Coumarin

Catalog No.S4170

For research use only.

Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties.

Coumarin Chemical Structure

CAS No. 91-64-5

Selleck's Coumarin has been cited by 1 Publication

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Biological Activity

Description Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties.
In vitro

Coumarin is a fragrant organic chemical compound in the benzopyrone chemical class, which is a colorless crystalline substance in its standard state. Coumarin is a naturally occurring constituent of many plants and essential oils, including tonka beans, sweet clover, woodruff, oil of cassia, and lavender. Coumarin is a member of a class of compounds called benzopyrones. Coumarin compounds have been used to treat such diverse ailments as cancer, bums, brucellosis, and rheumatic disease, and they have been used as antispasmodics. Although coumarin itself has no anticoagulant properties, it is transformed into the natural anticoagulant dicoumarol by a number of species of fungi. This occurs as the result of the production of 4-hydroxycoumarin, then further into the actual anticoagulant dicoumarol, a fermentation product and mycotoxin. This substance is responsible for the bleeding disease known historically as "sweet clover disease" in cattle eating moldy sweet clover silage.[1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 29 mg/mL
(198.43 mM)
Ethanol 29 mg/mL
(198.43 mM)
Water Insoluble

Chemical Information

Molecular Weight 146.14
Formula

C9H6O2

CAS No. 91-64-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=C2C(=C1)C=CC(=O)O2

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04952792 Recruiting Drug: Apixaban 2.5 milligram Oral Tablet Atrial Fibrillation|Hemodialysis Complication Hospital Universitari de Bellvitge May 20 2021 Phase 2
NCT01119300 Completed Other: Genotype-guided dosing algorithm|Other: Standard care Venous Thromboembolism|Atrial Fibrillation Utrecht Institute for Pharmaceutical Sciences|Utrecht University|Leiden University Medical Center|Erasmus Medical Center|University of Ulm|Newcastle University|University of Liverpool|LGC Limited|Uppsala University|Democritus University of Thrace|Elisabethinen Hospital January 2011 Phase 4
NCT00157118 Completed Drug: Protein C Concentrate (Human) Vapor Heated Protein C Deficiency Baxalta now part of Shire|Takeda August 22 2003 Phase 2|Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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