Curcumin

Catalog No.S1848 Synonyms: Diferuloylmethane, Natural Yellow 3, Turmeric yellow

For research use only.

Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase(IC50~25 μM)and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.

Curcumin Chemical Structure

CAS No. 458-37-7

Selleck's Curcumin has been cited by 37 publications

Purity & Quality Control

Choose Selective Histone Acetyltransferase Inhibitors

Biological Activity

Description Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase(IC50~25 μM)and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.
Targets
Nrf2 [1]
(Cell-free assay)
Ferroptosis [9]
()
HDAC [7]
(Cell-free assay)
NF-κB [8]
(Cell-free assay)
p300 [6]
(Cell-free assay)
~25 μM
In vitro

Curcumin induces the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal-regulated kinase 1/2 signaling. Curcumin inhibits cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and downregulation of cyclin D1[2]. Curcumin induces endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells[3].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
U87 Mlr4R4VtdCC4aXHibYxqfHliYYPzZZk> NYjNUYJyOCxiMUCsJFIxNCB|MDygOFAtKGGwZDC1NEDDvU1xTB?= Mn7hNlQhcG:3coO= M3excWF1KGOxbnPlcpRz[XSrb37zJIhq\2incjD0bIFvKDJyINM1UU9NNCClZXzsJJZq[WKrbHn0bYV{KHO2ZXXwcJkh\GWlbHnu[YQ> M4L3VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzME[yOVI4Lz5|MUC2NlUzPzxxYU6=
HEL cells MWPD[YxtKH[rYXLpcIl1gSCjc4PhfS=> NUjiW|lFOC1|MDFCuY1wdC:O M4HTZ|I1NzR6wrDoc5Vzew>? M1K0XXRp\SC4aXHibYxqfHlib3[geIhmKEiHTDDj[YxteyCneIDvd4VlKHSxIHP1doN2dWmwIIfhd{B{cWewaX\pZ4FvfGy7IHzve4VzKGOxbYDhdoVlKHSxIHPvcpRzd2xiY3XscJMh\X[nbjDheEBtd3diY3;uZ4VvfHKjdHnvcpMv MlzhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFyM{OyNFkoRjNzMEOzNlA6RC:jPh?=
Raw246.7 NH7VXXJE\WyuII\pZYJqdGm2eTDhd5NigQ>? NUnEOFJvOSxiNTygNVAtKDVyLDCxNFAtKDJyMDygZY5lKDVyMDDnM41N M3\TflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMEC3O|AyLz5|MUCwO|cxOTxxYU6=
RT112 NHO2eodE\WyuII\pZYJqdGm2eTDhd5NigQ>? NXznPHA6OC5zIH;yJFAvPCEQvHevcYw> NYrZVWE2OjRuIES4MEBidmRiN{KgbC=> NXO3VVlzS3W{Y4XtbY4h[WyxbnWsJIFl\GWmIHH0JIEh[2:wY3XueJJifGmxbjDmdo9uKDBwMTD0c{AxNjRizsznM41tNCCmaXSgco91KGGudHXyJINmdGxiZ4Lve5RpKG:oIGLUNVEzKGOnbHzzMEB{dGmpaITsfUBz\WS3Y3XkJHVOXUN|IHPlcIwh\3Kxd4ToJIF1KDBwNDFOwIcwdWxuIHHu[EBwdmy7IH3v[IVz[XSnbImgd5VxeHKnc4Pl[EBoem:5dHigc4YhXEOFU2XQJIF1KDBwMjDhcoQhOC52IN88[{9udCxiZXHjbEBkd22yYYLl[EB1dyC{ZYPw[YN1cX[nIHPvcpRzd2y| NGe5VYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEm4OFI4QCd-M{C5PFQzPzh:L3G+
UMUC3 MWnD[YxtKH[rYXLpcIl1gSCjc4PhfS=> Ml;kNE4yKG:{IECuOOKh|rypL33s MUCyOEwhPDhuIHHu[EA4OyCq MnPtR5Vz[3WvaX6gZYxwdmVuIHHk[IVlKGG2IHGgZ49v[2WwdILheIlwdiCocn;tJFAvOSC2bzCwMlQh|rypL33sMEBlcWRibn;0JIFtfGW{IHPlcIwh\3Kxd4ToJI9nKFKWMUGyJINmdGy|LDDzcIlocHSueTDy[YR2[2WmIGXNWWM{KGOnbHyg[5Jwf3SqIHH0JFAvPCEQvHevcYwtKGGwZDDvcox6KG2xZHXyZZRmdHlic4XwdJJme3OnZDDndo94fGhib3[gWGNEW1WSIHH0JFAvOiCjbnSgNE42KM7:Zz;tcEwh\WGlaDDjc41x[XKnZDD0c{Bz\XOyZXP0bZZmKGOxboTyc4x{ MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODl6NEK3PEc,OzB7OESyO|g9N2F-
TCCSUP Ml;4R4VtdCC4aXHibYxqfHliYYPzZZk> NYfVd3RpOC5zIH;yJFAvPMLizsznM41t M1e5VFI1NCB2ODygZY5lKDd2IHi= MXzDeZJkfW2rbjDhcI9v\SxiYXTk[YQh[XRiYTDjc45k\W62cnH0bY9vKG[{b32gNE4yKHSxIECuOEDPxGdxbXysJIRq\CCwb4SgZYx1\XJiY3XscEBoem:5dHigc4YhWlRzMUKgZ4VtdHNuIIPsbYdpfGy7IILl[JVk\WRiVV3VR|Mh[2WubDDndo94fGhiYYSgNE41KM7:Zz;tcEwh[W6mIH;ucJkhdW:mZYLheIVtgSC|dYDwdoV{e2WmIHfyc5d1cCCxZjDUR2NUXVBiYYSgNE4zKGGwZDCwMlYh|rypL33sMEBm[WOqIHPvcZBiemWmIITvJJJme3CnY4TpeoUh[2:wdILvcJM> MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODl6NEK3PEc,OzB7OESyO|g9N2F-
KBM5 M3fhOmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MUG3NkBpenN? Mki5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNQl21JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|Lki0JO69VS5? MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ6MEC2PUc,OjR{OECwOlk9N2F-
Jurkat M131OGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MljWO|IhcHK| M4TCemFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSoXyb4F1KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0MlI6KM7:TT6= NXvXOphFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyPFAxPjlpPkK0NlgxODZ7PD;hQi=>
U266 NIjySGZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NVniWFhWPzJiaILz NXPhR5RXSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVNlY3KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC3MlU4KM7:TT6= NWroNWNURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyPFAxPjlpPkK0NlgxODZ7PD;hQi=>
A549 NUniXXFSSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NXj0empTPzJiaILz NEXwXo1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG3MlMh|ryPLh?= MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ6MEC2PUc,OjR{OECwOlk9N2F-
MCF7 M{K4OmN6fG:2b4jpZ4l1gSCjc4PhfS=> NXrCXIJ4OjRiaILz Ml7GR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|IvOiEQvF2u M1XrOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUe0OVU2Lz5{NkG3OFU2PTxxYU6=
SKOV3 NVXrUm92S3m2b4TvfIlkcXS7IHHzd4F6 MmrsNlQhcHK| NWLkbXpCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDR|Lk[zJO69VS5? NXfDNG5GRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xO|Q2PTVpPkK2NVc1PTV3PD;hQi=>
CT26 MVPDfZRwfG:6aXPpeJkh[XO|YYm= MXu3NkBpenN? M{XnOmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGNVOjZiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIIDyc4xq\mW{YYTpc44hcW6ldXLheIVlKG[xcjC3NkBpenNiYomgUXRUKGG|c3H5MEBKSzVyIE2gO{44KM7:TT6= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjNzOEC1O{c,OjZ|MUiwOVc9N2F-
SW620 MlTrR5l1d3SxeHnjbZR6KGG|c3H5 MmTYO|IhcHK| NETq[mxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUXzZ{MDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFNiYYPzZZktKEmFNUCgQUAyOi53MjFOwG0v MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjNzOEC1O{c,OjZ|MUiwOVc9N2F-
SGC7901 NUPBZVFDS3m2b4TvfIlkcXS7IHHzd4F6 MWq3NkBpenN? MlzvR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2dEPzlyMTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFNiYYPzZZktKEmFNUCgQUAzPC52MTFOwG0v NHzJZ4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOxPFA2Pyd-Mk[zNVgxPTd:L3G+
GES-1 NFHZXpdEgXSxdH;4bYNqfHliYYPzZZk> NHvWS3k4OiCqcoO= NHTkVnREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBITVNvMTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFNiYYPzZZktKEmFNUCgQUAzPy56OTFOwG0v Mnq1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|MUiwOVcoRjJ4M{G4NFU4RC:jPh?=
MGC803 MXnDfZRwfG:6aXPpeJkh[XO|YYm= NWrGWGFHPzJiaILz MkDHR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWdEQDB|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JG1VWyCjc4PhfUwhUUN3MDC9JFMyNjN7IN88UU4> NVTLToZ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zNVgxPTdpPkK2N|E5ODV5PD;hQi=>
Caco2 NWizT|U4SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M325fWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ3Hjc|Ih[2WubIOsJGlEPTBiPTCxNE4{KM7:TT6= NUjR[4pxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1N|k3OjZpPkK2OVM6PjJ4PD;hQi=>
U2OS MoTqR5l1d3SxeHnjbZR6KGG|c3H5 NHWyN201QCCqcoO= NXfCRnE2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXTKRUzDj[YxteyCneIDy[ZN{cW6pIIfpcIQufHmyZTDwOVMh[W[2ZYKgOFghcHK|IHL5JINzgXO2YXygeolwdGW2LYP0ZYlvcW6pIHLhd4VlKHOyZXP0do9xcG:2b33leJJq[yCjc4PhfUwhTUN3MDC9JFIzNjhizszNMi=> NW\zTY5oRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2NFYzPDZpPkK2OlA3OjR4PD;hQi=>
Saos2 MkTUR5l1d3SxeHnjbZR6KGG|c3H5 NGjLclQ1QCCqcoO= M3XKRWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNid3N{IHPlcIx{KGW6cILld5NqdmdicEWzJI12fGGwdDDh[pRmeiB2ODDodpMh[nliY4L5d5RidCC4aX;s[ZQue3SjaX7pcoch[mG|ZXSgd5Bm[3S{b4Doc5RwdWW2cnnjJIF{e2G7LDDFR|UxKD1iMkiuNUDPxE1w MlL5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4ME[yOFYoRjJ4NkC2NlQ3RC:jPh?=
U2OS NHfuXY5EgXSxdH;4bYNqfHliYYPzZZk> M3;Bd|I1KGi{cx?= M3uz[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHUzV1NiY3XscJMh\XiycnXzd4lv\yC5aXzkMZR6eGVicEWzJIFnfGW{IEK0JIhzeyCkeTDjdpl{fGGuII\pc4xmfC2|dHHpcolv\yCkYYPl[EB{eGWldILvdIhwfG:vZYTybYMh[XO|YYmsJGVEPTBiPTCzOE41KM7:TT6= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjZyNkK0Okc,OjZ4ME[yOFY9N2F-
Saos2 M3XDcmN6fG:2b4jpZ4l1gSCjc4PhfS=> NHzRZYgzPCCqcoO= NX\YS|g6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW2Gxc{KgZ4VtdHNiZYjwdoV{e2mwZzDwOVMhdXW2YX70JIFnfGW{IEK0JIhzeyCkeTDjdpl{fGGuII\pc4xmfC2|dHHpcolv\yCkYYPl[EB{eGWldILvdIhwfG:vZYTybYMh[XO|YYmsJGVEPTBiPTC0PE43KM7:TT6= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjZyNkK0Okc,OjZ4ME[yOFY9N2F-
T98G NVnobotlSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NFPPUmozPCCqcoO= MoP1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCWOUjHJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCHWj3Uc5gh[XO|YYmsJGlEPTBiPTCxNEDPxE1w NU\I[3ZvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2N|E{OThpPkK2OlMyOzF6PD;hQi=>
T98G NF\OXlRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M2P2VFczKGi{cx?= NYqz[XZUSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDUPVhIKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyOUDPxE1w NXXFTY9ZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2N|E{OThpPkK2OlMyOzF6PD;hQi=>
T67 NYf2VVIxVmW3cn;wdo91\WO2aY\lJIF{e2G7 MmDZUoV2em:ycn;0[YN1cX[nIHXm[oVkfCCrbjDoeY1idiCWNkegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hVlGRMTDhZ5Rqfmm2eTD1d4lv\yCGQ1nQJIF{KHO3YoP0doF1\Q>? MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjZ7NkK1Nkc,OjZ4OU[yOVI9N2F-
SH-SY5Y MV;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M{j2T|Q5KGi{cx?= MkLPRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVSD3TXVV[KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyxiSVO1NEA:KDF4LkGg{txONg>? NFTFS5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkewOVE1PCd-Mk[3NFUyPDR:L3G+
HeLa M2L1[WFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NFfCSpA1QCCqcoO= MUHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEinTHGgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzMEBKSzVyIE2gNlEvQCEQvF2u MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjdyNUG0OEc,OjZ5MEWxOFQ9N2F-
HeLa NXzFXXhmS2WubDDjfYNt\SCjc4PhfS=> MoLsNVYhcHK| MkTYR4VtdCCleXPs[UBienKnc4SgbY4hcHWvYX6gTIVN[SClZXzsd{Bie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gZZQhTzFicHjhd4Uh[XRiSVO1NEB1dyB{IITpcYV{KEmFNUCgZYZ1\XJiMU[gbJJ{KGK7IF\BR3Mh[W6jbInzbZM> NX;s[pp5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3NFUyPDRpPkK2O|A2OTR2PD;hQi=>
HuH7 MX3DfZRwfG:6aXPpeJkh[XO|YYm= MlfGOFghcHK| NVHhSYJLS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUHWKNzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPDhizszNMi=> MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6M{G3PUc,OjZ5OEOxO|k9N2F-
HeLa NXX5VI15SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Mm[wN{Bl[Xm| NW\HU3FGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCC4aXHibYxqfHliYX\0[ZIhOyCmYYnzJIJ6KFeVVD2xJIF{e2G7LDDJR|UxKD1iMUKuNVEh|ryPLh?= NEfLemo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkiyO|E3OSd-Mk[4NlcyPjF:L3G+
LNCAP M1jCbmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NFnyO4U{KGSjeYO= MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEyQQ1HQJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEB3cWGkaXzpeJkh[W[2ZYKgN{Bl[Xm|IHL5JHdUXC1zIHHzd4F6NCCLQ{WwJF0hOTNwNkGg{txONg>? M4i4SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OEK3NVYyLz5{NkiyO|E3OTxxYU6=
PC3 MXXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NYDifnhwOyCmYYnz NXPxPZlFSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKH[rYXLpcIl1gSCjZoTldkA{KGSjeYOgZpkhX1OWLUGgZZN{[XluIFnDOVAhRSB{NT60N{DPxE1w NXTJ[W5ZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[4NlcyPjFpPkK2PFI4OTZzPD;hQi=>
DU145 NUmxSnl3SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M1PEOFMh\GG7cx?= M1nZSmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRGWxOFUh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKH[rYXLpcIl1gSCjZoTldkA{KGSjeYOgZpkhX1OWLUGgZZN{[XluIFnDOVAhRSB{Nj6yN{DPxE1w NEmyRYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkiyO|E3OSd-Mk[4NlcyPjF:L3G+
RAW264.7 MV3BcpRqcW6obHHtcYF1d3K7IHHzd4F6 M2HHfFI1KGi{cx?= NFHwSZRCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgcol1emmlIH;4bYRmKHC{b3T1Z5Rqd25iYX\0[ZIhOjRiaILzJIJ6KEe{aXXzd{Bie3OjeTygTWM2OCB;IEG5MlEh|ryPLh?= MmjiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ6NEGxOlgoRjJ4OESxNVY5RC:jPh?=
BV2 M4[5[GZ2dmO2aX;uJIF{e2G7 MWKyOEBpenN? NFe3O4NKdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJG5QKHC{b3T1Z5Rqd25iaX6gcY92e2ViQm[yJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCwaYTybZRmKGyndnXsJJBz\XS{ZXH0[YQh\m:{IEK0JIhzeyCkZX\vdoUhVFCVIITy[YF1dWWwdDDmc5Ih[WSmaYTpc45idCB{NDDodpMh[nliR4Lp[ZN{KHKnYXP0bY9vKG2ndHjv[EwhUUN3MDC9JFAvPTJizszNMi=> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjh3OUe3Okc,OjZ6NUm3O|Y9N2F-
HepG2 NUj6UFVxS3m2b4TvfIlkcXS7IHHzd4F6 NUjGUnd{S3m2b4TvfIlkcXS7IHHjeIl3cXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOE41OyEQvF2u MlvXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ6N{O0NVQoRjJ4OEezOFE1RC:jPh?=
A549 MUXDfZRwfG:6aXPpeJkh[XO|YYm= MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ|LkW0JO69VS5? MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjh5M{SxOEc,OjZ6N{O0NVQ9N2F-
