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Ceritinib (LDK378)

Name: Ceritinib (LDK378)
Brand: Selleck Chemicals
SKU: S7083
Rating: 5 (88 reviews)

Catalog No.S7083

For research use only.

Ceritinib (LDK378) is potent inhibitor against ALK with IC50 of 0.2 nM in cell-free assays. Ceritinib (LDK378) also inhibits IGF-1R, InsR, STK22D and FLT3 with IC50 of 8 nM, 7 nM, 23 nM and 60 nM, respectively. Phase 3.

CAS No. 1032900-25-6

Selleck's Ceritinib (LDK378) has been cited by 88 publications

Purity & Quality Control

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ALK Signaling Pathway Map

Biological Activity

Description

Features

Does not cross react with c-Met, and has an improved in vivo glucose homeostasis profile relative to TAE684. May be active in Crizotinib-relapsed tumors.

Targets

ALK ^[1] (Cell-free assay)	Insulin Receptor ^[1] (Cell-free assay)	IGF-1R ^[1] (Cell-free assay)	STK22D ^[1] (Cell-free assay)	FLT3 ^[1] (Cell-free assay)
0.2 nM	7 nM	8 nM	23 nM	60 nM

In vitro

LDK378 shows great anti-proliferative activity in Ba/F3-NPM-ALK and Karpas290 cells with IC50 of 26.0 nM and 22.8 nM, compared with IC50 of 319.5 nM and 2477 nM in Ba/F3-Tel-InsR and Ba/F3-WT cells. ^[1]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Parental(+IL3)	Mmn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NGLFc2k4OiCq	NIPNRmFFVVOR	NE\pW\|FKSzVyPUG1PFYhyrFiMUezJI5O	NGHYU289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe0PVA{PCd-MkW3OFkxOzR:L3G+
WT 70	NIm0bJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NFjj[nI4OiCq	M4WzT2ROW09?	Ml\VTWM2OD1{MTFCtUA5KG6P	M1vOfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{S5NFM1Lz5{NUe0PVA{PDxxYU6=
G1128S 1022	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NFjmVHc4OiCq	MWXEUXNQ	M4XG[2lEPTB;MUCyJOKyKDN6IH7N	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd2OUCzOEc,OjV5NEmwN\|Q9N2F-
C1156F 1293	MmT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NUPYXWw1PzJiaB?=	NUHibVFjTE2VTx?=	M{PCbGlEPTB;MkG3JOKyKDFzNTDuUS=>	NWnPRXNYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3OFkxOzRpPkK1O\|Q6ODN2PD;hQi=>
I1171N 519	NXnGVlJxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NXvvPHFKPzJiaB?=	Mn3ISG1UVw>?	MoXtTWM2OD1zOEegxtEhQDdibl2=	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd2OUCzOEc,OjV5NEmwN\|Q9N2F-
I1171T 445	NVzvN3QxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		Ml\iO\|IhcA>?	MVHEUXNQ	MX3JR\|UxRTh{INMxJFEzKG6P	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd2OUCzOEc,OjV5NEmwN\|Q9N2F-
F1174I 184	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NVu5XGdRPzJiaB?=	Mk[4SG1UVw>?	NHfzfnFKSzVyPUGzJOKyKDBwMTDuUS=>	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd2OUCzOEc,OjV5NEmwN\|Q9N2F-
N1178H 169	M4Hlcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NXHBWpRQPzJiaB?=	Mo\DSG1UVw>?	MYnJR\|UxRTR{INMxJFYhdk1?	Mn;hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5NEmwN\|QoRjJ3N{S5NFM1RC:jPh?=
E1210K 748	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MXq3NkBp	MYPEUXNQ	NH22dlhKSzVyPUG4O{DDuSB6NDDuUS=>	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd2OUCzOEc,OjV5NEmwN\|Q9N2F-
C1156F/D1203N 2809	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M1;zblczKGh?	NXvUUWhuTE2VTx?=	MUXJR\|UxRTJ3NDFCtUA6QSCwTR?=	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd2OUCzOEc,OjV5NEmwN\|Q9N2F-
Ba/F3 NA WT	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MkC3O\|IhcA>?		NYHZNZJXUUN3ME2wMlAzOCEQvF2=	NFi3dHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUeyO\|QxOCd-MkW3Nlc1ODB:L3G+
Ba/F3 NA C1156Y	M4nVVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NVKyTmNLPzJiaB?=		M3\XcmlEPTB;MD6wO\|Eh\|ryP	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd{N{SwNEc,OjV5Mke0NFA9N2F-
Ba/F3 NA L1196M	NXT3dW1jT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M1myb\|czKGh?		MVTJR\|UxRTBwMESyJO69VQ>?	MmjVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5Mke0NFAoRjJ3N{K3OFAxRC:jPh?=
Ba/F3 NA L1152R	MoTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M1vDPVczKGh?		MUPJR\|UxRTBwMki4JO69VQ>?	NWHpdW5FRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3Nlc1ODBpPkK1O\|I4PDByPD;hQi=>
Ba/F3 NA G1202R	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M{HyfFczKGh?		NGTkW25KSzVyPUCuNlc4KM7:TR?=	NEW5fmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUeyO\|QxOCd-MkW3Nlc1ODB:L3G+
Ba/F3 NA G1269A	NIf2ZXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NVzzXpp{PzJiaB?=		NHjiVZFKSzVyPUCuNFE6KM7:TR?=	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd{N{SwNEc,OjV5Mke0NFA9N2F-
Ba/F3 NA S1206Y	NEnTZ4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NVzvZVdUPzJiaB?=		NGPjOopKSzVyPUCuNFM4KM7:TR?=	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd{N{SwNEc,OjV5Mke0NFA9N2F-
Ba/F3 EA WT	NEHMdGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NFrMXVc4OiCq		NHXRPWhKSzVyPUCuNFIyKM7:TR?=	M1\uOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{K3OFAxLz5{NUeyO\|QxODxxYU6=
Ba/F3 EA C1156Y	NYSzdWk4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NUTG[VJiPzJiaB?=		MVPJR\|UxRTBwMEK2JO69VQ>?	M3XFTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{K3OFAxLz5{NUeyO\|QxODxxYU6=
Ba/F3 EA L1196M	NHr6VWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NIL2RmQ4OiCq		M3\5[GlEPTB;MD6wNVkh\|ryP	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd{N{SwNEc,OjV5Mke0NFA9N2F-
Ba/F3 EA L1152R	NXXxcYZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NFjocHc4OiCq		NUnFfZRGUUN3ME2wMlA6QSEQvF2=	M17wT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{K3OFAxLz5{NUeyO\|QxODxxYU6=
Ba/F3 EA G1202R	NYXtTo9vT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MnT0O\|IhcA>?		MYjJR\|UxRTBwNE[3JO69VQ>?	MlvpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5Mke0NFAoRjJ3N{K3OFAxRC:jPh?=
Ba/F3 EA G1269A	MmnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NILz[Jg4OiCq		MXzJR\|UxRTBwMEOzJO69VQ>?	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd{N{SwNEc,OjV5Mke0NFA9N2F-
Ba/F3 EA S1206Y	M4SxSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NGnKN3I4OiCq		MoS5TWM2OD1yLkCzPEDPxE1?	NFLzcHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUeyO\|QxOCd-MkW3Nlc1ODB:L3G+
BAF3	Mn\SRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NETB[2s4OiCqcoO=		NU\XUHV6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDCRWY{KGOnbHzzJIhiemKxcnnu[{BGVUx2LVHMT{Bi\nSncjC3NkBpenNiYomgV3JDKG:{IFPDT\|gh[XO\|YYmsJGlEPTBiPTCwMlAyODdizszNMi=>	M1zjUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Mki4PVQxLz5{OUK4PFk1ODxxYU6=
NCI-H3122	MoPDRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NHv3ZXo4OiCqcoO=		NGfaUXBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JOzF{MjDj[YxteyCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDMeY1qdmW\|Y3XueEBE\WyuIG\pZYJqdGm2eTDBd5NigSxiRVO1NEA:KDBwMEG1JO69VS5?	NFnrSpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW2PFI5QSd-Mk[1OlgzQDl:L3G+
NCI-H2228	M{jkPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		MnjLN{Bl[Xm\|		MYHHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDOR2kuUDJ{MkigZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KGy3bXnu[ZNk\W6lZT3iZZNm\CCFZXzsWIl1\XJvR3zvJIF{e2G7LDDJR\|UxKD1iMD6wNVUh\|ryPLh?=	MknFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4Mke3NlUoRjJ7NkK3O\|I2RC:jPh?=
SU-DHL1	NVjWXFZqT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		M3nV[VMh\GG7cx?=		NYHvephiT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hW1VvRFjMNUBk\WyuczDh[pRmeiB\|IHThfZMh[nlibIXtbY5me2OnbnPlMYJie2WmIFPlcIxVcXSncj3HcI8h[XO\|YYmsJGlEPTBiPTCwMlAyPSEQvF2u	M4iwTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkK3O\|I2Lz5{OU[yO\|czPTxxYU6=
DFCI114	NVfMV2JOSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NGLqb204OiCqcoO=		MYjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKESIQ1mxNVQh[2WubIOg[ZhxemW\|c3nu[{BGVUx2LVHMT{BIOTJ4OVGgcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJGx2dWmwZYPj[Y51KEOnbHygWoli[mmuaYT5JGF{e2G7LDDFR\|UxKD1iMD6wNVgh\|ryPLh?=	NV\LUYg5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1OlgzQDlpPkK2OVY5Ojh7PD;hQi=>
HCC78	NYHzbll1S3m2b4TvfIlkcXS7IHHzd4F6		M2qxOlczKGi{cx?=		M{i0PGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhESzd6IHPlcIx{KGijcnLvdolv\yCVTFOzOGEzNVKRU{GgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMD6wNVgh\|ryPLh?=	NGHvV5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{S3OFkzPSd-Mke0O\|Q6OjV:L3G+
KARPAS299	NF\1Z5ZEgXSxdH;4bYNqfHliYYPzZZk>		MnfTNkB1dyB\|IHThfZM>		NV2yXXJnS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hU0GUUFHTNlk6KGOnbHzzJIFnfGW{IEKgeI8hOyCmYYnzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygTWM2OCB;IECuNFIzQCEQvF2u	NE\4T3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{e0NlI2Oid-MkO3OFIzPTJ:L3G+
KARPAS299	NXfOWWtTS3m2b4TvfIlkcXS7IHHzd4F6				M3j6TGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGtCWlCDU{K5PUBk\WyuczDlfJBz\XO\|aX7nJG5RVS2DTFug[pV{cW:wIHflcoUh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25uIFnDOVAhRSByLkCyNlgh\|ryPLh?=	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh\|N{e5O{c,OjN6M{e3PVc9N2F-
NCI-H3122	Mn7GSpVv[3Srb36gZZN{[Xl?		MUS3NkBpenN?		NXm1fVVCUW6qaXLpeIlwdiCxZjDFUWw1KG[3c3XkJGFNUyCrbjDoeY1idiCQQ1mtTFMyOjJiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBu\WG\|dYLl[EBi\nSncjC3NkBpenNiYomgV3JDKGG\|c3H5MEBESzVyIE2gNE4xOjVizszNMi=>	MlrCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7MUWxOlkoRjJ5OUG1NVY6RC:jPh?=
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NCI-H3122	NFm2dlNHfW6ldHnvckBie3OjeR?=	NVHI[IlsOjBidH:gNlAxKG6P	M4DJNlEhcHJ?		Mm\2TY5pcWKrdHnvckBw\iCDTFugbY4hcHWvYX6gUmNKNUh\|MUKyJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCDa4SgdIhwe3Cqb4L5cIF1cW:wIHH0JHM1PzNicnXzbYR2\SCjdDCyNEB1dyB{MECgcm0h[W[2ZYKgNUBpeiCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM>	NFrOcYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUK4PFk1OCd-MkmyPFg6PDB:L3G+
SU-DHL1	MXHGeY5kfGmxbjDhd5NigQ>?	NGiwW4gzOCC2bzCyNFAhdk1?	NWK4T5puOSCqch?=		NF;HWVlKdmirYnn0bY9vKG:oIFHMT{BqdiCqdX3hckBUXS2GSFyxJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCDa4SgdIhwe3Cqb4L5cIF1cW:wIHH0JHM1PzNicnXzbYR2\SCjdDCyNEB1dyB{MECgcm0h[W[2ZYKgNUBpeiCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM>	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ6OEm0NEc,Ojl{OEi5OFA9N2F-
SU-DHL1	NEnIfmVHfW6ldHnvckBie3OjeR?=	NEPqPJQzOCC2bzCyNFAhdk1?	NEfsdlcyKGi{		NWK3cIJ4UW6qaXLpeIlwdiCxZjDBUGshcW5iaIXtZY4hW1VvRFjMNUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iRWLLJJBpd3OyaH;yfYxifGmxbjDheEBVOjB{Lz;ZNlA1KHKnc3nkeYV{KGG2IEKwJJRwKDJyMDDuUUBi\nSncjCxJIhzKGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=>	M{KyfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Mki4PVQxLz5{OUK4PFk1ODxxYU6=
NCI-H3122	MWHGeY5kfGmxbjDhd5NigQ>?	M1S4VVIxKHSxIEKwNEBvVQ>?	MkPMNUBpeg>?		NEHpWWVKdmirYnn0bY9vKG:oIFHMT{BxcG:\|cHjvdplt[XSrb36gZZQhYTF{N{igdoV{cWS3ZTDpckBpfW2jbjDOR2kuUDNzMkKgZ4VtdHNiYYSgNlAhfG9iMkCwJI5OKGGodHXyJFEhcHJiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{	NIfhb2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUK4PFk1OCd-MkmyPFg6PDB:L3G+
NCI-H3122	MmnVSpVv[3Srb36gZZN{[Xl?	NY\5SWM4OjBidH:gNlAxKG6P	M3HMTlEhcHJ?		MlXsTY5pcWKrdHnvckBw\iCDTFugbY4hcHWvYX6gUmNKNUh\|MUKyJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCVVFHUN{BxcG:\|cHjvdplt[XSrb36gZZQhYTdyNTDy[ZNq\HWnIHH0JFIxKHSxIEKwNEBvVSCjZoTldkAyKGi{IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>?	NUjuPFMxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyPFg6PDBpPkK5Nlg5QTRyPD;hQi=>
SU-DHL1	M3voOGZ2dmO2aX;uJIF{e2G7	MV[zNEBvVQ>?	NUX0[5ZqOTZiaILz		NGjr[G1KdmirYnn0bY9vKG:oIFHMT{BifXSxcHjvd5Bpd3K7bHH0bY9vKGG2IGmxOVA4KHKnc3nkeYUhcW5iaIXtZY4hW1VvRFjMNUBk\WyuczDheEA{OCCwTTDh[pRmeiBzNjDodpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ{N{eyOUc,Ojl4Mke3NlU9N2F-
SU-DHL1	M{PFWWZ2dmO2aX;uJIF{e2G7	NYfqfY9jOzBibl2=	MYexOkBpenN?		MWPJcohq[mm2aX;uJI9nKEGOSzDpckBpfW2jbjDTWU1FUExzIHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBUXEGWMzDwbI9{eGixconsZZRqd25iYYSgXVcxPSC{ZYPp[JVmKGG2IEOwJI5OKGGodHXyJFE3KGi{czDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN?	M2W5[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkK3O\|I2Lz5{OU[yO\|czPTxxYU6=
NCI-H3122	NIHFbI9HfW6ldHnvckBie3OjeR?=	M3vn[VUxKHSxIEK1NEBvVQ>?	MoLONVYhcHK\|		M{DsNmlv\HWldHnvckBw\iCDTFug[IVoemGmYYTpc44hcW5iaIXtZY4hVkOLLVizNVIzKGOnbHzzJIF{e2W\|c3XkJIF{KGSnY4LlZZNmKGmwIFHMT{BxcG:\|cHjvdplt[XSrb36gZZQhYTF4MESgZZQhPTBidH:gNlUxKG6PIHHmeIVzKDF4IHjyd{BjgSCrbX31co9jdG:2IH3leIhw\A>?	NVf3UVlVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2OlA6QDRpPkK5OlYxQTh2PD;hQi=>
SH-SY5Y	NUfYPXlZSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NIL4N\|A4OiCqcoO=		MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOKLWPZOXkh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hdHWvaX7ld4NmdnRiY3XscEB3cWGkaXzpeJkh[XO\|YYm=	MnWwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4NkC5PFQoRjJ7Nk[wPVg1RC:jPh?=
CHLA20	M{P0SWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MlvTO\|IhcHK\|		M{TjT2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ1jMRVIxKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKGy3bXnu[ZNk\W62IHPlcIwhfmmjYnnsbZR6KGG\|c3H5	MoXhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4NkC5PFQoRjJ7Nk[wPVg1RC:jPh?=
SH-SY5Y	M{XEcWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M1TKOlczKGi{cx?=		MkjlRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCVSD3TXVV[KGOnbHzzJIFnfGW{IEeyJIhzeyCrbjDwdoV{\W6lZTDv[kBCSkOEMTDpcohq[mm2b4KgeIFzcXG3aXThdkBjgSCFZXzsWIl1\XJvR3zvJIx2dWmwZYPj[Y51KGOnbHygeoli[mmuaYT5JIF{e2G7	M1fac\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Nk[wPVg1Lz5{OU[2NFk5PDxxYU6=
KARPAS299	NFLle49HfW6ldHnvckBie3OjeR?=	M33FXFUxKHSxIEK1NEBvVQ>?	MUGxOkBpenN?		NVXsO\|NMUW6mdXP0bY9vKG:oIFHMT{Bl\We{YXTheIlwdiCrbjDoeY1idiCNQWLQRXMzQTliY3XscJMh[XO\|ZYPz[YQh[XNiZHXjdoVie2ViaX6gRWxMKHCqb4PwbI9zgWyjdHnvckBifCC\MU[wOEBifCB3MDD0c{AzPTBibl2gZYZ1\XJiMU[gbJJ{KGK7IHntcZVvd2Kub4SgcYV1cG:m	NXrDTZgxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2OlA6QDRpPkK5OlYxQTh2PD;hQi=>
CHLA20	NWn0Z4JYSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MXG3NkBpenN?		NFPK[YNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPIUGEzOCClZXzsd{Bi\nSncjC3NkBpenNiaX6gdJJme2WwY3Wgc4YhSUKFQkGgbY5pcWKrdH;yJJRiemmzdXnkZZIh[nliQ3XscHRqfGW{LVfsc{BtfW2rbnXzZ4VvfCClZXzsJJZq[WKrbHn0fUBie3OjeR?=	MmLJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4NkC5PFQoRjJ7Nk[wPVg1RC:jPh?=
NCI-H3122	NV7ibmZRSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M1exTlczKGi{cx?=		NUDJRmVOSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDNzMkKgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gcJVucW6nc3PlcpQh[2WubDD2bYFjcWyrdImgZZN{[Xl?	M2n4W\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Nk[wPVg1Lz5{OU[2NFk5PDxxYU6=
KARPAS299	Ml7lRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MWm3NkBpenN?		M2jsTGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS1HSVGFUOjl7IHPlcIx{KGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIHz1cYlv\XOlZX70JINmdGxidnnhZoltcXS7IHHzd4F6	M{PEblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Nk[wPVg1Lz5{OU[2NFk5PDxxYU6=
SU-DHL1	MXfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		Mmr6O\|IhcHK\|		MXXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOXLVTIUFEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hdHWvaX7ld4NmdnRiY3XscEB3cWGkaXzpeJkh[XO\|YYm=	NUPTN3dPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2OlA6QDRpPkK5OlYxQTh2PD;hQi=>
KARPAS299	MXfBdI9xfG:\|aYOgZZN{[Xl?	MnTKOVAhdk1?	M{\FR\|I1KGi{cx?=		NYm1W2ZvUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDLRXJRSVN{OUmgZ4VtdHNiYYPz[ZN{\WRiYYOgeY5kdGWjcjDj[YxtKHOqcnnub4Fo\SCjdDC1NEBvVSCjZoTldkAzPCCqcoOgZpkhUG:nY3jzeEA{OzJ3ODDzeIFqdmmwZzDiZZNm\CCrbo\ldpRm\CCobIXvdoV{[2WwY3WgcYlkem:\|Y3;wfS=>	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJ{M{GyNEc,OzB{MkOxNlA9N2F-
KARPAS299	NVr0VpNYSXCxcITvd4l{KGG\|c3H5	MXK1NEBvVQ>?	MViyOEBpenN?		NEL3Vo9KdmS3Y4Tpc44hd2ZiYYDvdJRwe2m\|IHnuJIh2dWGwIFvBVnBCWzJ7OTDj[YxteyCjc4Pld5Nm\CCjczDsZZRmKGGyb4D0c5Rq[yClZXzsd{BifCB3MDDuUUBi\nSncjCyOEBpenNiYomgRW8wTUJiZH;1ZoxmKHO2YXnubY5oKGKjc3XkJIlvfmW{dHXkJIZtfW:{ZYPj[Y5k\SCvaXPyc5Nkd3C7	MmDoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MkOxNlAoRjNyMkKzNVIxRC:jPh?=
KARPAS299	NEL6WHpCeG:ydH;zbZMh[XO\|YYm=	M2fsT\|UxKG6P	NWHvU\|FzOjRiaILz		MUnJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKEuDUmDBV\|I6QSClZXzsd{Bie3Onc4Pl[EBieyCocnHncYVvfGG2aX;uJIF1KDVyIH7NJIFnfGW{IEK0JIhzeyCkeTDIc4VkcHO2IEOzNlU5KHO2YXnubY5oKGKjc3XkJIlvfmW{dHXkJIZtfW:{ZYPj[Y5k\SCvaXPyc5Nkd3C7	M2DV[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkKzNVIxLz5\|MEKyN\|EzODxxYU6=

Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID

Western blot	p-ALK / ALK / p-AKT / AKT / p-ERK / ERK ; pROS1 / ROS1 / pSTAT3 / STAT3	28425916 25351743
Growth inhibition assay	Cell viability	29067644

In vivo

LDK378 is designed to reduce the possibility of forming reactive metabolites and shows undetectable levels of glutathione (GSH) adducts (<1%) in liver microsomes. LDK378 has relatively good metabolic stability, with moderate CYP3A4 (Midazolam substrate) inhibition and hERG inhibition. LDK378 exhibits low plasma clearance in animals (mouse, rat, dog and monkey) compared to liver blood flow, with the oral bioavailability of above 55% in mouse, rat, dog and monkey. LDK378 induces a dose-dependent growth inhibition and tumor regression in the Karpas299 and H2228 rat xenograft models, with no body-weight loss. LDK378 shows no impact on insulin levels or plasma glucose utilization in the mouse upon chronic dosing up to 100 mg/kg. ^[1]

Protocol (from reference)

Kinase Assay:^[1]	Enzymatic kinase profiling description: All kinases are expressed as either Histidine- or GST-tagged fusion proteins using the baculovirus expression technology except for the untagged ERK2 which is produced in E. coli. The kinase activity is measured in the LabChip mobility shift assay. The assay is performed at 30°C for 60 min. The effect of LDK378 on the enzymatic activity is obtained from the linear progress curves in the absence and presence of LDK378 and routinely determines from one reading (end point measurement)
Cell Research:^[1]	Cell lines: Ba/F3-NPM-ALK, Ba/F3-Tel-InsR, Ba/F3-WT, Karpas299 cells Concentrations: ~100 μM Incubation Time: 2-3 days Method: Luciferase-expressing cells are incubated with serial dilutions of LDK378 or DMSO for 2-3 days. Luciferase expression is used as a measure of cell proliferation/survival and is evaluated with the Bright-Glo Luciferase Assay System. IC50 values are generated by using XLFit software.
Animal Research:^[1]	Animal Models: RNU nude rats bearing the Karpas299/H2228 tumors Dosages: ~50 mg/kg Administration: Oral gavage

References

[1] Marsilje TH, et al. J Med Chem. 2013, Jun 6.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight	558.14
Formula	C₂₈H₃₆ClN₅O₃S
CAS No.	1032900-25-6
Storage	3 years	-20°C	powder
Storage	2 years	-80°C	in solvent
Smiles	CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl

Download Ceritinib (LDK378) SDF

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

Clinical Trial Information

NCT Number	Recruitment	Interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02450903	Completed	Drug: LDK378	Non-Small-Cell Lung Cancer	Novartis Pharmaceuticals\|Novartis	August 21 2015	Phase 2
NCT02040870	Completed	Drug: LDK378	Non-Small Cell Lung Cancer	Novartis Pharmaceuticals\|Novartis	March 7 2014	Phase 1\|Phase 2
NCT01950481	Completed	Drug: LDK378	Normal Hepatic Function\|Impaired Hepatic Function	Novartis Pharmaceuticals\|Novartis	January 2014	Phase 1
NCT01772797	Completed	Drug: LDK378\|Drug: AUY922	Anaplastic Lymphoma Kinase (ALK)\|Non-small Cell Lung Cancer	Novartis Pharmaceuticals\|Novartis	June 2013	Phase 1
NCT01685060	Completed	Drug: LDK378	Non-Small Cell Lung Cancer	Novartis Pharmaceuticals\|Novartis	November 26 2012	Phase 2
NCT01634763	Completed	Drug: LDK378	Tumors Characterized by Genetic Alterations in Anaplastic Lymphoma Kinase (ALK)	Novartis Pharmaceuticals\|Novartis	June 2012	Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

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Frequently Asked Questions

Question 1:
how to reconstitute the inhibitor for oral administration to mice?

Answer:
You can resuspend LDK378 in 30% PEG400/0.5% Tween 80/5% propylene glycol and use the suspension for oral gavage feeding.

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