Catalog No.S2613 Synonyms: MK-401

Clorsulon Chemical Structure

Molecular Weight(MW): 380.66

Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.

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In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.
In vitro

Clorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. [1]

In vivo Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. [1] Clorsulon causes severe disruption to the tegument and gut of Fasciola hepatica after in vivo incubation. [3]


Animal Research:[3]
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  • Animal Models: Rat
  • Formulation: 1:2 mixture of polyethylene glycol 400:dimethyl sulphoxide
  • Dosages: 12.5 mg/kg
  • Administration: Orally
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 76 mg/mL (199.65 mM)
Ethanol 7 mg/mL (18.38 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% DMSO+30% polyethylene glycol+1% Tween 80
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 380.66


CAS No. 60200-06-8
Storage powder
in solvent
Synonyms MK-401

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID