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Captopril RAAS inhibitor

Name: Captopril
Brand: Selleck Chemicals
SKU: S2051
Availability: InStock
Rating: 5 (10 reviews)

Cat.No.S2051

Captopril (SQ 14225,Capoten) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.

Chemical Structure

Molecular Weight: 217.29

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: Purity: 99.93%

99.93

Related Targets	Adrenergic Receptor Estrogen/progestogen Receptor GPR Androgen Receptor Glucocorticoid Receptor ACE Opioid Receptor THR PGES Aromatase 5-alpha Reductase CCK receptor Mineralocorticoid Receptor GHSR SSTR TSH Receptor GNRH Receptor PGDS
Related Products	Temocapril HCl Delapril Hydrochloride Zofenopril calcium VTP-27999 TFA Temocapril Imidapril HCl

Chemical Information, Storage & Stability

Molecular Weight	217.29	Formula	C₉H₁₅NO₃S	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	62571-86-2	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	SQ 14225,Capoten			Smiles	CC(CS)C(=O)N1CCCC1C(=O)O

Solubility

In vitro
Batch:

DMSO : 43 mg/mL (197.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 43 mg/mL

Ethanol : 43 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.15mg/ml (9.89mM)	Taking the 1 mL working solution as an example, add 50 μL of 43 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.306mg/ml (1.41mM)	Taking the 1 mL working solution as an example, add 50 μL of 6.12 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	ACE ^[1] 6 nM
References	[1] https://pubmed.ncbi.nlm.nih.gov/12402502/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04964050	Withdrawn	Healthy Volunteers	GlaxoSmithKline	April 21 2022	Phase 1
NCT04878315	Withdrawn	Healthy Volunteers	GlaxoSmithKline	February 13 2022	Phase 1
NCT05826080	Recruiting	Primary Aldosteronism\|Aldosterone-Producing Adenoma\|Idiopathic Hyperaldosteronism	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School	September 1 2021	--
NCT04355429	Unknown status	Pneumonia\|Coronavirus Infection\|COVID-19	Assistance Publique - Hôpitaux de Paris	May 5 2020	Phase 2
NCT04224675	Unknown status	Aneurysm	Onassis Cardiac Surgery Centre	March 7 2020	Not Applicable

Tech Support

Handling Instructions

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