Calcium D-Panthotenate

For research use only.

Catalog No.S4503 Synonyms: D-Pantothenic Acid Calcium

Calcium D-Panthotenate Chemical Structure

Molecular Weight(MW): 476.53

Calcium D-Panthotenate, also called vitamin B5 Calcium, is a water-soluble vitamin and an essential nutrient for many animals.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 130 In stock
USD 97 In stock
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Biological Activity

Description Calcium D-Panthotenate, also called vitamin B5 Calcium, is a water-soluble vitamin and an essential nutrient for many animals.
In vitro

Pantothenic acid increases mainly the content of free glutathione, with little effect on protein-boundglutathione in human lymphoblastoic (Jurkat) cells. Pantothenic acid also increases cell respiration with pyruvate as the exogenous substrate.[1] Pantothenic acid belongs to vitamin B group and is the building stone of coenzyme A. Pantothenic acid can be therefore infer that its beneficial effect in various kinds of cell damage by ROS is related to the increased content or stimulated biosynthesis of this coenzyme. Pantothenic acid increases the glutathione content by more than 50% and increases the GSH/GSSG ratio by approximately the same factor. [2] Pantothenic acid and N-acetylcysteine alleviates the ultraviolet-induced decrease of glutathione content, diminished lipid peroxidation, and partly protects the cells against apoptosisproduced by ultraviolet irradiation. [3]

In vivo Pantothenic acid-treated rats exhibited higher basal levels of corticosterone and progesterone than control rats in Adrenal cells. The response of ACTH and/or PRL on corticosterone and progesterone release is higher in the pantothenic acid-treated rats than in the control rats. Pantothenic acid supplementation stimulates the ability of adrenal cells in male rats to secrete corticosterone and progesterone. Pantothenic acid supplementation induces adrenalhyperresponsiveness to ACTH stimulation, and PRL further stimulated adrenal sensitivity to ACTH. [4] Pantothenic acid prior to valproic acid (VPA) significantly protects against VPA-induced neural tube defects (NTDs) in CD-1mice. Pantothenic acid prevents VPA-induced alterations in NF-kappaB, Pim-1, and c-Myb in CD-1 mice. [5]

Protocol

Solubility (25°C)

In vitro DMSO 44 mg/mL (92.33 mM)
Water 44 mg/mL (92.33 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 476.53
Formula

C18H32CaN2O10

CAS No. 137-08-6
Storage powder
in solvent
Synonyms D-Pantothenic Acid Calcium
Smiles CC(C)(CO)C(O)C(=O)NCCC(=O)O[Ca]OC(=O)CCNC(=O)C(O)C(C)(C)CO

In vivo Formulation Calculator (Clear solution)

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID