Home Immunology & Inflammation Immunology & Inflammation related chemical Coumarin

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Coumarin Immunology & Inflammation related chemical

Cat.No.S4170

Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties.
Coumarin Immunology & Inflammation related chemical Chemical Structure

Chemical Structure

Molecular Weight: 146.14

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Quality Control

Batch: S417001 DMSO]29 mg/mL]false]Ethanol]29 mg/mL]false]Water]Insoluble]false Purity: 99.97%
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99.97

Solubility

In vitro
Batch:

DMSO : 29 mg/mL (198.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 29 mg/mL

Water : Insoluble

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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 146.14 Formula

C9H6O2

 Storage (From the date of receipt)
CAS No. 91-64-5 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles C1=CC=C2C(=C1)C=CC(=O)O2

Mechanism of Action

In vitro
Coumarin is a fragrant organic chemical compound in the benzopyrone chemical class, which is a colorless crystalline substance in its standard state. It is a naturally occurring constituent of many plants and essential oils, including tonka beans, sweet clover, woodruff, oil of cassia, and lavender. This compound is a member of a class of compounds called benzopyrones. These compounds have been used to treat such diverse ailments as cancer, bums, brucellosis, and rheumatic disease, and they have been used as antispasmodics. Although this chemical itself has no anticoagulant properties, it is transformed into the natural anticoagulant dicoumarol by a number of species of fungi. This occurs as the result of the production of 4-hydroxycoumarin, then further into the actual anticoagulant dicoumarol, a fermentation product and mycotoxin. This substance is responsible for the bleeding disease known historically as "sweet clover disease" in cattle eating moldy sweet clover silage.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04952792 Completed
Atrial Fibrillation|Hemodialysis Complication
Hospital Universitari de Bellvitge|Spanish Society of Nephrology|Baxter Healthcare Corporation
 May 20 2021 Phase 2
NCT01119300 Completed
Venous Thromboembolism|Atrial Fibrillation
Utrecht Institute for Pharmaceutical Sciences|Utrecht University|Leiden University Medical Center|Erasmus Medical Center|University of Ulm|Newcastle University|University of Liverpool|LGC Limited|Uppsala University|Democritus University of Thrace|Elisabethinen Hospital
 January 2011 Phase 4
NCT00157118 Completed
Protein C Deficiency
Baxalta now part of Shire|Takeda
 August 22 2003 Phase 2|Phase 3

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