Celecoxib (SC 58635)

Licensed by Pfizer Catalog No.S1261

For research use only.

Celecoxib (SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.

Celecoxib (SC 58635) Chemical Structure

CAS No. 169590-42-5

Selleck's Celecoxib (SC 58635) has been cited by 78 publications

Purity & Quality Control

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Biological Activity

Description Celecoxib (SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.
Targets
COX-2 [1]
(Sf9 cells)
40 nM
In vitro

Celecoxib shows low sensitivity against COX-1 with IC50 of 15 μM. [1] Celecoxib shows an anti-proliferative effect on nasopharyngeal carcinoma (NPC) cell lines including HNE1 and CNE1-LMP1 with IC50 of 32.86 μM and 61.31 μM, respectively. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 MXzGeY5kfGmxbjDBd5NigQ>? NWjF[4x[OC5zLUOwJO69VQ>? MUm0PEBp NEjIdJRqdmS3Y3XzJGlESU1vMTDlfJBz\XO|aX;uJI9vKGKxdHigdJJwfGWrbjDhcoQhdVKQQTDs[ZZmdA>? MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjVzM{G3Nkc,OjZ3MUOxO|I9N2F-
H460 M2CzVmZ2dmO2aX;uJGF{e2G7 MY[wMlEuOzBizszN M3LnZlQ5KGh? MU\pcoR2[2W|IFnDRW0uOSCneIDy[ZN{cW:wIH;uJIJwfGhicILveIVqdiCjbnSgcXJPSSCuZY\lcC=> NUPEU5FlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1NVMyPzJpPkK2OVE{OTd{PD;hQi=>
HKESC-2 NWi2bY81T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmT6NlDDqM7:TR?= NVfDdZhDPDkEoHlCpC=> MUXzbYdvcW[rY3HueIx6KGmwY4LlZZNmeyC2aHWgTWM2OMLidnHseYV{KG:oIH;4ZYxqeGyjdHnuxsA> NWDqT2I3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0O|Q3QTNpPkK2OFc1Pjl|PD;hQi=>
CaES-17 NWPqOnlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M135TlIxyqEQvF2= NYXKUIYxPDkEoHlCpC=> NYrPW3JKe2mpbnnmbYNidnSueTDpcoNz\WG|ZYOgeIhmKEmFNUFCpJZidHWnczDv[kBwgGGuaYDsZZRqdsLi Mm[yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2N{S2PVMoRjJ4NEe0Olk{RC:jPh?=
HKESC-2 NFXlVIZCeG:ydH;zbZMhSXO|YYm= NInFbFIzOMLizszN M1rYUVQ5yqCqwrC= NHfVOYFz\WS3Y3XzJI95[WyrcHzheIlvNWmwZIXj[YQh[XCxcITvd4l{ Ml7tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2N{S2PVMoRjJ4NEe0Olk{RC:jPh?=
CaES-17 MkPHRZBweHSxc3nzJGF{e2G7 M3nRdlIxyqEQvF2= MXi0POKhcMLi NITnWVlz\WS3Y3XzJI95[WyrcHzheIlvNWmwZIXj[YQh[XCxcITvd4l{ NWrlOW95RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0O|Q3QTNpPkK2OFc1Pjl|PD;hQi=>
A549 M3[wNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HEWlUuOTZyIN88US=> MYS0POKhcMLi NWTncXRSTE2VTx?= NEXIbGVKSzVyPUG2N{41KM7:TR?= NVu5cXhzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0OlQ3PDNpPkK2OFY1PjR|PD;hQi=>
HCC827 NH\nbWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGexfGc2NTF4MDFOwG0> NIDxNIM1QMLiaNMg NFjsbGRFVVOR NFXHSoRKSzVyPU[5MlIh|ryP NVvVfGt{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0OlQ3PDNpPkK2OFY1PjR|PD;hQi=>
A549 MmrzRZBweHSxc3nzJGF{e2G7 NHL5Noo5OCEEtV2= M1rUblQ5yqCqwrC= NF7SbYhFVVOR Ml:wbY5lfWOnczDhdI9xfG:|aYO= MlSxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2NkS2OFMoRjJ4NE[0OlQ{RC:jPh?=
HCC827 MXnBdI9xfG:|aYOgRZN{[Xl? MnrzPFAhyrWP MoHHOFjDqGkEoB?= NWjKUWEzTE2VTx?= NF70fXBqdmS3Y3XzJIFxd3C2b4Ppdy=> M2nuWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NE[0OlQ{Lz5{NkS2OFY1OzxxYU6=
SGC-7901/DDP NGTOeFdHfW6ldHnvckBCe3OjeR?= NYXBSXlsOTEEoNM1US=> NHzDblczPCCq MojxbY5pcWKrdIOgZ5lkdG:xeInn[Y5ie2VvMjDhcoQhWC2pbInjc5Bzd3SnaX6g[ZhxemW|c3nvci=> MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjRyN{[1N{c,OjZ2MEe2OVM9N2F-
SGC-7901  NF;RUpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\TNlTDqGkEoB?= MnPHTWM2OD1zMUWuNFgh|ryP Mm\pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2MEe2OVMoRjJ4NEC3OlU{RC:jPh?=
SGC-7901/DDP MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTjNlTDqGkEoB?= M3jPTWlEPTB;M{WuOFUh|ryP NI[0WHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkSwO|Y2Oyd-Mk[0NFc3PTN:L3G+
SGC-7901/DDP MUDBdI9xfG:|aYOgRZN{[Xl? MlzhNVDDqML3TR?= MlK3NlQhcA>? M{KxUYlv\HWlZYOgZZBweHSxc3nzJINwdWKrbnXkJJdqfGhid3n0bEBkcXOybHH0bY4> M16xRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NEC3OlU{Lz5{NkSwO|Y2OzxxYU6=
SGC-7901/DDP M334TWZ2dmO2aX;uJGF{e2G7 NYLvSmE6OTEEoNM1US=> NUX0UlN7OjRiaB?= NF3Qd|RqdmirYnn0d{B1cGViZYjwdoV{e2mxbjDv[kBRNWeueXPvdJJwfGWrbjD0bJJwfWeqIHLsc4NscW6pIFXQNkwh[W6mIHnuZYN1cX[jdHnu[{BRU0FiYX7kJGNTTUMEoB?= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjRyN{[1N{c,OjZ2MEe2OVM9N2F-
SGC-7901/DDP NUi0PFNpTnWwY4Tpc44hSXO|YYm= NGK2UmwyOMLiwsXN NHHGcmQzPCCq M1;2OYNifXOnczDhJI1iemunZDDk[YNz\WG|ZTDpckB1cGVibHX2[Ywhd2ZiQnPsMVIheHKxdHXpci=> M1u1RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NEC3OlU{Lz5{NkSwO|Y2OzxxYU6=
H357 M3;BWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\5O{42NzFyIN88US=> MXm0PEBp NWLmPZQ2TE2VTx?= M4rVb4lvcGmkaYTzJINmdGxiZ4Lve5RpyqClb33ibY5m\CC5aYToJHNi[nW2b3PsZZg> MkP5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyMEm4O|QoRjJ4MEC5PFc1RC:jPh?=
TAF M16yRmZ2dmO2aX;uJGF{e2G7 MWWxNOKhyrWP MXi3JIQ> NXLKZ5lH[W[oZXP0d{BVSU[|IHHkbIV{cX[nIIDyc5BmenSrZYO= NHTDeHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUm4O|EzPyd-MkW5PFcyOjd:L3G+
TAF MlXjSpVv[3Srb36gRZN{[Xl? Mlj0NVDDqML3TR?= MkS1N|AuOTJyIH3pci=> M4HoVpBwd3KueTDh[oZm[3S|IHTBb5QheGixc4Doc5J6dGG2aX;uJINwdnOncYXlcpQhfG9iRVfGJJNq\26jbHnu[y=> MkC5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7OEexNlcoRjJ3OUi3NVI4RC:jPh?=
TAF NXjsTGhrTnWwY4Tpc44hSXO|YYm= NHnKW4YyOMLiwsXN M4jqNlQ5KGh? M4rXbIlv[3KnYYPld{BGT0[UIH3SUmEh[W6mIIDyc5RmcW5iZYjwdoV{e2mxbh?= MoLOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7OEexNlcoRjJ3OUi3NVI4RC:jPh?=
PANC-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;EU4x2OjBxNkCvNVAxKM7:TR?= MX6yOE81QC95MjDo NEXXOXFqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDic5RpKHSrbXWgZY5lKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= M3W4OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUezNFYzLz5{NUm3N|A3OjxxYU6=
PANC-1 NEX1cG9HfW6ldHnvckBCe3OjeR?= M3P3U|IxNzZyL{GwNEDPxE1? NWjyb4xxOjRiaB?= MXvheJRmdnWjdIOgZ4VtdCCrbo\hd4lwdiCjbnSgcYloemG2aX;uJIlvKGFiY3;uZ4VvfHKjdHnvck1l\XCnbnTlcpQhdWGwbnXyxsA> NXjEU4lKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5O|MxPjJpPkK1PVc{ODZ{PD;hQi=>
HeLa  NGPOSXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PBVFIxyqEQvF5CpC=> M3;RbFI1yqCq MmTX[Y5p[W6lZYOgdoFlcWG2aX;uMYlv\HWlZXSgbY5pcWKrdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25? MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd5MESyN{c,OjV5N{C0NlM9N2F-
SACC-83 MmHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7VNlDDqM7:TdMg NVPMSGFoOjUEoHi= MUPlcohidmOnczDyZYRq[XSrb36tbY5lfWOnZDDpcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdg>? M{npcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{ewOFI{Lz5{NUe3NFQzOzxxYU6=
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SACC-83 NHL4eJpCeG:ydH;zbZMhSXO|YYm= NWjYfpNtOjEEoN88UeKh NIrob3EzPMLiaB?= MojZ[Y5p[W6lZYOgdoFlcWG2aX;uMYlv\HWlZXSgbY5pcWKrdHnvckBw\iClZXzsJIFxd3C2b4Ppdy=> MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd5MESyN{c,OjV5N{C0NlM9N2F-
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LMeC  M{XWVGZ2dmO2aX;uJGF{e2G7 NUDsTWUzOjBxNUCg{txO MXe0PEBp NGnD[VBl\WO{ZXHz[ZMhfGinIHX4dJJme3Orb36gc4YhS0:[LUKgdJJwfGWrbh?= MlfPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O|Q3RC:jPh?=
CMeC-1 MXvD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MmHxNlAwPTBizszN MnvjOFghcA>? MlTpbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHliaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? NWXMXm5yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OVY4PDZpPkK0OlU3PzR4PD;hQi=>
LMeC NUHsbWZUS2WubDDWbYFjcWyrdImgRZN{[Xl? NV;GXJl2OjBxNUCg{txO MVu0PEBp MWfpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? M{TmXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkW2O|Q3Lz5{NE[1Olc1PjxxYU6=
CMeC-1 MkP0SpVv[3Srb36gRZN{[Xl? MViyNE82OCEQvF2= NFnOSHM1QCCq MU\pcoR2[2W|IFexMXMh[XK{ZYP0 Mlz2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O|Q3RC:jPh?=
LMeC MnTISpVv[3Srb36gRZN{[Xl? NXLrPWE1OjBxNUCg{txO MWW0PEBp M4j2Uolv\HWlZYOgS|EuWyCjcoLld5Q> NFvRcWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[1Olc1Pid-MkS2OVY4PDZ:L3G+
CMeC-1 MnnJSpVv[3Srb36gRZN{[Xl? MXKyNE82OCEQvF2= NFLDcpo1QCCq M4H1XoRm[3KnYYPld{B1cGVibHX2[Yx{KG:oIHP5Z4xqdiCGMTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= M3PNXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkW2O|Q3Lz5{NE[1Olc1PjxxYU6=
LMeC MXzGeY5kfGmxbjDBd5NigQ>? NUD6cJlKOjBxNUCg{txO MoTrOFghcA>? M1[zRoRm[3KnYYPld{B1cGVibHX2[Yx{KG:oIHP5Z4xqdiCGMTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= M3:x[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkW2O|Q3Lz5{NE[1Olc1PjxxYU6=
CMeC-1 NFPZSpRHfW6ldHnvckBCe3OjeR?= MV6yNE82OCEQvF2= MX:0PEBp NUP1WnVVcW6mdXPld{Bk[XOyYYPlMVMh[WO2aY\heIlwdg>? NXSxTJZlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OVY4PDZpPkK0OlU3PzR4PD;hQi=>
LMeC NUfrPWRrTnWwY4Tpc44hSXO|YYm= NHjDU4QzOC93MDFOwG0> NY\ybFJRPDhiaB?= Mmq5bY5lfWOnczDjZZNx[XOnLUOgZYN1cX[jdHnvci=> MmfUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O|Q3RC:jPh?=
OVCAR-3 MoLSR4VtdCCYaXHibYxqfHliQYPzZZk> M3;JblExKML3TR?= NFuzZ5gyKGh? NUf5cmp3\W6qYX7j[ZMheGGlbHn0ZZhmdC2rbnT1Z4VlKG:4YYLpZY4h[2GwY3XyJINmdGxiZHXheIjDqA>? M3jCWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUKwNlI4Lz5{NEWyNFIzPzxxYU6=
OVCAR-3 NUPnSZc6SXCxcITvd4l{KEG|c3H5 MYOxNEDDvU1? Ml[5NUBp M3TLVZBzd22xdHXzJJBi[2yrdHH4[YwucW6mdXPl[EBieG:ydH;zbZPDqA>? MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV{MEKyO{c,OjR3MkCyNlc9N2F-
OVCAR-3 NF;FeHJHfW6ldHnvckBCe3OjeR?= NGPIZmgyOCEEtV2= M37sNlEhcA>? M3PlOYVvcGGwY3XzJJBi[2yrdHH4[YwucW6mdXPl[EBi[3SrdnH0bY9vKG:oIHPhd5Bie2VvOdMg Mn;iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MkCyNlcoRjJ2NUKwNlI4RC:jPh?=
OVCAR-3 NX;TXHd6TnWwY4Tpc44hSXO|YYm= MWGxNEDDvU1? M33h[|EhcA>? MVLkc5dvNXKnZ4XsZZRmeyCQRj5OvmIh[WO2aY\heIlwdiCrbnT1Z4VlKGK7IIDhZ4xqfGG6ZXy= MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV{MEKyO{c,OjR3MkCyNlc9N2F-
OVCAR-3 NV3OXVNSTnWwY4Tpc44hSXO|YYm= M2HiTlExKML3TR?= NEf3WZYyKGh? MX\pcohq[mm2czDwZYNtcXSjeHXsMYlv\HWlZXSgRYt1KHCqb4PwbI9zgWyjdHnvci=> M{TlO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUKwNlI4Lz5{NEWyNFIzPzxxYU6=
CF33 NYWydoFtTnWwY4Tpc44hSXO|YYm= MXuxNFAh|ryP MnjENlQhcA>? NEDuXG9qdmS3Y3XzJIRwf26{ZXf1cIF1cW:wIH;mJGNQYC1{IIDyc5RmcW5iZYjwdoV{e2mxbh?= NHWzWHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWwN|c5Oid-MkS1NFM4QDJ:L3G+
CF33 NF\3cG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nXZlExNTFyMDFOwG0> M1r2flAuPCCm MYDpcohq[mm2czDj[YxtKHC{b3zp[oVz[XSrb36gbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= M{nSVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUCzO|gzLz5{NEWwN|c5OjxxYU6=
CF33 NX7iOoRETnWwY4Tpc44hSXO|YYm= NGTQWW0yOC1zMECg{txO NH3xVYI1NTJ2IHi= NU\C[mY2\GWlcnXhd4V{KGOnbHzzJIlvKHSqZTDTJJBp[XOnIHHu[EBqdmO{ZXHz[ZMh[2WubIOgbY4hTzBxR{GgZZJz\XO2 MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVyM{e4Nkc,OjR3MEO3PFI9N2F-
LNCaP M1PIeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LNSVIwPS9zMDFOwG0> NUTFZm5PQTZiaB?= M{HDSYlvcGmkaYTzJINmdGxiZ4Lve5RpKHOrZ37p[olk[W62bImgZ49u[mmwZXSge4l1cCCjdH;yeoF{fGG2aX6= M1zKc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Mkm2PVc5Lz5{NEK5Olk4QDxxYU6=
LNCaP MULBdI9xfG:|aYOgRZN{[Xl? NGTYRXkzNzVxMUCg{txO NEXaSWY6PiCq MmPkbY5lfWOnczDhdI9xfG:|aYOgZ49u[mmwZXSge4l1cCCjdH;yeoF{fGG2aX6= M2TPZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Mkm2PVc5Lz5{NEK5Olk4QDxxYU6=
PC-3  NYLHSZNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVSwMVUxKM7:TR?= MlTGOFjjiImq NVvyW29XcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? NWH2R|dyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxNlc5QDJpPkK0NVI4QDh{PD;hQi=>
PC-3  NFTCXo1E\WyuIG\pZYJqdGm2eTDBd5NigQ>? M3X1U|AuOTByIN88US=> NXryeG96PzJiaB?= M3rDSoRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= NHvEXJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGyO|g5Oid-MkSxNlc5QDJ:L3G+
HCA-7 NGTNdJhHfW6ldHnvckBie3OjeR?= NHG1R4g4OiCqcoO= MUfJcohq[mm2aX;uJI9nKEmOLUHi[ZRiNWmwZIXj[YQhWEeHMjDwdo9lfWO2aX;uJIlvKGi3bXHuJGhESS15IHPlcIx{KGGodHXyJFczKGi{czDifUBGUUFuIFXDOVAhRSByLkCwNVE2KM7:TT6= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjVzNkK4Nkc,OjJ3MU[yPFI9N2F-
CHO M2XmSGZ2dmO2aX;uJIF{e2G7 M3LkWmlvKH[rdILvJIlvcGmkaYTvdpkheG:2ZX7jfUBi\2GrboP0JIh2dWGwIFPPXE0zKGmwIIP0ZYJtgSC2cnHud4Zm[3SnZDDjbIlv\XOnIHjhcZN1\XJib4\hdpkhMEOKTzmgZ4VtdHNuIFnDOVAhRSByLkCwNkDPxE1w NFfndJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEW3OlY5PCd-MUC1O|Y3QDR:L3G+
CHO MXPGeY5kfGmxbjDhd5NigQ>? MmmwTY5pcWKrdHnvckBw\iCSR1WtNkBxem:mdXP0bY9vKGmwIFPIU{Bk\WyuczDlfJBz\XO|aX7nJIh2dWGwIFPPXE0zNCCLQ{WwJF0hOC5yMEKg{txONg>? Mn73QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB3N{[2PFUoRjFyNUe2Olg2RC:jPh?=
CHO NXTEVHRjTnWwY4Tpc44h[XO|YYm= NInrSJVKdiC4aYTyc{Bxd3SnbnP5JIFo[Wmwc4SgbJVu[W5iUILvd5Ri\2yjbnTpckBIN0hic4nueIhie2ViMjDpckB1emGwc3\lZ5Rm\CCFSF:gZ4VtdHNuIFnDOVAhRSByLkCwNkDPxE1w MnGxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTBzOUe5O|AoRjFyMUm3PVcxRC:jPh?=
CHO NV:0[WdHTnWwY4Tpc44h[XO|YYm= M{\wNWlvcGmkaYTvdpkhd2ZiaIXtZY4hWHKxc4Th[4xidmSrbjDHM2ghe3mwdHjhd4UhOiCneIDy[ZN{\WRiaX6gR2hQKGOnbHzzMEBKSzVyIE2gNE4xODJizszNMi=> MljnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4NEO5OFIoRjF{NkSzPVQzRC:jPh?=
synovial cells NVvwO2ZGTnWwY4Tpc44h[XO|YYm= NFGyVllKdmirYnn0c5J6KGWoZnXjeEBwdiCycn;keYN1cW:wIH;mJIN6[2yxb4j5[4Vv[XOnLUKgLGNQYC1{KTDwdo9{fGGpbHHu[IlvKEV{IDjQS2UzMSCrbjDoeY1idiCLTEGtZoV1[SC|dHnteYxifGWmIIP5co93cWGuIHPlcIx{NCCLQ{WwJF0hOC5yMEe5JO69VS5? MlHEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB6MkG3NVYoRjFyOEKxO|E3RC:jPh?=
RAW264.7 NWPDWYluTnWwY4Tpc44h[XO|YYm= NWLQVFYyUW6qaXLpeIlwdiCxZjDDU3guOiCrbjDtc5V{\SCUQWeyOlQvPyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDMVHMucW6mdXPl[EBRT0V{IIDyc4R2[3Srb36geJJm[XSnZDDwdolweiC2bzDMVHMh[2ijbHzlcodmKGK7IHXufplu\SCrbX31co9ie3OjeTygTWM2OCB;IECuNFA5PyEQvF2u MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ3Nk[2Nkc,OjR4NU[2OlI9N2F-
HEK293 M1O3bmZ2dmO2aX;uJIF{e2G7 NEm3bY9KdmirYnn0bY9vKG:oIHPsc45m\CCVdInsc5Bpd3KjIIDpd5RqdGyjdHGgZYxxcGFvQ1Gg[ZhxemW|c3XkJIlvKGi3bXHuJGhGUzJ7MzDj[YxteyCkeTDzeI9xeGWmLX\sc5chS09{IHHzd4F6NCCNaTC9JFAvODN2MjFOwG0v M1XlWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NUKwOVc4Lz5zOUWyNFU4PzxxYU6=
SF9 MlvTSpVv[3Srb36gZZN{[Xl? MVrJcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUILvd5Ri\2yjbnTpckBIN0hic4nueIhie2ViMjDlfJBz\XO|ZXSgbY4he2ZvOTDj[YxteyCrbn\lZ5Rm\CC5aYToJIJi[3Wub4\pdpV{NCCLQ{WwJF0hOC5yM{[g{txONg>? MnL0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR4OUixPVAoRjF2Nkm4NVkxRC:jPh?=
SF9 MkjHSpVv[3Srb36gZZN{[Xl? NH;PcIxKdiC4aYTyc{BqdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhcHWvYX6gdoVkd22kaX7hcpQheHKxc4Th[4xidmSrbjDHM2ghe3mwdHjhd4UhOiCneIDy[ZN{\WRiaX6gd4YuQSClZXzsd{Bqdm[nY4Tl[EB4cXSqIHLhZ5Vtd3[rcoXzMEBKSzVyIE2gNE4xOzZizszNMi=> MoGzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTVyMk[wOVAoRjF3MEK2NFUxRC:jPh?=
CHO NWnhTIM6TnWwY4Tpc44h[XO|YYm= Mn3lTY5pcWKrdHnvckBw\iCFT2iyJIV5eHKnc4Pl[EBqdiCFSF:gZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCjcnHjbIlld26rYzDhZ4llNXO2aX31cIF1\WRiUFfFNkBxem:mdXP0bY9vKGK7IHXufplu\SCrbX31co9ie3OjeTygTWM2OCB;IECuNFM3KM7:TT6= NWrSPYtuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW1OlYzQTBpPkG1OVY3OjlyPD;hQi=>
insect cells NF7UPXNHfW6ldHnvckBie3OjeR?= MUWxJI1qdg>? MkPsTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCFT2iyJIV5eHKnc4Pl[EBqdiCrboPlZ5Qh[2WubIOgeZNqdmdiYYLhZ4hq\G:waXOgZYNq\CCjczDzeYJ{fHKjdHWgbY5kfWKjdHXkJIZweiBzIH3pckBxemmxcjD0c{B{fWK|dILheIUh[WSmaYTpc44hdWWjc4Xy[YQh\m:{IEK1JJNm[3NiYomgWG1RTC2kYYPl[EBkcHKxbX;n[Y5q[yCjc4PhfUwhUUN3MDC9JFAvODR{IN88UU4> NGnnSYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxNFI4OCd-MkOwNVAzPzB:L3G+
HNSCC 1483 NYq5WYdxTnWwY4Tpc44h[XO|YYm= NI\uVlg{OCCvaX7z MoXMTY5pcWKrdHnvckBw\iCFT2itNkBqdiCqdX3hckBJVlOFQzCxOFg{KGOnbHzzJJV{cW6pIGuxOGNeKGG{YXPobYRwdmmlIHHjbYQh[XNic4Xid5Rz[XSnIIDy[Ylv[3WkYYTl[EBnd3JiM{CgcYlveyCkZX\vdoUhe3Wkc4TyZZRmKGGmZHn0bY9vKG2nYYP1doVlKGGodHXyJFMxKG2rboOsJGlEPTBiPTCwMlA2PCEQvF2u NYLqUGJxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyOlM5QTRpPkKyNlY{QDl2PD;hQi=>
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Assay
Methods Test Index PMID
Western blot Fibronectin / Vimentin / N-cadherin / E-cadherin ; COX-2 ; pAKT / AKT / PPARγ / PTEN 28978083 29515134 24721996
Immunofluorescence PPARγ / PTEN 24721996
Growth inhibition assay Cell viability 28521485
In vivo Celecoxib exhibits a potent, oral anti-inflammatory activity. Celecoxib reduces acute inflammation in the carrageenan edema assay and chronic inflammation in the adjuvant arthritis model with ED50 of 7.1 mg/kg and 0.37 mg/kg/day, respectively. In addition, Celecoxib also exhibits analgesic activity in the Hargreaves hyperalgesia model with ED50 of 34.5 mg/kg. Besides, Celecoxib produces no acute GI toxicity in rats at doses up to 200 mg/kg and no chronic GI toxicity in rats at doses up to 600 mg/kg/day over 10 days. [1] In a C3Hf/KamLaw female mouse model, Celecoxib increases median survival time of 105 days (range, 79-145 days) after 13.5 Gy local thoracic irradiation (LTI) alone to 142 days (range, 94-155 days). [3]

Protocol (from reference)

Kinase Assay:[1]
  • COX enzyme assay in vitro:

    Expression of COX protein in insect cells is determined by assessing PG-synthetic capability in homogenates from cells incubated for 3 days with COX-1 or COX-2 baculovirus. Cells expressing COX-1 or COX-2 are homogenized and incubated with arachidonic acid (10 μM). COX activity is determined by monitoring PG production. No COX activity is detected in mock-infected Sf9 cells. Celecoxib are preincubated with crude 1% CHAPS homogenates (2-10 μg of protein) for 10 minutes before addition of arachidonic acid. PGE2 formed is detected by ELISA after 10 minute incubation.

Cell Research:[2]
  • Cell lines: HNE1 and CNE1-LMP1
  • Concentrations: 0-75 μM
  • Incubation Time: 48 hours
  • Method: The antiproliferative effect of Celecoxib on NPC cells is assessed using an MTT assay. Cells are seeded into 96-well plates and allowed to attach for 24 hours. The cells are then treated with increasing concentrations of Celecoxib (0 to 75 μM) dissolved in DMSO (final concentration ≤0.1%) and incubated for up to 48 hours. After the incubation, 20 μL of MTT dye (5 mg/mL) are added to each well and cells are incubated at 37 °C for 4 hours. After removing the supernatants, the crystals are dissolved in DMSO and the absorbance is measured at 490 nm. The half-maximal inhibitory concentration (IC50) values and the 95% confidence intervals are calculated using probit regression using SPSS 15.0 software. The experiment is performed in triplicate and repeated at least three times.
  • (Only for Reference)
Animal Research:[1]
  • Animal Models: A 0.1 mL aliquot of a 1% solution of carrageenan in 0.9% sterile saline or 1 mg of Mycobacterium butyricum in 50 μL of mineral oil is administered to the right hind foot pad of male Sprague−Dawley rats.
  • Dosages: ≤200 mg/kg
  • Administration: Administered via p.o.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 76 mg/mL
(199.28 mM)
Water Insoluble
Ethanol '33 mg/mL

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.

5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 381.37
Formula

C17H14F3N3O2S

CAS No. 169590-42-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01344200 Not yet recruiting Drug: Celecoxib|Drug: Placebo Pharmacokinetics of Celecoxib in Children Children''s Hospital of Eastern Ontario January 2022 Phase 2
NCT04526197 Completed Drug: ALXN1840|Drug: Celecoxib Wilson Disease Alexion Pharmaceuticals July 8 2020 Phase 1
NCT04447261 Completed Drug: BI 1356225|Drug: Placebo Obesity Boehringer Ingelheim June 30 2020 Phase 1
NCT03896113 Recruiting Drug: Celecoxib 200mg capsule Endometrium Cancer Cliniques universitaires Saint-Luc- Université Catholique de Louvain November 13 2019 Phase 2

(data from https://clinicaltrials.gov, updated on 2021-09-06)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
I am doing an animal experiment with mice and planning to administrate S1261 via oral gavage. what are your recommendations for diluting the compound?

Answer:
For oral administration, Celecoxib can be dissolved in vehicle one: "0.5% methyl cellulose and 0.025% Tween-20", or the vehicle 2 "2% DMSO/30% PEG 300/5% Tween 80/ ddH2O".

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