Clorsulon

Catalog No.S2613 Synonyms: MK-401

Clorsulon Chemical Structure

Molecular Weight(MW): 380.66

Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Purity & Quality Control

Choose Selective Anti-infection Inhibitors

Biological Activity

Description Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.
In vitro

Clorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. [1]

In vivo Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. [1] Clorsulon causes severe disruption to the tegument and gut of Fasciola hepatica after in vivo incubation. [3]

Protocol

Animal Research:[3]
+ Expand
  • Animal Models: Rat
  • Formulation: 1:2 mixture of polyethylene glycol 400:dimethyl sulphoxide
  • Dosages: 12.5 mg/kg
  • Administration: Orally
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 76 mg/mL (199.65 mM)
Ethanol 7 mg/mL (18.38 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% DMSO+30% polyethylene glycol+1% Tween 80
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 380.66
Formula

C8H8Cl3N3O4S2

CAS No. 60200-06-8
Storage powder
in solvent
Synonyms MK-401

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID