Celecoxib (SC 58635)

For research use only.

Licensed by Pfizer Catalog No.S1261

71 publications

Celecoxib (SC 58635) Chemical Structure

CAS No. 169590-42-5

Celecoxib (SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.

Selleck's Celecoxib (SC 58635) has been cited by 71 publications

Purity & Quality Control

Choose Selective COX Inhibitors

Biological Activity

Description Celecoxib (SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.
Targets
COX-2 [1]
(Sf9 cells)
40 nM
In vitro

Celecoxib shows low sensitivity against COX-1 with IC50 of 15 μM. [1] Celecoxib shows an anti-proliferative effect on nasopharyngeal carcinoma (NPC) cell lines including HNE1 and CNE1-LMP1 with IC50 of 32.86 μM and 61.31 μM, respectively. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 NYTLc2NGTnWwY4Tpc44hSXO|YYm= M2OyOlAvOS1|MDFOwG0> NH72[Yk1QCCq MnLSbY5lfWOnczDJR2FONTFiZYjwdoV{e2mxbjDvckBjd3SqIIDyc5RmcW5iYX7kJI1TVkFibHX2[Yw> MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjVzM{G3Nkc,OjZ3MUOxO|I9N2F-
H460 MULGeY5kfGmxbjDBd5NigQ>? MWewMlEuOzBizszN M2jLPFQ5KGh? MlrpbY5lfWOnczDJR2FONTFiZYjwdoV{e2mxbjDvckBjd3SqIIDyc5RmcW5iYX7kJI1TVkFibHX2[Yw> NELXTnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkWxN|E4Oid-Mk[1NVMyPzJ:L3G+
HKESC-2 NWLHTXZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\OZlFxOjEEoN88US=> MorxOFjDqGkEoB?= MUXzbYdvcW[rY3HueIx6KGmwY4LlZZNmeyC2aHWgTWM2OMLidnHseYV{KG:oIH;4ZYxqeGyjdHnuxsA> MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjR5NE[5N{c,OjZ2N{S2PVM9N2F-
CaES-17 NHLmWWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXSWmZjOjEEoN88US=> NFn3SlM1QMLiaNMg NIfie3B{cWewaX\pZ4FvfGy7IHnuZ5Jm[XOnczD0bIUhUUN3MNMgeoFtfWW|IH;mJI95[WyrcHzheIlvyqB? NIW5[4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS3OFY6Oyd-Mk[0O|Q3QTN:L3G+
HKESC-2 M{nsV2Fxd3C2b4Ppd{BCe3OjeR?= M{nvUlIxyqEQvF2= MkLHOFjDqGkEoB?= NXSx[mdUemWmdXPld{BwgGGuaYDsZZRqdi2rbnT1Z4VlKGGyb4D0c5Nqew>? MofWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2N{S2PVMoRjJ4NEe0Olk{RC:jPh?=
CaES-17 NEL3PZBCeG:ydH;zbZMhSXO|YYm= NGDPN|MzOMLizszN MUS0POKhcMLi MV;y[YR2[2W|IH;4ZYxqeGyjdHnuMYlv\HWlZXSgZZBweHSxc3nz NXTs[JpGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0O|Q3QTNpPkK2OFc1Pjl|PD;hQi=>
A549 M{X5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{mzZ|UuOTZyIN88US=> MXO0POKhcMLi NFHhNmtFVVOR MWrJR|UxRTF4Mz60JO69VQ>? NGLoe4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS2OFY1Oyd-Mk[0OlQ3PDN:L3G+
HCC827 NUjrSmwyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPBVXQ2NTF4MDFOwG0> M2LPXVQ5yqCqwrC= NVXXe|VmTE2VTx?= NXLkWJZHUUN3ME22PU4zKM7:TR?= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjR4NE[0N{c,OjZ2NkS2OFM9N2F-
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CMeC-1 NHnFOoVE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NF;4Z3ozOC93MDFOwG0> NETWeYw1QCCq Ml3JbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHliaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? NG[0O409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[1Olc1Pid-MkS2OVY4PDZ:L3G+
LMeC NXHFfVlHS2WubDDWbYFjcWyrdImgRZN{[Xl? NGPxNpYzOC93MDFOwG0> NEi2VnI1QCCq MXrpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? NGC0To89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[1Olc1Pid-MkS2OVY4PDZ:L3G+
CMeC-1 MlfESpVv[3Srb36gRZN{[Xl? MXGyNE82OCEQvF2= NXfBUWFTPDhiaB?= MVTpcoR2[2W|IFexMXMh[XK{ZYP0 M4mwT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkW2O|Q3Lz5{NE[1Olc1PjxxYU6=
LMeC NEDzbmZHfW6ldHnvckBCe3OjeR?= MmXSNlAwPTBizszN M4rqN|Q5KGh? M1jCV4lv\HWlZYOgS|EuWyCjcoLld5Q> MkHMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O|Q3RC:jPh?=
CMeC-1 MlXxSpVv[3Srb36gRZN{[Xl? MUGyNE82OCEQvF2= NWPoZWtlPDhiaB?= NFWwNndl\WO{ZXHz[ZMhfGinIHzleoVteyCxZjDjfYNtcW5iREGgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= M3LJdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkW2O|Q3Lz5{NE[1Olc1PjxxYU6=
LMeC M4HqemZ2dmO2aX;uJGF{e2G7 M{f3UlIxNzVyIN88US=> NFvDT4k1QCCq MnzJ[IVkemWjc3XzJJRp\SCuZY\lcJMhd2ZiY4njcIlvKERzIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ MmLLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O|Q3RC:jPh?=
CMeC-1 NGLQfG1HfW6ldHnvckBCe3OjeR?= NISzfpMzOC93MDFOwG0> MnT4OFghcA>? NX\zcGJGcW6mdXPld{Bk[XOyYYPlMVMh[WO2aY\heIlwdg>? MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ3Nke0Okc,OjR4NU[3OFY9N2F-
LMeC NUC2cINyTnWwY4Tpc44hSXO|YYm= NXXPSm9pOjBxNUCg{txO M2ntcFQ5KGh? NYPrdmxncW6mdXPld{Bk[XOyYYPlMVMh[WO2aY\heIlwdg>? MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ3Nke0Okc,OjR4NU[3OFY9N2F-
OVCAR-3 MULD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MWKxNEDDvU1? MlrwNUBp M364OoVvcGGwY3XzJJBi[2yrdHH4[YwucW6mdXPl[EBwfmG{aXHuJINidmOncjDj[YxtKGSnYYToxsA> M4HlOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUKwNlI4Lz5{NEWyNFIzPzxxYU6=
OVCAR-3 MVTBdI9xfG:|aYOgRZN{[Xl? NXLufJhlOTBiwsXN NV\qfpI5OSCq NHfYdmVxem:vb4Tld{Bx[WOuaYThfIVtNWmwZIXj[YQh[XCxcITvd4l{yqB? NGDnSo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWyNFIzPyd-MkS1NlAzOjd:L3G+
OVCAR-3 M1zFfmZ2dmO2aX;uJGF{e2G7 NYGxeWh1OTBiwsXN NILvOpQyKGh? NEH2[2JmdmijbnPld{Bx[WOuaYThfIVtNWmwZIXj[YQh[WO2aY\heIlwdiCxZjDjZZNx[XOnLUpCpC=> NWToPWlURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NlAzOjdpPkK0OVIxOjJ5PD;hQi=>
OVCAR-3 MnjOSpVv[3Srb36gRZN{[Xl? Mm\DNVAhyrWP Mly3NUBp MnLH[I94di2{ZXf1cIF1\XNiTl[t{tpDKGGldHn2ZZRqd25iaX7keYNm\CCkeTDwZYNtcXSjeHXs MmPIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MkCyNlcoRjJ2NUKwNlI4RC:jPh?=
OVCAR-3 NEfjPXRHfW6ldHnvckBCe3OjeR?= MmnTNVAhyrWP M{PIeFEhcA>? NYe0cIlNcW6qaXLpeJMheGGlbHn0ZZhmdC2rbnT1Z4VlKEGtdDDwbI9{eGixconsZZRqd25? MmHUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MkCyNlcoRjJ2NUKwNlI4RC:jPh?=
CF33 NYPHNYwyTnWwY4Tpc44hSXO|YYm= NGHpVlMyODBizszN M4f3WFI1KGh? NXfkeZJFcW6mdXPld{Bld3ewcnXneYxifGmxbjDv[kBEV1hvMjDwdo91\WmwIHX4dJJme3Orb36= MonuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MEO3PFIoRjJ2NUCzO|gzRC:jPh?=
CF33 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LmNVExNTFyMDFOwG0> NHfZXmsxNTRiZB?= NV3hPIlkcW6qaXLpeJMh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz NWnSR5pURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NFM4QDJpPkK0OVA{Pzh{PD;hQi=>
CF33 Ml7HSpVv[3Srb36gRZN{[Xl? M3XvXFExNTFyMDFOwG0> MkexOE0zPCCq Mof6[IVkemWjc3XzJINmdGy|IHnuJJRp\SCVIIDoZZNmKGGwZDDpcoNz\WG|ZYOgZ4VtdHNiaX6gS|AwTzFiYYLy[ZN1 MlTDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MEO3PFIoRjJ2NUCzO|gzRC:jPh?=
LNCaP NVnu[JlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LoT|IwPS9zMDFOwG0> NW\6ZZZKQTZiaB?= NHnWWlZqdmirYnn0d{Bk\WyuIHfyc5d1cCC|aXfubYZq[2GwdHz5JINwdWKrbnXkJJdqfGhiYYTvdpZie3SjdHnu NGG1eGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK5Olk4QCd-MkSyPVY6Pzh:L3G+
LNCaP M2DP[WFxd3C2b4Ppd{BCe3OjeR?= NEXpTIszNzVxMUCg{txO NEH1VHI6PiCq M2HCcIlv\HWlZYOgZZBweHSxc3nzJINwdWKrbnXkJJdqfGhiYYTvdpZie3SjdHnu M3HMeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Mkm2PVc5Lz5{NEK5Olk4QDxxYU6=
PC-3  NH7mXJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLOTlA2OC13MDFOwG0> MVi0PQKBkWh? MYDpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uh\GWyZX7k[Y51KG2jbn7ldi=> NXPDV4pqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxNlc5QDJpPkK0NVI4QDh{PD;hQi=>
PC-3  M3S1bWNmdGxiVnnhZoltcXS7IFHzd4F6 M2T1T|AuOTByIN88US=> MnTiO|IhcA>? NGC2dWJl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlJIRmeGWwZHXueEBu[W6wZYK= MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF{N{i4Nkc,OjRzMke4PFI9N2F-
HCA-7 M{j1N2Z2dmO2aX;uJIF{e2G7 NX7kXW9YPzJiaILz NX\KbWY{UW6qaXLpeIlwdiCxZjDJUE0y[mW2YT3pcoR2[2WmIGDHSVIheHKxZIXjeIlwdiCrbjDoeY1idiCKQ1GtO{Bk\WyuczDh[pRmeiB5MjDodpMh[nliRVnBMEBGSzVyIE2gNE4xODFzNTFOwG0v NFLXSYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkWxOlI5Oid-MkK1NVYzQDJ:L3G+
CHO MYLGeY5kfGmxbjDhd5NigQ>? M3P1XmlvKH[rdILvJIlvcGmkaYTvdpkheG:2ZX7jfUBi\2GrboP0JIh2dWGwIFPPXE0zKGmwIIP0ZYJtgSC2cnHud4Zm[3SnZDDjbIlv\XOnIHjhcZN1\XJib4\hdpkhMEOKTzmgZ4VtdHNuIFnDOVAhRSByLkCwNkDPxE1w Mk\jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB3N{[2PFQoRjFyNUe2Olg1RC:jPh?=
CHO NVXIe|M{TnWwY4Tpc44h[XO|YYm= M4DUXmlvcGmkaYTpc44hd2ZiUFfFMVIheHKxZIXjeIlwdiCrbjDDTG8h[2WubIOg[ZhxemW|c3nu[{BpfW2jbjDDU3guOixiSVO1NEA:KDBwMECyJO69VS5? MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODV5Nk[4OUc,OTB3N{[2PFU9N2F-
CHO MVXGeY5kfGmxbjDhd5NigQ>? MoP3TY4hfmm2cn:gdI91\W6leTDh[4FqdnO2IHj1cYFvKFC{b4P0ZYdt[W6maX6gS{9JKHO7boToZZNmKDJiaX6geJJidnOoZXP0[YQhS0iRIHPlcIx{NCCLQ{WwJF0hOC5yMEKg{txONg>? M13OW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyMUm3PVcxLz5zMEG5O|k4ODxxYU6=
CHO NXnuVnhyTnWwY4Tpc44h[XO|YYm= M1z6NWlvcGmkaYTvdpkhd2ZiaIXtZY4hWHKxc4Th[4xidmSrbjDHM2ghe3mwdHjhd4UhOiCneIDy[ZN{\WRiaX6gR2hQKGOnbHzzMEBKSzVyIE2gNE4xODJizszNMi=> M4nPSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NkSzPVQzLz5zMk[0N|k1OjxxYU6=
synovial cells MXnGeY5kfGmxbjDhd5NigQ>? MUfJcohq[mm2b4L5JIVn\mWldDDvckBxem:mdXP0bY9vKG:oIHP5Z4xwd3i7Z3XuZZNmNTJiKFPPXE0zMSCycn;zeIFodGGwZHnuJGUzKCiSR1WyLUBqdiCqdX3hckBKVDFvYnX0ZUB{fGmvdXzheIVlKHO7bn;2bYFtKGOnbHzzMEBKSzVyIE2gNE4xODd7IN88UU4> NIPmOGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEiyNVcyPid-MUC4NlE4OTZ:L3G+
RAW264.7 MV3GeY5kfGmxbjDhd5NigQ>? NHqzOlVKdmirYnn0bY9vKG:oIFPPXE0zKGmwIH3veZNmKFKDV{K2OE44KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIFzQV{1qdmS3Y3XkJHBITTJicILv[JVkfGmxbjD0doVifGWmIIDybY9zKHSxIFzQV{BkcGGubHXu[4Uh[nliZX76fY1mKGmvbYXuc4F{e2G7LDDJR|UxKD1iMD6wNFg4KM7:TT6= MoXPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[2OlIoRjJ2NkW2OlYzRC:jPh?=
HEK293 MXLGeY5kfGmxbjDhd5NigQ>? MlzITY5pcWKrdHnvckBw\iClbH;u[YQhW3S7bH;wbI9z[SCyaYP0bYxt[XSjIHHsdIhiNUODIHX4dJJme3OnZDDpckBpfW2jbjDISWszQTNiY3XscJMh[nlic4TvdJBm\C2obH;3JGNQOiCjc4PhfUwhU2liPTCwMlA{PDJizszNMi=> M{LwbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NUKwOVc4Lz5zOUWyNFU4PzxxYU6=
SF9 M3LWRWZ2dmO2aX;uJIF{e2G7 NWKwfGNIUW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJHBzd3O2YXfsZY5lcW5iRz;IJJN6dnSqYYPlJFIh\XiycnXzd4VlKGmwIIPmMVkh[2WubIOgbY5n\WO2ZXSge4l1cCCkYXP1cI93cXK3czygTWM2OCB;IECuNFM3KM7:TT6= M{Cy[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2Nkm4NVkxLz5zNE[5PFE6ODxxYU6=