MCF7 NV;sTZdmS3m2b4TvfIlkcXS7IHHzd4F6 NIe2SWFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IES2MlI2KM7:TT6= NIWwc|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nki3N|QyPCd-Mk[4O|M1OTR:L3G+
SKOV3 MlG0R5l1d3SxeHnjbZR6KGG|c3H5 MkDPR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNEmuPFUh|ryPLh?= MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjh5M{SxOEc,OjZ6N{O0NVQ9N2F-
A549/CDDP NYjMeppZSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NH\l[HI4OiCqcoO= NHP3[FJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkwS0SGUDDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOzJwM{mg{txONg>? MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjh7MUC5PUc,OjZ6OUGwPVk9N2F-
A549 M2qwbGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NWn2d|FiPzJiaILz MkfjRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|OD6xNkDPxE1w NU\LOXhZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[4PVExQTlpPkK2PFkyODl7PD;hQi=>
A549/CDDP MULGeY5kfGmxbjDhd5NigQ>? NHzOPYZKdmirYnn0bY9vKG:oIITobY9z\WSxeHnuJJJm\HWldHHz[UBqdiCqdX3hckBCPTR7L1PESHAh[2WubIOgZpkhTFSQQjDkfYUh[mG|ZXSgcYlkem:ybHH0[UB{eGWldILvdIhwfG:vZYTyfUwhUUN3MDC9JFM6NjR{IN88UU4> MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjh7MUC5PUc,OjZ6OUGwPVk9N2F-
A549 Mmf4SpVv[3Srb36gZZN{[Xl? NUP2e494UW6qaXLpeIlwdiCxZjD0bIlwemWmb4jpckBz\WS3Y4Thd4UhcW5iaIXtZY4hSTV2OTDj[YxteyCkeTDEWG5DKGS7ZTDiZZNm\CCvaXPyc5Bt[XSnIIPw[YN1em:yaH;0c41mfHK7LDDJR|UxKD1iNECuOVYh|ryPLh?= MkLLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ6OUGwPVkoRjJ4OEmxNFk6RC:jPh?=
A549 NULkZ|FTSXCxcITvd4l{KGG|c3H5 NXzHfJRtOi5zIITvJFQvOiC3TR?= M2jpUVI1KGi{cx?= Mkf5TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCDNUS5JINmdGy|IHH0JFIvOSC2bzC0MlIhfU1iYX\0[ZIhOjRiaILzJIJ6KGGwbnX4bY4hXi2ISWTDM5Bzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnetZoF{\WRiZnzve{BkgXSxbXX0dpk> M{PWVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OEmxNFk6Lz5{Nki5NVA6QTxxYU6=
A549/CDDP M3;EZ2Fxd3C2b4Ppd{Bie3OjeR?= MXGwMlYhfG9iMT6yJJVO NX:4O5NUOjRiaILz MlvITY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCDNUS5M2NFTFBiY3XscJMh[XRiMD62JJRwKDFwMjD1UUBi\nSncjCyOEBpenNiYomgZY5v\XirbjDWMWZKXENxcILvdIllcXWvIHnv[Ill\SC|dHHpcolv\y2kYYPl[EBndG:5IHP5eI9u\XS{eR?= MlPDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ6OUGwPVkoRjJ4OEmxNFk6RC:jPh?=
bone marrow MWfGeY5kfGmxbjDhd5NigQ>? NVmzOWhyPDhiaILz NWW5eGRrUW6qaXLpeIlwdiCxZjDSRW5MVC2rbnT1Z4VlKG:|dHXvZ4xie3RiZHnm[oVz\W62aXH0bY9vKGmwIFnDVkBud3W|ZTDic45mKG2jcoLve{Bk\WyuczDh[pRmeiB2ODDodpMh[nliVGLBVEBie3OjeTygTWM2OCB;IEeuOUDPxE1w NV[zfpl4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[5NlM3QTZpPkK2PVI{Pjl4PD;hQi=>
U937 MUHGeY5kfGmxbjDhd5NigQ>? M1T0bFE4KHSxIEKwJIhzew>? NGnyb5BKdmirYnn0bY9vKG:oIFzQV{9KTk5vZ3HtcYEucW6mdXPl[EBRT0V{IIDyc4R2[3Srb36gbY4hWE2DLYTy[YF1\WRiaIXtZY4hXTl|NzDj[YxteyCjZoTldkAyPyC2bzCyNEBpenNiYomg[Y57gW2nIHntcZVvd2G|c3H5MEBKSzVyIE2gNU45QCEQvF2u NVH6UnVyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewOFA3PTlpPkK3NFQxPjV7PD;hQi=>
RAW264.7 MnS5SpVv[3Srb36gZZN{[Xl? M2r1blE4KHSxIEKwJIhzew>? MkLQTY5pcWKrdHnvckBw\iCOUGOvTWZPNWejbX3hMYlv\HWlZXSgVGdGOiCycn;keYN1cW:wIHnuJI1wfXOnIGLBW|I3PC55IHPlcIx{KGGodHXyJFE4KHSxIEKwJIhzeyCkeTDlcpp6dWViaX3teY5w[XO|YYmsJGlEPTBiPTCxOU46PSEQvF2u NVf2UZBTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewOFA3PTlpPkK3NFQxPjV7PD;hQi=>
BV2 MY\BcpRqcW6obHHtcYF1d3K7IHHzd4F6 NFHjb4gzPCCqcoO= M17kVGFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hdW:3c3WgRnYzKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gUHBUNWmwZIXj[YQhdmm2cnnjJI95cWSnIIDyc4R2[3Srb36gZYZ1\XJiMkSgbJJ{KGK7IFfybYV{eyCjc4PhfUwhUUN3MDC9JFQvPzdizszNMi=> NHPWPIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{KyPFIzPyd-MkeyNlgzOjd:L3G+
SH-SY5Y MXfO[ZVzd3C{b4TlZ5RqfmViYYPzZZk> Mmm0NlQhcHK| NVH1WIZVVmW3cn;wdo91\WO2aY\lJIFkfGm4aYT5JIlvKGi3bXHuJHNJNVO\NWmgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKDZvT1jERU1qdmS3Y3XkJINmdGxiZHXheIghdWWjc4Xy[YQh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhTUN3MDC9JFYvOiEQvF2u NUXRPY44RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke0NlA6OTlpPkK3OFIxQTF7PD;hQi=>
PC3 M2LyZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> MmqzNlQhcHK| NGK2fVNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDN7IN88UU4> MoHiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd2OU[yNVIoRjJ5NEm2NlEzRC:jPh?=
DU145 MlLER5l1d3SxeHnjbZR6KGG|c3H5 NYj6UoZnOjRiaILz NUPaZmJTS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTFVzNEWgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IESxJO69VS5? NWDCWHBbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke0PVYzOTJpPkK3OFk3OjF{PD;hQi=>
4T1 MnLLR5l1d3SxeHnjbZR6KGG|c3H5 M2\XWFI1KGi{cx?= M3PLO2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJFRVOSClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPDlwNDFOwG0v M3\TUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NEm2NlEzLz5{N{S5OlIyOjxxYU6=
T47D MXfDfZRwfG:6aXPpeJkh[XO|YYm= NIT0ZmEzPCCqcoO= NGXGWIREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBVPDeGIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB{NDDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{Cg{txONg>? NYj4dnBvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1NVc5ODZpPkK3OVE4QDB4PD;hQi=>
CHOK1 MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFu5bXg4OiCqcoO= M2rvSWdzd3e2aDDpcohq[mm2aX;uJI9nKEOKT1uxJINmdGy|IHHzd4V{e2WmIHHzJI1qfG:laH;u[JJq[WxiYXP0bZZqfHlibXXhd5Vz\WRiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDdwNTFOwG0v NH:4bXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{WyNVU5QSd-Mke1NlE2QDl:L3G+
LNCAP M1XqN2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NXf5fHNiOyCmYYnz MkDCRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCOTlPBVEBk\WyuczDh[pRmeiB|IHThfZMh[nliV2PUJI9zKHS{eYDhckBjdHWnIHHzd4F6NCCLQ{WwJF0hOTNwNkGg{txONg>? M2LBVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUSzN|kyLz5{N{W0N|M6OTxxYU6=
PC3 NYSzUYs5SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M1vGRVMh\GG7cx?= M{DvN2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IHHmeIVzKDNiZHH5d{BjgSCZU2Sgc5IhfHK7cHHuJIJtfWViYYPzZZktKEmFNUCgQUAzPS52MzFOwG0v NF3uV3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{W0N|M6OSd-Mke1OFM{QTF:L3G+
DU145 NGjEdIdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MVGzJIRigXN? M4G1VWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRGWxOFUh[2WubIOgZYZ1\XJiMzDkZZl{KGK7IGfTWEBweiC2conwZY4h[my3ZTDhd5NigSxiSVO1NEA:KDJ4LkKzJO69VS5? M{fjSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUSzN|kyLz5{N{W0N|M6OTxxYU6=
BV2 Moi1SpVv[3Srb36gZZN{[Xl? M4WwVFEhcHJ? MmLMTY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDubZRzcWNib4jp[IUheHKxZIXjeIlwdiCrbjDtc5V{\SCEVkKgZ4VtdHNicILleJJm[XSnZDDmc5IhOSCqcjDi[YZwemViTGDTJJN1cW23bHH0bY9vKG2nYYP1doVlKGGodHXyJFI1KGi{czDifUBIemmnc4OgZZN{[XluIFnDOVAhRSBzLkSyJO69VS5? NFHVU2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{W5NlE{PSd-Mke1PVIyOzV:L3G+
BV2 M2rN[GZ2dmO2aX;uJIF{e2G7 M33xNlEhcHJ? M4HtR2lvcGmkaYTpc44hd2ZiU4LjJIlvKG2xdYPlJGJXOiClZXzsd{Bie3Onc4Pl[EBieyC|dYDwdoV{e2mxbjDv[kBNWFNvaX7keYNm\CCQTzDy[Yxm[XOnIIDy[Ylv[3WkYYTl[EBnd3JiMTDodkBnd2yub4fl[EBjgSCOUGOgZYRlcXSrb36gcYVie3W{ZXSgZYZ1\XJiMkSgbJJ{KGK7IFfybYV{eyCjc4PhfUwhUUN3MDC9JFIvOiEQvF2u M3nXflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NkG3PFA{Lz5{N{[xO|gxOzxxYU6=
A549 M2HGNGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 Ml63OFghcHK| MmThRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNT6wOkDPxE1w MmjNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd6MU[yOlcoRjJ5OEG2NlY4RC:jPh?=
MDA-MB-231 NWLydXhUSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MkfzOFghcHK| NFy2Zm1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ2LkW0JO69VS5? M3zTfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OEG2NlY4Lz5{N{ixOlI3PzxxYU6=
DU145 M1LDR2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MVG0PEBpenN? MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKESXMUS1JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2ND63NUDPxE1w Ml:0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd6MU[yOlcoRjJ5OEG2NlY4RC:jPh?=
EAhy926 MYLDfZRwfG:6aXPpeJkh[XO|YYm= Ml;iOFghcHK| NHTkSlhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBGSWi7OUK2JINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyOE43KM7:TT6= NFzXdIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{i0N|EyOyd-Mke4OFMyOTN:L3G+
Caco2 Mkn3R5l1d3SxeHnjbZR6KGG|c3H5 NVrLUnV[PDhiaILz NIDDNIZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBE[WOxMjDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{iuN{DPxE1w M3jHUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OESzNVE{Lz5{N{i0N|EyOzxxYU6=
CHOK1 NUXreXlrS3m2b4TvfIlkcXS7IHHzd4F6 M1yxVlQ5KGi{cx?= MoTTR5l1d3SxeHnjbZR6KGGpYXnud5QhS0iRS{GgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IESyJO69VS5? NGPSWGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{i0N|EyOyd-Mke4OFMyOTN:L3G+
SH-SY5Y M4DnZ2Z2dmO2aX;uJIF{e2G7 NX;kcpNyOSC2bzC1JJVO MnH4NlQhcHK| MmPPRY51cW:6aXThcpQh[WO2aY\peJkh[WejaX7zeEB1NUKKUD3pcoR2[2WmIH;4bYRifGm4ZTDzeJJme3NiaX6gbJVu[W5iU1itV3k2YSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJHJQWyCycn;keYN1cW:wIHH0JFEhfG9iNTD1UUBi\nSncjCyOEBpenNiYomgSGNHUC2GQTDwdo9j\SCkYYPl[EBndG:5IHP5eI9u\XS{aXOgZY5idHm|aYO= M{XQVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OEW2NlM3Lz5{N{i1OlI{PjxxYU6=
NCI-H1650 M2\zVGN6fG:2b4jpZ4l1gSCjc4PhfS=> NWPaXY9uPzJiaILz NVvYSXp{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLVixOlUxKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyNE44KM7:TT6= NInyNnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{i4OlU1QCd-Mke4PFY2PDh:L3G+
LLC MkDER5l1d3SxeHnjbZR6KGG|c3H5 NG\Zcno4OiCqcoO= MmrzR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgUGxEKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyOE44KM7:TT6= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzh6NkW0PEc,Ojd6OE[1OFg9N2F-
A549 MXjDfZRwfG:6aXPpeJkh[XO|YYm= MlXsO|IhcHK| M3uyR2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMhdWWjc4Xy[YQh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFI4NjhizszNMi=> MmPCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd6OE[1OFgoRjJ5OEi2OVQ5RC:jPh?=
K562 NFXxbJRHfW6ldHnvckBie3OjeR?= MX[0PEBpenN? NGjFRVVKdmirYnn0bY9vKG:oIGCt[5AhcW5iZH;4c5J2[mmlaX6gdoV{cXO2YX70JIh2dWGwIFu1OlIh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KG2nYYP1doVlKGGodHXyJFQ5KGi{czDifUBRemW|dH:gZox2\SCjc4PhfUwhT0l3MDC9JFE6NjZ5IN88UU4> M{nuUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUC4O|U3Lz5{N{mwPFc2PjxxYU6=
K562 MVfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NVPh[XZQPDhiaILz MXnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNibXXhd5Vz\WRiYX\0[ZIhPDhiaILzJIJ6KFC{ZYP0c{BjdHWnIHHzd4F6NCCJSUWwJF0hOjFwNkeg{txONg>? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzlyOEe1Okc,Ojd7MEi3OVY9N2F-
H460 M{CxbmZ2dmO2aX;uJIF{e2G7 MkT4OFghcHK| MX7Jcohq[mm2aX;uJI9nKFBvZ4CgbY4h\HK3ZzDy[ZNqe3SjboSgbJVu[W5iSES2NEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkhdWWjc4Xy[YQh[W[2ZYKgOFghcHK|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFfJOVAhRSB{NjFOwG0v NXnLcYZCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5NFg4PTZpPkK3PVA5PzV4PD;hQi=>
NCI-H460 NFLHRmNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MYe0PEBpenN? Ml;IRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCQQ1mtTFQ3OCClZXzsd{Bu\WG|dYLl[EBi\nSncjC0PEBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiR1m1NEA:KDJ5LkOg{txONg>? NIrIZlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{mwPFc2Pid-Mke5NFg4PTZ:L3G+
K562 M1GzNmZ2dmO2aX;uJIF{e2G7 M1L6blIxKHSxIEOwJJVO MlzUOFghcHK| NWGyO2FZTG:5bjDy[Yd2dGG2aX;uJI9nKHBvZ4Cg[ZhxemW|c3nvckBqdiCmb4jvdpVjcWOrbjDy[ZNqe3SjboSgbJVu[W5iS{W2NkBk\WyuczDheEAzOCC2bzCzNEB2VSCvZXHzeZJm\CCjZoTldkA1QCCqcoOgZpkhX2W|dHXyckBjdG:2IH3leIhw\A>? NHnZcGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{mwPFc2Pid-Mke5NFg4PTZ:L3G+
K562 NYHtR41LS2WubDDjfYNt\SCjc4PhfS=> NE\TUGkzOCC3TR?= NH\qSW41QCCqcoO= NHHjSXRE\WyuIHP5Z4xmKGG{cnXzeEBqdiCmb4jvdpVjcWOrbjDy[ZNqe3SjboSgbJVu[W5iS{W2NkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCJMD;HNUBxcGG|ZTDheEAzOCC3TTDt[YF{fXKnZDDh[pRmeiB2ODDodpMh[nlicILvdIllcXWvIHnv[Ill\SC|dHHpcolv\yCkYYPl[EBndG:5IHP5eI9u\XS{eR?= MlzVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7MEi3OVYoRjJ5OUC4O|U3RC:jPh?=
K562 MmO0R4VtdCCleXPs[UBie3OjeR?= MkPoNlAhfU1? NGDaNpc1QCCqcoO= MmLMR4VtdCCleXPs[UBienKnc4SgbY4h\G:6b4L1ZolkcW5icnXzbZN1[W62IHj1cYFvKEt3NkKgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hTzJxTTDwbIF{\SCjdDCyNEB2VSCvZXHzeZJm\CCjZoTldkA1QCCqcoOgZpkheHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{Bj[XOnZDDmcI94KGO7dH;t[ZRzgQ>? NFTpepU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{mwPFc2Pid-Mke5NFg4PTZ:L3G+
K562 MVjGeY5kfGmxbjDhd5NigQ>? NYDBZnp1OjBidH:gOFAhfU1? NG[3elk1QCCqcoO= MVnVdEBz\We3bHH0bY9vKG:oIIC1N{BmgHC{ZYPzbY9vKGmwIHTvfI9zfWKrY3nuJJJme2m|dHHueEBpfW2jbjDLOVYzKGOnbHzzJIF1KDJyIITvJFQxKHWPIH3lZZN2emWmIHHmeIVzKDR6IHjyd{BjgSCZZYP0[ZJvKGKub4SgcYV1cG:m M3\PVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUC4O|U3Lz5{N{mwPFc2PjxxYU6=
K562 M2TJSGNmdGxiY4njcIUh[XO|YYm= MV:yNEB2VQ>? NH\KcWY1QCCqcoO= NG\p[4RE\WyuIHP5Z4xmKGG{cnXzeEBqdiCmb4jvdpVjcWOrbjDy[ZNqe3SjboSgbJVu[W5iS{W2NkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCVIIDoZZNmKGG2IEKwJJVOKG2nYYP1doVlKGGodHXyJFQ5KGi{czDifUBxem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nJIJie2WmIH\sc5ch[3m2b33leJJ6 M37nUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUC4O|U3Lz5{N{mwPFc2PjxxYU6=
K562 M1TIN2NmdGxiY4njcIUh[XO|YYm= MmPHN|AhfG9iNECgeW0> NVv5fFVMPDhiaILz MWLD[YxtKGO7Y3zlJIFzemW|dDDpckBld3ixcoXibYNqdiC{ZYPpd5RidnRiaIXtZY4hUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDhZ4N2dXWuYYTpc44h[XRiR{CvS|EheGijc3WgZZQhOzBidH:gOFAhfU1ibXXhd5Vz\WRiYX\0[ZIhPDhiaILzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcoch[mG|ZXSg[oxwfyCleYTvcYV1enl? MmKwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7MEi3OVYoRjJ5OUC4O|U3RC:jPh?=
K562 NEjIXWtE\WyuIHP5Z4xmKGG|c3H5 M3Ky[FMxKHSxIESwJJVO NWnuc4hKPDhiaILz NIfibIpE\WyuIHP5Z4xmKGG{cnXzeEBqdiCmb4jvdpVjcWOrbjDy[ZNqe3SjboSgbJVu[W5iS{W2NkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCJMj;NJJBp[XOnIHH0JFMxKHSxIESwJJVOKG2nYYP1doVlKGGodHXyJFQ5KGi{czDifUBxem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nJIJie2WmIH\sc5ch[3m2b33leJJ6 NIn1c|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{mwPFc2Pid-Mke5NFg4PTZ:L3G+
K562 NXWzc4Q1TnWwY4Tpc44h[XO|YYm= NXTDfGVYOjBidH:gOFAhfU1? M2fNclQ5KGi{cx?= MUXEc5dvKHKnZ4XsZZRqd25ib3[gZ5lkdGmwIFKxJIV5eHKnc4Ppc44hcW5iZH;4c5J2[mmlaX6gdoV{cXO2YX70JIh2dWGwIFu1OlIh[2WubIOgZZQhOjBidH:gOFAhfU1ibXXhd5Vz\WRiYX\0[ZIhPDhiaILzJIJ6KFenc4Tldo4h[myxdDDt[ZRpd2R? MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzlyOEe1Okc,Ojd7MEi3OVY9N2F-
K562 NYXyNmdNSXCxcITvd4l{KGG|c3H5 NFPlc4ozOCC2bzC0NEB2VQ>? M{njZlQ5KGi{cx?= NGnQcG9KdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIRwgG:{dXLpZ4lvKHKnc3nzeIFvfCCqdX3hckBMPTZ{IHPlcIx{KGSnY4LlZZNmKGmwIIDyc{1k[XOyYYPlJFMhdGW4ZXygZZQhOjBidH:gOFAhfU1ibXXhd5Vz\WRiYX\0[ZIhPDhiaILzJIJ6KFenc4Tldo4h[myxdDDt[ZRpd2R? NWfEfIlQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5NFg4PTZpPkK3PVA5PzV4PD;hQi=>
K562 NH6yV5RCeG:ydH;zbZMh[XO|YYm= M{POdVIxKHSxIESwJJVO Ml;4OFghcHK| M2fJ[mlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6g[I95d3K3YnnjbY4hemW|aYP0ZY51KGi3bXHuJGs2PjJiY3XscJMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gVGFTWC1zIHPs[YF3[WenIHH0JFIxKHSxIESwJJVOKG2nYYP1doVlKGGodHXyJFQ5KGi{czDifUBY\XO2ZYLuJIJtd3RibXX0bI9l M{jhNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUC4O|U3Lz5{N{mwPFc2PjxxYU6=
Raji NHPVSlVHfW6ldHnvckBie3OjeR?= Mn3JOFghcHK| M2Doe2lvcGmkaYTpc44hd2ZiVGDBMYlv\HWlZXSgSWJXNWWjcnz5JIFvfGmpZX6gZYN1cX[jdHnvckBqdiCqdX3hckBT[WqrIHPlcIx{KGGodHXyJFQ5KGi{czDifUBqdmSrcnXjeEBqdW23bn;mcJVwemW|Y3XuZ4UhdWW2aH;kMEBKSzVyIE2gNVIvOSEQvF2u NYP5bXRpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5N|M5QTZpPkK3PVM{QDl4PD;hQi=>
BV2 M4\Nd2Z2dmO2aX;uJIF{e2G7 M1m1S|I1KGi{cx?= MlzsTY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDubZRzcWNib4jp[IUheHKxZIXjeIlwdiCrbjDtc5V{\SCEVkKgZ4VtdHNicILleJJm[XSnZDDmc5IhOjRiaILzJIZwdGyxd3XkJIJ6KEySUz3zeIlufWyjdHnvckBi\nSncjCyOEBpenNiYomgS5Jq\XO|IHHzd4F6NCCLQ{WwJF0hOi5|NjFOwG0v MmP3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyM{K3OVkoRjJ6MEOyO|U6RC:jPh?=
PC3 M1O1e2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MkH1OFghcHK| M4nES2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMj6yNkDPxE1w MmnHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyM{izNlMoRjJ6MEO4N|I{RC:jPh?=
MDA-MB-231 MVnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NYrCbG5mPDhiaILz MWjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE2NjhzIN88UU4> NVrDNY8zRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwN|g{OjNpPkK4NFM5OzJ|PD;hQi=>
BT549 MmLiRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MoPEOFghcHK| M37URWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQmS1OFkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK0Mlk{KM7:TT6= NE[3VIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OECzPFMzOyd-MkiwN|g{OjN:L3G+
HeLa MnnJRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NEntcXI1QCCqcoO= MortRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZVzhJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{NT60NUDPxE1w NFnQcZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OECzPFMzOyd-MkiwN|g{OjN:L3G+
DU145 NX63[lk2SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Mn\xOFghcHK| M3LxSGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRGWxOFUh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK4MlQyKM7:TT6= NYmzXok5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwN|g{OjNpPkK4NFM5OzJ|PD;hQi=>
BV2 NHfBNHNHfW6ldHnvckBie3OjeR?= NGG1T|A{OCCvaX7z NE\tRldKdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJI5qfHKrYzDvfIll\SCycn;keYN1cW:wIHnuJI1wfXOnIFLWNkBk\WyuczDwdoV1emWjdHXkJIZweiB|MDDtbY5{KG[xbHzve4VlKGK7IFzQV{1{fGmvdXzheIlwdiCjZoTldkAzPCCqcoOgZpkhT3KrZYPzJIF{e2G7LDDJR|UxKD1iND61JO69VS5? MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB3NUKxNEc,OjhyNUWyNVA9N2F-
THP1 NHTOSXJHfW6ldHnvckBie3OjeR?= NXrJe254OSCqch?= MoHtTY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDD0bZN{fWViZnHjeI9zKHC{b3PvZYd2dGGwdDDhZ5Rqfmm2eTDpckBpfW2jbjDUTHAyKGOnbHzzJJBz\WmwY4XiZZRm\CCob4KgNUBpeiCob3zsc5dm\CCkeTDMVHMh[WSmaYTpc44hdWWjc4Xy[YQh[W[2ZYKgOUBpenNidYPpcoch\mGldH;yJFEx[SClaILvcY9o\W6rYzDzeYJ{fHKjdHWgbY4heHKnc3XuZ4Uhd2ZicILveIhzd22kaX6gZ49ueGyneDygTWM2OCB;IECuNFE{OTZizszNMi=> MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDFyOUe4PEc,OjhzMEm3PFg9N2F-
RAW264.7 MV3BcpRqcW6obHHtcYF1d3K7IHHzd4F6 M2SwPVIxKHWP Mnm2RY51cS2rbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hdW:3c3WgVmFYOjZ2LkegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDJUE03KHC{b3T1Z5Rqd25iYYSgNlAhfU1iYomgSWxKW0F? NWXSR2FDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyPFQ5ODZpPkK4Nlg1QDB4PD;hQi=>
RAW264.7 NH;GSHVCdnSraX7mcIFudWG2b4L5JIF{e2G7 MorZNlAhfU1? M4HZXmFvfGlvaX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgWG5H[WyyaHGgdJJw\HWldHnvckBifCB{MDD1UUBjgSCHTFnTRS=> M37tbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6Mki0PFA3Lz5{OEK4OFgxPjxxYU6=
PC12 MknFUoV2em:ycn;0[YN1cX[nIHHzd4F6 NUS5ToN1OC5zIITvJFExKHWP Mke2NlQhcHK| NVjmfXlzVmW3cn;wdo91\WO2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgTFIxOi2rbnT1Z4VlKHSxeHnjbZR6KGmwIILheEBRSzF{IHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJINmdGxidnnhZoltcXS7IHH0JFAvOSC2bzCxNEB2VSCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6 NWT1NZRwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizNFI2OTFpPkK4N|AzPTFzPD;hQi=>
PC12 MnLMUoV2em:ycn;0[YN1cX[nIHHzd4F6 MXiwMlEhfG9iMUCgeW0> NHHGTY8zPCCqcoO= NXjjTJh{VmW3cn;wdo91\WO2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgRYJmfGF2Mj3pcoR2[2WmIITvfIlkcXS7IHnuJJJifCCSQ{GyJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGOnbHygeoli[mmuaYT5JIF1KDBwMTD0c{AyOCC3TTDh[pRmeiB{NDDodpMh[nliTWTUJIF{e2G7 MmfwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|MEK1NVEoRjJ6M{CyOVEyRC:jPh?=
HCT116 NH35RpNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NWDJZ2Q6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMhfXBidH:gO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE{Njd5IN88UU4> MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDNzOUe4NEc,Ojh|MUm3PFA9N2F-
MDA-MB-231 MkHSRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MlTHRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KHWyIITvJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyPi5{MzFOwG0v M{\rUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{G5O|gxLz5{OEOxPVc5ODxxYU6=
PC3 Mk\vRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M3\vWmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IIXwJJRwKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzOD64JO69VS5? M3LMbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{G5O|gxLz5{OEOxPVc5ODxxYU6=
BT474 M2nXNGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MWWyOEBpenN? MXXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFjFVlIheG:|aYTpeoUhcHWvYX6gRnQ1PzRiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMxNjF2IN88UU4> MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDNzOUe4NEc,Ojh|MUm3PFA9N2F-
MDA-MB-453 NELieHRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NHXGd4kzPCCqcoO= MmrXRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDISXIzKHCxc3n0bZZmKGi3bXHuJG1FSS2PQj20OVMh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOyMlQh|ryPLh?= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDNzOUe4NEc,Ojh|MUm3PFA9N2F-
MDA-MB-157 MUfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Mn\kNlQhcHK| NHLJcVRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1zNUegZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDRyLkO4JO69VS5? NHvoeZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEOxPVc5OCd-MkizNVk4QDB:L3G+
SKBR3 NXr4WXhZSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M4jCPVI1KGi{cx?= MWjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFjFVlIheG:|aYTpeoUhcHWvYX6gV2tDWjNiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQzNjh|IN88UU4> M2XjcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{G5O|gxLz5{OEOxPVc5ODxxYU6=
MCF7 NVft[YQ{SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Mo\SNlQhcHK| MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFXSM3BTKHCxc3n0bZZmKGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQzNjh7IN88UU4> MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDNzOUe4NEc,Ojh|MUm3PFA9N2F-
MDA-MB-468 M2jtTmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NGPBSo4zPCCqcoO= MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk01PjhiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQzNjh7IN88UU4> MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDNzOUe4NEc,Ojh|MUm3PFA9N2F-
T47D NFHUSpNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MnXYNlQhcHK| NYK1NGM6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBGWi:SUjDwc5NqfGm4ZTDoeY1idiCWNEfEJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2Nz65NUDPxE1w NELQNJU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEOxPVc5OCd-MkizNVk4QDB:L3G+
cells at NY\5WXR1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVn1Onp3OzBidV2= NGfEXHo1QCCqcoO= M2fUWGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhmeDOEIHPlcIx{KGG2IEOwJJVOKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZk> MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDN2MkSwNEc,Ojh|NEK0NFA9N2F-
PWR-1E Mle0RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MmLFN{Bl[Xm| Mn6zRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSV2KtNWUh[2WubIOgZYZ1\XJiMzDkZZl{KGK7IGfTWE0yKGG|c3H5MEBKSzVyIE2gPE4yPCEQvF2u MlS0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|OEi1NlMoRjJ6M{i4OVI{RC:jPh?=
LNCAP MXXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NYXrN4pVOyCmYYnz NHXObGxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzOR2FRKGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDXV3QuOSCjc4PhfUwhUUN3MDC9JFE{NjZzIN88UU4> NEfMb4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEO4PFUzOyd-MkizPFg2OjN:L3G+
PC3 MVXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NW[5UY5kOyCmYYnz MnPMRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KFeVVD2xJIF{e2G7LDDJR|UxKD1iMkWuOFMh|ryPLh?= Mm\sQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|OEi1NlMoRjJ6M{i4OVI{RC:jPh?=
DU145 NH3EeHpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MkPKN{Bl[Xm| MV3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKESXMUS1JINmdGy|IHHmeIVzKDNiZHH5d{BjgSCZU2StNUBie3OjeTygTWM2OCB;IEK2MlI{KM7:TT6= NGj1OmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEO4PFUzOyd-MkizPFg2OjN:L3G+
HepG2 NEPrVYtHfW6ldHnvckBie3OjeR?= MnjqOUB2VQ>? NGPmSIIzPCCqcoO= M3TmU2FkfGm4YYTpc44hd2ZiToLmNkBqdiCqdX3hckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDjfZRweHKxdHXjeIlwdiCjZ3HpcpN1KHRvQljQMYlv\HWlZXSgc5hq\GG2aY\lJINmdGxiZHXheIgh[XRiNTD1UUBqdmO3YnH0[YQh\m:{IEK0JIhzeyCob3zsc5dm\CCkeTDjc41xd3WwZDDy[Y1wfmGuIIfpeIghe3Wkc3XxeYVvfCCrbnP1ZoF1cW:wIIfpeIghQTByIIXNJI9nKHRvQljQJIZweiB4IHjyd{BjgSCPVGSgZZN{[Xl? M3\CTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{m5OFUzLz5{OEO5PVQ2OjxxYU6=
BV2 MlnIRY51cW6ndYLvbY5ndGGvbXH0c5J6KGG|c3H5 M3;OT|E2KG2rboO= NF7BVohCdnSrbnX1do9qdm[uYX3tZZRwenliYXP0bZZqfHliaX6gcY92e2ViQm[yJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgcol1emmlIH;4bYRmKHC{b3T1Z5Rqd25icILleJJm[XSnZDDmc5IhOTVibXnud{Bnd2yub4fl[EBjgSCOUGOtd5RqdXWuYYTpc44hdWWjc4Xy[YQh[W[2ZYKgNlQhcHK|IHL5JINwdG:{aX3leJJq[yCvZYToc4QtKEmFNUCgQUA3KM7:TT6= M4rOb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUG0NVQ5Lz5{OEWxOFE1QDxxYU6=
L428 NV[y[Xk{TnWwY4Tpc44h[XO|YYm= MVKyJIhzew>? M2jsSGlvcGmkaYTpc44hd2ZiTl[tb4FxeGGEIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJIh2dWGwIFy0Nlgh[2WubIOgZYZ1\XJiMjDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5 NFn2XmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEWyOlM3QSd-Mki1NlY{Pjl:L3G+
PWR-1E NHPvVlZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MUSzJIRigXN? NETUb5hCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDXVk0yTSClZXzsd{BmgHC{ZYPzbY5oKGGwZILv[4VvKHKnY3XweI9zKGGwZDDQV2Eh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhOyCmYYnzJIJ6KFeVVDDhd5NigSxiSVO1NEA:KDhwOEWg{txONg>? MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZyMUeyNEc,Ojh4MEG3NlA9N2F-
LNCAP MUnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NIHWOFc{KGSjeYO= MmfxRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCOTlPBVEBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjCzJIRigXNiYomgW3NVKGG|c3H5MEBKSzVyIE2gNVMvPjFizszNMi=> MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZyMUeyNEc,Ojh4MEG3NlA9N2F-
PC3 NVjkOnYySW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M3jMOVMh\GG7cx?= MlTPRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiMzDkZZl{KGK7IGfTWEBie3OjeTygTWM2OCB;IEK1MlQ{KM7:TT6= MmP1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4MEG3NlAoRjJ6NkCxO|IxRC:jPh?=
DU145 NXfDT4Z7SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NYjKTotZOyCmYYnz NXzQSHZxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA{KGSjeYOgZpkhX1OWIHHzd4F6NCCLQ{WwJF0hOjZwMkOg{txONg>? MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZyMUeyNEc,Ojh4MEG3NlA9N2F-
MDA-MB-231 M13JemN6fG:2b4jpZ4l1gSCjc4PhfS=> Mn7COFghcHK| NXL6RmF4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTJizszNMi=> MnvwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4NUSyOlUoRjJ6NkW0NlY2RC:jPh?=
HT-29 MULDfZRwfG:6aXPpeJkh[XO|YYm= MX60PEBpenN? M1\id2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhVNTJ7IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNDFOwG0v M2n6U|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkW0NlY2Lz5{OE[1OFI3PTxxYU6=
NCI-H460 M4DmOWN6fG:2b4jpZ4l1gSCjc4PhfS=> NHL2PVI1QCCqcoO= M4PIWGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KNE[wJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxOUDPxE1w NVPvVItWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2OVQzPjVpPkK4OlU1OjZ3PD;hQi=>
LN229 MWnDfZRwfG:6aXPpeJkh[XO|YYm= NHHMb2I1QCCqcoO= MkT3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUG4zOjliY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF3IN88UU4> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ3NEK2OUc,Ojh4NUSyOlU9N2F-
U87 M1zFZmN6fG:2b4jpZ4l1gSCjc4PhfS=> NVXzWpZHPDhiaILz M3nUbmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHU5PyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTZizszNMi=> NX7qd|NjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2OVQzPjVpPkK4OlU1OjZ3PD;hQi=>
COLO201 NHfJepJEgXSxdH;4bYNqfHliYYPzZZk> NH:3fnQ1QCCqcoO= NFPaUnpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBEV0yRMkCxJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxPEDPxE1w NHi2TYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[1OFI3PSd-Mki2OVQzPjV:L3G+
A549 NWWwb4QzS3m2b4TvfIlkcXS7IHHzd4F6 Mn3sOFghcHK| MmP4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOThizszNMi=> MmCxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4NUSyOlUoRjJ6NkW0NlY2RC:jPh?=
T47D MXvDfZRwfG:6aXPpeJkh[XO|YYm= M{\0dFQ5KGi{cx?= NYXJTJdHS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXDR5RDDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUmg{txONg>? NELGdVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[1OFI3PSd-Mki2OVQzPjV:L3G+
MML1 MX;DfZRwfG:6aXPpeJkh[XO|YYm= NWfqNFZsPDhiaILz M32xZ2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1OVDFiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF7IN88UU4> NIfjR5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[1OFI3PSd-Mki2OVQzPjV:L3G+
BxPC3 MkHQR5l1d3SxeHnjbZR6KGG|c3H5 MYm0PEBpenN? M3\5VmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJ5WEN|IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{OTFOwG0v NYPUZmZnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2OVQzPjVpPkK4OlU1OjZ3PD;hQi=>
SK-MEL-2 Mk\2R5l1d3SxeHnjbZR6KGG|c3H5 M{PWeVQ5KGi{cx?= M3PQ[GN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMNU2HTD2yJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzOkDPxE1w NYfibpdIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2OVQzPjVpPkK4OlU1OjZ3PD;hQi=>
HCT116 MorhRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NGLWV5Q1QCCqcoO= M4Ll[2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6NCCJSUWwJF0hOy53IN88UU4> NIfvPVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEexOlQ6PSd-Mki3NVY1QTV:L3G+
HCT116 NU\hfFZRTnWwY4Tpc44h[XO|YYm= MmDzOFghcHK| MV7JcoR2[3Srb36gc4YhdWm2b3Poc45lemmjbDDt[Y1jemGwZTDwc5RmdnSrYXygcI9{eyCrbjDoeY1idiCKQ2SxNVYh[2WubIOgZZQh[W62aYDyc4xq\mW{YYTpeoUhT0l3MDDh[pRmeiB2ODDodpMh[nliSlOtNUB{fGGrbnnu[{Bj[XOnZDDmcJVwemW|Y3XuZ4Uh[XO|YYm= NIPYR2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEexOlQ6PSd-Mki3NVY1QTV:L3G+
HCT116 NGjSVlJHfW6ldHnvckBie3OjeR?= MnrXOlAhdWmwcx?= NED4[21KdmS3Y4Tpc44hd2ZibXn0c4Npd26mcnnhcEB{fXCncn;4bYRmKGenbnXyZZRqd25iaX6gbJVu[W5iSFPUNVE3KGOnbHzzJIF1KGGwdHnwdo9tcW[ncnH0bZZmKEeLNUCgZYZ1\XJiNkCgcYlveyCkeTDtbZRwW0:[IILl[E1xem:kZTDiZZNm\CCobIXvdoV{[2WwY3WgZZN{[Xl? Mn\GQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5MU[0PVUoRjJ6N{G2OFk2RC:jPh?=
HCT116 NWG0e|E3TnWwY4Tpc44h[XO|YYm= M1zpclYxKG2rboO= Mo\UTY5lfWO2aX;uJI9nKHKnYXP0bZZmKG:6eXflckB{eGWlaXXzJIdmdmW{YYTpc44hcW5iaIXtZY4hUEOWMUG2JINmdGy|IHH0JIFvfGmycn;sbYZmemG2aY\lJGdKPTBiYX\0[ZIhPjBibXnud{BjgSCGQ1\IMWRCKHC{b3LlJIJie2WmIHHzd4F6 M1u2O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{G2OFk2Lz5{OEexOlQ6PTxxYU6=
HCT116 M375fWZ2dmO2aX;uJIF{e2G7 MX21NFAhfU1? MmD1OFghcHK| M4LSW2lv\HWldHnvckBw\iCpbIX0ZZRpcW:wZTDvfIll[XSrb36gbY4hcHWvYX6gTGNVOTF4IHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJGdUW0dxR2PIJJJifGmxIHH0JFUxOCC3TTDpckBxemW|ZX7j[UBw\iCQQVTQTEBi\nSncjC0PEBpenNiYomgSYxtdWGwJ4OgcYV1cG:m Moe4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5MU[0PVUoRjJ6N{G2OFk2RC:jPh?=
MCF7 MorZSpVv[3Srb36gZZN{[Xl? NXrPVFhRPDhiaILz NFvLZXdOd2S3bHH0bY9vKGGldHn2bZR6KGG2IFXSJIlvKGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2ODFOwG0v MluyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5OUe3PVcoRjJ6N{m3O|k4RC:jPh?=
A549 NYLJVm1ST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYHHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDBOVQ6KGOnbHzzMEBKSzVyIE2gNlMh|ryPLh?= M3\MTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OEG0N|c1Lz5{OEixOFM4PDxxYU6=
BGC823 NHrYVnFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUXwOHJ{OjBidV2= M3iwZlczKGi{cx?= MWDHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDCS2M5OjNiY3XscJMh[XRiMkCgeW0h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfS=> M1vNdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OEixNlg3Lz5{OEi4NVI5PjxxYU6=
SGC7901 NEXW[4hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYCyNEB2VQ>? NX3iZok6PzJiaILz NHOyNnNIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBUT0N5OUCxJINmdGy|IHH0JFIxKHWPIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[Xl? NIq2UpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEi4NVI5Pid-Mki4PFEzQDZ:L3G+
MFC NXf2dYNrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV6yNEB2VQ>? MlPxO|IhcHK| MXXHdo94fGhiaX7obYJqfGmxbjDv[kBOTkNiY3XscJMh[XRiMkCgeW0h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfS=> NVvC[3lMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki4PFEzQDZpPkK4PFgyOjh4PD;hQi=>
BV2 M4rzemFvfGmrbn\sZY1u[XSxcomgZZN{[Xl? MYSyOEBpenN? NWG0dGl5SW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLWNkBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJI5qfHKrYzDvfIll\SCycn;keYN1cW:wIHHmeIVzKDJ2IHjyd{BjgSCpcnnld5Mh[XO|YYmsJGlEPTBiPTC0JO69VS5? NXjtWGtpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmwN|U2OjVpPkK5NFM2PTJ3PD;hQi=>
NCI-H460 Mmq5R5l1d3SxeHnjbZR6KGG|c3H5 M1rpO|Q5KGi{cx?= M1r4OWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KNE[wJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE4NjF2IN88UU4> M4K0WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUe0PFE3Lz5{OUG3OFgyPjxxYU6=
PC3 M2m3PWN6fG:2b4jpZ4l1gSCjc4PhfS=> NVy3bGNoPDhiaILz MUPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOThwN{Gg{txONg>? M2DSN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUe0PFE3Lz5{OUG3OFgyPjxxYU6=
DU145 M1T4VGN6fG:2b4jpZ4l1gSCjc4PhfS=> NW\KblVZPDhiaILz MYfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|Mz6xNkDPxE1w NVSxeY9PRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxO|Q5OTZpPkK5NVc1QDF4PD;hQi=>
HepG2 MUDGeY5kfGmxbjDhd5NigQ>? MlvoOUBpenN? NHvib2pC[3SrdnH0bY9vKG:oIF7y[lIhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPSCqcoOgZpkhSVKHLXTybZZmdiCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTBiPTCyNUDPxE1w MljUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl{MkOxNFAoRjJ7MkKzNVAxRC:jPh?=
BGC823 NH:5S2lEgXSxdH;4bYNqfHliYYPzZZk> MWC3NkBpenN? M1XaVGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJISzh{MzDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyQS53IN88UU4> NFi1VWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUK4PFk1Pid-MkmyPFg6PDZ:L3G+
NCI-H460 NHviRWpEgXSxdH;4bYNqfHliYYPzZZk> MnjMO|IhcHK| NEH3b2VEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSES2NEBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{MD6zJO69VS5? M1LYV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Mki4PVQ3Lz5{OUK4PFk1PjxxYU6=
SGC7901 NYLyPGhxS3m2b4TvfIlkcXS7IHHzd4F6 MX63NkBpenN? M{\xemN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNISzd7MEGgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjZwMjFOwG0v M4rP[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Mki4PVQ3Lz5{OUK4PFk1PjxxYU6=
NCI-H460 MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVy1JJRwKDFyIIXN MkXoNlQhfG9iN{KgbJJ{ MlSxS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUmNKNUh2NkCgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIF1KDVidH:gNVAhfU1iaX7jeYJifGWmIH\vdkAzPCC2bzC3NkBpenNiYomgUXRVKGG|c3H5 MmiyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl{OEi5OFYoRjJ7Mki4PVQ3RC:jPh?=
NCI-H460 MlHCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{HVd|IxKHWP MlH1NVghcHK| NHPlPXRCdnSrLXfyc5d1cCCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KNE[wJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClb3zvcpkh\m:{bXH0bY9vKGG2IEKwJJVOKGGodHXyJFE5KGi{czDifUBkenm|dHHsJJZqd2yndD3iZZNm\CClb3zvcpkh\m:{bXnu[{Bie3OjeR?= M4XM[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Mki4PVQ3Lz5{OUK4PFk1PjxxYU6=
NCI-H460 MnHzRY51cW2rZ4LheI9zgSCjc4PhfS=> MVyyNEB2VQ>? NFi2R4U1QCCqcoO= MXfBcpRqNW2rZ4LheI9zgSCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KNE[wJINmdGy|IHH0JFIxKHWPIHnuZ5Vj[XSnZDDmc5IhPDhiaILzJIJ6KHexdX7kJIhm[WyrbnegZZN{[Xl? M3f0U|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Mki4PVQ3Lz5{OUK4PFk1PjxxYU6=
NCI-H460 MnnHRZBweHSxc3nzJIF{e2G7 NW\mOHhFOTVibXevb4c> M1fzPFE2KGSjeYO= NWfLVXFsUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckB1fW2xcjDv[kBpfW2jbjDOR2kuUDR4MDDj[YxteyC6ZX7v[5Ji\nSnZDDpckBDSUyEL1OgcpUhdnWmZTDtc5V{\SCjc4Pld5Nm\CCjczDkc5dvemWpdXzheIlwdiCxZjDiZ4wzKGW6cILld5Nqd25iYYSgNVUhdWdxa3esJIlxKGGmbXnubZN1\XKnZDDleoVzgWSjeTDmc5IhOTViZHH5d{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ6OEm0Okc,Ojl{OEi5OFY9N2F-
HepG2 MWLDfZRwfG:6aXPpeJkh[XO|YYm= M3KwTFI1KGi{cx?= MlGxR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMz63PEDPxE1w NWrTNlN6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0NlE2PjhpPkK5OFIyPTZ6PD;hQi=>
THP1 M1z4XmN6fG:2b4jpZ4l1gSCjc4PhfS=> MmL2NlQhcHK| NHPyRWdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBVUFBzIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB{NDDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkKuOVQh|ryPLh?= M4C3N|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEKxOVY5Lz5{OUSyNVU3QDxxYU6=
K562 NGjpdnZEgXSxdH;4bYNqfHliYYPzZZk> NV36RVFZOjRiaILz M3fjXWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{Mz6xNkDPxE1w NUXORmxwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0NlE2PjhpPkK5OFIyPTZ6PD;hQi=>
LO2 NX\NcVlJS3m2b4TvfIlkcXS7IHHzd4F6 Mle5NlQhcHK| MYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMU|Ih[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzPS54NzFOwG0v M13ndlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEKxOVY5Lz5{OUSyNVU3QDxxYU6=
HeLa M1TEeWN6fG:2b4jpZ4l1gSCjc4PhfS=> MYOyOEBpenN? MlPLR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNzLki5JO69VS5? M1[yXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEKxOVY5Lz5{OUSyNVU3QDxxYU6=
NCI-H460 MV\DfZRwfG:6aXPpeJkh[XO|YYm= NFnnXHo1QCCqcoO= NUGwO5BkS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLVi0OlAh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyPy5zMTFOwG0v M4\tZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEK5PFM1Lz5{OUSyPVg{PDxxYU6=
PC3 NFXoO4lEgXSxdH;4bYNqfHliYYPzZZk> NV;IVWppPDhiaILz MmnlR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOThwNkWg{txONg>? MmrkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2Mkm4N|QoRjJ7NEK5PFM1RC:jPh?=
DU145 NEDZUZZEgXSxdH;4bYNqfHliYYPzZZk> M13rUlQ5KGi{cx?= MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDN|LkG1JO69VS5? NFPh[G49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSyPVg{PCd-Mkm0Nlk5OzR:L3G+
MCF7 NFnse3BEgXSxdH;4bYNqfHliYYPzZZk> NX;1V4M{PCCqcoO= M2XzRmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMheHKnaX7jeYJifGWmIH\vdkA1KGi{czDmc4xtd3enZDDifUBqdmO3YnH0bY9vKGmwIHPvcZBwfW6mIH\y[YUhdWWmaXGg[o9zKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{Mj6xJO69VS5? NY\3bY9xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2NFU5ODhpPkK5OlA2QDB6PD;hQi=>
WRL68 M13XeGN6fG:2b4jpZ4l1gSCjc4PhfS=> M1zoWFQhcHK| NUTzWJM2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hX1KONkigZ4VtdHNicILlbY5kfWKjdHXkJIZweiB2IHjyd{Bnd2yub4fl[EBjgSCrbnP1ZoF1cW:wIHnuJINwdXCxdX7kJIZz\WVibXXkbYEh\m:{IEK0JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyO{45KM7:TT6= NXThNXBORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2NFU5ODhpPkK5OlA2QDB6PD;hQi=>
A549 M1uw[2N6fG:2b4jpZ4l1gSCjc4PhfS=> MkPoOEBpenN? M3L6eGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMheHKnaX7jeYJifGWmIH\vdkA1KGi{czDmc4xtd3enZDDifUBqdmO3YnH0bY9vKGmwIHPvcZBwfW6mIH\y[YUhdWWmaXGg[o9zKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2Mz65JO69VS5? NITIZZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[wOVgxQCd-Mkm2NFU5ODh:L3G+
NCI-H1975 M{XZTmN6fG:2b4jpZ4l1gSCjc4PhfS=> MVq3NkBpenN? MYfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOR2kuUDF7N{WgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxMlQh|ryPLh?= M4HifVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkW1NFg{Lz5{OU[1OVA5OzxxYU6=
A549 NEOzb3dEgXSxdH;4bYNqfHliYYPzZZk> M3;MWlczKGi{cx?= M4rZdmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB4Lkig{txONg>? M4Lsc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkW1NFg{Lz5{OU[1OVA5OzxxYU6=
HL7702 NUXTZnNyS3m2b4TvfIlkcXS7IHHzd4F6 M{XDZVczKGi{cx?= MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUFc4ODJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB5LkKg{txONg>? MmDSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4NUWwPFMoRjJ7NkW1NFg{RC:jPh?=
H460 M{HNcGN6fG:2b4jpZ4l1gSCjc4PhfS=> NF3rVmo4OiCqcoO= NGHPPVJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJPDZyIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iOD61JO69VS5? MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ3NUC4N{c,Ojl4NUWwPFM9N2F-
NCI-H1650 NGS3RmlEgXSxdH;4bYNqfHliYYPzZZk> MnnXO|IhcHK| MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOR2kuUDF4NUCgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyNE42KM7:TT6= M1X2XVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkW1NFg{Lz5{OU[1OVA5OzxxYU6=
HepG2 MVrDfZRwfG:6aXPpeJkh[XO|YYm= M{e1WlI1KGi{cx?= NYLPUGZwS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxNEDPxE1w NETtXHM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUe5PFgzPyd-Mkm3PVg5Ojd:L3G+
HCT116 M3HNc2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NH7Nbnc4OiCqcoO= MnLSRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGwMlkyKM7:TT6= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTh6NkCyNUc,Ojl6OE[wNlE9N2F-
HepG2 MYXDfZRwfG:6aXPpeJkh[XO|YYm= MVGyOEBpenN? NIXqSZZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG2MlAyKM7:TT6= M1n2SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OUC5N|M5Lz5{OUmwPVM{QDxxYU6=
SMMC7721 M3;xd2N6fG:2b4jpZ4l1gSCjc4PhfS=> MVqyOEBpenN? MYrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTUW1EPzd{MTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG5MlQ4KM7:TT6= M{j0RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OUC5N|M5Lz5{OUmwPVM{QDxxYU6=
QGY7703 M{XKT2N6fG:2b4jpZ4l1gSCjc4PhfS=> NYnYWYJ4OjRiaILz MnuyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVWd[PzdyMzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKxMlQ1KM7:TT6= NYTUdW5LRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm5NFk{OzhpPkK5PVA6OzN6PD;hQi=>
HHL5 MmrCR5l1d3SxeHnjbZR6KGG|c3H5 MmnuNlQhcHK| NVjFWlVMS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEiONTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKyMlI4KM7:TT6= NGLXTms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUmwPVM{QCd-Mkm5NFk{Ozh:L3G+
LO2 Ml[yR5l1d3SxeHnjbZR6KGG|c3H5 MWOyOEBpenN? MknWR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUG8zKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjNwOEeg{txONg>? MknBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl7MEmzN|goRjJ7OUC5N|M5RC:jPh?=
Vero MUjDfZRwfG:6aXPpeJkh[XO|YYm= MVrDfZRwfG:6aXPpeJkh[WejaX7zeEBC\nKrY3HuJIdz\WWwIH3vcotmgSCYZYLvJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uMEBESzVyIE2gN|YvQCEQvF2u NUTNdWcyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm5NlA1PTRpPkK5PVIxPDV2PD;hQi=>
HT22 NXzHNmJWS3m2b4TvfIlkcXS7IHHzd4F6 NW\LdFJmOjRiaILz NUjDXXNYS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhUFR{MjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygUW5VTCB;IEGg{txONg>? NYfTRXA5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwN|E3PTNpPkOwNFMyPjV|PD;hQi=>
HT22 MWHDfZRweHKxdHXjeIlwdiCjc4PhfS=> NGnRWIEyKHWP NEHIcGUzPCCqcoO= M3nydGN6fG:ycn;0[YN1cW:wIHHnZYlve3RiZ3z1eIFu[XSnLXnu[JVk\WRiYYDvdJRwe2m|IHnuJI1wfXOnIFjUNlIh[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iQnH4M2JkdDJicnH0bY8h[XRiMTD1UUBi\nSncjCyOEBpenNiYomgVnQuWEOUIH3leIhw\A>? NWni[5hLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwN|E3PTNpPkOwNFMyPjV|PD;hQi=>
HT22 NWGz[oJqS3m2b4Dyc5Rm[3Srb36gZZN{[Xl? M2nX[lEhfU1? MVyyOEBpenN? NIL1dY1EgXSxcILveIVkfGmxbjDh[4FqdnO2IHfseZRidWG2ZT3pcoR2[2WmIH;4bYRifGm4ZTDzeJJme3NiaX6gcY92e2ViSGSyNkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCrTl;TJI1TVkFibHX2[Ywh[XRiMTD1UUBi\nSncjCyOEBpenNiYomgVnQuWEOUIH3leIhw\A>? MoTHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByM{G2OVMoRjNyMEOxOlU{RC:jPh?=
HT22 NVr1c25uS3m2b4Dyc5Rm[3Srb36gZZN{[Xl? MmnaNUB2VQ>? NFjVeG4zPCCqcoO= Mk\zR5l1d3C{b4TlZ5Rqd25iYXfhbY5{fCCpbIX0ZY1ifGVvaX7keYNm\CCneHPpeI91d3irY3n0fUBqdiCvb4Xz[UBJXDJ{IHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJINmdGxidnnhZoltcXS7IHH0JFEhfU1iYX\0[ZIhOjRiaILzJIJ6KG:ydHnjZYwhdWmlcn;zZ49xcWNiYYPzZZk> NVzOdVRCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwN|E3PTNpPkOwNFMyPjV|PD;hQi=>
HT22 MmHUR5l1d3C{b4TlZ5Rqd25iYYPzZZk> NYT2S4tlOSC3TR?= M1HzOVI1KGi{cx?= MWTDfZRweHKxdHXjeIlwdiCjZ3HpcpN1KGeudYThcYF1\S2rbnT1Z4VlKGW6Y3n0c5RwgGmlaYT5JIlvKG2xdYPlJGhVOjJiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6g[4x2fGGvYYTlMYlv\HWlZXSgZ4VtdCCleXPs[UBienKnc4SgZZQhe3WkLVexJJBp[XOnIHH0JFEhfU1iYX\0[ZIhOjRiaILzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcoch[mG|ZXSg[oxwfyCleYTvcYV1enl? NHfDemg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MECzNVY2Oyd-M{CwN|E3PTN:L3G+
HT22 M4rqSGN6fG:ycn;0[YN1cW:wIHHzd4F6 M{D2d|EhfU1? MY[yOEBpenN? MYjDfZRweHKxdHXjeIlwdiCjZ3HpcpN1KGeudYThcYF1\S2rbnT1Z4VlKGW6Y3n0c5RwgGmlaYT5JIlvKG2xdYPlJGhVOjJiY3XscJMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZ4VtdCCycn;sbYZmemG2aX;uJIF1KDFidV2gZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeR?= NHuwWY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MECzNVY2Oyd-M{CwN|E3PTN:L3G+
LNCAP MVrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NVXHXYQzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBidmS{b3flck1{\W6|aYTpeoUhcHWvYX6gUG5ESVBiY3XscJMtKEmFNUCgQUAzKM7:TT6= NIPVeFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEGyNVIyPCd-M{CxNlEzOTR:L3G+
DU145 MnXiRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MX\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHHu[JJw\2WwLXnud4Vve2m2aY\lJIh2dWGwIFTVNVQ2KGOnbHzzMEBKSzVyIE2gNkDPxE1w M3rJT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUKxNlE1Lz5|MEGyNVIyPDxxYU6=
PC3 NHv0b4xCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NV;KdJl7SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBidmS{b3flck1qdnOnboPpeIl3\SCqdX3hckBRSzNiY3XscJMtKEmFNUCgQUAzKM7:TT6= M3P4WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUKxNlE1Lz5|MEGyNVIyPDxxYU6=
LNCAP NGrje2RCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M{LFNFMh\GG7cx?= NF\xXmFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIFv\HKxZ3XuMZNmdnOrdHn2[UBpfW2jbjDMUmNCWCClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA{KGSjeYOgZpkhX1OWIHHzd4F6NCCLQ{WwJF0hOTNwNkGg{txONg>? MknVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzMkGyNVQoRjNyMUKxNlE1RC:jPh?=
PC3 M3TmcGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NULkPHo3OyCmYYnz MWLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHHu[JJw\2WwLXnud4Vve2m2aY\lJIh2dWGwIGDDN{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjCzJIRigXNiYomgW3NVKGG|c3H5MEBKSzVyIE2gNlUvPDNizszNMi=> NV7Xd21nRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxNlEzOTRpPkOwNVIyOjF2PD;hQi=>
DU145 M3fpUGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NIOzdY0{KGSjeYO= NULyU49USW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBidmS{b3flck1qdnOnboPpeIl3\SCqdX3hckBFXTF2NTDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB|IHThfZMh[nliV2PUJIF{e2G7LDDJR|UxKD1iMk[uNlMh|ryPLh?= MknVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzMkGyNVQoRjNyMUKxNlE1RC:jPh?=
MCF7 NYLE[3JjS3m2b4TvfIlkcXS7IHHzd4F6 NWDtXHBxPzJiaILz NYroU2VoS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQS56IN88UU4> MlrFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzM{i4NFMoRjNyMUO4PFA{RC:jPh?=
EJ28 Mn\OR5l1d3SxeHnjbZR6KGG|c3H5 MVS3NkBpenN? NH7WVGJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBGUjJ6IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOC53IN88UU4> NIeyT4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEGzPFgxOyd-M{CxN|g5ODN:L3G+
HT1080 NV\NV5h7S3m2b4TvfIlkcXS7IHHzd4F6 MoDWO|IhcHK| NFPh[FVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXDFyOECgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF|LkGg{txONg>? M1[zZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUO4PFA{Lz5|MEGzPFgxOzxxYU6=
SW620 M3TqdWN6fG:2b4jpZ4l1gSCjc4PhfS=> M1PEPFczKGi{cx?= M13rcGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNYPjJyIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyPCEQvF2u NYGzOFdFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxN|g5ODNpPkOwNVM5QDB|PD;hQi=>
A549 NXjHfXI{S3m2b4TvfIlkcXS7IHHzd4F6 NHy4WmQ4OiCqcoO= M2Xa[WN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE4NjlizszNMi=> MnO5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzM{i4NFMoRjNyMUO4PFA{RC:jPh?=
SMMC7721 NFLHPHpEgXSxdH;4bYNqfHliYYPzZZk> MmjjNlQhcHK| Ml3UR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV21OSzd5MkGgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG2MlY5KM7:TT6= M1r6R|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyN{exOlA2Lz5|MEe3NVYxPTxxYU6=
HepG2 NFPrO4NEgXSxdH;4bYNqfHliYYPzZZk> NX\lc29zOjRiaILz NXjG[JplS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG3MlM4KM7:TT6= M1vhUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyN{exOlA2Lz5|MEe3NVYxPTxxYU6=
LO2 Ml\GR5l1d3SxeHnjbZR6KGG|c3H5 NXW3SmpOOjRiaILz NIXmeJFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNVzJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHnuZ5Vj[XSnZDDmc5IhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ{Lk[5JO69VS5? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd5MU[wOUc,OzB5N{G2NFU9N2F-
QGY7703 MojwR5l1d3SxeHnjbZR6KGG|c3H5 MmjCNlQhcHK| M1jpcWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHFIYTd5MEOgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKzMlkyKM7:TT6= M1PvbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyN{exOlA2Lz5|MEe3NVYxPTxxYU6=
HHL5 M2DofGN6fG:2b4jpZ4l1gSCjc4PhfS=> MmGzNlQhcHK| MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDITGw2KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCrbnP1ZoF1\WRiZn;yJFI1KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzPC5zOTFOwG0v Ml;aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB5N{G2NFUoRjNyN{exOlA2RC:jPh?=
HCT-116 M3;TU2Z2dmO2aX;uJIF{e2G7 MnzyNlQhcHK| NVrQOJdPUW6qaXLpeIlwdiCxZjDjbJlud3S{eYDzbY4udGmtZTDhZ5Rqfmm2eTDv[kBpfW2jbjCyOnMheHKxdHXhd49u\SCrbjDoeY1idiCKQ2StNVE3KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIFHNR{BpgWS{b3z5d4l{KHW|aX7nJHN2[y2OTG\ZMWFOSyCjczDzeYJ{fHKjdHWgdJJmcW6ldXLheIVlKG[xcjCyOEBpenNiZn;scI94\WRiYomgZYRlcXSrb36gc4Yhe3Wkc4TyZZRmKGGwZDDt[YF{fXKnZDDh[pRmeiB{IHjyd{BjgSCobIXvdo9u\XS{LDDJR|UxKD1iMUCg{txONg>? MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd5Nk[5Nkc,OzB5N{[2PVI9N2F-
SW480 NHXPV4dHfW6ldHnvckBie3OjeR?= M1myNVI1KGi{cx?= NFPkb4hKdmirYnn0bY9vKG:oIHPofY1wfHK7cIPpck1tcWunIHHjeIl3cXS7IH;mJIh2dWGwIEK2V{Bxem:2ZXHzc41mKGmwIHj1cYFvKFOZNEiwJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKEGPQzDofYRzd2y7c3nzJJV{cW6pIGP1Z{1NVF[\LVHNR{BieyC|dXLzeJJifGVicILlbY5kfWKjdHXkJIZweiB{NDDodpMh\m:ubH;3[YQh[nliYXTkbZRqd25ib3[gd5Vje3S{YYTlJIFv\CCvZXHzeZJm\CCjZoTldkAzKGi{czDifUBndHWxcn;t[ZRzcWNuIFnDOVAhRSBzMDFOwG0v MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd5Nk[5Nkc,OzB5N{[2PVI9N2F-
RAW264.7 NWHafIZmTnWwY4Tpc44h[XO|YYm= MnjnNVAhfU1? MVWwMlUhcHK| M{LYOmlvcGmkaYTpc44hd2ZiTVHQT{9PTmujcIDhRkBqdiCLQ2KgcY92e2ViUlHXNlY1NjdiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJGxRWy2rbnT1Z4VlKFSQRnHsdIhiKHC{b3T1Z5Rqd25iYYSgNVAhfU1icILleJJm[XSnZDDmc5IhOC53IHjyd{Bnd2yub4fl[EBjgSCOUGOgZ4hidGynbnflJIFv\CCvZXHzeZJm\CCjZoTldkAzPCCqcoOgZpkhTUyLU1GgdoVt[XSrdnWgeI8h[2:wdILvcC=> MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd6MEC4PEc,OzB5OECwPFg9N2F-
RAW264.7 MmH0SpVv[3Srb36gZZN{[Xl? M3Pnd|AvPSCqcoO= MmGzTY5pcWKrdHnvckBw\iCPQWDLM25Hc2GycHHCJIlvKEmFUjDtc5V{\SCUQWeyOlQvPyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gUHBUNWmwZIXj[YQhXE6IYXzwbIEheHKxZIXjeIlwdiCycnX0doVifGWmIH\vdkAxNjViaILzJIZwdGyxd3XkJIJ6KEySUzDjbIFtdGWwZ3WgZY5lKG2nYYP1doVlKGGodHXyJFI1KGi{czDifUBGVEmVQR?= MnH1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB5OECwPFgoRjNyN{iwNFg5RC:jPh?=
RAW264.7 NU\1VmduTnWwY4Tpc44h[XO|YYm= NWGyXIo4OC53IHjydy=> M3zISmlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgUmZs[XCyYVKgdFY2KG63Y3zlZZIhfHKjboPsc4NifGmxbjDpckBKS1JibX;1d4UhWkGZMk[0Mlch[2WubIOgdJJmcW6ldXLheIVlKG[xcjCwMlUhcHK|IH\vcIxwf2WmIHL5JGxRWyClaHHscIVv\2ViYX7kJI1m[XO3cnXkJIFnfGW{IESwJI1qdnNiYomgSGFRUSC|dHHpcolv\y2kYYPl[EBqdW23bn;mcJVwemW|Y3XuZ4UhdWmlcn;zZ49xcWNiYX7hcJl{cXN? NVTh[4M4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C3PFAxQDhpPkOwO|gxODh6PD;hQi=>
RAW264.7 MUTGeY5kfGmxbjDhd5NigQ>? NI\UToMyOCC3TR?= NWrZVFJyOC53IHjydy=> MlXkTY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDwN|ghVUGSSzDwbI9{eGixconsZZRqd25iaX6gTWNTKG2xdYPlJHJCXzJ4ND63JINmdGy|IHH0JFExKHWPIIDy[Ylv[3WkYYTl[EBnd3JiMD61JIhzeyCob3zsc5dm\CCkeTDMVHMh[2ijbHzlcodmKGGwZDDt[YF{fXKnZDDh[pRmeiB|MDDtbY5{KGK7IHntcZVvd2Kub4T0bY5oKGGwYXz5d4l{ MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd6MEC4PEc,OzB5OECwPFg9N2F-
RAW264.7 NVOxUWRkTnWwY4Tpc44h[XO|YYm= NIrWbokyOCC3TR?= NXrjbHh7OC53IHjydy=> MUjJcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIFXST{BxcG:|cHjvdplt[XSrb36gbY4hUUOUIH3veZNmKFKDV{K2OE44KGOnbHzzJIF1KDFyIIXNJJBz\WmwY4XiZZRm\CCob4KgNE42KGi{czDmc4xtd3enZDDifUBNWFNiY3jhcIxmdmenIHHu[EBu\WG|dYLl[EBi\nSncjCzNEBucW6|IHL5JIludXWwb3Lsc5R1cW6pIHHuZYx6e2m| NUfrVGJJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C3PFAxQDhpPkOwO|gxODh6PD;hQi=>
RAW264.7 MV7GeY5kfGmxbjDhd5NigQ>? MUixNEB2VQ>? M3PuPFAvPSCqcoO= M{WzUmlvcGmkaYTpc44hd2ZiTl\rZZBx[UJxTVHQT{B{cWewYXzpcochcW5iTGDTMYlv\HWlZXSgcY92e2ViUlHXNlY1NjdiY3XscJMh[XO|ZYPz[YQh[XNiZH;3ckBz\We3bHH0bY9vKG:oIFnrZZBx[UJiZYjwdoV{e2mxbjDheEAyOCC3TTDwdoVqdmO3YnH0[YQh\m:{IECuOUBpenNiZn;scI94\WRiYomgUHBUNWOqYXzs[Y5o\SCjbnSgcYVie3W{ZXSgZYZ1\XJiM{CgcYlveyCkeTDpcY12dm:kbH;0eIlv\yCjbnHsfZNqew>? NWfBR49WRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C3PFAxQDhpPkOwO|gxODh6PD;hQi=>
RAW264.7 NUX2XopbTnWwY4Tpc44h[XO|YYm= M{HaS|ExKHWP NFnjV2MxNjViaILz M3\GNWlvcGmkaYTpc44hd2ZiTVHQT{9PTmujcIDhRkBqdiCLQ2KgcY92e2ViUlHXNlY1NjdiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJGxRWy2rbnT1Z4VlKEmONjDwdo9lfWO2aX;uJIF1KDFyIIXNJJBz\XS{ZXH0[YQh\m:{IECuOUBpenNiZn;scI94\WRiYomgUHBUKGOqYXzs[Y5o\SCjbnSgcYVie3W{ZXSgZYZ1\XJiMkSgbJJ{KGK7IFXMTXNCKHKnbHH0bZZmKHSxIHPvcpRzd2x? M1fZPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyN{iwNFg5Lz5|MEe4NFA5QDxxYU6=
RAW264.7 M{SxT2Z2dmO2aX;uJIF{e2G7 NUiyNGdpOC53IHjydy=> MXHJcohq[mm2aX;uJI9nKE2DUFuvUmZs[XCyYVKgbY4hUUOUIH3veZNmKFKDV{K2OE44KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDMVHMucW6mdXPl[EBKVDZicILv[JVkfGmxbjDwdoV1emWjdHXkJIZweiByLkWgbJJ{KG[xbHzve4VlKGK7IFzQV{BkcGGubHXu[4Uh[W6mIH3lZZN2emWmIHHmeIVzKDJ2IHjyd{BjgSCHTFnTRS=> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd6MEC4PEc,OzB5OECwPFg9N2F-
RAW264.7 M{\temZ2dmO2aX;uJIF{e2G7 MnW0OEBpenN? NHjLbI9KdmirYnn0bY9vKG:oIGLBUmtNNWmwZIXj[YQhd3O2ZX;jcIF{fG:pZX7ld4l{KGmwIH31dolv\SCUQWeyOlQvPyClZXzsd{Bie3Onc4Pl[EBieyCob4LtZZRqd25ib3[gWHJCWCCyb4PpeIl3\SCvdXz0bY52[2ynYYTl[EBwe3Snb3PsZZN1eyCycnX0doVifGWmIH\vdkA1KGi{czDmc4xtd3enZDDifUBTSU6NTDDh[IRqfGmxbjDt[YF{fXKnZDDh[pRmeiB5MjDodpMtKEmFNUCgQUA{KM7:TT6= NHvVb409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEe5OFQyOid-M{C3PVQ1OTJ:L3G+
BV2 MWnBcpRqdmW3cn;pcoZt[W2vYYTvdpkh[XO|YYm= M17Te|EhcHJ? M{Py[WFvfGlvbnX1do9qdm[uYX3tZZRwenliYXP0bZZqfHliaX6gbJVu[W5iQm[yJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgUm8heHKxZIXjeIlwdiCycnXpcoN2[mG2ZXSg[o9zKDFiaIKg[o9tdG:5ZXSgZpkhVFCVIIP0bY12dGG2aX;uJI1m[XO3cnXkJIFnfGW{IEK0JIhzeyCkeTDHdolme3NicnXh[4VvfCCkYYPl[EBie3OjeTygTWM2OCB;IEGuOVgh|ryPLh?= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTByNUC1Okc,OzFyMEWwOVY9N2F-
HeLa MULBcpRq[2GwY3XyJIF{e2G7 NWnsemxjSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMtKEmFNUCgQUA1NjN|IN88UU4> MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{OUS1OUc,OzFzMkm0OVU9N2F-
HL60 MkmwR5l1d3SxeHnjbZR6KGG|c3H5 NVK4b3BlS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEx4MDDj[YxteyxiSVO1NEA:KDZwMzFOwG0v NYDlTIkyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlk1PTVpPkOxNVI6PDV3PD;hQi=>
SKOV3 NXn4cGVjS3m2b4TvfIlkcXS7IHHzd4F6 NXTMdoNnPDhiaILz M4nObWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMV1Z|IFPlcIx{KGGodHXyJFQ5KGi{czDifUBE\WyuIGTpeIVzKEKudXWgZZN{[XluIFnDOVAhRSB4Lkeg{txONg>? MmPPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
HSC4 NEPVXZNEgXSxdH;4bYNqfHliYYPzZZk> MonlR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHNEPCClZXzsd{whUUN3MDC9JFcvOSEQvF2u NHnEcHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
U87MG M1K1TWN6fG:2b4jpZ4l1gSCjc4PhfS=> M{nYVFQ5KGi{cx?= MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVPFdOTyCFZXzsd{A1QCCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwJF0hPy5zNTFOwG0v M3zyTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK5OFU2Lz5|MUGyPVQ2PTxxYU6=
HSC2 NX[zOm8yS3m2b4TvfIlkcXS7IHHzd4F6 MlfmR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHNEOiClZXzsd{whUUN3MDC9JFcvQCEQvF2u MkPZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
LX2 MWHDfZRwfG:6aXPpeJkh[XO|YYm= MnfZOFghcHK| MmnJR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUHgzKEOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC5MlE1KM7:TT6= MmXoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
MCF7 M{Lx[2N6fG:2b4jpZ4l1gSCjc4PhfS=> M2fqZlQ5KGi{cx?= NGDKOnZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IFPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA6NjJ6IN88UU4> NFrmcGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
HepG2 MmnoR5l1d3SxeHnjbZR6KGG|c3H5 M{\KfFQ5KGi{cx?= MknJR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiQ3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFkvPDRizszNMi=> MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{OUS1OUc,OzFzMkm0OVU9N2F-
3T3 NGi5WnFEgXSxdH;4bYNqfHliYYPzZZk> MojIOFghcHK| NInKSXREgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UA{XDNiQ3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFkvPTFizszNMi=> NV3jOGJ[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlk1PTVpPkOxNVI6PDV3PD;hQi=>
AGS M{XaV2N6fG:2b4jpZ4l1gSCjc4PhfS=> MmP5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRWdUKEOnbHzzMEBKSzVyIE2gPU44PyEQvF2u NVnvVZh1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlk1PTVpPkOxNVI6PDV3PD;hQi=>
HSC3 NHPoOJREgXSxdH;4bYNqfHliYYPzZZk> NHPvW5lEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJW0N|IHPlcIx{NCCLQ{WwJF0hOTFizszNMi=> MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{OUS1OUc,OzFzMkm0OVU9N2F-
MDA-MB-231 M{j3fmFvfGmlYX7j[ZIh[XO|YYm= M{K5XlczKGi{cx?= M{L1UmFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMT60OUDPxE1w NHLFN3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
SMMC7721 M4\kZmFvfGmlYX7j[ZIh[XO|YYm= MonnO|IhcHK| NYeyW|FqSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJHNOVUN5N{KxJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMj61O{DPxE1w NWXzRo01RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlk1PTVpPkOxNVI6PDV3PD;hQi=>
LX2 Mn;2RY51cWOjbnPldkBie3OjeR?= MY[3NkBpenN? MYPBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTGiyJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzMz65O{DPxE1w M4LkeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK5OFU2Lz5|MUGyPVQ2PTxxYU6=
HeLa M2\FVWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3HMVGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiQ3XscJMtKEmFNUCgQUAyPC5yMzFOwG0v MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{OUS1OUc,OzFzMkm0OVU9N2F-
SW480 NE\RSVJEgXSxdH;4bYNqfHliYYPzZZk> MonyNlQhfG9iNEigbJJ{ NHLwUJVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUXzR6MDDD[YxteyCjZoTldkAzPCC2bzC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVUh|ryPLh?= MlzrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
U251MG NXu0W4xUS3m2b4TvfIlkcXS7IHHzd4F6 NGmyXIE1QCCqcoO= NHLxU|BEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWOjVzTVegZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WUzDhd5NigSxiSVO1NEA:KDF3LkK2JO69VS5? MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{OUS1OUc,OzFzMkm0OVU9N2F-
RWPE1 NWfUXo8{S3m2b4TvfIlkcXS7IHHzd4F6 NXz3[4hWS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWleSRUGgZ4VtdHNuIFnDOVAhRSBzNT62NkDPxE1w MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{OUS1OUc,OzFzMkm0OVU9N2F-
MCF7 NG\uOW5CeG:ydH;zbZMh[XO|YYm= Mle4TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCPQ1[3JINmdGy|LDDJR|UxKD1iMUeuNUDPxE1w MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{OUS1OUc,OzFzMkm0OVU9N2F-
BGC823 MYfDfZRwfG:6aXPpeJkh[XO|YYm= MWHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCS2M5OjNiY3XscJMtKEmFNUCgQUAyPy53IN88UU4> NEjs[WE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
BxPC3 MUjDfZRwfG:6aXPpeJkh[XO|YYm= M{niNmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJ5WEN|IHPlcIx{NCCLQ{WwJF0hOThwMkWg{txONg>? NUXROFRoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlk1PTVpPkOxNVI6PDV3PD;hQi=>
HT-29 MkfER5l1d3SxeHnjbZR6KGG|c3H5 Mo\vR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliQ3XscJMtKEmFNUCgQUAyQC55NDFOwG0v NV3CVph{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlk1PTVpPkOxNVI6PDV3PD;hQi=>
H1299 NX3WdGZWS3m2b4TvfIlkcXS7IHHzd4F6 M2m5TGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGgyOjl7IHPlcIx{NCCLQ{WwJF0hOThwOUOg{txONg>? NYSxcnFpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlk1PTVpPkOxNVI6PDV3PD;hQi=>
PC3 MnnWR5l1d3SxeHnjbZR6KGG|c3H5 MXLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOsJGlEPTBiPTCxPU46QCEQvF2u NWSwTHNTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlk1PTVpPkOxNVI6PDV3PD;hQi=>
EAhy926 NXG1eYhZS3m2b4TvfIlkcXS7IHHzd4F6 MWG3NkBpenN? NECxfnJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBGSWi7OUK2JGNmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB{MDFOwG0v M{[3PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK5OFU2Lz5|MUGyPVQ2PTxxYU6=
HepG2 MXPDfZRwfG:6aXPpeJkh[XO|YYm= MmrqO|IhcHK| MUfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiCFZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlAvOyEQvF2u NGH2fFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
AGS MmPqR5l1d3SxeHnjbZR6KGG|c3H5 NXfGT49US3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSUeVIFPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKwMlc3KM7:TT6= NGrTS2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
PC3 NH70bYFCdnSrY3HuZ4VzKGG|c3H5 NHG2dXZCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzMEBKSzVyIE2gNlAvQSEQvF2u MojhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
MGC803 NFXHWHZEgXSxdH;4bYNqfHliYYPzZZk> MXfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMtKEmFNUCgQUAzOS5{IN88UU4> MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{OUS1OUc,OzFzMkm0OVU9N2F-
CHOK1 MYnDfZRwfG:6aXPpeJkh[XO|YYm= MlfpO|IhcHK| M1;6UWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNJV0tzIFPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzOS5|IN88UU4> M2DoOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK5OFU2Lz5|MUGyPVQ2PTxxYU6=
Hep2 MWrDfZRwfG:6aXPpeJkh[XO|YYm= NID2cY1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XB{IFPlcIx{NCCLQ{WwJF0hOjFwM{eg{txONg>? NVTVbnJORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlk1PTVpPkOxNVI6PDV3PD;hQi=>
MCF7 NHTjUYxEgXSxdH;4bYNqfHliYYPzZZk> M1fLbGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMtKEmFNUCgQUAzOi53IN88UU4> M1;UeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK5OFU2Lz5|MUGyPVQ2PTxxYU6=
SGC7901 MYTDfZRwfG:6aXPpeJkh[XO|YYm= MmXTR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2dEPzlyMTDj[YxteyxiSVO1NEA:KDJ{LkWg{txONg>? NFj1U2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
HT-29 M{Ow[GN6fG:2b4jpZ4l1gSCjc4PhfS=> NHK1O2s4OiCqcoO= NF\yd4tEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXC1{OTDD[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjNwNDFOwG0v M{mwT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK5OFU2Lz5|MUGyPVQ2PTxxYU6=
A549 NX3tUW9MS3m2b4TvfIlkcXS7IHHzd4F6 NYDLN5lNS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDD[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyOU4{OyEQvF2u NWPV[YFvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlk1PTVpPkOxNVI6PDV3PD;hQi=>
MDA-MB-231 MV7DfZRwfG:6aXPpeJkh[XO|YYm= M17JSmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOsJGlEPTBiPTCyOk42KM7:TT6= M1vyXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK5OFU2Lz5|MUGyPVQ2PTxxYU6=
A549 MofSR5l1d3SxeHnjbZR6KGG|c3H5 NX;Ob4QxOjRidH:gOFghcHK| MnrSR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSCFZXzsd{Bi\nSncjCyOEB1dyB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMkig{txONg>? NEW4XYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
Caco2 NXnaUXRZS3m2b4TvfIlkcXS7IHHzd4F6 MXu3NkBpenN? NGjLfXVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBE[WOxMjDD[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjhizszNMi=> MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{OUS1OUc,OzFzMkm0OVU9N2F-
GES-1 MX7DfZRwfG:6aXPpeJkh[XO|YYm= NIfuTZFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBITVNvMTDj[YxteyxiSVO1NEA:KDJ7LkGg{txONg>? NFjkVG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
DU145 MUfBcpRq[2GwY3XyJIF{e2G7 MXLBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRGWxOFUh[2WubIOsJGlEPTBiPTCzNU44KM7:TT6= M{TxTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK5OFU2Lz5|MUGyPVQ2PTxxYU6=
MDCK2 NV:zTY0zS3m2b4TvfIlkcXS7IHHzd4F6 M{LuXVE2KG2rboO= MmrNR5l1d3SxeHnjbZR6KGGpYXnud5QhdWm2b4jhcpRzd26nIILld4l{fGGwdDDoeY1idiCPRFPLNkBk\WyuczDlfJBz\XO|aX7nJGJEWlBiYX\0[ZIhOTVibXnud{BjgSCobIXvdoV{[2WwY3WgZZN{[XluIFnDOVAhRSB|MjFOwG0v NUm0doR{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlk1PTVpPkOxNVI6PDV3PD;hQi=>
HL-7702 M{GyUGN6fG:2b4jpZ4l1gSCjc4PhfS=> M16zSmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhNNTd5MEKgZ4VtdHNuIFnDOVAhRSB|Mj6zN{DPxE1w NH;oUWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPVQ2PSd-M{GxNlk1PTV:L3G+
K562 MVnDfZRwfG:6aXPpeJkh[XO|YYm= NIHNUnIzPCC2bzC0PEBpenN? M4nxTmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiQ3XscJMh[W[2ZYKgNlQhfG9iNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEO2JO69VS5? MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{OUS1OUc,OzFzMkm0OVU9N2F-
HepG2 M{G4bGN6fG:2b4jpZ4l1gSCjc4PhfS=> M{nE[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IFPlcIx{NCCLQ{WwJF0hOzZwN{eg{txONg>? NU\mSHg1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlk1PTVpPkOxNVI6PDV3PD;hQi=>
GBM1 MmfYR5l1d3SxeHnjbZR6KGG|c3H5 MYC0PEBpenN? MkHSR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gS2JOOSCFZXzsd{A1QCCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwJF0hOzlwNkWg{txONg>? MkPCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkm0OVUoRjNzMUK5OFU2RC:jPh?=
PC12 NXW2b2NbS3m2b4TvfIlkcXS7IHHzd4F6 NIqxcmkzPCCqcoO= M1TVU2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KHKjdDDQR|EzKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEK0JIhzeyCkeTDXV3Q5N1CPUzDhd5NigSxiQ1O1NEA:KDR{IN88UU4> NYjlS41WRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyOlI2PTlpPkOxNlYzPTV7PD;hQi=>
HCT116 NVHVd25MSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M{jwUVczKGi{cx?= NH7W[nlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTBwNTFOwG0v NGjaR4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUOyOlI1OSd-M{GzNlYzPDF:L3G+
HeLa M{T0e2N6fG:2b4jpZ4l1gSCjc4PhfS=> NVnCSJB6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyxiSVO1NEA:KDhwMjFOwG0v MljxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF|M{[zNVAoRjNzM{O2N|ExRC:jPh?=
B16 MYPDfZRwfG:6aXPpeJkh[XO|YYm= M33DemN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGIyPiClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB6LkWg{txONg>? M2Dre|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzM{O2N|ExLz5|MUOzOlMyODxxYU6=
HT1080 MX7GeY5kfGmxbjDhd5NigQ>? NWHmPWpvTGWlcnXhd4UhcW5iVWDBJIV5eHKnc4Ppc44hcW5iaIXtZY4hUFRzMEiwJINmdGy|LDDJR|UxKD1iMUCg{txONg>? MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTN|NkOxNEc,OzF|M{[zNVA9N2F-
Hep3B Mny4R5l1d3SxeHnjbZR6KGG|c3H5 NVe3fINpS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyM1KgZ4VtdHNuIFnDOVAhRSBzMDFOwG0v NHKzNm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUOzOlMyOCd-M{GzN|Y{OTB:L3G+
BT474 M4nr[2N6fG:2b4jpZ4l1gSCjc4PhfS=> MkK2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRnQ1PzRiY3XscJMtKEmFNUCgQUAyOSEQvF2u NFvFcJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUOzOlMyOCd-M{GzN|Y{OTB:L3G+
T47D NGW2ZldEgXSxdH;4bYNqfHliYYPzZZk> M{frXGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHQ1P0RiY3XscJMtKEmFNUCgQUAyOSEQvF2u M4nQRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzM{O2N|ExLz5|MUOzOlMyODxxYU6=
HaCaT MYnDfZRwfG:6aXPpeJkh[XO|YYm= MoXTR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIFE[VRiY3XscJMtKEmFNUCgQUAyOyEQvF2u NITYNVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUOzOlMyOCd-M{GzN|Y{OTB:L3G+
KM12 M{LRb2N6fG:2b4jpZ4l1gSCjc4PhfS=> NHXucmg1KGi{cx?= M{PqNGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGtOOTJiY3XscJMh[W[2ZYKgOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVYh|ryPLh?= MmXDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF|M{[zNVAoRjNzM{O2N|ExRC:jPh?=
HPL1D NXvvepZJS3m2b4TvfIlkcXS7IHHzd4F6 NGC1eHhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJWExzRDDj[YxteyxiSVO1NEA:KDF4IN88UU4> MmDGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF|M{[zNVAoRjNzM{O2N|ExRC:jPh?=
SW480 NGjWTZlEgXSxdH;4bYNqfHliYYPzZZk> MmrVOEBpenN? NXTENHZyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW1d2OECgZ4VtdHNiYX\0[ZIhPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTdwOUSg{txONg>? MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTN|NkOxNEc,OzF|M{[zNVA9N2F-
MCF7 NEjoT|hEgXSxdH;4bYNqfHliYYPzZZk> MlfRR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{whUUN3MDC9JFE6NjlizszNMi=> MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTN|NkOxNEc,OzF|M{[zNVA9N2F-
HT-29 MX;DfZRwfG:6aXPpeJkh[XO|YYm= NGfrdIY1KGi{cx?= NI\sVZhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXC1{OTDj[YxteyCjZoTldkA1KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzOC55MzFOwG0v M{DkbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzM{O2N|ExLz5|MUOzOlMyODxxYU6=
WiDr NGXBe2VEgXSxdH;4bYNqfHliYYPzZZk> M4LJc|QhcHK| M3P2NGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHdqTHJiY3XscJMh[W[2ZYKgOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlYvQDJizszNMi=> NWPKTXlRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GzN|Y{OTBpPkOxN|M3OzFyPD;hQi=>
SW116 MW\DfZRwfG:6aXPpeJkh[XO|YYm= M3fBOVQhcHK| MlrPR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV3cyOTZiY3XscJMh[W[2ZYKgOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlcvPDZizszNMi=> NVf0R4RTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GzN|Y{OTBpPkOxN|M3OzFyPD;hQi=>
Colon 26 MXTDfZRwfG:6aXPpeJkh[XO|YYm= NFXrb2M1KGi{cx?= M2X0WGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGNwdG:wIEK2JINmdGy|IHHmeIVzKDRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNyLkO0JO69VS5? MnP0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF|M{[zNVAoRjNzM{O2N|ExRC:jPh?=
22Rv1 M1;jZWZ2dmO2aX;uJIF{e2G7 NUXRfFUyUW6qaXLpeIlwdiCxZjDOSotieHCjQjDwOlUhdnWlbHXhdkB1emGwc3zvZ4F1cW:wIHnuJIh2dWGwIEKyVpYyKGOnbHzzJIF1KEeLNUCgZpkhTEGSSTDzeIFqdmmwZzDiZZNm\CCrbX31co9ndHWxcnXzZ4Vv[2ViYYPzZZk> MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTd4N{K2Okc,OzF5NkeyOlY9N2F-
PC3 NYrXTGhGSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MoCxOFghcHK| NISwUm5CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBpfW2jbjDQR|Mh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIFvpOlcheHKxdHXpckBt\X[nbDDheEBIUTVyIHnuZ5Vj[XSnZDDmc5IhPDhiaILzJIJ6KESDUFmgd5RicW6rbnegZoF{\WRiaX3teY5w\my3b4Lld4NmdmOnIHHzd4F6 MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTd4N{K2Okc,OzF5NkeyOlY9N2F-
22Rv1 MYnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NV\FfVJCPDhiaILz NF;XOJdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBpfW2jbjCyNnJ3OSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gT4k3PyCycn;0[YlvKGyndnXsJIF1KEeLNUCgbY5kfWKjdHXkJIZweiB2ODDodpMh[nliRFHQTUB{fGGrbnnu[{Bj[XOnZDDpcY12dm:obIXvdoV{[2WwY3WgZZN{[Xl? MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTd4N{K2Okc,OzF5NkeyOlY9N2F-
PC3 M17JVmZ2dmO2aX;uJIF{e2G7 MW\Jcohq[mm2aX;uJI9nKE6Ia3HwdIFDKHB4NTDueYNt\WG{IITyZY5{dG:lYYTpc44hcW5iaIXtZY4hWEN|IHPlcIx{KGG2IFfJOVAh[nliRFHQTUB{fGGrbnnu[{Bj[XOnZDDpcY12dm:obIXvdoV{[2WwY3WgZZN{[Xl? M4GxXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzN{[3NlY3Lz5|MUe2O|I3PjxxYU6=
PC3 NWjrXlV7TnWwY4Tpc44h[XO|YYm= M1X0SGlvcGmkaYTpc44hd2ZiTl\rZZBx[UJicE[1JJRz[W6|Y4LpdJRqd26jbDDhZ5Rqfmm2eTDpckBpfW2jbjDQR|Mh[2WubIOgZZQhT0l3MDDifUB{[W6md3njbEBGVEmVQR?= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTd4N{K2Okc,OzF5NkeyOlY9N2F-
22Rv1 Mlu0SpVv[3Srb36gZZN{[Xl? MnLETY5pcWKrdHnvckBw\iCQRnvhdJBiSiCyNkWgeJJidnOlcnnweIlwdmGuIHHjeIl3cXS7IHnuJIh2dWGwIEKyVpYyKGOnbHzzJIF1KEeLNUCgZpkhe2GwZIfpZ4ghTUyLU1G= M{DIcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzN{[3NlY3Lz5|MUe2O|I3PjxxYU6=
Sf21 MYPGeY5kfGmxbjDhd5NigQ>? MVWxNEBucW6| MoO2TY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCodXzsMYxmdme2aDDIbZM3NXSjZ3fl[EBxOzByIHX4dJJme3OnZDDpckBj[WO3bH;2bZJ2eyCrbn\lZ5Rm\CCVZkKxJIlve2WldDDj[YxteyC3c3nu[{BcO0ifYXPleJltS2:DIHHzJJN2[nO2cnH0[UBxemWrbnP1ZoF1\WRiZn;yJFExKG2rboOg[o9tdG:5ZXSgZpkhe3Wkc4TyZZRmKGGmZHn0bY9vKGGwZDDt[YF{fXKnZDDh[pRmeiBzMDDtbY5{KGK7IHzpdZVq\CC|Y3nueIltdGG2aX;uJINwNCCLQ{WwJF0hOjVizszNMi=> NF7xXIs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUmxNFAyPyd-M{G5NVAxOTd:L3G+
COS7 NYXRbJhCTnWwY4Tpc44h[XO|YYm= M2XUe|ExKG2rboO= NYTVNZRNUW6qaXLpeIlwdiCxZjDyZYJjcXRiU1XSR2Ey[iCneIDy[ZN{\WRiaX6gR29UPyClZXzsd{BucWO{b4PvcYFtKG2nbXLyZY5meyCycnXpcoN2[mG2ZXSg[o9zKDFyIH3pcpMh\m:ubH;3[YQh[nliYXTkbZRqd25ib3[gRXRRKGGwZDDt[YF{fXKnZDDh[pRmeiB2MDDtbY5{KGK7IFXMTXNCKG2ndHjv[EwhU2liPTC1Mlgh|ryPLh?= M2\YelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzN{MEOwPVc3Lz5|MkCzNFk4PjxxYU6=
COS7 MUTGeY5kfGmxbjDhd5NigQ>? NEjV[2YyOCCvaX7z NIHNTphKdmirYnn0bY9vKG:oIHj1cYFvKFOHUlPBN4Eh\XiycnXzd4VlKGmwIFPPV|ch[2WubIOgcYlkem:|b33hcEBu\W2kcnHu[ZMheHKnaX7jeYJifGWmIH\vdkAyOCCvaX7zJIZwdGyxd3XkJIJ6KGGmZHn0bY9vKG:oIFHUVEBidmRibXXhd5Vz\WRiYX\0[ZIhPDBibXnud{BjgSCHTFnTRUBu\XSqb3SsJGtqKD1iOD62JO69VS5? MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OjB|MEm3Okc,OzJyM{C5O|Y9N2F-
A549 NI\iUoZHfW6ldHnvckBie3OjeR?= NXXBSWJJOTVibXnudy=> NGLFWVZKdmirYnn0bY9vKG:oIH3pZ5Jwe2:vYXygVGdGWzFiaX6gTWxj\XSjLYP0bY12dGG2ZXSgbJVu[W5iQUW0PUBk\WyuczD1d4lv\yCSR1iyJIF{KHO3YoP0doF1\SCycnXpcoN2[mG2ZXSg[o9zKDF3IH3pcpMh\m:ubH;3[YQh[nlic4Xid5Rz[XSnIHHk[Il1cW:wIH3lZZN2emWmIHHmeIVzKDFibXnuJIJ6KFKSLVjQUGMh[W6jbInzbZMtKEmFNUCgQUAxNjJizszNMi=> NFe2cJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTZ2M{ivK|5EcEWPQly8M4E,
RAW264.7 MoDYSpVv[3Srb36gZZN{[Xl? NWjqSWdrOjBiaILz NGX0[m1KdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJI5qfHKrYzDvfIll\SCycn;keYN1cW:wIHnuJI1wfXOnIGLBW|I3PC55IHPlcIx{KG2nYYP1doVlKGGodHXyJFIxKGi{czDifUBoemmnc4OgZZN{[XluIFnDOVAhRSByLkig{txONg>? Mo\TQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE3PDN6Lze+R4hGVUKOPD;hQi=>
MDCK M3HHOWFvfGm4aYLhcEBie3OjeR?= NGLBb2Y1OCCqcoO= NI\xUIhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBKdm[udXXufoEhSSC4aYL1d{ApSS:ZU16vN|MpUDGQMTmpJIlv\mWldHXkJIlvKE2GQ1ugZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JIlv[3WkYYTl[EBnd3JiNECgbJJ{KGK7IFPlcIxVcXSncj3HcI8h[XO|YYmsJGlEPTBiPTC2Mlch|ryPLh?= NV3tRmQyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF4NEO4M{c,S2iHTVLMQE9iRg>?
MDCK NXvPboxxSW62aY\pdoFtKGG|c3H5 MnrJOFAhcHK| MXHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDJcoZtfWWwenGgRUB3cXK3czCoRU9YW05xM{OoTFFPOSlrIHnu[oVkfGWmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhPDBiaILzJIJ6KEOnbHzUbZRmei2JbH:gZZN{[XluIFnDOVAhRSB4Lkeg{txONg>? NHrUWIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTZ2M{ivK|5EcEWPQly8M4E,
RAW264.7 NYDOdWxLSW62aXnu[oxidW2jdH;yfUBie3OjeR?= NGrJPJcyPyCqcoO= Mkn5RY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBud3W|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEySUz;JSm4u\2GvbXGtd5RqdXWuYYTl[EBvcXS{aXOgc5hq\GVicILv[JVkfGmxbjDh[pRmeiBzNzDodpMh[nliR4Lp[ZN{KGG|c3H5MEBKSzVyIE2gNVQvPyEQvF2u NWXQU2pbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF4NEO4M{c,S2iHTVLMQE9iRg>?
HEK293T Mle0R5l1d3SxeHnjbZR6KGG|c3H5 MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBJTUt{OUPUJINmdGy|LDDJR|UxKD1iMUWuNkDPxE1w NVrUR2loRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF4NEO4M{c,S2iHTVLMQE9iRg>?
J774.1 MX3DfZRwfG:6aXPpeJkh[XO|YYm= NIO5bINEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBLPzd2LkGgZ4VtdHNuIFnDOVAhRSB|MTFOwG0v M3\kdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPjR|OD:nQmNpTU2ETEyvZV4>
MDCK MlT1R5l1d3SxeHnjbZR6KGG|c3H5 MkDPOFAhcHK| NWP2b2R6S3m2b4TvfIlkcXS7IHHnZYlve3RiTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC0NEBpenNiYomgR4VtdFSrdHXyMWdtdyCjc4PhfUwhS0N3MDC9JFQ5NjNizszNMi=> MnPWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE3PDN6Lze+R4hGVUKOPD;hQi=>
MDCK NV24XYRrS3m2b4TvfIlkcXS7IHHzd4F6 M3zr[FQxKGi{cx?= MnzqR5l1d3SxeHnjbZR6KGGpYXnud5QhVUSFSzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNECgbJJ{KGK7IFPlcIxVcXSncj3HcI8h[XO|YYmsJGNEPTBiPTC0PE4{KM7:TT6= Mn3tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE3PDN6Lze+R4hGVUKOPD;hQi=>
3T3L1 NI\mPG9HfW6ldHnvckBie3OjeR?= MVuxNEBv\y:vbB?= NITGOmtKdmirYnn0bY9vKG:oIGTOSoFteGijLXnu[JVk\WRiTl\rZZBx[UJiYXP0bZZifGmxbjCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W|ZTCzWFNNOSClZXzsd{BifCBzMDDu[{9udCCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZk> MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVY1OzhxJ{7DbGVOSkx:L3G+
Assay
Methods Test Index PMID
Western blot p-IRE1α / IREα ; HDAC1/ HDAC2 ; p-STAT3 / STAT3 29901626 31196210 23874455
Immunofluorescence β-catenin ; PKD1 ; EGFR / LC3 22523587 31196210
Growth inhibition assay Cell proliferation ; Cell viability 22523587 19809577
In vivo

