Cysteamine HCl

Catalog No.S4206

Cysteamine HCl Chemical Structure

Molecular Weight(MW): 113.61

Cysteamine is an agent for the treatment of nephropathic cystinosis and an antioxidant.

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Biological Activity

Description Cysteamine is an agent for the treatment of nephropathic cystinosis and an antioxidant.
In vitro

Cysteamine has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells. Also increased rates of apoptosis in cystinotic cells, which are thought to be the result of increased caspase 3 and protein kinase Cε activity, is counteracted by Cysteamine administration. Cysteamine has antioxidant properties as a result of increasing glutathione production. Cysteamine is an excellent scavenger of OH and HOCl; it also reacts with H2O2. Cysteamine increases the production of several heat shock proteins (HSP), including the murine Hsp40. Cysteamine exerts a dose-dependent effect on the doxorubicin-induced death of cancer cells, measured in both HeLa cells and B16 cells, whereas Cysteamine treatment alone had no influence on cell survival. In addition, in a doxorubicin-resistant breast cancer cell line, the addition of Cysteamine to doxorubicin results in a dramatic increase in cell death. [1] Cysteamine (100 μM) significantly is able to increase the intracellular GSH levels and the percentage of embryos that developed to the blastocyst stage of culture matured oocytes. [2]

In vivo Cysteamine is introduced as a treatment for cystinosis by depleting lysosomal cystine. Cystamine can inhibit transglutaminase activity by binding to the cysteine in its active center. Cysteamine increases brain levels of brain-derived neurotrophic factor (BDNF), which is caused by the increased expression of the heat shock DNAJ-containing protein 1 (HSJ1). Cysteamine inhibits the formation of gastric and mammary tumors that are induced chemically or after irradiation, respectively. The administration of Cysteamine is also able to inhibit the metastasis of pancreatic cancer in a mouse model by decreasing the expression and activity of metalloproteinases. [1]

Protocol

Solubility (25°C)

In vitro DMSO 23 mg/mL (202.44 mM)
Water 23 mg/mL (202.44 mM)
Ethanol 23 mg/mL (202.44 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 113.61
Formula

C2H7NS.HCl

CAS No. 156-57-0
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03000348 Completed Drug: Cysteamine|Drug: Placebo Oral Capsule Cystic Fibrosis NovaBiotics Ltd.|Agility Clinical Inc.|PSR Group B.V. December 2016 Phase 2
NCT02212431 Completed Drug: Cysteamine Cystic Fibrosis University of Aberdeen|Cystic Fibrosis Trust|NHS Grampian|University of Huddersfield August 2014 Phase 1|Phase 2
NCT01733316 Completed Drug: RP103|Drug: Cystagon® Cystinosis Horizon Pharma USA Inc. January 31 2013 Phase 3
NCT01744782 Completed Drug: RP103 Cystinosis Horizon Pharma USA Inc. December 20 2012 Phase 3
NCT02012114 Unknown status Other: Cysteamine bitartrate Cystinosis Hospices Civils de Lyon December 2011 Not Applicable
NCT01432561 Completed Drug: Cysteamine bitartrate Cystinosis|Nephropathic Cystinosis University of California San Diego|Raptor Pharmaceuticals Corp. September 2011 Not Applicable

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