Home Neuronal Signaling Dopamine Receptor chemical C-DIM12

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C-DIM12 Dopamine Receptor chemical

Cat.No.S8097

C-DIM12 is a Nurr1 activator that stimulates this compound mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells.
C-DIM12 Dopamine Receptor chemical Chemical Structure

Chemical Structure

Molecular Weight: 356.85

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Quality Control

Batch: Purity: 99.79%
99.79

Solubility

In vitro
Batch:

DMSO : 71 mg/mL (198.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 71 mg/mL

Water : Insoluble

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 356.85 Formula

C23H17ClN2

 Storage (From the date of receipt)
CAS No. 178946-89-9 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles C1=CC=C2C(=C1)C(=CN2)C(C3=CC=C(C=C3)Cl)C4=CNC5=CC=CC=C54

Mechanism of Action

Targets/IC50/Ki
Nurr1
In vitro
C-DIM12 induces Nurr1 and DA gene expression in cell lines and primary neurons. This compound suppresses astrocyte inflammatory signaling in vitro. It inhibits lipopolysaccharide (LPS)–induced expression of NF-κB-regulated genes in BV-2 microglia including nitric oxide synthase (NOS2), interleukin-6 (IL-6), and chemokine (C-C motif) ligand 2 (CCL2), and the effects were attenuated by Nurr1-RNA interference. Additionally, this chemical decreased NF-κB activation in NF-κB–GFP (green fluorescent protein) reporter cells and enhanced nuclear translocation of Nurr1 primary microglia. It decreases lipopolysaccharide-induced p65 binding to the NOS2 promoter and concurrently enhanced binding of Nurr1 to the p65-binding site. This compound also stabilized binding of the Corepressor for Repressor Element 1 Silencing Transcription Factor (CoREST) and the Nuclear Receptor Corepressor 2 (NCOR2).
In vivo
C-DIM12 has the neuroprotective activity in MPTPp-treated mice.
References

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