CORM-3

Catalog No.S7448

For research use only.

CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.

CORM-3 Chemical Structure

CAS No. 475473-26-8

Selleck's CORM-3 has been cited by 6 Publications

Purity & Quality Control

Choose Selective Immunology & Inflammation related Inhibitors

Biological Activity

Description CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.
In vitro

CORM-3 protects against hypoxia-reoxygenation and oxidative stress by promoting CO release in cardiac cells. [1] CORM-3 attenuates the inflammatory response induced by LPS in RAW264.7 murine macrophages. [2] CORM-3 also uncouples mitochondrial respiration via interaction with the phosphate carrier. [4]

In vivo CORM-3 (40 mg/kg i.p.) prolongs the survival of murine cardiac grafts and attenuates organ rejection in CBA mice transplanted with BALB/c hearts. [1] CORM-3 (20 mg/kg i.p.) decreases cellular infiltration, joint inflammation and destruction in a collagen-induced arthritis mouse model. [3]

Protocol (from reference)

Animal Research:[1]
  • Animal Models: CBA mice transplanted with BALB/c hearts.
  • Dosages: ~40 mg/kg daily
  • Administration: i.p.

Solubility (25°C)

In vitro

DMSO 38 mg/mL
(128.98 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 294.61
Formula

C5 H4 Cl N O5 Ru

CAS No. 475473-26-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles [CH+]=O.[CH+]=O.[CH+]=O.C(C(=O)O)[NH-].Cl[Ru]

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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