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Celecoxib (SC 58635)

Name: Celecoxib (SC 58635)
Brand: Selleck Chemicals
SKU: S1261
Rating: 5 (78 reviews)

Licensed by Pfizer Catalog No.S1261

For research use only.

Celecoxib (SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.

CAS No. 169590-42-5

Selleck's Celecoxib (SC 58635) has been cited by 78 publications

Purity & Quality Control

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Related Compound Libraries

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COX Signaling Pathway Map

Biological Activity

Description

Celecoxib (SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.

Targets

COX-2 ^[1]
(Sf9 cells)

40 nM

In vitro

Celecoxib shows low sensitivity against COX-1 with IC50 of 15 μM. ^[1] Celecoxib shows an anti-proliferative effect on nasopharyngeal carcinoma (NPC) cell lines including HNE1 and CNE1-LMP1 with IC50 of 32.86 μM and 61.31 μM, respectively. ^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

A549	MXzGeY5kfGmxbjDBd5NigQ>?	NWjF[4x[OC5zLUOwJO69VQ>?	MUm0PEBp		NEjIdJRqdmS3Y3XzJGlESU1vMTDlfJBz\XO\|aX;uJI9vKGKxdHigdJJwfGWrbjDhcoQhdVKQQTDs[ZZmdA>?	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjVzM{G3Nkc,OjZ3MUOxO\|I9N2F-
H460	M2CzVmZ2dmO2aX;uJGF{e2G7	MY[wMlEuOzBizszN	M3LnZlQ5KGh?		MU\pcoR2[2W\|IFnDRW0uOSCneIDy[ZN{cW:wIH;uJIJwfGhicILveIVqdiCjbnSgcXJPSSCuZY\lcC=>	NUPEU5FlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1NVMyPzJpPkK2OVE{OTd{PD;hQi=>
HKESC-2	NWi2bY81T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmT6NlDDqM7:TR?=	NVfDdZhDPDkEoHlCpC=>		MUXzbYdvcW[rY3HueIx6KGmwY4LlZZNmeyC2aHWgTWM2OMLidnHseYV{KG:oIH;4ZYxqeGyjdHnuxsA>	NWDqT2I3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0O\|Q3QTNpPkK2OFc1Pjl\|PD;hQi=>
CaES-17	NWPqOnlXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M135TlIxyqEQvF2=	NYXKUIYxPDkEoHlCpC=>		NYrPW3JKe2mpbnnmbYNidnSueTDpcoNz\WG\|ZYOgeIhmKEmFNUFCpJZidHWnczDv[kBwgGGuaYDsZZRqdsLi	Mm[yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2N{S2PVMoRjJ4NEe0Olk{RC:jPh?=
HKESC-2	NFXlVIZCeG:ydH;zbZMhSXO\|YYm=	NInFbFIzOMLizszN	M1rYUVQ5yqCqwrC=		NHfVOYFz\WS3Y3XzJI95[WyrcHzheIlvNWmwZIXj[YQh[XCxcITvd4l{	Ml7tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2N{S2PVMoRjJ4NEe0Olk{RC:jPh?=
CaES-17	MkPHRZBweHSxc3nzJGF{e2G7	M3nRdlIxyqEQvF2=	MXi0POKhcMLi		NITnWVlz\WS3Y3XzJI95[WyrcHzheIlvNWmwZIXj[YQh[XCxcITvd4l{	NWrlOW95RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0O\|Q3QTNpPkK2OFc1Pjl\|PD;hQi=>
A549	M3[wNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4HEWlUuOTZyIN88US=>	MYS0POKhcMLi	NWTncXRSTE2VTx?=	NEXIbGVKSzVyPUG2N{41KM7:TR?=	NVu5cXhzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0OlQ3PDNpPkK2OFY1PjR\|PD;hQi=>
HCC827	NH\nbWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGexfGc2NTF4MDFOwG0>	NIDxNIM1QMLiaNMg	NFjsbGRFVVOR	NFXHSoRKSzVyPU[5MlIh\|ryP	NVvVfGt{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0OlQ3PDNpPkK2OFY1PjR\|PD;hQi=>
A549	MmrzRZBweHSxc3nzJGF{e2G7	NHL5Noo5OCEEtV2=	M1rUblQ5yqCqwrC=	NF7SbYhFVVOR	Ml:wbY5lfWOnczDhdI9xfG:\|aYO=	MlSxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2NkS2OFMoRjJ4NE[0OlQ{RC:jPh?=
HCC827	MXnBdI9xfG:\|aYOgRZN{[Xl?	MnrzPFAhyrWP	MoHHOFjDqGkEoB?=	NWjKUWEzTE2VTx?=	NF70fXBqdmS3Y3XzJIFxd3C2b4Ppdy=>	M2nuWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NE[0OlQ{Lz5{NkS2OFY1OzxxYU6=
SGC-7901/DDP	NGTOeFdHfW6ldHnvckBCe3OjeR?=	NYXBSXlsOTEEoNM1US=>	NHzDblczPCCq		MojxbY5pcWKrdIOgZ5lkdG:xeInn[Y5ie2VvMjDhcoQhWC2pbInjc5Bzd3SnaX6g[ZhxemW\|c3nvci=>	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjRyN{[1N{c,OjZ2MEe2OVM9N2F-
SGC-7901	NF;RUpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		Mo\TNlTDqGkEoB?=		MnPHTWM2OD1zMUWuNFgh\|ryP	Mm\pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2MEe2OVMoRjJ4NEC3OlU{RC:jPh?=
SGC-7901/DDP	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MkTjNlTDqGkEoB?=		M3jPTWlEPTB;M{WuOFUh\|ryP	NI[0WHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkSwO\|Y2Oyd-Mk[0NFc3PTN:L3G+
SGC-7901/DDP	MUDBdI9xfG:\|aYOgRZN{[Xl?	MlzhNVDDqML3TR?=	MlK3NlQhcA>?		M{KxUYlv\HWlZYOgZZBweHSxc3nzJINwdWKrbnXkJJdqfGhid3n0bEBkcXOybHH0bY4>	M16xRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NEC3OlU{Lz5{NkSwO\|Y2OzxxYU6=
SGC-7901/DDP	M334TWZ2dmO2aX;uJGF{e2G7	NYLvSmE6OTEEoNM1US=>	NUX0UlN7OjRiaB?=		NF3Qd\|RqdmirYnn0d{B1cGViZYjwdoV{e2mxbjDv[kBRNWeueXPvdJJwfGWrbjD0bJJwfWeqIHLsc4NscW6pIFXQNkwh[W6mIHnuZYN1cX[jdHnu[{BRU0FiYX7kJGNTTUMEoB?=	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjRyN{[1N{c,OjZ2MEe2OVM9N2F-
SGC-7901/DDP	NUi0PFNpTnWwY4Tpc44hSXO\|YYm=	NGK2UmwyOMLiwsXN	NHHGcmQzPCCq		M1;2OYNifXOnczDhJI1iemunZDDk[YNz\WG\|ZTDpckB1cGVibHX2[Ywhd2ZiQnPsMVIheHKxdHXpci=>	M1u1RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NEC3OlU{Lz5{NkSwO\|Y2OzxxYU6=
H357	M3;BWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mm\5O{42NzFyIN88US=>	MXm0PEBp	NWLmPZQ2TE2VTx?=	M4rVb4lvcGmkaYTzJINmdGxiZ4Lve5RpyqClb33ibY5m\CC5aYToJHNi[nW2b3PsZZg>	MkP5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyMEm4O\|QoRjJ4MEC5PFc1RC:jPh?=
TAF	M16yRmZ2dmO2aX;uJGF{e2G7	MWWxNOKhyrWP	MXi3JIQ>		NXLKZ5lH[W[oZXP0d{BVSU[\|IHHkbIV{cX[nIIDyc5BmenSrZYO=	NHTDeHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUm4O\|EzPyd-MkW5PFcyOjd:L3G+
TAF	MlXjSpVv[3Srb36gRZN{[Xl?	Mlj0NVDDqML3TR?=	MkS1N\|AuOTJyIH3pci=>		M4HoVpBwd3KueTDh[oZm[3S\|IHTBb5QheGixc4Doc5J6dGG2aX;uJINwdnOncYXlcpQhfG9iRVfGJJNq\26jbHnu[y=>	MkC5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7OEexNlcoRjJ3OUi3NVI4RC:jPh?=
TAF	NXjsTGhrTnWwY4Tpc44hSXO\|YYm=	NHnKW4YyOMLiwsXN	M4jqNlQ5KGh?		M4rXbIlv[3KnYYPld{BGT0[UIH3SUmEh[W6mIIDyc5RmcW5iZYjwdoV{e2mxbh?=	MoLOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7OEexNlcoRjJ3OUi3NVI4RC:jPh?=
PANC-1	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX;EU4x2OjBxNkCvNVAxKM7:TR?=	MX6yOE81QC95MjDo		NEXXOXFqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDic5RpKHSrbXWgZY5lKGSxc3Wg[IVx\W6mZX70JI1idm6nch?=	M3W4OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUezNFYzLz5{NUm3N\|A3OjxxYU6=
PANC-1	NEX1cG9HfW6ldHnvckBCe3OjeR?=	M3P3U\|IxNzZyL{GwNEDPxE1?	NWjyb4xxOjRiaB?=		MXvheJRmdnWjdIOgZ4VtdCCrbo\hd4lwdiCjbnSgcYloemG2aX;uJIlvKGFiY3;uZ4VvfHKjdHnvck1l\XCnbnTlcpQhdWGwbnXyxsA>	NXjEU4lKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5O\|MxPjJpPkK1PVc{ODZ{PD;hQi=>
HeLa	NGPOSXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4PBVFIxyqEQvF5CpC=>	M3;RbFI1yqCq		MmTX[Y5p[W6lZYOgdoFlcWG2aX;uMYlv\HWlZXSgbY5pcWKrdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25?	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd5MESyN{c,OjV5N{C0NlM9N2F-
SACC-83	MmHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn7VNlDDqM7:TdMg	NVPMSGFoOjUEoHi=		MUPlcohidmOnczDyZYRq[XSrb36tbY5lfWOnZDDpcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdg>?	M{npcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{ewOFI{Lz5{NUe3NFQzOzxxYU6=
HeLa	MUnBdI9xfG:\|aYOgRZN{[Xl?	M4XT[FIxyqEQvF5CpC=>	MXiyOOKhcA>?		NULnSJRu\W6qYX7j[ZMhemGmaXH0bY9vNWmwZIXj[YQhcW6qaXLpeIlwdiCxZjDj[YxtKGGyb4D0c5Nqew>?	NV7CTINvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3O\|A1OjNpPkK1O\|cxPDJ\|PD;hQi=>
SACC-83	NHL4eJpCeG:ydH;zbZMhSXO\|YYm=	NWjYfpNtOjEEoN88UeKh	NIrob3EzPMLiaB?=		MojZ[Y5p[W6lZYOgdoFlcWG2aX;uMYlv\HWlZXSgbY5pcWKrdHnvckBw\iClZXzsJIFxd3C2b4Ppdy=>	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd5MESyN{c,OjV5N{C0NlM9N2F-
HeLa	NFnMO2ZHfW6ldHnvckBCe3OjeR?=	NGT2OGUzOC92MD:4NEDPxE1?	NVvqbJJIOjUEoHi=		NGjpS\|N2eHKnZ4XsZZR{KFCWRV6gdIFzfGmjbHz5JIJ6KGmwaHnibZRqdmdiU4CxMEBidmRiYXP0bZZifGW\|IGDUSW4h[W6mIHnuZYN1cX[jdHXzJGFMXA>?	NFXKZlY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe3NFQzOyd-MkW3O\|A1OjN:L3G+
SACC-83	NESxbVNHfW6ldHnvckBCe3OjeR?=	MYKyNE81OC96MDFOwG0>	NVPmT4toOjUEoHi=		MX31dJJm\3WuYYTzJHBVTU5icHHyeIlidGy7IHL5JIlvcGmkaYTpcochW3BzLDDhcoQh[WO2aY\heIV{KFCWRV6gZY5lKGmwYXP0bZZifGW\|IFHLWC=>	MliwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5N{C0NlMoRjJ3N{ewOFI{RC:jPh?=
HLCZ01	NH7HUphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4jkXlDjiJN4MNMgxtVO	MVK0PEBp	NFq5N2hFVVOR	MnjtbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmKGSncHXu[IVvfCCvYX7u[ZI>	NXTFSJhyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3NlQ5QTlpPkK1O\|I1QDl7PD;hQi=>
HLCZ01	M3;oc2Z2dmO2aX;uJGF{e2G7	NV75V215PDEEoN88US=>	MVeyOEBp	M4TyfWROW09?	NGT1WnZqdmO{ZXHz[ZMh[WOldX31cIF1cW:wIH;mJGcxN0dzLYDoZZNmKGOnbHzzJINwdWKrbnXkJJdqfGhiSV\OMe6y	MlTOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5MkS4PVkoRjJ3N{K0PFk6RC:jPh?=
HLCZ01	NHrU[FdCeG:ydH;zbZMhSXO\|YYm=	NF3oNI01OMLizszN	M{TYSlI1KGh?	NYP5bWluTE2VTx?=	M2jQc4VvcGGwY3XzJIFxd3C2b4Ppd{Bkd22kaX7l[EB4cXSqIFnGUk3PuQ>?	NVjYS2FLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3NlQ5QTlpPkK1O\|I1QDl7PD;hQi=>
HLCZ01	NEDkZ4tHfW6ldHnvckBCe3OjeR?=	M{jTe\|QxyqEQvF2=	MkjENlQhcA>?	NHTz[ZlFVVOR	NWfSUmFHcW6lcnXhd4V{KFSUQVnMJIV5eHKnc4Ppc44h[2:vYnnu[YQhf2m2aDDJcpRmem[ncn;uMe6y	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd{NEi5PUc,OjV5MkS4PVk9N2F-
MGC803	NInYXpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIXaeYwxNTZyIN88US=>	MYS3NkBp		NIHlfHdKSzVyPUS3MlI26oDLwsJihKk3NjR\|IN88US=>	MnfjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5MEGzO\|goRjJ3N{CxN\|c5RC:jPh?=
SGC7901	MmrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mk\5NE03OCEQvF2=	MlezO\|IhcA>?		M{n4VGlEPTB;NEOuOVPjiIoEsfMAjVUvOTJizszN	NIrhOYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUewNVM4QCd-MkW3NFE{Pzh:L3G+
MGC803	M3LlSGZ2dmO2aX;uJGF{e2G7	MmnUOFDDqM7:TR?=	M{\6cVgwOTZxMkSgbC=>		NEWwSmh2eHKnZ4XsZZR{KEOkbD3iJIV5eHKnc4Ppc44>	NHu3NHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUewNVM4QCd-MkW3NFE{Pzh:L3G+
SGC7901	NH;uWYZHfW6ldHnvckBCe3OjeR?=	M2ntd\|QxyqEQvF2=	NWrqXpNDQC9zNj:yOEBp		Mln3eZBz\We3bHH0d{BE[mxvYjDlfJBz\XO\|aX;u	NWe1V4tTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3NFE{PzhpPkK1O\|AyOzd6PD;hQi=>
MCF-7	NGLIdVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3L1R\|EwOTBizszN	MkDaO\|IhcA>?	NUC0eWNoTE2VTx?=	NFnFeW1mdmijbnPld{Bk[WylaYTybY9tNWmwZIXj[YQh[2WubDDndo94fGhiaX7obYJqfGmxbh?=	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ4N{WxNEc,OjV4Nke1NVA9N2F-
MDA-MB-231	NYDV[pJvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUPvSHBsOS9zMDFOwG0>	NH;qSWw4OiCq	M4LCd2ROW09?	NXSzfWlG\W6qYX7j[ZMh[2GuY3n0dolwdC2rbnT1Z4VlKGOnbHyg[5Jwf3SqIHnubIljcXSrb36=	M3v1cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nk[3OVExLz5{NU[2O\|UyODxxYU6=
MDA-MB-231	MY\GeY5kfGmxbjDBd5NigQ>?	M1XxdFAuPDBiwsXN	M1nQVlQuOjRiaB?=		NGHRZm5qdmO{ZXHz[ZMhS0:[LUKgdJJwfGWrbjDlfJBz\XO\|aX;uJIlvKGKxdHigeIlu\SCjbnSg[I9{\SCmZYDlcoRmdnRibXHucoVz	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTV6N{OyPUc,OjV3OEezNlk9N2F-
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SGC-7901	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXSxNE82OC9zMECg{txO	NITkNFYzPC92OD:3NkBp	NUKy[FhXTE2VTx?=	MV7pcohq[mm2czDj[YxtKGe{b4f0bEBqdiCkb4ToJJRqdWViYX7kJIRwe2ViZHXw[Y5l\W62IH3hco5meg>?	NYXubINtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5PVI6PThpPkK0PVkzQTV6PD;hQi=>
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SGC-7901	Ml7hSpVv[3Srb36gRZN{[Xl?	MmTtNVAwPTBxMUCwJO69VQ>?	NVPXS5dZPDhiaB?=	MonrSG1UVw>?	M4mwb4Rwf26{ZXf1cIF1\XNidHjlJI1TVkFiZYjwdoV{e2mxbjDs[ZZmdHNib3[gR29ZNTJiYX7kJHBEVkFiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ?	MofVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7OUK5OVgoRjJ2OUmyPVU5RC:jPh?=
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SNU-1041	NFn0UXZHfW6ldHnvckBCe3OjeR?=	NH\4cVgxNTRyIN88US=>	NWXPT4RmPCCq		MmLBeZAuemWpdXzheIV{KEOKT2FCpIFnfGW{IITy[YF1dWWwdDD3bZRpKGirZ3igZ49v[2WwdILheIlwdnN?	MmXQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4OUK3NFMoRjJ2NkmyO\|A{RC:jPh?=
SGC-7901	NFvtfXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUW1NE0yOjVizszN	MXSyOE81QC95MjDo		M1e4NolvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHLveIghfGmvZTDhcoQh\G:\|ZTDk[ZBmdmSnboSgcYFvdmW{	NXvEbWdZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2O\|Y{QTRpPkK0Olc3Ozl2PD;hQi=>
SGC-7901	NVXhdXNnSXCxcITvd4l{KEG\|c3H5	NV\mUmhbOTByIN88US=>	MU[3NkBp		MXnpcoR2[2W\|IHHwc5B1d3Orcx?=	M3y4NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Nke2N\|k1Lz5{NE[3OlM6PDxxYU6=
SGC-7901	MVTGeY5kfGmxbjDBd5NigQ>?	NWD4XFZ4PzVxMUCwM\|EzPSEQvF2=	NFf2d2UzPC92OD:3NkBp		M1KzfIlv[3KnYYPld{Bk[XOyYYPlMVgh[W6mID25JI1TVkFiZYjwdoV{e2mxbjDpckBjd3SqIITpcYUh[W6mIHTvd4UhdWGwbnXy	M{jLeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Nke2N\|k1Lz5{NE[3OlM6PDxxYU6=
LMeC	M{XWVGZ2dmO2aX;uJGF{e2G7	NUDsTWUzOjBxNUCg{txO	MXe0PEBp		NGnD[VBl\WO{ZXHz[ZMhfGinIHX4dJJme3Orb36gc4YhS0:[LUKgdJJwfGWrbh?=	MlfPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O\|Q3RC:jPh?=
CMeC-1	MXvD[YxtKF[rYXLpcIl1gSCDc4PhfS=>	MmHxNlAwPTBizszN	MnvjOFghcA>?		MlTpbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHliaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ?	NWXMXm5yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OVY4PDZpPkK0OlU3PzR4PD;hQi=>
LMeC	NUHsbWZUS2WubDDWbYFjcWyrdImgRZN{[Xl?	NV;GXJl2OjBxNUCg{txO	MVu0PEBp		MWfpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>?	M{TmXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkW2O\|Q3Lz5{NE[1Olc1PjxxYU6=
CMeC-1	MkP0SpVv[3Srb36gRZN{[Xl?	MViyNE82OCEQvF2=	NFnOSHM1QCCq		MU\pcoR2[2W\|IFexMXMh[XK{ZYP0	Mlz2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O\|Q3RC:jPh?=
LMeC	MnTISpVv[3Srb36gRZN{[Xl?	NXLrPWE1OjBxNUCg{txO	MWW0PEBp		M4j2Uolv\HWlZYOgS\|EuWyCjcoLld5Q>	NFvRcWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[1Olc1Pid-MkS2OVY4PDZ:L3G+
CMeC-1	MnnJSpVv[3Srb36gRZN{[Xl?	MXKyNE82OCEQvF2=	NFLDcpo1QCCq		M4H1XoRm[3KnYYPld{B1cGVibHX2[Yx{KG:oIHP5Z4xqdiCGMTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?=	M3PNXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkW2O\|Q3Lz5{NE[1Olc1PjxxYU6=
LMeC	MXzGeY5kfGmxbjDBd5NigQ>?	NUD6cJlKOjBxNUCg{txO	MoTrOFghcA>?		M1[zRoRm[3KnYYPld{B1cGVibHX2[Yx{KG:oIHP5Z4xqdiCGMTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?=	M3:x[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkW2O\|Q3Lz5{NE[1Olc1PjxxYU6=
CMeC-1	NFPZSpRHfW6ldHnvckBCe3OjeR?=	MV6yNE82OCEQvF2=	MX:0PEBp		NUP1WnVVcW6mdXPld{Bk[XOyYYPlMVMh[WO2aY\heIlwdg>?	NXSxTJZlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OVY4PDZpPkK0OlU3PzR4PD;hQi=>
LMeC	NUfrPWRrTnWwY4Tpc44hSXO\|YYm=	NHjDU4QzOC93MDFOwG0>	NY\ybFJRPDhiaB?=		Mmq5bY5lfWOnczDjZZNx[XOnLUOgZYN1cX[jdHnvci=>	MmfUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O\|Q3RC:jPh?=
OVCAR-3	MoLSR4VtdCCYaXHibYxqfHliQYPzZZk>	M3;JblExKML3TR?=	NFuzZ5gyKGh?		NUf5cmp3\W6qYX7j[ZMheGGlbHn0ZZhmdC2rbnT1Z4VlKG:4YYLpZY4h[2GwY3XyJINmdGxiZHXheIjDqA>?	M3jCWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUKwNlI4Lz5{NEWyNFIzPzxxYU6=
OVCAR-3	NUPnSZc6SXCxcITvd4l{KEG\|c3H5	MYOxNEDDvU1?	Ml[5NUBp		M3TLVZBzd22xdHXzJJBi[2yrdHH4[YwucW6mdXPl[EBieG:ydH;zbZPDqA>?	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV{MEKyO{c,OjR3MkCyNlc9N2F-
OVCAR-3	NF;FeHJHfW6ldHnvckBCe3OjeR?=	NGPIZmgyOCEEtV2=	M37sNlEhcA>?		M3PlOYVvcGGwY3XzJJBi[2yrdHH4[YwucW6mdXPl[EBi[3SrdnH0bY9vKG:oIHPhd5Bie2VvOdMg	Mn;iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MkCyNlcoRjJ2NUKwNlI4RC:jPh?=
OVCAR-3	NX;TXHd6TnWwY4Tpc44hSXO\|YYm=	MWGxNEDDvU1?	M33h[\|EhcA>?		MVLkc5dvNXKnZ4XsZZRmeyCQRj5OvmIh[WO2aY\heIlwdiCrbnT1Z4VlKGK7IIDhZ4xqfGG6ZXy=	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV{MEKyO{c,OjR3MkCyNlc9N2F-
OVCAR-3	NV3OXVNSTnWwY4Tpc44hSXO\|YYm=	M2HiTlExKML3TR?=	NEf3WZYyKGh?		MX\pcohq[mm2czDwZYNtcXSjeHXsMYlv\HWlZXSgRYt1KHCqb4PwbI9zgWyjdHnvci=>	M{TlO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUKwNlI4Lz5{NEWyNFIzPzxxYU6=
CF33	NYWydoFtTnWwY4Tpc44hSXO\|YYm=	MXuxNFAh\|ryP	MnjENlQhcA>?		NEDuXG9qdmS3Y3XzJIRwf26{ZXf1cIF1cW:wIH;mJGNQYC1{IIDyc5RmcW5iZYjwdoV{e2mxbh?=	NHWzWHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWwN\|c5Oid-MkS1NFM4QDJ:L3G+
CF33	NF\3cG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2nXZlExNTFyMDFOwG0>	M1r2flAuPCCm		MYDpcohq[mm2czDj[YxtKHC{b3zp[oVz[XSrb36gbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK=	M{nSVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUCzO\|gzLz5{NEWwN\|c5OjxxYU6=
CF33	NX7iOoRETnWwY4Tpc44hSXO\|YYm=	NGTQWW0yOC1zMECg{txO	NH3xVYI1NTJ2IHi=		NU\C[mY2\GWlcnXhd4V{KGOnbHzzJIlvKHSqZTDTJJBp[XOnIHHu[EBqdmO{ZXHz[ZMh[2WubIOgbY4hTzBxR{GgZZJz\XO2	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVyM{e4Nkc,OjR3MEO3PFI9N2F-
LNCaP	M1PIeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1LNSVIwPS9zMDFOwG0>	NUTFZm5PQTZiaB?=		M{HDSYlvcGmkaYTzJINmdGxiZ4Lve5RpKHOrZ37p[olk[W62bImgZ49u[mmwZXSge4l1cCCjdH;yeoF{fGG2aX6=	M1zKc\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Mkm2PVc5Lz5{NEK5Olk4QDxxYU6=
LNCaP	MULBdI9xfG:\|aYOgRZN{[Xl?	NGTYRXkzNzVxMUCg{txO	NEXaSWY6PiCq		MmPkbY5lfWOnczDhdI9xfG:\|aYOgZ49u[mmwZXSge4l1cCCjdH;yeoF{fGG2aX6=	M2TPZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Mkm2PVc5Lz5{NEK5Olk4QDxxYU6=
PC-3	NYLHSZNPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVSwMVUxKM7:TR?=	MlTGOFjjiImq		NVvyW29XcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ?	NWH2R\|dyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxNlc5QDJpPkK0NVI4QDh{PD;hQi=>
PC-3	NFTCXo1E\WyuIG\pZYJqdGm2eTDBd5NigQ>?	M3X1U\|AuOTByIN88US=>	NXryeG96PzJiaB?=		M3rDSoRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?=	NHvEXJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGyO\|g5Oid-MkSxNlc5QDJ:L3G+
HCA-7	NGTNdJhHfW6ldHnvckBie3OjeR?=		NHG1R4g4OiCqcoO=		MUfJcohq[mm2aX;uJI9nKEmOLUHi[ZRiNWmwZIXj[YQhWEeHMjDwdo9lfWO2aX;uJIlvKGi3bXHuJGhESS15IHPlcIx{KGGodHXyJFczKGi{czDifUBGUUFuIFXDOVAhRSByLkCwNVE2KM7:TT6=	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjVzNkK4Nkc,OjJ3MU[yPFI9N2F-
CHO	M2XmSGZ2dmO2aX;uJIF{e2G7				M3LkWmlvKH[rdILvJIlvcGmkaYTvdpkheG:2ZX7jfUBi\2GrboP0JIh2dWGwIFPPXE0zKGmwIIP0ZYJtgSC2cnHud4Zm[3SnZDDjbIlv\XOnIHjhcZN1\XJib4\hdpkhMEOKTzmgZ4VtdHNuIFnDOVAhRSByLkCwNkDPxE1w	NFfndJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEW3OlY5PCd-MUC1O\|Y3QDR:L3G+
CHO	MXPGeY5kfGmxbjDhd5NigQ>?				MmmwTY5pcWKrdHnvckBw\iCSR1WtNkBxem:mdXP0bY9vKGmwIFPIU{Bk\WyuczDlfJBz\XO\|aX7nJIh2dWGwIFPPXE0zNCCLQ{WwJF0hOC5yMEKg{txONg>?	Mn73QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB3N{[2PFUoRjFyNUe2Olg2RC:jPh?=
CHO	NXTEVHRjTnWwY4Tpc44h[XO\|YYm=				NInrSJVKdiC4aYTyc{Bxd3SnbnP5JIFo[Wmwc4SgbJVu[W5iUILvd5Ri\2yjbnTpckBIN0hic4nueIhie2ViMjDpckB1emGwc3\lZ5Rm\CCFSF:gZ4VtdHNuIFnDOVAhRSByLkCwNkDPxE1w	MnGxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTBzOUe5O\|AoRjFyMUm3PVcxRC:jPh?=
CHO	NV:0[WdHTnWwY4Tpc44h[XO\|YYm=				M{\wNWlvcGmkaYTvdpkhd2ZiaIXtZY4hWHKxc4Th[4xidmSrbjDHM2ghe3mwdHjhd4UhOiCneIDy[ZN{\WRiaX6gR2hQKGOnbHzzMEBKSzVyIE2gNE4xODJizszNMi=>	MljnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4NEO5OFIoRjF{NkSzPVQzRC:jPh?=
synovial cells	NVvwO2ZGTnWwY4Tpc44h[XO\|YYm=				NFGyVllKdmirYnn0c5J6KGWoZnXjeEBwdiCycn;keYN1cW:wIH;mJIN6[2yxb4j5[4Vv[XOnLUKgLGNQYC1{KTDwdo9{fGGpbHHu[IlvKEV{IDjQS2UzMSCrbjDoeY1idiCLTEGtZoV1[SC\|dHnteYxifGWmIIP5co93cWGuIHPlcIx{NCCLQ{WwJF0hOC5yMEe5JO69VS5?	MlHEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB6MkG3NVYoRjFyOEKxO\|E3RC:jPh?=
RAW264.7	NWPDWYluTnWwY4Tpc44h[XO\|YYm=				NWLQVFYyUW6qaXLpeIlwdiCxZjDDU3guOiCrbjDtc5V{\SCUQWeyOlQvPyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDMVHMucW6mdXPl[EBRT0V{IIDyc4R2[3Srb36geJJm[XSnZDDwdolweiC2bzDMVHMh[2ijbHzlcodmKGK7IHXufplu\SCrbX31co9ie3OjeTygTWM2OCB;IECuNFA5PyEQvF2u	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ3Nk[2Nkc,OjR4NU[2OlI9N2F-
HEK293	M1O3bmZ2dmO2aX;uJIF{e2G7				NEm3bY9KdmirYnn0bY9vKG:oIHPsc45m\CCVdInsc5Bpd3KjIIDpd5RqdGyjdHGgZYxxcGFvQ1Gg[ZhxemW\|c3XkJIlvKGi3bXHuJGhGUzJ7MzDj[YxteyCkeTDzeI9xeGWmLX\sc5chS09{IHHzd4F6NCCNaTC9JFAvODN2MjFOwG0v	M1XlWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NUKwOVc4Lz5zOUWyNFU4PzxxYU6=
SF9	MlvTSpVv[3Srb36gZZN{[Xl?				MVrJcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUILvd5Ri\2yjbnTpckBIN0hic4nueIhie2ViMjDlfJBz\XO\|ZXSgbY4he2ZvOTDj[YxteyCrbn\lZ5Rm\CC5aYToJIJi[3Wub4\pdpV{NCCLQ{WwJF0hOC5yM{[g{txONg>?	MnL0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR4OUixPVAoRjF2Nkm4NVkxRC:jPh?=
SF9	MkjHSpVv[3Srb36gZZN{[Xl?				NH;PcIxKdiC4aYTyc{BqdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhcHWvYX6gdoVkd22kaX7hcpQheHKxc4Th[4xidmSrbjDHM2ghe3mwdHjhd4UhOiCneIDy[ZN{\WRiaX6gd4YuQSClZXzsd{Bqdm[nY4Tl[EB4cXSqIHLhZ5Vtd3[rcoXzMEBKSzVyIE2gNE4xOzZizszNMi=>	MoGzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTVyMk[wOVAoRjF3MEK2NFUxRC:jPh?=
CHO	NWnhTIM6TnWwY4Tpc44h[XO\|YYm=				Mn3lTY5pcWKrdHnvckBw\iCFT2iyJIV5eHKnc4Pl[EBqdiCFSF:gZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCjcnHjbIlld26rYzDhZ4llNXO2aX31cIF1\WRiUFfFNkBxem:mdXP0bY9vKGK7IHXufplu\SCrbX31co9ie3OjeTygTWM2OCB;IECuNFM3KM7:TT6=	NWrSPYtuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW1OlYzQTBpPkG1OVY3OjlyPD;hQi=>
insect cells	NF7UPXNHfW6ldHnvckBie3OjeR?=		MUWxJI1qdg>?		MkPsTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCFT2iyJIV5eHKnc4Pl[EBqdiCrboPlZ5Qh[2WubIOgeZNqdmdiYYLhZ4hq\G:waXOgZYNq\CCjczDzeYJ{fHKjdHWgbY5kfWKjdHXkJIZweiBzIH3pckBxemmxcjD0c{B{fWK\|dILheIUh[WSmaYTpc44hdWWjc4Xy[YQh\m:{IEK1JJNm[3NiYomgWG1RTC2kYYPl[EBkcHKxbX;n[Y5q[yCjc4PhfUwhUUN3MDC9JFAvODR{IN88UU4>	NGnnSYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxNFI4OCd-MkOwNVAzPzB:L3G+
HNSCC 1483	NYq5WYdxTnWwY4Tpc44h[XO\|YYm=		NI\uVlg{OCCvaX7z		MoXMTY5pcWKrdHnvckBw\iCFT2itNkBqdiCqdX3hckBJVlOFQzCxOFg{KGOnbHzzJJV{cW6pIGuxOGNeKGG{YXPobYRwdmmlIHHjbYQh[XNic4Xid5Rz[XSnIIDy[Ylv[3WkYYTl[EBnd3JiM{CgcYlveyCkZX\vdoUhe3Wkc4TyZZRmKGGmZHn0bY9vKG2nYYP1doVlKGGodHXyJFMxKG2rboOsJGlEPTBiPTCwMlA2PCEQvF2u	NYLqUGJxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyOlM5QTRpPkKyNlY{QDl2PD;hQi=>
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J774	MX;GeY5kfGmxbjDhd5NigQ>?		NGTWblcyPSCvaX7z		NIDmOZdKdmirYnn0bY9vKG:oIFPPXFIhcW5iTGDTMZN1cW23bHH0[YQhdW:3c3WgTlc4PCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJHBITTJicILv[JVkfGmxbjDh[pRmeiBzNTDtbY5{KGK7IILh[IlwcW2vdX7vZZN{[XluIFnDOVAhRSByLkC2JO69VS5?	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDd3Mkm1O{c,OTh5NUK5OVc9N2F-
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RAW264.7	M{PxcmFvfGmrbn\sZY1u[XSxcomgZZN{[Xl?		NHzKWpAyQCCqcoO=		MlXFRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBud3W\|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIH7peJJq[yCxeHnk[UBxem:mdXP0bY9vKGGodHXyJFE5KGi{czDifUBoemmnc4OgdoVi[3Srb36gZY5idHm\|aYOsJGlEPTBiPTCxMlg1KM7:TT6=	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ5OUS0NUc,OjR4N{m0OFE9N2F-
HCA-7	NYj0Om1QS3m2b4TvfIlkcXS7IHHzd4F6		MXWxPEBpenN?		MYXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR2EuPyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKHO3co\peoFtKGGodHXyJFE5KGi{czDifUBOXFNiYYPzZZktKEmFNUCgQUAzKM7:TT6=	NHG1flk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{WxO\|czOSd-MkO1NVc4OjF:L3G+
A549	NIjWTIFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NETsU4I1QCCqcoO=		NVXMfWV[SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIlv[3WkYYTl[EBnd3JiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuNVUh\|ryPLh?=	M376UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{S2N\|Y4Lz5{NkO0OlM3PzxxYU6=
Escherichia coli Arctic cells	M1S0ZWZ2dmO2aX;uJIF{e2G7		MlmzNVUhdWmwcx?=		M2SzUWlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgV5Rz\XC2b3PvZ4N2eyCvdYThcpMhXUFzNUmgZoV1[S2lYYLic45q[yCjbnj5[JJie2ViZYjwdoV{e2WmIHnuJGV{[2incnnjbIliKGOxbHmgRZJkfGmlIHPlcIx{KHC{ZXnuZ5Vj[XSnZDDmc5IhOTVibXnud{BjgSC\|dH;wdIVlKG[ub4egR28zKGi7ZILhd4Uh[XO\|YYmsJGtqKD1iMj60NlUh\|ryPLh?=	MojoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7MUOxPVkoRjJ3OUGzNVk6RC:jPh?=
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J774	M17mbmZ2dmO2aX;uJIF{e2G7				MVLJcohq[mm2aX;uJI9nKEORWEGgbY4hdW:3c3WgTlc4PCClZXzsd{Bie3Onc4Pl[EBieyCjcnHjbIlld26rYzDhZ4llNWmwZIXj[YQhWEeHMjDs[ZZmdHNiYomgdoFlcW9iaX3teY5w[XO\|YYmsJGlEPTBiPTCzMlch\|ryPLh?=	NYTz[ZpSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5NVU5PTRpPkG3PVE2QDV2PD;hQi=>
J774	NV3KOYE6TnWwY4Tpc44h[XO\|YYm=		Ml;VNVUhdWmwcx?=		Mor3TY5pcWKrdHnvckBw\iCFT2ixJIlvKGG{YXPobYRwdmmlIHHjbYQue3SrbYXsZZRm\CCvb4Xz[UBLPzd2IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YhWEeHMjDwdo9lfWO2aX;uJIFnfGW{IEG1JI1qdnNiYomgdoFlcW:rbX31co9ie3OjeTygTWM2OCB;IEOuO{DPxE1w	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDd3Mkm1O{c,OTh5NUK5OVc9N2F-
J774	MmPBSpVv[3Srb36gZZN{[Xl?		M{e0e\|E2KG2rboO=		NGXOTndKdmirYnn0bY9vKG:oIFPPXE0yNW2nZHnheIVlKFCJRUKgdJJw\HWldHnvckBqdiCjcnHjbIlld26rYzDhZ4llNXO2aX31cIF1\WRibX;1d4UhUjd5NDDj[YxteyCrbnP1ZoF1\WRiZn;yJFE2KG2rboOgdJJqd3JidH:gZZJi[2irZH;ubYMh[WOrZD3jbIFtdGWwZ3WgZpkhemGmaX;pcY12dm:jc4PhfUwhUUN3MDC9JFMvQDRizszNMi=>	Mk[2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7OUKxO\|YoRjJzOUmyNVc3RC:jPh?=
J774	NE[2SXZHfW6ldHnvckBie3OjeR?=		Mkm2NVUhdWmwcx?=		NGTvfnVKdmirYnn0bY9vKG:oIFPPXFEhcW5ibX;1d4UhUjd5NDDj[YxteyC3c3nu[{BiemGlaHnkc45q[yCjY3nkJIF{KHO3YoP0doF1\SCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKFCJRUKgdJJw\HWldHnvckBqdmO3YnH0[YQh\m:{IEG1JI1qdnNicILpc5IhfG9ic4Xid5Rz[XSnIHHk[Il1cW:wIH3lZZN2emWmIHHmeIVzKDNyIH3pcpMh[nlicnHkbY9qdW23bn;hd5NigSxiSVO1NEA:KDNwOESg{txONg>?	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ6MES0OEc,OjN4OEC0OFQ9N2F-
APC10.1	MY\DfZRwfG:6aXPpeJkh[XO\|YYm=		MlvHNVghcHK\|		MljPR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgRXBEOTBwMTDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG\|ZTDpckBk\WyuIIP1dpZqfmGuIHHmeIVzKDF6IHjyd{BjgSCPVGOgZZN{[XluIFnDOVAhRSB2LkKg{txONg>?	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzVzN{eyNUc,OjN3MUe3NlE9N2F-
B16F10	Ml3hRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NXjOXGdpOjRiaILz		NH3HS5FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFKxOmYyOCClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gOE42PiEQvF2u	NHnQZYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi2OlI1OCd-MkW4OlYzPDB:L3G+
HCA-7	M4nw[WN6fG:2b4jpZ4l1gSCjc4PhfS=>				MoLVR5l1d3SxeHnjbZR6KGGpYXnud5QhS0:[LUKgdI9{cXSrdnWgbJVu[W5iSFPBMVch[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[nliQ3XscHRqfGW{LUm2JGFSfWWxdYOgZZN{[XluIFnDOVAhRSB2Lkmg{txONg>?	NGfjcIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK5OVc5Pyd-MkSyPVU4QDd:L3G+
SH-SY5Y	MVHBcpRqdmW3cn;0c5hq[2m2eTDhd5NigQ>?		NIf4[WU4OiCqcoO=		M1fFT2FvfGmwZYXyc5RwgGmlaYT5JIlvKGi3bXHuJHNJNVO\NWmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBpfW2jbjDUTHAyKGOnbHygd5Vx\XKwYYThcpQucW6mdXPl[EBkgXSxdH;4bYNqfHliY3;tdI92dmRicILleJJm[XSnZDCyOEB1dyB2ODDodpMhfG9iVFjQNUBk\WyuczDt[YF{fXKnZDDh[pRmeiB5MjDodpMhd2Zic4Xw[ZJv[XSjboSgZYRlcXSrb36sJGlEPTBiPTC1JO69VS5?	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF\|OEe3NEc,OjBzM{i3O\|A9N2F-
THP1	NVn3dYpwVmW3cn;wdo91\WO2aY\lJIF{e2G7		NF;zWIo4OiCqcoO=		M2C2R25mfXKxcILveIVkfGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFzQV{BidmRiSV\OMYdidW2jLYP0bY12dGG2ZXSgcoV2em:2b4jpckBxem:mdXP0bY9vKGmwIHj1cYFvKFSKUEGgZ4VtdCCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKFSKUEGgZ4VtdCC\|ZXPy[ZRqd25vaX7keYNm\CC2b4jpZ4l1gSC2bzDoeY1idiCVSD3TXVV[KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTC1JO69VS5?	NYSxXmFsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2NFk2QDlpPkKwOlA6PTh7PD;hQi=>
U-937	NXPXV\|FYTnWwY4Tpc44h[XO\|YYm=				M1nxbmlvcGmkaYTpc44hd2ZiUILvd5Ri\2yjbnTpckBIN0hic4nueIhie2ViMTDpckBWNTl\|NzDj[YxteyCocn;tJIh2dWGwIHjpd5Rqd2O7dHnjJIx6dXCqb33hMEBKSzVyIE2gOU4yKM7:TT6=	NF7zOYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUS2Nlk4Pid-MUG0OlI6PzZ:L3G+
U-937	NWHVSXlrTnWwY4Tpc44h[XO\|YYm=				MkjWTY4hfmm2cn:gbY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDyc5N1[WeuYX7kbY4hTy:KIIP5cpRp[XOnIEGgLGNQYC1zKTDpckBWNTl\|NzDj[YxteyxiSVO1NEA:KDVwMTFOwG0v	Mn7hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ6N{e1PFQoRjF{OEe3OVg1RC:jPh?=
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J774	NFPINZNHfW6ldHnvckBie3OjeR?=				MmjiTY5pcWKrdHnvckBw\iCFT2ixMYRmeGWwZHXueEBRT0V{IIDyc4R2[3Srb36gbY4hVFCVLYP0bY12dGG2ZXSgcY92e2ViSke3OEBk\WyuczDifUBTUUFuIFnDOVAhRSB3LkGg{txONg>?	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl3N{mzNUc,OTl7NUe5N\|E9N2F-
HT-29	MVzDfZRwfG:6aXPpeJkh[XO\|YYm=				MUHDfZRwfG:6aXPpeJkh[WejaX7zeEBEV1hvMjDwc5NqfGm4ZTDoeY1idiCKVD2yPUBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBjgSCFZXzsWIl1\XJvOU[gRXF2\W:3czDhd5NigSxiSVO1NEA:KDVwNzFOwG0v	MnLBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{OUW3PFcoRjJ2Mkm1O\|g4RC:jPh?=
MCF7	MVfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MkTsNlQhcHK\|		MknDRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPQ1[3JINmdGy\|IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB3Lkm0JO69VS5?	M13SflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OE[2NlQxLz5{NUi2OlI1ODxxYU6=
APC10.1	M3zHU2Z2dmO2aX;uJIF{e2G7		M3TNclE5KGi{cx?=		Ml21TY5pcWKrdHnvckBw\iCqeXHseZJwdmGwLXnu[JVk\WRiQ1S0OEBidnSrZ3XuJJZiemmjboSg[ZhwdiB4IHHjeIl3cXS7IHnuJI1wfXOnIFHQR\|ExNjFiY3XscJMh\XiycnXzd4lv\yCKYYOyJIF{e2W\|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhe3W{dnn2ZYwh[W[2ZYKgNVghcHK\|IHL5JG1VWyCjc4PhfUwhUUN3MDC9JFYh\|ryPLh?=	M1XwflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NUG3O\|IyLz5{M{WxO\|czOTxxYU6=
MCF7	Mn7sRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MoPlOFghcHK\|		MmDaRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPQ1[3JINmdGy\|IHnuZ5Vj[XSnZDDmc5IhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDZwOEig{txONg>?	MnLhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ\|NE[zOlcoRjJ4M{S2N\|Y4RC:jPh?=
SW480	NYf4d5lFS3m2b4TvfIlkcXS7IHHzd4F6				NYLFS29CS3m2b4TvfIlkcXS7IHHnZYlve3RiQ1;YMVIhdmWpYYTpeoUhcHWvYX6gV3c1QDBiY3XscJMh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYomgR4VtdFSrdHXyMVk3KEGTdXXveZMh[XO\|YYmsJGlEPTBiPTC2Mlkh\|ryPLh?=	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ7NUe4O{c,OjR{OUW3PFc9N2F-
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Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID

Western blot	Fibronectin / Vimentin / N-cadherin / E-cadherin ; COX-2 ; pAKT / AKT / PPARγ / PTEN	28978083 29515134 24721996
Immunofluorescence	PPARγ / PTEN	24721996
Growth inhibition assay	Cell viability	28521485

In vivo

Celecoxib exhibits a potent, oral anti-inflammatory activity. Celecoxib reduces acute inflammation in the carrageenan edema assay and chronic inflammation in the adjuvant arthritis model with ED50 of 7.1 mg/kg and 0.37 mg/kg/day, respectively. In addition, Celecoxib also exhibits analgesic activity in the Hargreaves hyperalgesia model with ED50 of 34.5 mg/kg. Besides, Celecoxib produces no acute GI toxicity in rats at doses up to 200 mg/kg and no chronic GI toxicity in rats at doses up to 600 mg/kg/day over 10 days. ^[1] In a C3Hf/KamLaw female mouse model, Celecoxib increases median survival time of 105 days (range, 79-145 days) after 13.5 Gy local thoracic irradiation (LTI) alone to 142 days (range, 94-155 days). ^[3]

Protocol (from reference)

Kinase Assay:^[1]	COX enzyme assay in vitro: Expression of COX protein in insect cells is determined by assessing PG-synthetic capability in homogenates from cells incubated for 3 days with COX-1 or COX-2 baculovirus. Cells expressing COX-1 or COX-2 are homogenized and incubated with arachidonic acid (10 μM). COX activity is determined by monitoring PG production. No COX activity is detected in mock-infected Sf9 cells. Celecoxib are preincubated with crude 1% CHAPS homogenates (2-10 μg of protein) for 10 minutes before addition of arachidonic acid. PGE2 formed is detected by ELISA after 10 minute incubation.
Cell Research:^[2]	Cell lines: HNE1 and CNE1-LMP1 Concentrations: 0-75 μM Incubation Time: 48 hours Method: The antiproliferative effect of Celecoxib on NPC cells is assessed using an MTT assay. Cells are seeded into 96-well plates and allowed to attach for 24 hours. The cells are then treated with increasing concentrations of Celecoxib (0 to 75 μM) dissolved in DMSO (final concentration ≤0.1%) and incubated for up to 48 hours. After the incubation, 20 μL of MTT dye (5 mg/mL) are added to each well and cells are incubated at 37 °C for 4 hours. After removing the supernatants, the crystals are dissolved in DMSO and the absorbance is measured at 490 nm. The half-maximal inhibitory concentration (IC50) values and the 95% confidence intervals are calculated using probit regression using SPSS 15.0 software. The experiment is performed in triplicate and repeated at least three times. (Only for Reference)
Animal Research:^[1]	Animal Models: A 0.1 mL aliquot of a 1% solution of carrageenan in 0.9% sterile saline or 1 mg of Mycobacterium butyricum in 50 μL of mineral oil is administered to the right hind foot pad of male Sprague−Dawley rats. Dosages: ≤200 mg/kg Administration: Administered via p.o. (Only for Reference)

References

Solubility (25°C)

In vitro	DMSO	76 mg/mL (199.28 mM)
	Water	Insoluble
	Ethanol	'33 mg/mL
In vivo	Add solvents to the product individually and in order (Data is from Selleck tests instead of citations): 2% DMSO+30% PEG 300+5% Tween 80+ddH2O For best results, use promptly after mixing. Click to purchase: PEG300 Tween 80	5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight	381.37
Formula	C₁₇H₁₄F₃N₃O₂S
CAS No.	169590-42-5
Storage	3 years	-20°C	powder
Storage	2 years	-80°C	in solvent
Smiles	CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F

Download Celecoxib (SC 58635) SDF

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

Clinical Trial Information

NCT Number	Recruitment	Interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01344200	Not yet recruiting	Drug: Celecoxib\|Drug: Placebo	Pharmacokinetics of Celecoxib in Children	Children''s Hospital of Eastern Ontario	January 2022	Phase 2
NCT04526197	Completed	Drug: ALXN1840\|Drug: Celecoxib	Wilson Disease	Alexion Pharmaceuticals	July 8 2020	Phase 1
NCT04447261	Completed	Drug: BI 1356225\|Drug: Placebo	Obesity	Boehringer Ingelheim	June 30 2020	Phase 1
NCT03896113	Recruiting	Drug: Celecoxib 200mg capsule	Endometrium Cancer	Cliniques universitaires Saint-Luc- Université Catholique de Louvain	November 13 2019	Phase 2

(data from https://clinicaltrials.gov, updated on 2021-09-06)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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Frequently Asked Questions

Question 1:
I am doing an animal experiment with mice and planning to administrate S1261 via oral gavage. what are your recommendations for diluting the compound?

Answer:
For oral administration, Celecoxib can be dissolved in vehicle one: "0.5% methyl cellulose and 0.025% Tween-20", or the vehicle 2 "2% DMSO/30% PEG 300/5% Tween 80/ ddH2O".

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