Catalog No.S5253 Synonyms: Kaudalit, Kinestase, Prepulsid, Presid, Pridesia, Propulsid
Molecular Weight(MW): 465.95
Cisapride is a nonselective 5-HT4 receptor agonist with gastroprokinetic effects.
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|Description||Cisapride is a nonselective 5-HT4 receptor agonist with gastroprokinetic effects.|
Cisapride is a 5-HT4 receptor agonist, also a hERG blockers. It is widely used for the treatment of gastrointestinal motility dysfunctions, such as gastroesophageal reflux disorder (GERD), chronic intestinal pseudo-obstruction, and slow-transit constipation gastroparesis. Cisapride works by promoting gastrointestinal motility through stimulating the release of intestinal acetylcholine from muscarinic receptors. Cisapride inhibits Kv 4.3 channels that are stably expressed in Chinese hamster ovary (CEO) cells as well as the current in L-type Ca2+ channels of ventricular myocytes. Cisapride inhibited Kv channel current in a concentration-dependent manner independent of its own function as a selective serotonin 5-HT4-receptor agonist.
|In vitro||DMSO||93 mg/mL (199.59 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||Kaudalit, Kinestase, Prepulsid, Presid, Pridesia, Propulsid|
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