Home Ubiquitin E3 Ligase inhibitor CC-90009 For research use only.

CC-90009

CC-90009 is a novel cereblon (CRBN) E3 ligase modulator and specifically targets GSPT1 (G1 to S phase transition 1) for proteasomal degradation.

CC-90009 Chemical Structure

CC-90009 Chemical Structure

CAS: 1860875-51-9

Purity & Quality Control

Batch: Purity: 99.84%
99.84

CC-90009 Related Products

Signaling Pathway

E3 Ligase Signaling Pathways

E3 Ligase Signaling Pathway

Choose Selective E3 Ligase Inhibitors

Biological Activity

Description CC-90009 is a novel cereblon (CRBN) E3 ligase modulator and specifically targets GSPT1 (G1 to S phase transition 1) for proteasomal degradation.
Targets
CRBN [1]
In vitro
In vitro

CC-90009 is a new type of cereblon (CRBN) E3 ligase regulator, which specifically aims at proteasome degradation of GSPT1.<sup><a class="sref" href="#s_ref">[2]</a></sup>
Cell Research Cell lines NB4 cells
Concentrations 0.001, 0.01, 0.1, 1 μM
Incubation Time 4 h
Method

NB4 cells were treated for 4 h and then processed for Western blotting.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02848001 Active not recruiting
Leukemia Myeloid Acute|Myelodysplastic Syndromes
Celgene
 November 14 2016 Phase 1

Chemical Information & Solubility

Molecular Weight 461.85 Formula

C22H18ClF2N3O4
CAS No. 1860875-51-9 SDF --
Smiles FC(F)(C(=O)NCC1=CC2=C(C=C1)C(=O)N(C2)C3CCC(=O)NC3=O)C4=CC=C(Cl)C=C4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 92 mg/mL ( (199.19 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy CC-90009 | CC-90009 supplier | purchase CC-90009 | CC-90009 cost | CC-90009 manufacturer | order CC-90009 | CC-90009 distributor