Cefazedone

Catalog No.S4874 Synonyms: Refosporen, Cefazedonum

For research use only.

Cefazedone (Refosporen, Cefazedonum) is a semisynthetic first-generation cephalosporin with antibacterial activity.

Cefazedone Chemical Structure

CAS No. 56187-47-4

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Cefazedone (Refosporen, Cefazedonum) is a semisynthetic first-generation cephalosporin with antibacterial activity.
Targets
α-glucosidase [2]
(Cell-free assay)
578 nM(Ki)
In vitro

Ceftezole exhibited potent α-glucosidase inhibitory activity. In in vitro α-glucosidase assays, ceftezole was shown to be a reversible, non-competitive inhibitor of yeast α-glucosidase with a Ki value of 5.78×10−7 M when the enzyme mixture was pretreated with ceftezole[2].

In vivo In mice, dogs, and rabbits, cefazedone produced high and prolonged serum levels. It does not penetrate the CSF or brain tissue[1]. Ceftezole inhibits the blood glucose increase that occurs following glucose uptake. Expression levels of glycogen synthase kinase-3, peroxisome proliferator-activated receptor-γ, and uncoupling protein-3 mRNA were also slightly decreased compared to controls following ceftezole treatment. It exhibits anti-diabetic activity in vivo[2].

Protocol (from reference)

Animal Research:

[2]

  • Animal Models: Diabetic female mice (C57BL/6Nkist)
  • Dosages: 30 mg/kg/day
  • Administration: i.p.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 548.44
Formula

C18H15Cl2N5O5S3

CAS No. 56187-47-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=NN=C(S1)SCC2=C(N3C(C(C3=O)NC(=O)CN4C=C(C(=O)C(=C4)Cl)Cl)SC2)C(=O)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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