES4VFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEOwNlUyOSd-MkizNFI2OTF:L3G+
PC12 Mn\pUoV2em:ycn;0[YN1cX[nIHHzd4F6 MVSwMlEhfG9iMUCgeW0> NVG3XWl7OjRiaILz MUfO[ZVzd3C{b4TlZ5RqfmViYXP0bZZqfHliYXfhbY5{fCCDYnX0ZVQzNWmwZIXj[YQhfG:6aXPpeJkhcW5icnH0JHBEOTJiY3XscJMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYYSgNE4yKHSxIEGwJJVOKGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZk> M1\lcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{CyOVEyLz5{OEOwNlUyOTxxYU6=
HCT116 M1v0RmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NH;tfHZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{B2eCC2bzC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVMvPzdizszNMi=> MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDNzOUe4NEc,Ojh|MUm3PFA9N2F-
MDA-MB-231 NXixXZh3SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M1PNbWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyC3cDD0c{A4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTZwMkOg{txONg>? MnjZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|MUm3PFAoRjJ6M{G5O|gxRC:jPh?=
PC3 NFfleYlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MkHURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNidYCgeI8hPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF6Lkig{txONg>? MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDNzOUe4NEc,Ojh|MUm3PFA9N2F-
BT474 NX;Ob2pmSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MknoNlQhcHK| NIjTVGRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGhGWjJicH;zbZRqfmViaIXtZY4hSlR2N{SgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNyLkG0JO69VS5? NI[xNFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEOxPVc5OCd-MkizNVk4QDB:L3G+
MDA-MB-453 NH\nXJJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M4Dr[FI1KGi{cx?= M2DucmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgTGVTOiCyb4PpeIl3\SCqdX3hckBOTEFvTVKtOFU{KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzNk41KM7:TT6= NETIO2U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEOxPVc5OCd-MkizNVk4QDB:L3G+
MDA-MB-157 MXPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MonQNlQhcHK| NXv3cnNvSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMUW3JINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2MD6zPEDPxE1w MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDNzOUe4NEc,Ojh|MUm3PFA9N2F-
SKBR3 Mn7oRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MXOyOEBpenN? M1XQU2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgTGVTOiCyb4PpeIl3\SCqdX3hckBUU0KUMzDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPDJwOEOg{txONg>? M{LEXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{G5O|gxLz5{OEOxPVc5ODxxYU6=
MCF7 M2PQZ2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NELS[YMzPCCqcoO= MWHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFXSM3BTKHCxc3n0bZZmKGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQzNjh7IN88UU4> M{j3RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{G5O|gxLz5{OEOxPVc5ODxxYU6=
MDA-MB-468 MlTZRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NGfyUnkzPCCqcoO= NWjNRZBxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNE[4JINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2Mj64PUDPxE1w M4fjTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{G5O|gxLz5{OEOxPVc5ODxxYU6=
T47D M3n6ZWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M{P2e|I1KGi{cx?= MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFXSM3BTKHCxc3n0bZZmKGi3bXHuJHQ1P0RiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQ4NjlzIN88UU4> MlvmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|MUm3PFAoRjJ6M{G5O|gxRC:jPh?=
cells at NVnsdHAxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MljMN|AhfU1? NEDKe4U1QCCqcoO= NWC4S|kzT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUGWyM1KgZ4VtdHNiYYSgN|AhfU1iYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigQ>? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDN2MkSwNEc,Ojh|NEK0NFA9N2F-
PWR-1E M{iwOGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NGfRPIE{KGSjeYO= NV\lU|J6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQW3IuOUViY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JHdUXC1zIHHzd4F6NCCLQ{WwJF0hQC5zNDFOwG0v NVPab5VqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizPFg2OjNpPkK4N|g5PTJ|PD;hQi=>
LNCAP M3nieWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M3vveFMh\GG7cx?= NV\XdYVMSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDMUmNCWCClZXzsd{Bi\nSncjCzJIRigXNiYomgW3NVNTFiYYPzZZktKEmFNUCgQUAyOy54MTFOwG0v Mn\TQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|OEi1NlMoRjJ6M{i4OVI{RC:jPh?=
PC3 M4jud2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 Mn3yN{Bl[Xm| Mo[2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KFeVVD2xJIF{e2G7LDDJR|UxKD1iMkWuOFMh|ryPLh?= NHP6bXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEO4PFUzOyd-MkizPFg2OjN:L3G+
DU145 MX\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MlXSN{Bl[Xm| MojxRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCGVUG0OUBk\WyuczDh[pRmeiB|IHThfZMh[nliV2PUMVEh[XO|YYmsJGlEPTBiPTCyOk4zOyEQvF2u NWO4cWZrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizPFg2OjNpPkK4N|g5PTJ|PD;hQi=>
HepG2 MXzGeY5kfGmxbjDhd5NigQ>? MlvYOUB2VQ>? M{f1UlI1KGi{cx?= M{T6UmFkfGm4YYTpc44hd2ZiToLmNkBqdiCqdX3hckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDjfZRweHKxdHXjeIlwdiCjZ3HpcpN1KHRvQljQMYlv\HWlZXSgc5hq\GG2aY\lJINmdGxiZHXheIgh[XRiNTD1UUBqdmO3YnH0[YQh\m:{IEK0JIhzeyCob3zsc5dm\CCkeTDjc41xd3WwZDDy[Y1wfmGuIIfpeIghe3Wkc3XxeYVvfCCrbnP1ZoF1cW:wIIfpeIghQTByIIXNJI9nKHRvQljQJIZweiB4IHjyd{BjgSCPVGSgZZN{[Xl? NX[yVnBwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizPVk1PTJpPkK4N|k6PDV{PD;hQi=>
BV2 MVzBcpRqdmW3cn;pcoZt[W2vYYTvdpkh[XO|YYm= NXTVXphmOTVibXnudy=> NHLLboNCdnSrbnX1do9qdm[uYX3tZZRwenliYXP0bZZqfHliaX6gcY92e2ViQm[yJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgcol1emmlIH;4bYRmKHC{b3T1Z5Rqd25icILleJJm[XSnZDDmc5IhOTVibXnud{Bnd2yub4fl[EBjgSCOUGOtd5RqdXWuYYTpc44hdWWjc4Xy[YQh[W[2ZYKgNlQhcHK|IHL5JINwdG:{aX3leJJq[yCvZYToc4QtKEmFNUCgQUA3KM7:TT6= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDVzNEG0PEc,Ojh3MUSxOFg9N2F-
L428 MoTwSpVv[3Srb36gZZN{[Xl? MWKyJIhzew>? MULJcohq[mm2aX;uJI9nKE6ILXvhdJBiSiBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDoeY1idiCONEK4JINmdGy|IHHmeIVzKDJiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeR?= M1\GUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUK2N|Y6Lz5{OEWyOlM3QTxxYU6=
PWR-1E NGrDOVhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M2Cy[lMh\GG7cx?= MWHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCZUj2xSUBk\WyuczDlfJBz\XO|aX7nJIFv\HKxZ3XuJJJm[2WydH;yJIFv\CCSU1GgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgN{Bl[Xm|IHL5JHdUXCCjc4PhfUwhUUN3MDC9JFgvQDVizszNMi=> NVTaRpl{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2NFE4OjBpPkK4OlAyPzJyPD;hQi=>
LNCAP MX\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Mo[5N{Bl[Xm| NF3jRmlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzOR2FRKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFMh\GG7czDifUBYW1RiYYPzZZktKEmFNUCgQUAyOy54MTFOwG0v NF3GTmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[wNVczOCd-Mki2NFE4OjB:L3G+
PC3 MkPFRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Mn7FN{Bl[Xm| M33udmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEOg[IF6eyCkeTDXV3Qh[XO|YYmsJGlEPTBiPTCyOU41OyEQvF2u MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZyMUeyNEc,Ojh4MEG3NlA9N2F-
