Ceftaroline Fosamil

Catalog No.S4417 Synonyms: CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo

For research use only.

Ceftaroline fosamil (CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo) is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA).

Ceftaroline Fosamil Chemical Structure

CAS No. 400827-46-5

Purity & Quality Control

Choose Selective Anti-infection Inhibitors

Biological Activity

Description

Ceftaroline fosamil (CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo) is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA).

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 744.74
Formula

C24H25N8O10PS4

CAS No. 400827-46-5
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01789528 Completed Drug: CAZ-AVI|Drug: CXL Pharmacokinetics|Open Label|CAZ-AVI|CXL|Effect on Intestinal Flora|Safety Pfizer August 2013 Phase 1
NCT01701219 Completed Drug: Ceftaroline fosamil Staphylococcus Aureus Bacteremia|Methicillin-resistant Staphylococcus Aureus (MRSA) Bacteremia Forest Laboratories January 2013 Phase 4
NCT01666743 Withdrawn Drug: Ceftaroline fosamil Community-Acquired Bacterial Pneumonia (CABP) Forest Laboratories November 2012 Phase 4
NCT01612507 Completed Drug: 600 mg Ceftaroline fosamil|Drug: Placebo Healthy Volunteers Pfizer July 2012 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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