Home GPCR & G Protein Adrenergic Receptor agonist CL316243

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CL316243 Adrenergic Receptor agonist

Cat.No.E1049

CL316243 is a highly potent and selective agonist of β3-adrenoceptor with an EC50 value of 3 nM, respectively but is an extremely poor to β1/2- receptors.It effectively stimulates adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate.
CL316243 Adrenergic Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 467.81

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Chemical Information, Storage & Stability

Molecular Weight 467.81 Formula

C20H20ClNO7.2Na

 Storage (From the date of receipt)
CAS No. 138908-40-4 Download SDF Storage of Stock Solutions

Solubility

In vitro
Batch:

Water : 38 mg/mL

DMSO : 5 mg/mL (10.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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%
% Tween 80
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
β3-adrenoceptor [1]
(in vitro binding assays)
3 nM(EC50)
References

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