Home ER stress & UPR ATF-6 inhibitor Ceapin-A7 For research use only.

Ceapin-A7

Ceapin-A7 is a selective and highly potent inhibitor of the ATF6α, which can activate the response to ER stress, with IC50 of 0.59 μM.

Ceapin-A7 Chemical Structure

Ceapin-A7 Chemical Structure

CAS: 2323027-38-7

Selleck's Ceapin-A7 has been cited by 2 publications

Purity & Quality Control

Batch: E109901 DMSO] 100 mg/mL] false] Ethanol] 8 mg/mL] false] Water] Insoluble] false Purity: 99.94%
99.94

Ceapin-A7 Related Products

Choose Selective ATF-6 Inhibitors

Biological Activity

Description

Ceapin-A7 is a selective and highly potent inhibitor of the ATF6α, which can activate the response to ER stress, with IC50 of 0.59 μM.
Targets
ATF6α [1]
0.59 μM
In vitro
In vitro

Ceapin-A7 inhibits activation of ATF6α in response to ER stress without inhibiting ATF6β or SREBP activation. In U2-OS cells, Ceapin-A7 inhibits ER stress-induced upregulation of BiP.[1]
Cell Research Cell lines U2-OS cells
Concentrations 6 μM
Incubation Time 8 h
Method

U2-OS cells are treated without or with ER stressor in the absence or presence of 6 μM Ceapin-A7. After eight hours, cells are harvested and analyzed by Western Blot for BiP and GAPDH.

Chemical Information & Solubility

Molecular Weight 470.32 Formula

C20H12F6N4O3
CAS No. 2323027-38-7 SDF --
Smiles FC(F)(F)C1=CC=C(C[N]2C=C(NC(=O)C3=NOC(=C3)C4=CC=CO4)C=N2)C(=C1)C(F)(F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (212.62 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 8 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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