Chronic treatment with curcumin significantly reverses the CMS-induced behavioral abnormalities in stressed rats. Additionally, curcumin effectively inhibits cytokine gene expression at both the mRNA and the protein level and reduces the activation of NF-κB[4].

Protocol (from reference)

Cell Research:

[5]

  • Cell lines: murine melanoma cell subline(B16-R)
  • Concentrations: 0-100 μM
  • Incubation Time: 24-48 h
  • Method:

    1×104 B16-R cells are cultivated as monolayer culture for 12 hr. They were then incubated in 200 μL of RPMI, 10% FBS containing curcumin at final concentrations from 1–100 μM in 96-multiwell plates for 24-48 hr. After these incubations, cells are washed twice in PBS and 500 μl of fresh culture medium containing MTT (0.3 mg/mL) are added for colorimetric assay.

Animal Research:

[5]

  • Animal Models: Female B6D2F1 mice (6-8 weeks old)
  • Dosages: 25 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

DMSO 73 mg/mL
(198.16 mM)
Water Insoluble
Ethanol Insoluble

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
5%DMSO+10%PEG300+5%Tween80+80%ddH2O
For best results, use promptly after mixing.

4mg/mL

Chemical Information

Molecular Weight 368.38
Formula

C21H20O6

CAS No. 458-37-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04458116 Not yet recruiting Dietary Supplement: Curcumin Coronary Artery Disease|Oxidative Stress|Inflammation Universidade Federal Fluminense March 10 2022 Not Applicable
NCT04731844 Not yet recruiting Drug: Curcumin plus Piperine Prostate Cancer|Multiple Myeloma|Smoldering Multiple Myeloma (SMM)|Monoclonal Gammopathy of Undetermined Significance University of Rochester December 1 2021 Phase 2
NCT05045443 Recruiting Drug: Curcumin|Dietary Supplement: Standard of Care Acute Lymphoblastic Leukemia Pediatric Ain Shams University August 22 2021 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Curcumin | Curcumin ic50 | Curcumin price | Curcumin cost | Curcumin solubility dmso | Curcumin purchase | Curcumin manufacturer | Curcumin research buy | Curcumin order | Curcumin mouse | Curcumin chemical structure | Curcumin mw | Curcumin molecular weight | Curcumin datasheet | Curcumin supplier | Curcumin in vitro | Curcumin cell line | Curcumin concentration | Curcumin nmr