DU145 M2KxZmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NFna[lQ{KGSjeYO= NEnvSVBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFTVNVQ2KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFMh\GG7czDifUBYW1RiYYPzZZktKEmFNUCgQUAzPi5{MzFOwG0v NYX1dVdURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2NFE4OjBpPkK4OlAyPzJyPD;hQi=>
MDA-MB-231 MWLDfZRwfG:6aXPpeJkh[XO|YYm= M2PDTFQ5KGi{cx?= M{\kbWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFEzKM7:TT6= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ3NEK2OUc,Ojh4NUSyOlU9N2F-
HT-29 MnTRR5l1d3SxeHnjbZR6KGG|c3H5 MonWOFghcHK| NIfpRllEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXC1{OTDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUSg{txONg>? M13pN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkW0NlY2Lz5{OE[1OFI3PTxxYU6=
NCI-H460 M3\sWWN6fG:2b4jpZ4l1gSCjc4PhfS=> MX[0PEBpenN? MkW1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmNKNUh2NkCgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG1JO69VS5? MkT3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4NUSyOlUoRjJ6NkW0NlY2RC:jPh?=
LN229 Mk\mR5l1d3SxeHnjbZR6KGG|c3H5 M{O0U|Q5KGi{cx?= NUDCUGNtS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVE5{MkmgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG1JO69VS5? NU\jR2kzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2OVQzPjVpPkK4OlU1OjZ3PD;hQi=>
U87 MXHDfZRwfG:6aXPpeJkh[XO|YYm= M3jqVFQ5KGi{cx?= M3fnRWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHU5PyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTZizszNMi=> MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ3NEK2OUc,Ojh4NUSyOlU9N2F-
COLO201 MUPDfZRwfG:6aXPpeJkh[XO|YYm= MkL4OFghcHK| NUXQZ49mS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0:OT{KwNUBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVgh|ryPLh?= NX7DfIhNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2OVQzPjVpPkK4OlU1OjZ3PD;hQi=>
A549 M1W4T2N6fG:2b4jpZ4l1gSCjc4PhfS=> NHjyZZo1QCCqcoO= M2PrR2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF6IN88UU4> NFy3SpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[1OFI3PSd-Mki2OVQzPjV:L3G+
T47D M1vxbWN6fG:2b4jpZ4l1gSCjc4PhfS=> NX\Db4prPDhiaILz MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDUOFdFKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyQSEQvF2u NEHtUoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[1OFI3PSd-Mki2OVQzPjV:L3G+
MML1 Ml\4R5l1d3SxeHnjbZR6KGG|c3H5 MXW0PEBpenN? MVPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNUWwyKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyQSEQvF2u NUe5U3huRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2OVQzPjVpPkK4OlU1OjZ3PD;hQi=>
BxPC3 MYTDfZRwfG:6aXPpeJkh[XO|YYm= NXfWcmh4PDhiaILz M3X6UWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJ5WEN|IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{OTFOwG0v M3ntNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkW0NlY2Lz5{OE[1OFI3PTxxYU6=
SK-MEL-2 M1TqW2N6fG:2b4jpZ4l1gSCjc4PhfS=> NYmzOnN5PDhiaILz NEPrNmREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUUy2PRVytNkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|Yh|ryPLh?= Mm[5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4NUSyOlUoRjJ6NkW0NlY2RC:jPh?=
HCT116 MXHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MUO0PEBpenN? NGHlN4hCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bi\nSncjC0PEBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiR1m1NEA:KDNwNTFOwG0v MoG1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5MU[0PVUoRjJ6N{G2OFk2RC:jPh?=
HCT116 MlLCSpVv[3Srb36gZZN{[Xl? M{e4ZVQ5KGi{cx?= MXPJcoR2[3Srb36gc4YhdWm2b3Poc45lemmjbDDt[Y1jemGwZTDwc5RmdnSrYXygcI9{eyCrbjDoeY1idiCKQ2SxNVYh[2WubIOgZZQh[W62aYDyc4xq\mW{YYTpeoUhT0l3MDDh[pRmeiB2ODDodpMh[nliSlOtNUB{fGGrbnnu[{Bj[XOnZDDmcJVwemW|Y3XuZ4Uh[XO|YYm= M2W4d|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{G2OFk2Lz5{OEexOlQ6PTxxYU6=
HCT116 M2jyXGZ2dmO2aX;uJIF{e2G7 NWrGR3MzPjBibXnudy=> MYrJcoR2[3Srb36gc4YhdWm2b3Poc45lemmjbDDzeZBmem:6aXTlJIdmdmW{YYTpc44hcW5iaIXtZY4hUEOWMUG2JINmdGy|IHH0JIFvfGmycn;sbYZmemG2aY\lJGdKPTBiYX\0[ZIhPjBibXnud{BjgSCvaYTvV29ZKHKnZD3wdo9j\SCkYYPl[EBndHWxcnXzZ4Vv[2ViYYPzZZk> MmPqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5MU[0PVUoRjJ6N{G2OFk2RC:jPh?=
HCT116 MVLGeY5kfGmxbjDhd5NigQ>? NXzOWGtUPjBibXnudy=> M4fTXWlv\HWldHnvckBw\iC{ZXHjeIl3\SCxeInn[Y4he3CnY3nld{Bo\W6ncnH0bY9vKGmwIHj1cYFvKEiFVEGxOkBk\WyuczDheEBidnSrcILvcIln\XKjdHn2[UBIUTVyIHHmeIVzKDZyIH3pcpMh[nliRFPGTE1FSSCycn;i[UBj[XOnZDDhd5NigQ>? Mnz3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5MU[0PVUoRjJ6N{G2OFk2RC:jPh?=
HCT116 MX;GeY5kfGmxbjDhd5NigQ>? NUDR[lg6PTByIIXN NXjJNXFkPDhiaILz MnG3TY5lfWO2aX;uJI9nKGeudYTheIhqd26nIH;4bYRifGmxbjDpckBpfW2jbjDIR3QyOTZiY3XscJMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gS3NUTy:JU1igdoF1cW9iYYSgOVAxKHWPIHnuJJBz\XOnbnPlJI9nKE6DRGDIJIFnfGW{IES4JIhzeyCkeTDFcIxu[W5pczDt[ZRpd2R? M3rWTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{G2OFk2Lz5{OEexOlQ6PTxxYU6=
MCF7 Mn3vSpVv[3Srb36gZZN{[Xl? M{DwfVQ5KGi{cx?= MnfyUY9lfWyjdHnvckBi[3Srdnn0fUBifCCHUjDpckBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPDhizszNMi=> NFe2Wm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEe5O|c6Pyd-Mki3PVc4QTd:L3G+
A549 MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVHHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDBOVQ6KGOnbHzzMEBKSzVyIE2gNlMh|ryPLh?= NF\rW5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEixOFM4PCd-Mki4NVQ{PzR:L3G+
BGC823 NHq4TXhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYHPSWtuOjBidV2= M{HDO|czKGi{cx?= M1[4V2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGJISzh{MzDj[YxteyCjdDCyNEB2VSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6 MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDh6MUK4Okc,Ojh6OEGyPFY9N2F-
SGC7901 MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3;DfVIxKHWP MUm3NkBpenN? NFPGbGdIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBUT0N5OUCxJINmdGy|IHH0JFIxKHWPIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[Xl? NXLCO2F3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki4PFEzQDZpPkK4PFgyOjh4PD;hQi=>
MFC NFPFW4JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2SwSFIxKHWP MVW3NkBpenN? NHu4NlBIem:5dHigbY5pcWKrdHnvckBw\iCPRlOgZ4VtdHNiYYSgNlAhfU1iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigQ>? MljqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh6OEGyPFYoRjJ6OEixNlg3RC:jPh?=
BV2 M1\TbmFvfGmrbn\sZY1u[XSxcomgZZN{[Xl? MmjVNlQhcHK| M{TXSGFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCEVkKgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDubZRzcWNib4jp[IUheHKxZIXjeIlwdiCjZoTldkAzPCCqcoOgZpkh\3KrZYPzJIF{e2G7LDDJR|UxKD1iNDFOwG0v M360WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEO1OVI2Lz5{OUCzOVUzPTxxYU6=
NCI-H460 MmHkR5l1d3SxeHnjbZR6KGG|c3H5 MUe0PEBpenN? Mn[5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmNKNUh2NkCgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVcvOTRizszNMi=> M2X5b|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUe0PFE3Lz5{OUG3OFgyPjxxYU6=
PC3 NULjNWpxS3m2b4TvfIlkcXS7IHHzd4F6 MYe0PEBpenN? M{jtXmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEOyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzOD63NUDPxE1w M37vOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUe0PFE3Lz5{OUG3OFgyPjxxYU6=
DU145 MV7DfZRwfG:6aXPpeJkh[XO|YYm= M33NV|Q5KGi{cx?= MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|Mz6xNkDPxE1w MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTF5NEixOkc,OjlzN{S4NVY9N2F-
HepG2 NGKyZ|RHfW6ldHnvckBie3OjeR?= NVzBdoVIPSCqcoO= NXXSOHJJSWO2aY\heIlwdiCxZjDOdoYzKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDViaILzJIJ6KEGURT3kdol3\W5ibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyIE2gNlEh|ryPLh?= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ{M{GwNEc,Ojl{MkOxNFA9N2F-
BGC823 M1i4T2N6fG:2b4jpZ4l1gSCjc4PhfS=> M2DzN|czKGi{cx?= NIPycJVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDT0N6MkOgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTlwNTFOwG0v NFfDWoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUK4PFk1Pid-MkmyPFg6PDZ:L3G+
NCI-H460 Ml64R5l1d3SxeHnjbZR6KGG|c3H5 NWT6SokyPzJiaILz MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOR2kuUDR4MDDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzOC5|IN88UU4> MlHZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl{OEi5OFYoRjJ7Mki4PVQ3RC:jPh?=
SGC7901 NFz2ZpREgXSxdH;4bYNqfHliYYPzZZk> M2TlT|czKGi{cx?= M124ZWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNISzd7MEGgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjZwMjFOwG0v NV:3W3I1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyPFg6PDZpPkK5Nlg5QTR4PD;hQi=>
NCI-H460 MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mm\lOUB1dyBzMDD1US=> M1rWT|I1KHSxIEeyJIhzew>? MljOS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUmNKNUh2NkCgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIF1KDVidH:gNVAhfU1iaX7jeYJifGWmIH\vdkAzPCC2bzC3NkBpenNiYomgUXRVKGG|c3H5 MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ6OEm0Okc,Ojl{OEi5OFY9N2F-
NCI-H460 NXq1RlFOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlHUNlAhfU1? M3e5U|E5KGi{cx?= MUjBcpRqNWe{b4f0bEBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JPDZyIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBkd2yxbomg[o9zdWG2aX;uJIF1KDJyIIXNJIFnfGW{IEG4JIhzeyCkeTDjdpl{fGGuII\pc4xmfC2kYYPl[EBkd2yxbomg[o9zdWmwZzDhd5NigQ>? MnGwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl{OEi5OFYoRjJ7Mki4PVQ3RC:jPh?=
NCI-H460 MlTjRY51cW2rZ4LheI9zgSCjc4PhfS=> Mmm3NlAhfU1? MlPnOFghcHK| Mn:1RY51cS2vaXfyZZRwenliYXP0bZZqfHliYXfhbY5{fCCqdX3hckBPS0lvSES2NEBk\WyuczDheEAzOCC3TTDpcoN2[mG2ZXSg[o9zKDR6IHjyd{BjgSC5b4Xu[EBp\WGuaX7nJIF{e2G7 NWjBdVJlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyPFg6PDZpPkK5Nlg5QTR4PD;hQi=>
NCI-H460 M{jseGFxd3C2b4Ppd{Bie3OjeR?= M1m2bVE2KG2pL3vn M3rE[lE2KGSjeYO= NXewcIZrUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckB1fW2xcjDv[kBpfW2jbjDOR2kuUDR4MDDj[YxteyC6ZX7v[5Ji\nSnZDDpckBDSUyEL1OgcpUhdnWmZTDtc5V{\SCjc4Pld5Nm\CCjczDkc5dvemWpdXzheIlwdiCxZjDiZ4wzKGW6cILld5Nqd25iYYSgNVUhdWdxa3esJIlxKGGmbXnubZN1\XKnZDDleoVzgWSjeTDmc5IhOTViZHH5d{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ6OEm0Okc,Ojl{OEi5OFY9N2F-
HepG2 NYXzbnRZS3m2b4TvfIlkcXS7IHHzd4F6 NXrRdWFvOjRiaILz NILTZmNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGzMlc5KM7:TT6= M331clxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEKxOVY5Lz5{OUSyNVU3QDxxYU6=
THP1 M3fVdWN6fG:2b4jpZ4l1gSCjc4PhfS=> NH;sWlYzPCCqcoO= Mm\XR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWGhROSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ{LkW0JO69VS5? MkTrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2MkG1OlgoRjJ7NEKxOVY5RC:jPh?=
K562 MVLDfZRwfG:6aXPpeJkh[XO|YYm= MX:yOEBpenN? MULDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjNwMUKg{txONg>? MnPZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2MkG1OlgoRjJ7NEKxOVY5RC:jPh?=
LO2 NXvuO2EyS3m2b4TvfIlkcXS7IHHzd4F6 M{LoXlI1KGi{cx?= NVPJfGVOS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVE9{IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB{NDDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkWuOlch|ryPLh?= M2LJRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEKxOVY5Lz5{OUSyNVU3QDxxYU6=
HeLa NGn3NFJEgXSxdH;4bYNqfHliYYPzZZk> MojVNlQhcHK| MVzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOzFwOEmg{txONg>? NXnIU5MyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0NlE2PjhpPkK5OFIyPTZ6PD;hQi=>
NCI-H460 M3SyS2N6fG:2b4jpZ4l1gSCjc4PhfS=> NHzoZnc1QCCqcoO= MkDmR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmNKNUh2NkCgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxO{4yOSEQvF2u NXjCNJp5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0Nlk5OzRpPkK5OFI6QDN2PD;hQi=>
PC3 NUfvTHNXS3m2b4TvfIlkcXS7IHHzd4F6 NFnqfYc1QCCqcoO= MmDjR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOThwNkWg{txONg>? M2faTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEK5PFM1Lz5{OUSyPVg{PDxxYU6=
DU145 M3\i[GN6fG:2b4jpZ4l1gSCjc4PhfS=> NFzqflk1QCCqcoO= NFP2UVhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFXTF2NTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOzMlE2KM7:TT6= M1W3cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEK5PFM1Lz5{OUSyPVg{PDxxYU6=
MCF7 MlT6R5l1d3SxeHnjbZR6KGG|c3H5 MXu0JIhzew>? M4\6[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMheHKnaX7jeYJifGWmIH\vdkA1KGi{czDmc4xtd3enZDDifUBqdmO3YnH0bY9vKGmwIHPvcZBwfW6mIH\y[YUhdWWmaXGg[o9zKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{Mj6xJO69VS5? MkLSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4MEW4NFgoRjJ7NkC1PFA5RC:jPh?=
WRL68 NHXxd4tEgXSxdH;4bYNqfHliYYPzZZk> M{nC[lQhcHK| MnP3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gW3JNPjhiY3XscJMheHKnaX7jeYJifGWmIH\vdkA1KGi{czDmc4xtd3enZDDifUBqdmO3YnH0bY9vKGmwIHPvcZBwfW6mIH\y[YUhdWWmaXGg[o9zKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{Nz64JO69VS5? NWDZ[GxxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2NFU5ODhpPkK5OlA2QDB6PD;hQi=>
A549 MnXMR5l1d3SxeHnjbZR6KGG|c3H5 M4PJb|QhcHK| NUDSOHJvS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCycnXpcoN2[mG2ZXSg[o9zKDRiaILzJIZwdGyxd3XkJIJ6KGmwY4XiZZRqd25iaX6gZ49ueG:3bnSg[pJm\SCvZXTpZUBnd3JiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IESzMlkh|ryPLh?= MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZyNUiwPEc,Ojl4MEW4NFg9N2F-
NCI-H1975 NX23TYpDS3m2b4TvfIlkcXS7IHHzd4F6 NH;FSY84OiCqcoO= Mn3ER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmNKNUhzOUe1JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNU41KM7:TT6= NX;ES|ZyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2OVUxQDNpPkK5OlU2ODh|PD;hQi=>
A549 NH3I[m9EgXSxdH;4bYNqfHliYYPzZZk> Mnm5O|IhcHK| NXv1V5d5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IE[uPEDPxE1w MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ3NUC4N{c,Ojl4NUWwPFM9N2F-
HL7702 MVrDfZRwfG:6aXPpeJkh[XO|YYm= MWW3NkBpenN? MVLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUFc4ODJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB5LkKg{txONg>? NVz2dFlXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2OVUxQDNpPkK5OlU2ODh|PD;hQi=>
H460 M1i5NGN6fG:2b4jpZ4l1gSCjc4PhfS=> NF\nbnI4OiCqcoO= NIr2fnBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJPDZyIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iOD61JO69VS5? M1fpVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkW1NFg{Lz5{OU[1OVA5OzxxYU6=
NCI-H1650 NEDacFdEgXSxdH;4bYNqfHliYYPzZZk> NVXPZWwyPzJiaILz M{LnbmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KMU[1NEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFIxNjVizszNMi=> MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ3NUC4N{c,Ojl4NUWwPFM9N2F-
HepG2 MkK0R5l1d3SxeHnjbZR6KGG|c3H5 MlzpNlQhcHK| NIHkbFhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGwJO69VS5? Mk[4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl5OUi4NlcoRjJ7N{m4PFI4RC:jPh?=
HCT116 NXX2Wo5RSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M3[xNlczKGi{cx?= MVjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUCuPVEh|ryPLh?= M{TabVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OEi2NFIyLz5{OUi4OlAzOTxxYU6=
HepG2 MluyR5l1d3SxeHnjbZR6KGG|c3H5 NHnQUYUzPCCqcoO= M{WyUmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB{NDDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMU[uNFEh|ryPLh?= M2fMclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OUC5N|M5Lz5{OUmwPVM{QDxxYU6=
SMMC7721 Mn;ER5l1d3SxeHnjbZR6KGG|c3H5 NYrrdVlmOjRiaILz NGDudIJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUVU2FN{eyNUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE6NjR5IN88UU4> MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTlyOUOzPEc,Ojl7MEmzN|g9N2F-
QGY7703 Mn;2R5l1d3SxeHnjbZR6KGG|c3H5 MlTnNlQhcHK| M{fjcGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHFIYTd5MEOgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyNU41PCEQvF2u NYHPbnZTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm5NFk{OzhpPkK5PVA6OzN6PD;hQi=>
HHL5 MV\DfZRwfG:6aXPpeJkh[XO|YYm= NXHSOGVqOjRiaILz NHmyZ2dEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJUEx3IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB{NDDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkKuNlch|ryPLh?= MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTlyOUOzPEc,Ojl7MEmzN|g9N2F-
LO2 Mn;sR5l1d3SxeHnjbZR6KGG|c3H5 MmHBNlQhcHK| M4O1VWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGxQOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ|Lki3JO69VS5? M2P5ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OUC5N|M5Lz5{OUmwPVM{QDxxYU6=
Vero NGC1PZlEgXSxdH;4bYNqfHliYYPzZZk> MUnDfZRwfG:6aXPpeJkh[WejaX7zeEBC\nKrY3HuJIdz\WWwIH3vcotmgSCYZYLvJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uMEBESzVyIE2gN|YvQCEQvF2u Ml:yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl7MkC0OVQoRjJ7OUKwOFU1RC:jPh?=
HT22 MULDfZRwfG:6aXPpeJkh[XO|YYm= NX;hVVV[OjRiaILz NYXZOXhDS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhUFR{MjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygUW5VTCB;IEGg{txONg>? MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB|MU[1N{c,OzByM{G2OVM9N2F-
HT22 NFHvNnVEgXSxcILveIVkfGmxbjDhd5NigQ>? MkHPNUB2VQ>? MnjNNlQhcHK| NXPoSHNKS3m2b4Dyc5Rm[3Srb36gZYdicW6|dDDncJV1[W2jdHWtbY5lfWOnZDDhdI9xfG:|aYOgbY4hdW:3c3WgTHQzOiClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDCZZgwSmOuMjDyZZRqdyCjdDCxJJVOKGGodHXyJFI1KGi{czDifUBTXC2SQ2KgcYV1cG:m MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB|MU[1N{c,OzByM{G2OVM9N2F-
HT22 NY[zPJlzS3m2b4Dyc5Rm[3Srb36gZZN{[Xl? MlTRNUB2VQ>? NXLMcW9POjRiaILz MnnmR5l1d3C{b4TlZ5Rqd25iYXfhbY5{fCCpbIX0ZY1ifGVvaX7keYNm\CCxeHnkZZRqfmVic4Ty[ZN{KGmwIH3veZNmKEiWMkKgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hcU6RUzDtVm5CKGyndnXsJIF1KDFidV2gZYZ1\XJiMkSgbJJ{KGK7IGLUMXBEWiCvZYToc4Q> Ml6zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByM{G2OVMoRjNyMEOxOlU{RC:jPh?=
HT22 M3PXVmN6fG:ycn;0[YN1cW:wIHHzd4F6 NWPkXnNUOSC3TR?= MWeyOEBpenN? NVXZbGtkS3m2b4Dyc5Rm[3Srb36gZYdicW6|dDDncJV1[W2jdHWtbY5lfWOnZDDlfINqfG:2b4jpZ4l1gSCrbjDtc5V{\SCKVEKyJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGOnbHygeoli[mmuaYT5JIF1KDFidV2gZYZ1\XJiMkSgbJJ{KGK7IH;weIlk[WxibXnjdo9{[2:yaXOgZZN{[Xl? NYD6fFI1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwN|E3PTNpPkOwNFMyPjV|PD;hQi=>
HT22 NXzRcHl{S3m2b4Dyc5Rm[3Srb36gZZN{[Xl? NET5eGoyKHWP NXHINoh1OjRiaILz NWm4d|lQS3m2b4Dyc5Rm[3Srb36gZYdicW6|dDDncJV1[W2jdHWtbY5lfWOnZDDlfINqfG:2b4jpZ4l1gSCrbjDtc5V{\SCKVEKyJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGeudYThcYF1\S2rbnT1Z4VlKGOnbHygZ5lkdGViYYLy[ZN1KGG2IIP1Zk1IOSCyaHHz[UBifCBzIIXNJIFnfGW{IEK0JIhzeyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pIHLhd4VlKG[ub4egZ5l1d22ndIL5 Ml7qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByM{G2OVMoRjNyMEOxOlU{RC:jPh?=
HT22 MYnDfZRweHKxdHXjeIlwdiCjc4PhfS=> NGWwe2oyKHWP NFTFWoEzPCCqcoO= NFXJfFhEgXSxcILveIVkfGmxbjDh[4FqdnO2IHfseZRidWG2ZT3pcoR2[2WmIHX4Z4l1d3SxeHnjbZR6KGmwIH3veZNmKEiWMkKgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4h[2WubDDwdo9tcW[ncnH0bY9vKGG2IEGgeW0h[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfS=> NGP1S|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MECzNVY2Oyd-M{CwN|E3PTN:L3G+
LNCAP MX7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NWXqdYp1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBidmS{b3flck1{\W6|aYTpeoUhcHWvYX6gUG5ESVBiY3XscJMtKEmFNUCgQUAzKM7:TT6= NHvQSZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEGyNVIyPCd-M{CxNlEzOTR:L3G+
DU145 Mkj6RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NXfxbnd2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBidmS{b3flck1qdnOnboPpeIl3\SCqdX3hckBFXTF2NTDj[YxteyxiSVO1NEA:KDJizszNMi=> MnfoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzMkGyNVQoRjNyMUKxNlE1RC:jPh?=
PC3 M{CwUWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MlfLRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDhcoRzd2enbj3pcpNmdnOrdHn2[UBpfW2jbjDQR|Mh[2WubIOsJGlEPTBiPTCyJO69VS5? M3HoPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUKxNlE1Lz5|MEGyNVIyPDxxYU6=
LNCAP MW\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M{PMflMh\GG7cx?= NH3OVFdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIFv\HKxZ3XuMZNmdnOrdHn2[UBpfW2jbjDMUmNCWCClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA{KGSjeYOgZpkhX1OWIHHzd4F6NCCLQ{WwJF0hOTNwNkGg{txONg>? M{PkbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUKxNlE1Lz5|MEGyNVIyPDxxYU6=
PC3 MXLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NUjyXoJUOyCmYYnz MULBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHHu[JJw\2WwLXnud4Vve2m2aY\lJIh2dWGwIGDDN{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjCzJIRigXNiYomgW3NVKGG|c3H5MEBKSzVyIE2gNlUvPDNizszNMi=> NWThcmVjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxNlEzOTRpPkOwNVIyOjF2PD;hQi=>
DU145 M4iyc2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NVzpe3p6OyCmYYnz NHnldFdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIFv\HKxZ3XuMYlve2Wwc3n0bZZmKGi3bXHuJGRWOTR3IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDNiZHH5d{BjgSCZU2SgZZN{[XluIFnDOVAhRSB{Nj6yN{DPxE1w M2LzVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUKxNlE1Lz5|MEGyNVIyPDxxYU6=
MCF7 Mn;MR5l1d3SxeHnjbZR6KGG|c3H5 MlL0O|IhcHK| NUXle4doS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQS56IN88UU4> MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF|OEiwN{c,OzBzM{i4NFM9N2F-
EJ28 NWTMbpB7S3m2b4TvfIlkcXS7IHHzd4F6 M1\tUlczKGi{cx?= NE\3V|FEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBGUjJ6IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOC53IN88UU4> MnfLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzM{i4NFMoRjNyMUO4PFA{RC:jPh?=
HT1080 NVvXOJk{S3m2b4TvfIlkcXS7IHHzd4F6 NFu5VGw4OiCqcoO= NW[4SZJvS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRzMEiwJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMz6xJO69VS5? M2HIWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUO4PFA{Lz5|MEGzPFgxOzxxYU6=
SW620 NY\PUWlmS3m2b4TvfIlkcXS7IHHzd4F6 MlH2O|IhcHK| NX7yTWtXS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW1d4MkCgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF2IN88UU4> NX;jfIlvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxN|g5ODNpPkOwNVM5QDB|PD;hQi=>
A549 M1zyZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> M1rrS|czKGi{cx?= NEPj[IJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyPy57IN88UU4> NFTmfHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEGzPFgxOyd-M{CxN|g5ODN:L3G+
SMMC7721 NYK4[2Z3S3m2b4TvfIlkcXS7IHHzd4F6 MmjYNlQhcHK| NU\vVJZnS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW02PQ{e3NlEh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE3NjZ6IN88UU4> NVHBSIpIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C3O|E3ODVpPkOwO|cyPjB3PD;hQi=>
HepG2 NI\Nd5NEgXSxdH;4bYNqfHliYYPzZZk> M{fVcFI1KGi{cx?= NGHXXVVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgbY5kfWKjdHXkJIZweiB{NDDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUeuN|ch|ryPLh?= MmX0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB5N{G2NFUoRjNyN{exOlA2RC:jPh?=
LO2 NFzzU|NEgXSxdH;4bYNqfHliYYPzZZk> M1;FWlI1KGi{cx?= M{jIbmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGxQOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjJwNkmg{txONg>? MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd5MU[wOUc,OzB5N{G2NFU9N2F-
QGY7703 MoPHR5l1d3SxeHnjbZR6KGG|c3H5 MnPxNlQhcHK| M3r6cmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHFIYTd5MEOgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKzMlkyKM7:TT6= M2TIXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyN{exOlA2Lz5|MEe3NVYxPTxxYU6=
HHL5 M4fpbWN6fG:2b4jpZ4l1gSCjc4PhfS=> MojkNlQhcHK| NH3QNllEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJUEx3IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDpcoN2[mG2ZXSg[o9zKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{ND6xPUDPxE1w MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd5MU[wOUc,OzB5N{G2NFU9N2F-
HCT-116 NYjK[2Z6TnWwY4Tpc44h[XO|YYm= MlTKNlQhcHK| MWrJcohq[mm2aX;uJI9nKGOqeX3veJJ6eHOrbj3sbYtmKGGldHn2bZR6KG:oIHj1cYFvKDJ4UzDwdo91\WG|b33lJIlvKGi3bXHuJGhEXC1zMU[gZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hSU2FIHj5[JJwdHm|aYOgeZNqdmdiU4XjMWxNXllvQV3DJIF{KHO3YoP0doF1\SCycnXpcoN2[mG2ZXSg[o9zKDJ2IHjyd{Bnd2yub4fl[EBjgSCjZHTpeIlwdiCxZjDzeYJ{fHKjdHWgZY5lKG2nYYP1doVlKGGodHXyJFIhcHK|IHL5JIZtfW:{b33leJItKEmFNUCgQUAyOCEQvF2u NUn5SFRvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C3O|Y3QTJpPkOwO|c3Pjl{PD;hQi=>
SW480 M{XDeGZ2dmO2aX;uJIF{e2G7 MWWyOEBpenN? MlTuTY5pcWKrdHnvckBw\iClaIntc5RzgXC|aX6tcIls\SCjY4Tpeol1gSCxZjDoeY1idiB{NmOgdJJwfGWjc3;t[UBqdiCqdX3hckBUXzR6MDDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBCVUNiaInkdo9tgXOrczD1d4lv\yCVdXOtUGxXYS2DTVOgZZMhe3Wkc4TyZZRmKHC{ZXnuZ5Vj[XSnZDDmc5IhOjRiaILzJIZwdGyxd3XkJIJ6KGGmZHn0bY9vKG:oIIP1ZpN1emG2ZTDhcoQhdWWjc4Xy[YQh[W[2ZYKgNkBpenNiYomg[ox2d3KxbXX0dolkNCCLQ{WwJF0hOTBizszNMi=> NYiySJNVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C3O|Y3QTJpPkOwO|c3Pjl{PD;hQi=>
RAW264.7 NYDx[G5{TnWwY4Tpc44h[XO|YYm= MlnkNVAhfU1? M2fxW|AvPSCqcoO= NWXJZZRpUW6qaXLpeIlwdiCxZjDNRXBMN06Ia3HwdIFDKGmwIFnDVkBud3W|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hVFCVLXnu[JVk\WRiVF7GZYxxcGFicILv[JVkfGmxbjDheEAyOCC3TTDwdoV1emWjdHXkJIZweiByLkWgbJJ{KG[xbHzve4VlKGK7IFzQV{BkcGGubHXu[4Uh[W6mIH3lZZN2emWmIHHmeIVzKDJ2IHjyd{BjgSCHTFnTRUBz\WyjdHn2[UB1dyClb370do9t MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd6MEC4PEc,OzB5OECwPFg9N2F-
RAW264.7 NEPxfmZHfW6ldHnvckBie3OjeR?= NF3FOpcxNjViaILz M4\IVWlvcGmkaYTpc44hd2ZiTVHQT{9PTmujcIDhRkBqdiCLQ2KgcY92e2ViUlHXNlY1NjdiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJGxRWy2rbnT1Z4VlKFSQRnHsdIhiKHC{b3T1Z5Rqd25icILleJJm[XSnZDDmc5IhOC53IHjyd{Bnd2yub4fl[EBjgSCOUGOgZ4hidGynbnflJIFv\CCvZXHzeZJm\CCjZoTldkAzPCCqcoOgZpkhTUyLU1G= MkTNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB5OECwPFgoRjNyN{iwNFg5RC:jPh?=
RAW264.7 NXvC[3FtTnWwY4Tpc44h[XO|YYm= MoTGNE42KGi{cx?= NXLzTHlqUW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBPTmujcIDhRkBxPjViboXjcIVieiC2cnHud4xw[2G2aX;uJIlvKEmFUjDtc5V{\SCUQWeyOlQvPyClZXzsd{BxemWrbnP1ZoF1\WRiZn;yJFAvPSCqcoOg[o9tdG:5ZXSgZpkhVFCVIHPoZYxt\W6pZTDhcoQhdWWjc4Xy[YQh[W[2ZYKgOFAhdWmwczDifUBFSVCLIIP0ZYlvcW6pLXLhd4VlKGmvbYXuc4ZtfW:{ZYPj[Y5k\SCvaXPyc5Nkd3CrYzDhcoFtgXOrcx?= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd6MEC4PEc,OzB5OECwPFg9N2F-
RAW264.7 NEHqWWJHfW6ldHnvckBie3OjeR?= M4rKd|ExKHWP NIm0O2kxNjViaILz NYTiUZRCUW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBxOzhiTVHQT{BxcG:|cHjvdplt[XSrb36gbY4hUUOUIH3veZNmKFKDV{K2OE44KGOnbHzzJIF1KDFyIIXNJJBz\WmwY4XiZZRm\CCob4KgNE42KGi{czDmc4xtd3enZDDifUBNWFNiY3jhcIxmdmenIHHu[EBu\WG|dYLl[EBi\nSncjCzNEBucW6|IHL5JIludXWwb3Lsc5R1cW6pIHHuZYx6e2m| NIHCUWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEe4NFA5QCd-M{C3PFAxQDh:L3G+
RAW264.7 NGfwO2RHfW6ldHnvckBie3OjeR?= Ml;TNVAhfU1? Ml7UNE42KGi{cx?= NFjlSZBKdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJGVTUyCyaH;zdIhwenmuYYTpc44hcW5iSVPSJI1wfXOnIGLBW|I3PC55IHPlcIx{KGG2IEGwJJVOKHC{ZXnuZ5Vj[XSnZDDmc5IhOC53IHjyd{Bnd2yub4fl[EBjgSCOUGOgZ4hidGynbnflJIFv\CCvZXHzeZJm\CCjZoTldkA{OCCvaX7zJIJ6KGmvbYXuc4Jtd3S2aX7nJIFv[Wy7c3nz NW[3dohERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C3PFAxQDhpPkOwO|gxODh6PD;hQi=>
RAW264.7 Mn3jSpVv[3Srb36gZZN{[Xl? M2fEXVExKHWP MV[wMlUhcHK| MoXZTY5pcWKrdHnvckBw\iCQRnvhdJBiSi:PQWDLJJNq\26jbHnu[{BqdiCOUGOtbY5lfWOnZDDtc5V{\SCUQWeyOlQvPyClZXzsd{Bie3Onc4Pl[EBieyCmb4fuJJJm\3WuYYTpc44hd2ZiSXvhdJBiSiCneIDy[ZN{cW:wIHH0JFExKHWPIIDy[Ylv[3WkYYTl[EBnd3JiMD61JIhzeyCob3zsc5dm\CCkeTDMVHMu[2ijbHzlcodmKGGwZDDt[YF{fXKnZDDh[pRmeiB|MDDtbY5{KGK7IHntcZVvd2Kub4T0bY5oKGGwYXz5d4l{ NEDB[JM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEe4NFA5QCd-M{C3PFAxQDh:L3G+
RAW264.7 MY\GeY5kfGmxbjDhd5NigQ>? NVT2bmJ6OTBidV2= MoDSNE42KGi{cx?= NHHBToxKdmirYnn0bY9vKG:oIF3BVGswVk[tYYDwZWIhcW5iSVPSJI1wfXOnIGLBW|I3PC55IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBNWFNvaX7keYNm\CCLTE[gdJJw\HWldHnvckBifCBzMDD1UUBxemW2cnXheIVlKG[xcjCwMlUhcHK|IH\vcIxwf2WmIHL5JGxRWyClaHHscIVv\2ViYX7kJI1m[XO3cnXkJIFnfGW{IEK0JIhzeyCkeTDFUGlUSSC{ZXzheIl3\SC2bzDjc451em:u M4nZb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyN{iwNFg5Lz5|MEe4NFA5QDxxYU6=
RAW264.7 MlyxSpVv[3Srb36gZZN{[Xl? NWD5clhKOC53IHjydy=> NXrNPHRkUW6qaXLpeIlwdiCxZjDNRXBMN06Ia3HwdIFDKGmwIFnDVkBud3W|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hVFCVLXnu[JVk\WRiSVy2JJBzd2S3Y4Tpc44heHKndILlZZRm\CCob4KgNE42KGi{czDmc4xtd3enZDDifUBNWFNiY3jhcIxmdmenIHHu[EBu\WG|dYLl[EBi\nSncjCyOEBpenNiYomgSWxKW0F? MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd6MEC4PEc,OzB5OECwPFg9N2F-
RAW264.7 M3;yRmZ2dmO2aX;uJIF{e2G7 MYS0JIhzew>? NVTUe|VCUW6qaXLpeIlwdiCxZjDSRW5MVC2rbnT1Z4VlKG:|dHXvZ4xie3SxZ3Xu[ZNqeyCrbjDteZJqdmViUlHXNlY1NjdiY3XscJMh[XO|ZYPz[YQh[XNiZn;ycYF1cW:wIH;mJHRTSVBicH;zbZRqfmVibYXseIlvfWOuZXH0[YQhd3O2ZX;jcIF{fHNicILleJJm[XSnZDDmc5IhPCCqcoOg[o9tdG:5ZXSgZpkhWkGQS1ygZYRlcXSrb36gcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{NCCLQ{WwJF0hOyEQvF2u NFH2Too9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEe5OFQyOid-M{C3PVQ1OTJ:L3G+
BV2 MVzBcpRqdmW3cn;pcoZt[W2vYYTvdpkh[XO|YYm= M4Ptd|EhcHJ? MnfkRY51cS2wZYXyc4lv\myjbX3heI9zgSCjY4Tpeol1gSCrbjDoeY1idiCEVkKgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDOU{Bxem:mdXP0bY9vKHC{ZXnuZ5Vj[XSnZDDmc5IhOSCqcjDmc4xtd3enZDDifUBNWFNic4TpcZVt[XSrb36gcYVie3W{ZXSgZYZ1\XJiMkSgbJJ{KGK7IFfybYV{eyC{ZXHn[Y51KGKjc3XkJIF{e2G7LDDJR|UxKD1iMT61PEDPxE1w MnzjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFyMEWwOVYoRjNzMEC1NFU3RC:jPh?=
HeLa NGjxXW1CdnSrY3HuZ4VzKGG|c3H5 MY\BcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXMZUBk\WyuczygTWM2OCB;IESuN|Mh|ryPLh?= MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{OUS1OUc,OzFzMkm0OVU9N2F-
HL60 MkXFR5l1d3SxeHnjbZR6KGG|c3H5 MXrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzMEBKSzVyIE2gOk4{KM7:TT6= NXT1d3g{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlk1PTVpPkOxNVI6PDV3PD;hQi=>
SKOV3 MUHDfZRwfG:6aXPpeJkh[XO|YYm= NXPOT|B5PDhiaILz NHjGUVBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0:YMzDD[YxteyCjZoTldkA1QCCqcoOgZpkhS2WubDDUbZRmeiCEbIXlJIF{e2G7LDDJR|UxKD1iNj63JO69VS5? NH71Z3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
HSC4 NF7ZU4dEgXSxdH;4bYNqfHliYYPzZZk> MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIV2M1KGOnbHzzMEBKSzVyIE2gO{4yKM7:TT6= MnXEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
U87MG MWjDfZRwfG:6aXPpeJkh[XO|YYm= M2TXUFQ5KGi{cx?= MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVPFdOTyCFZXzsd{A1QCCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwJF0hPy5zNTFOwG0v NWDFXIR5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlk1PTVpPkOxNVI6PDV3PD;hQi=>