SF9 NUjkOWRYTnWwY4Tpc44h[XO|YYm= M3;VUGlvKH[rdILvJIlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDy[YNwdWKrbnHueEBxem:|dHHncIFv\GmwIFevTEB{gW62aHHz[UAzKGW6cILld5Nm\CCrbjDz[k06KGOnbHzzJIlv\mWldHXkJJdqfGhiYnHjeYxwfmm{dYOsJGlEPTBiPTCwMlA{PiEQvF2u NXG4[mVlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWwNlYxPTBpPkG1NFI3ODVyPD;hQi=>
CHO NUe1SGhETnWwY4Tpc44h[XO|YYm= MlPQTY5pcWKrdHnvckBw\iCFT2iyJIV5eHKnc4Pl[EBqdiCFSF:gZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCjcnHjbIlld26rYzDhZ4llNXO2aX31cIF1\WRiUFfFNkBxem:mdXP0bY9vKGK7IHXufplu\SCrbX31co9ie3OjeTygTWM2OCB;IECuNFM3KM7:TT6= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTV4NkK5NEc,OTV3Nk[yPVA9N2F-
insect cells MX;GeY5kfGmxbjDhd5NigQ>? NYjCbZhmOSCvaX6= NYnMUGt3UW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDDU3gzKGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMhfXOrbnegZZJi[2irZH;ubYMh[WOrZDDhd{B{fWK|dILheIUhcW6ldXLheIVlKG[xcjCxJI1qdiCycnnvdkB1dyC|dXLzeJJifGViYXTkbZRqd25ibXXhd5Vz\WRiZn;yJFI2KHOnY4OgZpkhXE2SRD3iZZNm\CClaILvcY9o\W6rYzDhd5NigSxiSVO1NEA:KDBwMESyJO69VS5? M13vPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEGwNlcxLz5{M{CxNFI4ODxxYU6=
HNSCC 1483 NIrZSoFHfW6ldHnvckBie3OjeR?= Mo[2N|AhdWmwcx?= M1\Qc2lvcGmkaYTpc44hd2ZiQ1;YMVIhcW5iaIXtZY4hUE6VQ1OgNVQ5OyClZXzsd{B2e2mwZzDbNVREZSCjcnHjbIlld26rYzDhZ4llKGG|IIP1ZpN1emG2ZTDwdoVqdmO3YnH0[YQh\m:{IEOwJI1qdnNiYnXmc5JmKHO3YoP0doF1\SCjZHTpeIlwdiCvZXHzeZJm\CCjZoTldkA{OCCvaX7zMEBKSzVyIE2gNE4xPTRizszNMi=> MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ4M{i5OEc,OjJ{NkO4PVQ9N2F-
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RAW264.7 MlrWRY51cWmwZnzhcY1ifG:{eTDhd5NigQ>? NV;OWndKOjBidV2= NGrvSXEzKGi{cx?= NIC3co5CdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViUlHXNlY1NjdiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBNWFNiaX7keYNm\CClb4itNkBmgHC{ZYPzbY9vKGG2IEKwJJVOKHC{ZXnuZ5Vj[XSnZDDmc5IhOiCqcoOg[o9tdG:5ZXSgZpkhVFCVIHPoZYxt\W6pZTDt[YF{fXKnZDDh[pRmeiB{NDDodpMh[nliV3XzeIVzdiCkbH;0JI1mfGixZB?= NWT1R5hDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxNFA4QTlpPkK5NVAxPzl7PD;hQi=>
RAW264.7 MmLoRY51cWmwZnzhcY1ifG:{eTDhd5NigQ>? MnXXNlAhfU1? NYXwW2RHOiCqcoO= NFvxfXNCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViUlHXNlY1NjdiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBNWFNiaX7keYNm\CCrTl;TJIV5eHKnc4Ppc44h[XRiMkCgeW0heHKnaX7jeYJifGWmIH\vdkAzKGi{czDmc4xtd3enZDDifUBNWFNiY3jhcIxmdmenIH3lZZN2emWmIHHmeIVzKDJ2IHjyd{BjgSCZZYP0[ZJvKGKub4SgcYV1cG:m NFr0bmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUGwNFc6QSd-MkmxNFA4QTl:L3G+

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Fibronectin / Vimentin / N-cadherin / E-cadherin ; 

PubMed: 28978083     


(A) Celecoxib treatment reduces the mesenchymal phenotype in SUM149 cells.

COX-2; 

PubMed: 29515134     


L02 cells exposed to PA (200 μM) with different concentrations of celecoxib (Cel, 5-40 μM) for 24 h. Celecoxib decreased protein expression of COX-2 compared with control as indicated by western blot. 

pAKT / AKT / PPARγ / PTEN ; 

PubMed: 24721996     


Immunoblots from N1-S1 cells treated with different dose celecoxib for 48 h. 

28978083 29515134 24721996
Immunofluorescence
PPARγ / PTEN ; 

PubMed: 24721996     


Immunofluorescence analysis in N1-S1 cells treated with 10 μM celecoxib for 48 h.

24721996
Growth inhibition assay
Cell viability; 

PubMed: 28521485     


Celecoxib caused the concentration-dependent inhibition of (A) GBC-SD and (B) NOZ cell growth. 

28521485
In vivo Celecoxib exhibits a potent, oral anti-inflammatory activity. Celecoxib reduces acute inflammation in the carrageenan edema assay and chronic inflammation in the adjuvant arthritis model with ED50 of 7.1 mg/kg and 0.37 mg/kg/day, respectively. In addition, Celecoxib also exhibits analgesic activity in the Hargreaves hyperalgesia model with ED50 of 34.5 mg/kg. Besides, Celecoxib produces no acute GI toxicity in rats at doses up to 200 mg/kg and no chronic GI toxicity in rats at doses up to 600 mg/kg/day over 10 days. [1] In a C3Hf/KamLaw female mouse model, Celecoxib increases median survival time of 105 days (range, 79-145 days) after 13.5 Gy local thoracic irradiation (LTI) alone to 142 days (range, 94-155 days). [3]

Protocol

Kinase Assay:[1]
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COX enzyme assay in vitro:

Expression of COX protein in insect cells is determined by assessing PG-synthetic capability in homogenates from cells incubated for 3 days with COX-1 or COX-2 baculovirus. Cells expressing COX-1 or COX-2 are homogenized and incubated with arachidonic acid (10 μM). COX activity is determined by monitoring PG production. No COX activity is detected in mock-infected Sf9 cells. Celecoxib are preincubated with crude 1% CHAPS homogenates (2-10 μg of protein) for 10 minutes before addition of arachidonic acid. PGE2 formed is detected by ELISA after 10 minute incubation.
Cell Research:[2]
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  • Cell lines: HNE1 and CNE1-LMP1
  • Concentrations: 0-75 μM
  • Incubation Time: 48 hours
  • Method: The antiproliferative effect of Celecoxib on NPC cells is assessed using an MTT assay. Cells are seeded into 96-well plates and allowed to attach for 24 hours. The cells are then treated with increasing concentrations of Celecoxib (0 to 75 μM) dissolved in DMSO (final concentration ≤0.1%) and incubated for up to 48 hours. After the incubation, 20 μL of MTT dye (5 mg/mL) are added to each well and cells are incubated at 37 °C for 4 hours. After removing the supernatants, the crystals are dissolved in DMSO and the absorbance is measured at 490 nm. The half-maximal inhibitory concentration (IC50) values and the 95% confidence intervals are calculated using probit regression using SPSS 15.0 software. The experiment is performed in triplicate and repeated at least three times.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: A 0.1 mL aliquot of a 1% solution of carrageenan in 0.9% sterile saline or 1 mg of Mycobacterium butyricum in 50 μL of mineral oil is administered to the right hind foot pad of male Sprague−Dawley rats.
  • Dosages: ≤200 mg/kg
  • Administration: Administered via p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 76 mg/mL (199.28 mM)
Water Insoluble
Ethanol '33 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 381.37
Formula

C17H14F3N3O2S

CAS No. 169590-42-5
Storage powder
in solvent
Synonyms N/A
Smiles CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01344200 Not yet recruiting Drug: Celecoxib|Drug: Placebo Pharmacokinetics of Celecoxib in Children Children''s Hospital of Eastern Ontario January 2022 Phase 2
NCT04526197 Completed Drug: ALXN1840|Drug: Celecoxib Wilson Disease Alexion Pharmaceuticals July 8 2020 Phase 1
NCT04447261 Completed Drug: BI 1356225|Drug: Placebo Obesity Boehringer Ingelheim June 30 2020 Phase 1
NCT03896113 Recruiting Drug: Celecoxib 200mg capsule Endometrium Cancer Cliniques universitaires Saint-Luc- Université Catholique de Louvain November 13 2019 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    I am doing an animal experiment with mice and planning to administrate S1261 via oral gavage. what are your recommendations for diluting the compound?

  • Answer:

    For oral administration, Celecoxib can be dissolved in vehicle one: "0.5% methyl cellulose and 0.025% Tween-20", or the vehicle 2 "2% DMSO/30% PEG 300/5% Tween 80/ ddH2O".

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID