CC-90009

Catalog No.S9832

For research use only.

CC-90009 is a novel cereblon (CRBN) E3 ligase modulator and specifically targets GSPT1 (G1 to S phase transition 1) for proteasomal degradation.

CC-90009 Chemical Structure

CAS No. 1860875-51-9

Purity & Quality Control

Choose Selective E3 Ligase Inhibitors

Biological Activity

Description CC-90009 is a novel cereblon (CRBN) E3 ligase modulator and specifically targets GSPT1 (G1 to S phase transition 1) for proteasomal degradation.
Targets
CRBN [1]
()

Protocol (from reference)

Chemical Information

Molecular Weight 461.85
Formula

C22H18ClF2N3O4

CAS No. 1860875-51-9
Storage 3 years -20°C powder
2 years -80°C in solvent

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02848001 Suspended Drug: CC-90009 Leukemia Myeloid Acute|Myelodysplastic Syndromes Celgene November 14 2016 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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