HSC2 MWTDfZRwfG:6aXPpeJkh[XO|YYm= M2m3b2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhUSzJiY3XscJMtKEmFNUCgQUA4NjhizszNMi=> NIS2fII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
LX2 M2HoW2N6fG:2b4jpZ4l1gSCjc4PhfS=> NYTrUJA6PDhiaILz M3uyUmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGxZOiCFZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gPU4yPCEQvF2u MoLOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
MCF7 MmPGR5l1d3SxeHnjbZR6KGG|c3H5 NXjEU3pXPDhiaILz NHjlOolEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IFPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA6NjJ6IN88UU4> MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{OUS1OUc,OzFzMkm0OVU9N2F-
HepG2 MoHOR5l1d3SxeHnjbZR6KGG|c3H5 NV3DWmFrPDhiaILz M3f4R2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IFPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA6NjR2IN88UU4> NI\TenQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
3T3 M4DKe2N6fG:2b4jpZ4l1gSCjc4PhfS=> MnTCOFghcHK| NXj6d5lpS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhO1R|IFPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA6NjVzIN88UU4> NYDpNY1ZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlk1PTVpPkOxNVI6PDV3PD;hQi=>
AGS NFXQbGJEgXSxdH;4bYNqfHliYYPzZZk> NYLlOI14S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSUeVIFPlcIx{NCCLQ{WwJF0hQS55NzFOwG0v NETaem89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
HSC3 M1\SeWN6fG:2b4jpZ4l1gSCjc4PhfS=> MmXwR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHNEOyClZXzsd{whUUN3MDC9JFEyKM7:TT6= NILGT3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
MDA-MB-231 NIjTfWZCdnSrY3HuZ4VzKGG|c3H5 NYq3ZXY4PzJiaILz MnHYRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFzLkS1JO69VS5? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{OUS1OUc,OzFzMkm0OVU9N2F-
SMMC7721 MXnBcpRq[2GwY3XyJIF{e2G7 NF3BUHc4OiCqcoO= NUOzTGJHSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJHNOVUN5N{KxJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMj61O{DPxE1w MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{OUS1OUc,OzFzMkm0OVU9N2F-
LX2 NH\1eHlCdnSrY3HuZ4VzKGG|c3H5 MkfSO|IhcHK| NHLMOnNCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUHgzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxN{46PyEQvF2u NVHNR3I{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlk1PTVpPkOxNVI6PDV3PD;hQi=>
HeLa NEDwOYJEgXSxdH;4bYNqfHliYYPzZZk> NXXiV|JnS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDD[YxteyxiSVO1NEA:KDF2LkCzJO69VS5? MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{OUS1OUc,OzFzMkm0OVU9N2F-
SW480 NGjOWpNEgXSxdH;4bYNqfHliYYPzZZk> MYGyOEB1dyB2ODDodpM> M3XTOmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNYPDhyIFPlcIx{KGGodHXyJFI1KHSxIES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOUDPxE1w NEjY[XI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
U251MG NHnscmpEgXSxdH;4bYNqfHliYYPzZZk> M4\OVlQ5KGi{cx?= MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVNlUyVUdiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VWyCjc4PhfUwhUUN3MDC9JFE2NjJ4IN88UU4> NX\DUHNkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlk1PTVpPkOxNVI6PDV3PD;hQi=>
RWPE1 M3\BZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> M4TBN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHJYWEVzIHPlcIx{NCCLQ{WwJF0hOTVwNkKg{txONg>? NYDBPGxXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlk1PTVpPkOxNVI6PDV3PD;hQi=>
MCF7 M1HGNWFxd3C2b4Ppd{Bie3OjeR?= M1fFd2lv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iTVPGO{Bk\WyuczygTWM2OCB;IEG3MlEh|ryPLh?= NF\TNWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
BGC823 M{HNN2N6fG:2b4jpZ4l1gSCjc4PhfS=> NYrWboVQS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSkeFOEKzJINmdGy|LDDJR|UxKD1iMUeuOUDPxE1w M2XTSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK5OFU2Lz5|MUGyPVQ2PTxxYU6=
BxPC3 M1jUcmN6fG:2b4jpZ4l1gSCjc4PhfS=> NWXPOnloS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSniSQ{OgZ4VtdHNuIFnDOVAhRSBzOD6yOUDPxE1w M4CxUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK5OFU2Lz5|MUGyPVQ2PTxxYU6=
HT-29 NWDUe2s{S3m2b4TvfIlkcXS7IHHzd4F6 MoTkR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliQ3XscJMtKEmFNUCgQUAyQC55NDFOwG0v NELmSIs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
H1299 MX3DfZRwfG:6aXPpeJkh[XO|YYm= MoO0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTFEzQTliY3XscJMtKEmFNUCgQUAyQC57MzFOwG0v MnjjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
PC3 NVnreItWS3m2b4TvfIlkcXS7IHHzd4F6 MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOsJGlEPTBiPTCxPU46QCEQvF2u MoHmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
EAhy926 NFzzbmxEgXSxdH;4bYNqfHliYYPzZZk> MX[3NkBpenN? MVrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDFRYh6QTJ4IFPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzOCEQvF2u NF\YWnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
HepG2 NY[4XHFMS3m2b4TvfIlkcXS7IHHzd4F6 MUe3NkBpenN? MX7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiCFZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlAvOyEQvF2u MlHkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
AGS MmHhR5l1d3SxeHnjbZR6KGG|c3H5 M2Xoe2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGFIWyCFZXzsd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{MD63OkDPxE1w MmD5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
PC3 Mlm2RY51cWOjbnPldkBie3OjeR?= M3jCW2FvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOsJGlEPTBiPTCyNE46KM7:TT6= MkSxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
MGC803 MV3DfZRwfG:6aXPpeJkh[XO|YYm= NGn6XWlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOT0N6MEOgZ4VtdHNuIFnDOVAhRSB{MT6yJO69VS5? MkTkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
CHOK1 NUH5VJlsS3m2b4TvfIlkcXS7IHHzd4F6 M163U|czKGi{cx?= NUOwbnNGS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0iRS{GgR4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJzLkOg{txONg>? M4fWdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK5OFU2Lz5|MUGyPVQ2PTxxYU6=
Hep2 M{f1d2N6fG:2b4jpZ4l1gSCjc4PhfS=> NFfvZYlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XB{IFPlcIx{NCCLQ{WwJF0hOjFwM{eg{txONg>? MnG3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
MCF7 M1TWe2N6fG:2b4jpZ4l1gSCjc4PhfS=> NULhUlVSS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyxiSVO1NEA:KDJ{LkWg{txONg>? M4nPTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK5OFU2Lz5|MUGyPVQ2PTxxYU6=
SGC7901 M2mxNmN6fG:2b4jpZ4l1gSCjc4PhfS=> M3HKWGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNISzd7MEGgZ4VtdHNuIFnDOVAhRSB{Mj61JO69VS5? NHPOV4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
HT-29 M3jDTmN6fG:2b4jpZ4l1gSCjc4PhfS=> MkTZO|IhcHK| NF\LcpNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXC1{OTDD[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjNwNDFOwG0v NEK5XmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
A549 MY\DfZRwfG:6aXPpeJkh[XO|YYm= NFnje5BEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IFPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK1MlM{KM7:TT6= MnfhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
MDA-MB-231 MoTxR5l1d3SxeHnjbZR6KGG|c3H5 M3zTRWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOsJGlEPTBiPTCyOk42KM7:TT6= NFzFN5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
A549 NGjUWoxEgXSxdH;4bYNqfHliYYPzZZk> MkSzNlQhfG9iNEigbJJ{ NWXiSow5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDD[YxteyCjZoTldkAzPCC2bzC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlgh|ryPLh?= NIPMUYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
