Cysteamine HCl

Synonyms: Mercaptamine

Cysteamine HCl(Mercaptamine) is an autophagy-stimulatory proteostasis regulator. Cysteamine can be used for the treatment of nephropathic cystinosis and an antioxidant.

Cysteamine HCl Chemical Structure

Cysteamine HCl Chemical Structure

CAS No. 156-57-0

Purity & Quality Control

Batch: S420601 DMSO]23 mg/mL]false]Water]23 mg/mL]false]Ethanol]23 mg/mL]false Purity: 100.0%
100.0

Cysteamine HCl Related Products

Biological Activity

Description Cysteamine HCl(Mercaptamine) is an autophagy-stimulatory proteostasis regulator. Cysteamine can be used for the treatment of nephropathic cystinosis and an antioxidant.
In vitro
In vitro

Cysteamine has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells. Also increased rates of apoptosis in cystinotic cells, which are thought to be the result of increased caspase 3 and protein kinase Cε activity, is counteracted by Cysteamine administration. Cysteamine has antioxidant properties as a result of increasing glutathione production. Cysteamine is an excellent scavenger of OH and HOCl; it also reacts with H2O2. Cysteamine increases the production of several heat shock proteins (HSP), including the murine Hsp40. Cysteamine exerts a dose-dependent effect on the doxorubicin-induced death of cancer cells, measured in both HeLa cells and B16 cells, whereas Cysteamine treatment alone had no influence on cell survival. In addition, in a doxorubicin-resistant breast cancer cell line, the addition of Cysteamine to doxorubicin results in a dramatic increase in cell death. [1] Cysteamine (100 μM) significantly is able to increase the intracellular GSH levels and the percentage of embryos that developed to the blastocyst stage of culture matured oocytes. [2]

In Vivo
In vivo

Cysteamine is introduced as a treatment for cystinosis by depleting lysosomal cystine. Cystamine can inhibit transglutaminase activity by binding to the cysteine in its active center. Cysteamine increases brain levels of brain-derived neurotrophic factor (BDNF), which is caused by the increased expression of the heat shock DNAJ-containing protein 1 (HSJ1). Cysteamine inhibits the formation of gastric and mammary tumors that are induced chemically or after irradiation, respectively. The administration of Cysteamine is also able to inhibit the metastasis of pancreatic cancer in a mouse model by decreasing the expression and activity of metalloproteinases. [1]

Chemical Information & Solubility

Molecular Weight 113.61 Formula

C2H7NS.HCl

CAS No. 156-57-0 SDF Download Cysteamine HCl SDF
Smiles C(CS)N.Cl
Storage (From the date of receipt) 3 years -20°C powder (seal)

In vitro
Batch:

DMSO : 23 mg/mL ( (202.44 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 23 mg/mL

Ethanol : 23 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Cysteamine HCl | Cysteamine HCl ic50 | Cysteamine HCl price | Cysteamine HCl cost | Cysteamine HCl solubility dmso | Cysteamine HCl purchase | Cysteamine HCl manufacturer | Cysteamine HCl research buy | Cysteamine HCl order | Cysteamine HCl mouse | Cysteamine HCl chemical structure | Cysteamine HCl mw | Cysteamine HCl molecular weight | Cysteamine HCl datasheet | Cysteamine HCl supplier | Cysteamine HCl in vitro | Cysteamine HCl cell line | Cysteamine HCl concentration | Cysteamine HCl nmr