Catalog No.S2613 Synonyms: MK-401
Molecular Weight(MW): 380.66
Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.
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|Description||Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.|
Clorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. 
|In vivo||Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep.  Clorsulon causes severe disruption to the tegument and gut of Fasciola hepatica after in vivo incubation. |
|In vitro||DMSO||76 mg/mL (199.65 mM)|
|Ethanol||7 mg/mL (18.38 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% DMSO+30% polyethylene glycol+1% Tween 80
For best results, use promptly after mixing.
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