Caco2 NVK2eoprS3m2b4TvfIlkcXS7IHHzd4F6 NIDsb5Y4OiCqcoO= NYrlSVBCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS2Glb{KgR4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ6IN88UU4> MnfkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
GES-1 M3q3N2N6fG:2b4jpZ4l1gSCjc4PhfS=> NF\sWVBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBITVNvMTDj[YxteyxiSVO1NEA:KDJ7LkGg{txONg>? M2H6c|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK5OFU2Lz5|MUGyPVQ2PTxxYU6=
DU145 NY\xNmFRSW62aXPhcoNmeiCjc4PhfS=> NYG3fVJTSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{NCCLQ{WwJF0hOzFwNzFOwG0v NIXMTFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
MDCK2 NHrYZYJEgXSxdH;4bYNqfHliYYPzZZk> MYqxOUBucW6| NGLEW29EgXSxdH;4bYNqfHliYXfhbY5{fCCvaYTvfIFvfHKxbnWgdoV{cXO2YX70JIh2dWGwIF3ER2szKGOnbHzzJIV5eHKnc4PpcochSkOUUDDh[pRmeiBzNTDtbY5{KGK7IH\seY9z\XOlZX7j[UBie3OjeTygTWM2OCB;IEOyJO69VS5? M1TJeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK5OFU2Lz5|MUGyPVQ2PTxxYU6=
HL-7702 NFzUSJFEgXSxdH;4bYNqfHliYYPzZZk> MmHCR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGwuPzdyMjDj[YxteyxiSVO1NEA:KDN{LkOzJO69VS5? NEHYN|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
K562 MYDDfZRwfG:6aXPpeJkh[XO|YYm= M{nU[|I1KHSxIES4JIhzew>? MnL5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT|U3OiCFZXzsd{Bi\nSncjCyOEB1dyB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{[g{txONg>? M1foWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK5OFU2Lz5|MUGyPVQ2PTxxYU6=
HepG2 M{Pze2N6fG:2b4jpZ4l1gSCjc4PhfS=> M2\LV2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IFPlcIx{NCCLQ{WwJF0hOzZwN{eg{txONg>? NGXpb2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
GBM1 Mm\HR5l1d3SxeHnjbZR6KGG|c3H5 NEXiUms1QCCqcoO= MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDHRm0yKEOnbHzzJFQ5KGi{czDifUBOXFNiYYPzZZktKEmFNUCgQUA{QS54NTFOwG0v M3zkOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK5OFU2Lz5|MUGyPVQ2PTxxYU6=
PC12 NWj6WWp1S3m2b4TvfIlkcXS7IHHzd4F6 MX[yOEBpenN? NI[2N|JEgXSxdH;4bYNqfHliYXfhbY5{fCC{YYSgVGMyOiClZXzsd{Bu\WG|dYLl[EBi\nSncjCyOEBpenNiYomgW3NVQC:STWOgZZN{[XluIFPDOVAhRSB2MjFOwG0v NWPiOmRERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyOlI2PTlpPkOxNlYzPTV7PD;hQi=>
HCT116 MV;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MoPuO|IhcHK| MmX2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFExNjVizszNMi=> NXWzXWdpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GzNlYzPDFpPkOxN|I3OjRzPD;hQi=>
HeLa NWP3[5RPS3m2b4TvfIlkcXS7IHHzd4F6 MXjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzMEBKSzVyIE2gPE4zKM7:TT6= NG\OS4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUOzOlMyOCd-M{GzN|Y{OTB:L3G+
B16 NEXBOpREgXSxdH;4bYNqfHliYYPzZZk> MVLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCNVYh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQC53IN88UU4> MnLJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF|M{[zNVAoRjNzM{O2N|ExRC:jPh?=
HT1080 NFvnXWVHfW6ldHnvckBie3OjeR?= MYTE[YNz\WG|ZTDpckBWWEFiZYjwdoV{e2mxbjDpckBpfW2jbjDIWFExQDBiY3XscJMtKEmFNUCgQUAyOCEQvF2u MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTN|NkOxNEc,OzF|M{[zNVA9N2F-
Hep3B M{PLTWN6fG:2b4jpZ4l1gSCjc4PhfS=> MlvWR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxO0JiY3XscJMtKEmFNUCgQUAyOCEQvF2u MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTN|NkOxNEc,OzF|M{[zNVA9N2F-
BT474 MXzDfZRwfG:6aXPpeJkh[XO|YYm= M{HSXGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJVPDd2IHPlcIx{NCCLQ{WwJF0hOTFizszNMi=> NXrRZW0yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GzN|Y{OTBpPkOxN|M3OzFyPD;hQi=>
T47D MlXLR5l1d3SxeHnjbZR6KGG|c3H5 MkfaR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWFQ4TCClZXzsd{whUUN3MDC9JFEyKM7:TT6= MkTDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF|M{[zNVAoRjNzM{O2N|ExRC:jPh?=
HaCaT M{K5R2N6fG:2b4jpZ4l1gSCjc4PhfS=> MljmR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIFE[VRiY3XscJMtKEmFNUCgQUAyOyEQvF2u MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTN|NkOxNEc,OzF|M{[zNVA9N2F-
KM12 NHTabXJEgXSxdH;4bYNqfHliYYPzZZk> NHLyZlU1KGi{cx?= MWTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLUVEzKGOnbHzzJIFnfGW{IESgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG2JO69VS5? MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTN|NkOxNEc,OzF|M{[zNVA9N2F-
HPL1D MYrDfZRwfG:6aXPpeJkh[XO|YYm= M1rJb2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhRVDGGIHPlcIx{NCCLQ{WwJF0hOTZizszNMi=> NV:5XJNnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GzN|Y{OTBpPkOxN|M3OzFyPD;hQi=>
SW480 MkKzR5l1d3SxeHnjbZR6KGG|c3H5 NWPuNJo1PCCqcoO= M17DPWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNYPDhyIHPlcIx{KGGodHXyJFQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE4Njl2IN88UU4> NFi1N4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUOzOlMyOCd-M{GzN|Y{OTB:L3G+
MCF7 NUPPS|NVS3m2b4TvfIlkcXS7IHHzd4F6 MlG2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{whUUN3MDC9JFE6NjlizszNMi=> NUC1ZoZHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GzN|Y{OTBpPkOxN|M3OzFyPD;hQi=>
HT-29 MX3DfZRwfG:6aXPpeJkh[XO|YYm= NIe5PXc1KGi{cx?= MmrKR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[W[2ZYKgOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlAvPzNizszNMi=> Mkj3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF|M{[zNVAoRjNzM{O2N|ExRC:jPh?=
WiDr NUPtUHRJS3m2b4TvfIlkcXS7IHHzd4F6 NXm5eHRWPCCqcoO= M2HpRWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHdqTHJiY3XscJMh[W[2ZYKgOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlYvQDJizszNMi=> Mn3LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF|M{[zNVAoRjNzM{O2N|ExRC:jPh?=
SW116 NWXsW|RmS3m2b4TvfIlkcXS7IHHzd4F6 MWi0JIhzew>? NWS0eGhkS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW1dzMU[gZ4VtdHNiYX\0[ZIhPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjdwNE[g{txONg>? NYjGblBlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GzN|Y{OTBpPkOxN|M3OzFyPD;hQi=>
Colon 26 MWLDfZRwfG:6aXPpeJkh[XO|YYm= NEjHVGk1KGi{cx?= Ml;PR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgR49td25iMk[gZ4VtdHNiYX\0[ZIhPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOzBwM{Sg{txONg>? M3KzOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzM{O2N|ExLz5|MUOzOlMyODxxYU6=
22Rv1 M3XFN2Z2dmO2aX;uJIF{e2G7 NYXLeGRYUW6qaXLpeIlwdiCxZjDOSotieHCjQjDwOlUhdnWlbHXhdkB1emGwc3zvZ4F1cW:wIHnuJIh2dWGwIEKyVpYyKGOnbHzzJIF1KEeLNUCgZpkhTEGSSTDzeIFqdmmwZzDiZZNm\CCrbX31co9ndHWxcnXzZ4Vv[2ViYYPzZZk> MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTd4N{K2Okc,OzF5NkeyOlY9N2F-
PC3 MlPrRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M2my[|Q5KGi{cx?= MnjpRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgbJVu[W5iUFOzJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCNaU[3JJBzd3SnaX6gcIV3\WxiYYSgS2k2OCCrbnP1ZoF1\WRiZn;yJFQ5KGi{czDifUBFSVCLIIP0ZYlvcW6pIHLhd4VlKGmvbYXuc4ZtfW:{ZYPj[Y5k\SCjc4PhfS=> MoHRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF5NkeyOlYoRjNzN{[3NlY3RC:jPh?=
22Rv1 MXjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M3LWOVQ5KGi{cx?= NUL6RYFqSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkhcHWvYX6gNlJTfjFiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJGtqPjdicILveIVqdiCuZY\lcEBifCCJSUWwJIlv[3WkYYTl[EBnd3JiNEigbJJ{KGK7IFTBVGkhe3SjaX7pcoch[mG|ZXSgbY1ufW6xZnz1c5Jme2OnbnPlJIF{e2G7 NGjMdJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUe2O|I3Pid-M{G3OlczPjZ:L3G+
PC3 M2D2S2Z2dmO2aX;uJIF{e2G7 NWO2R5Q{UW6qaXLpeIlwdiCxZjDOSotieHCjQjDwOlUhdnWlbHXhdkB1emGwc3zvZ4F1cW:wIHnuJIh2dWGwIGDDN{Bk\WyuczDheEBIUTVyIHL5JGRCWElic4ThbY5qdmdiYnHz[YQhcW2vdX7v[ox2d3Knc3PlcoNmKGG|c3H5 M4\CTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzN{[3NlY3Lz5|MUe2O|I3PjxxYU6=
PC3 MX\GeY5kfGmxbjDhd5NigQ>? NYP6e4dHUW6qaXLpeIlwdiCxZjDOSotieHCjQjDwOlUhfHKjboPjdolxfGmxbnHsJIFkfGm4aYT5JIlvKGi3bXHuJHBEOyClZXzsd{BifCCJSUWwJIJ6KHOjbnT3bYNpKEWOSWPB MmfDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF5NkeyOlYoRjNzN{[3NlY3RC:jPh?=
22Rv1 NYPMfZJ{TnWwY4Tpc44h[XO|YYm= NIT0WoZKdmirYnn0bY9vKG:oIF7Gb4FxeGGEIIC2OUB1emGwc3PybZB1cW:wYXygZYN1cX[rdImgbY4hcHWvYX6gNlJTfjFiY3XscJMh[XRiR1m1NEBjgSC|YX7ke4lkcCCHTFnTRS=> NVvUc3huRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G3OlczPjZpPkOxO|Y4OjZ4PD;hQi=>
Sf21 NYrkT5loTnWwY4Tpc44h[XO|YYm= NF23T|gyOCCvaX7z M1LVOWlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgbJVu[W5iZoXscE1t\W6pdHigTIl{Pi22YXfn[YQheDNyMDDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRiU3[yNUBqdnOnY4SgZ4VtdHNidYPpcochYzOKXXHj[ZR6dEOxQTDhd{B{fWK|dILheIUheHKnaX7jeYJifGWmIH\vdkAyOCCvaX7zJIZwdGyxd3XkJIJ6KHO3YoP0doF1\SCjZHTpeIlwdiCjbnSgcYVie3W{ZXSgZYZ1\XJiMUCgcYlveyCkeTDsbZF2cWRic3PpcpRqdGyjdHnvckBkdyxiSVO1NEA:KDJ3IN88UU4> MnGxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF7MUCwNVcoRjNzOUGwNFE4RC:jPh?=
COS7 NIr2e3dHfW6ldHnvckBie3OjeR?= M2H0e|ExKG2rboO= M1;WS2lvcGmkaYTpc44hd2ZicnHiZol1KFOHUlPBNYIh\XiycnXzd4VlKGmwIFPPV|ch[2WubIOgcYlkem:|b33hcEBu\W2kcnHu[ZMheHKnaX7jeYJifGWmIH\vdkAyOCCvaX7zJIZwdGyxd3XkJIJ6KGGmZHn0bY9vKG:oIFHUVEBidmRibXXhd5Vz\WRiYX\0[ZIhPDBibXnud{BjgSCHTFnTRUBu\XSqb3SsJGtqKD1iNT64JO69VS5? MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OjB|MEm3Okc,OzJyM{C5O|Y9N2F-
COS7 Mk\QSpVv[3Srb36gZZN{[Xl? MlfvNVAhdWmwcx?= Ml64TY5pcWKrdHnvckBw\iCqdX3hckBUTVKFQUPhJIV5eHKnc4Pl[EBqdiCFT2O3JINmdGy|IH3pZ5Jwe2:vYXygcYVu[nKjbnXzJJBz\WmwY4XiZZRm\CCob4KgNVAhdWmwczDmc4xtd3enZDDifUBi\GSrdHnvckBw\iCDVGCgZY5lKG2nYYP1doVlKGGodHXyJFQxKG2rboOgZpkhTUyLU1GgcYV1cG:mLDDLbUA:KDhwNjFOwG0v NXnpXG5XRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{KwN|A6PzZpPkOyNFMxQTd4PD;hQi=>
A549 M1m1SmZ2dmO2aX;uJIF{e2G7 M1nJ[|E2KG2rboO= M4L1ZWlvcGmkaYTpc44hd2ZibXnjdo9{d22jbDDQS2VUOSCrbjDJUIJmfGFvc4TpcZVt[XSnZDDoeY1idiCDNUS5JINmdGy|IIXzbY5oKFCJSEKgZZMhe3Wkc4TyZZRmKHC{ZXnuZ5Vj[XSnZDDmc5IhOTVibXnud{Bnd2yub4fl[EBjgSC|dXLzeJJifGViYXTkbZRqd25ibXXhd5Vz\WRiYX\0[ZIhOSCvaX6gZpkhWlBvSGDMR{BidmGueYPpd{whUUN3MDC9JFAvOiEQvF2u NXHiNFNzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF4NEO4M{c,S2iHTVLMQE9iRg>?
RAW264.7 MYXGeY5kfGmxbjDhd5NigQ>? M2rPN|IxKGi{cx?= NX7qNFdvUW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBvcXS{aXOgc5hq\GVicILv[JVkfGmxbjDpckBud3W|ZTDSRXczPjRwNzDj[YxteyCvZXHzeZJm\CCjZoTldkAzOCCqcoOgZpkh\3KrZYPzJIF{e2G7LDDJR|UxKD1iMD64JO69VS5? MkWzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE3PDN6Lze+R4hGVUKOPD;hQi=>
MDCK NWX6ZmpUSW62aY\pdoFtKGG|c3H5 MUO0NEBpenN? MlnURY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTY5ndHWnborhJGEhfmm{dYOgLGEwX1OQL{OzLGgyVjFrKTDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDpcoN2[mG2ZXSg[o9zKDRyIHjyd{BjgSCFZXzsWIl1\XJvR3zvJIF{e2G7LDDJR|UxKD1iNj63JO69VS5? NGr3U4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTZ2M{ivK|5EcEWPQly8M4E,
MDCK MlS5RY51cX[rcnHsJIF{e2G7 NHiwb241OCCqcoO= NYrxfGNjSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUW6obIXlcppiKEFidnnyeZMhMEFxV2POM|M{MEhzTkGpLUBqdm[nY4Tl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JIFnfGW{IESwJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKGG|c3H5MEBKSzVyIE2gOk44KM7:TT6= MkOyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE3PDN6Lze+R4hGVUKOPD;hQi=>
RAW264.7 MYXBcpRqcW6obHHtcYF1d3K7IHHzd4F6 M{nuSVE4KGi{cx?= NXfWdHNsSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzQV{9KTk5vZ3HtcYEue3SrbYXsZZRm\CCwaYTybYMhd3irZHWgdJJw\HWldHnvckBi\nSncjCxO{BpenNiYomgS5Jq\XO|IHHzd4F6NCCLQ{WwJF0hOTRwNzFOwG0v MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVY1OzhxJ{7DbGVOSkx:L3G+
HEK293T NXe4[ZYzS3m2b4TvfIlkcXS7IHHzd4F6 NXHpOmpMS3m2b4TvfIlkcXS7IHHnZYlve3RiSFXLNlk{XCClZXzsd{whUUN3MDC9JFE2NjJizszNMi=> MmfmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE3PDN6Lze+R4hGVUKOPD;hQi=>
J774.1 M2T1WmN6fG:2b4jpZ4l1gSCjc4PhfS=> NHHpdHZEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBLPzd2LkGgZ4VtdHNuIFnDOVAhRSB|MTFOwG0v MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVY1OzhxJ{7DbGVOSkx:L3G+
MDCK NYO5UnNbS3m2b4TvfIlkcXS7IHHzd4F6 MYS0NEBpenN? Ml7IR5l1d3SxeHnjbZR6KGGpYXnud5QhVUSFSzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2MDDodpMh[nliQ3XscHRqfGW{LVfsc{Bie3OjeTygR2M2OCB;IES4MlMh|ryPLh?= MnPiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE3PDN6Lze+R4hGVUKOPD;hQi=>
MDCK M1nCN2N6fG:2b4jpZ4l1gSCjc4PhfS=> MYG0NEBpenN? MnXZR5l1d3SxeHnjbZR6KGGpYXnud5QhVUSFSzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNECgbJJ{KGK7IFPlcIxVcXSncj3HcI8h[XO|YYmsJGNEPTBiPTC0PE4{KM7:TT6= NHfKeJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTZ2M{ivK|5EcEWPQly8M4E,
3T3L1 MoC0SpVv[3Srb36gZZN{[Xl? M1fRcVExKG6pL33s MoXmTY5pcWKrdHnvckBw\iCWTl\hcJBp[S2rbnT1Z4VlKE6Ia3HwdIFDKGGldHn2ZZRqd25iKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViM2SzUFEh[2WubIOgZZQhOTBibnevcYwh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5 NG\w[249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTZ2M{ivK|5EcEWPQly8M4E,
Assay
Methods Test Index PMID
Western blot p-IRE1α / IREα ; HDAC1/ HDAC2 ; p-STAT3 / STAT3 29901626 31196210 23874455
Immunofluorescence β-catenin ; PKD1 ; EGFR / LC3 22523587 31196210
Growth inhibition assay Cell proliferation ; Cell viability 22523587 19809577
In vivo

Chronic treatment with curcumin significantly reverses the CMS-induced behavioral abnormalities in stressed rats. Additionally, curcumin effectively inhibits cytokine gene expression at both the mRNA and the protein level and reduces the activation of NF-κB[4].

Protocol (from reference)

Cell Research:

[5]

  • Cell lines: murine melanoma cell subline(B16-R)
  • Concentrations: 0-100 μM
  • Incubation Time: 24-48 h
  • Method:

    1×104 B16-R cells are cultivated as monolayer culture for 12 hr. They were then incubated in 200 μL of RPMI, 10% FBS containing curcumin at final concentrations from 1–100 μM in 96-multiwell plates for 24-48 hr. After these incubations, cells are washed twice in PBS and 500 μl of fresh culture medium containing MTT (0.3 mg/mL) are added for colorimetric assay.

Animal Research:

[5]

  • Animal Models: Female B6D2F1 mice (6-8 weeks old)
  • Dosages: 25 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
5%DMSO+10%PEG300+5%Tween80+80%ddH2O
For best results, use promptly after mixing.

4mg/mL

Chemical Information

Molecular Weight 368.38
Formula

C21H20O6

CAS No. 458-37-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04458116 Not yet recruiting Dietary Supplement: Curcumin Coronary Artery Disease|Oxidative Stress|Inflammation Universidade Federal Fluminense March 10 2022 Not Applicable
NCT04731844 Recruiting Drug: Curcumin plus Piperine Prostate Cancer|Multiple Myeloma|Smoldering Multiple Myeloma (SMM)|Monoclonal Gammopathy of Undetermined Significance University of Rochester December 14 2021 Phase 2
NCT05045443 Recruiting Drug: Curcumin|Dietary Supplement: Standard of Care Acute Lymphoblastic Leukemia Pediatric Ain Shams University August 22 2021 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Curcumin | Curcumin ic50 | Curcumin price | Curcumin cost | Curcumin solubility dmso | Curcumin purchase | Curcumin manufacturer | Curcumin research buy | Curcumin order | Curcumin mouse | Curcumin chemical structure | Curcumin mw | Curcumin molecular weight | Curcumin datasheet | Curcumin supplier | Curcumin in vitro | Curcumin cell line | Curcumin concentration | Curcumin nmr