Cefazedone

For research use only.

Catalog No.S4874 Synonyms: Refosporen, Cefazedonum

Cefazedone Chemical Structure

CAS No. 56187-47-4

Cefazedone (Refosporen, Cefazedonum) is a semisynthetic first-generation cephalosporin with antibacterial activity.

Purity & Quality Control

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Biological Activity

Description Cefazedone (Refosporen, Cefazedonum) is a semisynthetic first-generation cephalosporin with antibacterial activity.
Targets
α-glucosidase [2]
(Cell-free assay)
578 nM(Ki)
In vitro

Ceftezole exhibited potent α-glucosidase inhibitory activity. In in vitro α-glucosidase assays, ceftezole was shown to be a reversible, non-competitive inhibitor of yeast α-glucosidase with a Ki value of 5.78×10−7 M when the enzyme mixture was pretreated with ceftezole[2].

In vivo In mice, dogs, and rabbits, cefazedone produced high and prolonged serum levels. It does not penetrate the CSF or brain tissue[1]. Ceftezole inhibits the blood glucose increase that occurs following glucose uptake. Expression levels of glycogen synthase kinase-3, peroxisome proliferator-activated receptor-γ, and uncoupling protein-3 mRNA were also slightly decreased compared to controls following ceftezole treatment. It exhibits anti-diabetic activity in vivo[2].

Protocol

Animal Research:

[2]

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  • Animal Models: Diabetic female mice (C57BL/6Nkist)
  • Dosages: 30 mg/kg/day
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (182.33 mM)
Ethanol '-1 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 548.44
Formula

C18H15Cl2N5O5S3

CAS No. 56187-47-4
Storage powder
in solvent
Synonyms Refosporen, Cefazedonum
Smiles CC1=NN=C(S1)SCC2=C(N3C(C(C3=O)NC(=O)CN4C=C(C(=O)C(=C4)Cl)Cl)SC2)C(=O)O

In vivo Formulation Calculator (Clear solution)

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID