Celecoxib (SC 58635)

Licensed by Pfizer Catalog No.S1261

For research use only.

Celecoxib (SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.

Celecoxib (SC 58635) Chemical Structure

CAS No. 169590-42-5

Selleck's Celecoxib (SC 58635) has been cited by 84 publications

Purity & Quality Control

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Biological Activity

Description Celecoxib (SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.
Targets
COX-2 [1]
(Sf9 cells)
40 nM
In vitro

Celecoxib shows low sensitivity against COX-1 with IC50 of 15 μM. [1] Celecoxib shows an anti-proliferative effect on nasopharyngeal carcinoma (NPC) cell lines including HNE1 and CNE1-LMP1 with IC50 of 32.86 μM and 61.31 μM, respectively. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 MVjGeY5kfGmxbjDBd5NigQ>? MnTmNE4yNTNyIN88US=> M1nTTlQ5KGh? MkDnbY5lfWOnczDJR2FONTFiZYjwdoV{e2mxbjDvckBjd3SqIIDyc5RmcW5iYX7kJI1TVkFibHX2[Yw> MkXDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3MUOxO|IoRjJ4NUGzNVczRC:jPh?=
H460 MlHOSpVv[3Srb36gRZN{[Xl? MYGwMlEuOzBizszN MkHtOFghcA>? NUS0[WQ{cW6mdXPld{BKS0GPLUGg[ZhxemW|c3nvckBwdiCkb4ToJJBzd3SnaX6gZY5lKG2UTlGgcIV3\Wx? M{jvR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUGzNVczLz5{NkWxN|E4OjxxYU6=
HKESC-2 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELZbnkzOMLizszN M2rreVQ5yqCqwrC= MVzzbYdvcW[rY3HueIx6KGmwY4LlZZNmeyC2aHWgTWM2OMLidnHseYV{KG:oIH;4ZYxqeGyjdHnuxsA> M{m5V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NEe0Olk{Lz5{NkS3OFY6OzxxYU6=
CaES-17 NFSxTYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmGwNlDDqM7:TR?= NXzHVWFtPDkEoHlCpC=> Mlzjd4lodmmoaXPhcpRtgSCrbnPy[YF{\XNidHjlJGlEPTEEoI\hcJVmeyCxZjDvfIFtcXCuYYTpcuKh MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjR5NE[5N{c,OjZ2N{S2PVM9N2F-
HKESC-2 NH3LOXpCeG:ydH;zbZMhSXO|YYm= MnvaNlDDqM7:TR?= NYD3fXZTPDkEoHlCpC=> M3G4fZJm\HWlZYOgc5hidGmybHH0bY4ucW6mdXPl[EBieG:ydH;zbZM> M1nFSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NEe0Olk{Lz5{NkS3OFY6OzxxYU6=
CaES-17 MXTBdI9xfG:|aYOgRZN{[Xl? MU[yNOKh|ryP MVK0POKhcMLi NHS5TnNz\WS3Y3XzJI95[WyrcHzheIlvNWmwZIXj[YQh[XCxcITvd4l{ NH\xTWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS3OFY6Oyd-Mk[0O|Q3QTN:L3G+
A549 M13CWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MliwOU0yPjBizszN M4TuTFQ5yqCqwrC= MoPTSG1UVw>? NF61VWxKSzVyPUG2N{41KM7:TR?= Ml[1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2NkS2OFMoRjJ4NE[0OlQ{RC:jPh?=
HCC827 NH7WWoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWq1MVE3OCEQvF2= MV:0POKhcMLi MYLEUXNQ NVj4fIFHUUN3ME22PU4zKM7:TR?= NEG5Tmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS2OFY1Oyd-Mk[0OlQ3PDN:L3G+
A549 M2PVd2Fxd3C2b4Ppd{BCe3OjeR?= MWW4NEDDvU1? M3vUflQ5yqCqwrC= NYL2PJU1TE2VTx?= NV\pNHNXcW6mdXPld{BieG:ydH;zbZM> MnzCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2NkS2OFMoRjJ4NE[0OlQ{RC:jPh?=
HCC827 MW\BdI9xfG:|aYOgRZN{[Xl? MlrpPFAhyrWP M1vvVVQ5yqCqwrC= NHn2dWdFVVOR M2DQWolv\HWlZYOgZZBweHSxc3nz MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjR4NE[0N{c,OjZ2NkS2OFM9N2F-
SGC-7901/DDP MV3GeY5kfGmxbjDBd5NigQ>? MVexNOKhyrWP NWe2[I9MOjRiaB?= NVzOWpl7cW6qaXLpeJMh[3mlbH;vfJlo\W6jc3WtNkBidmRiUD3ncJlkd3C{b4TlbY4h\XiycnXzd4lwdg>? MoLkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2MEe2OVMoRjJ4NEC3OlU{RC:jPh?=
SGC-7901  M{\1Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HhRlI1yqCqwrC= M2D3c2lEPTB;MUG1MlA5KM7:TR?= MlLJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2MEe2OVMoRjJ4NEC3OlU{RC:jPh?=
SGC-7901/DDP NEHrVIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljmNlTDqGkEoB?= MlnITWM2OD1|NT60OUDPxE1? NIjabmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkSwO|Y2Oyd-Mk[0NFc3PTN:L3G+
SGC-7901/DDP NXzRZpU1SXCxcITvd4l{KEG|c3H5 NGXZSVAyOMLiwsXN MYWyOEBp MYDpcoR2[2W|IHHwc5B1d3OrczDjc41jcW6nZDD3bZRpKHerdHigZ4l{eGyjdHnu MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjRyN{[1N{c,OjZ2MEe2OVM9N2F-
SGC-7901/DDP M4i2U2Z2dmO2aX;uJGF{e2G7 NVPsWYJKOTEEoNM1US=> NWmyRoluOjRiaB?= MXvpcohq[mm2czD0bIUh\XiycnXzd4lwdiCxZjDQMYdtgWOxcILveIVqdiC2aILveYdpKGKub3PrbY5oKEWSMjygZY5lKGmwYXP0bZZifGmwZzDQT2Eh[W6mIFPSSWLDqA>? M3HndVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NEC3OlU{Lz5{NkSwO|Y2OzxxYU6=
SGC-7901/DDP MUPGeY5kfGmxbjDBd5NigQ>? M{\CUlExyqEEtV2= NXjJZW5wOjRiaB?= M4LTd4NifXOnczDhJI1iemunZDDk[YNz\WG|ZTDpckB1cGVibHX2[Ywhd2ZiQnPsMVIheHKxdHXpci=> MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjRyN{[1N{c,OjZ2MEe2OVM9N2F-
H357 NV7VXXNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTpO{42NzFyIN88US=> NFzPXVY1QCCq Mn\MSG1UVw>? M2fYNYlvcGmkaYTzJINmdGxiZ4Lve5RpyqClb33ibY5m\CC5aYToJHNi[nW2b3PsZZg> M{nqRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MEC5PFc1Lz5{NkCwPVg4PDxxYU6=
TAF M2jBU2Z2dmO2aX;uJGF{e2G7 MYKxNOKhyrWP NH3HdHg4KGR? NV\tUYhv[W[oZXP0d{BVSU[|IHHkbIV{cX[nIIDyc5BmenSrZYO= M2HsOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUi3NVI4Lz5{NUm4O|EzPzxxYU6=
TAF MkfaSpVv[3Srb36gRZN{[Xl? NXq2SIFnOTEEoNM1US=> NH;Dd5M{OC1zMkCgcYlv NYXmO5hFeG:xcnz5JIFn\mWldIOg[GFsfCCyaH;zdIhwenmuYYTpc44h[2:wc3XxeYVvfCC2bzDFS2Yhe2mpbnHsbY5o NXj4R3Z[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5PFcyOjdpPkK1PVg4OTJ5PD;hQi=>
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PANC-1 NX;ZVngyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVT6Z49QOjBxNkCvNVAxKM7:TR?= Ml:2NlQwPDhxN{KgbC=> MmG5bY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYn;0bEB1cW2nIHHu[EBld3OnIHTldIVv\GWwdDDtZY5v\XJ? MlezQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7N{OwOlIoRjJ3OUezNFYzRC:jPh?=
PANC-1 NXT1UVBGTnWwY4Tpc44hSXO|YYm= MYmyNE83OC9zMECg{txO NIHqSJozPCCq NGDnTXBifHSnboXheJMh[2WubDDpcpZie2mxbjDhcoQhdWmpcnH0bY9vKGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVzyqB? M2DublxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUezNFYzLz5{NUm3N|A3OjxxYU6=
HeLa  MnvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjVWYszOMLizszNxsA> NX63cVNmOjUEoHi= M1L6OIVvcGGwY3XzJJJi\GmjdHnvck1qdmS3Y3XkJIlvcGmkaYTpc44hd2ZiY3XscEBxem:uaX\ldoF1cW:w MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd5MESyN{c,OjV5N{C0NlM9N2F-
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HeLa  NWG3T5dDSXCxcITvd4l{KEG|c3H5 NFf6SmgzOMLizszNxsA> NELLW2IzPMLiaB?= MYTlcohidmOnczDyZYRq[XSrb36tbY5lfWOnZDDpcohq[mm2aX;uJI9nKGOnbHygZZBweHSxc3nz M{\GelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{ewOFI{Lz5{NUe3NFQzOzxxYU6=
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SACC-83 MoK2SpVv[3Srb36gRZN{[Xl? M4T4TlIxNzRyL{iwJO69VQ>? NYXm[opzOjUEoHi= NEPXV5h2eHKnZ4XsZZR{KFCWRV6gdIFzfGmjbHz5JIJ6KGmwaHnibZRqdmdiU4CxMEBidmRiYXP0bZZifGW|IGDUSW4h[W6mIHnuZYN1cX[jdHXzJGFMXA>? M2PofFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{ewOFI{Lz5{NUe3NFQzOzxxYU6=
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HLCZ01 Ml;4RZBweHSxc3nzJGF{e2G7 Mo\uOFDDqM7:TR?= MlPBNlQhcA>? NIHHdGFFVVOR MULlcohidmOnczDhdI9xfG:|aYOgZ49u[mmwZXSge4l1cCCLRl6t{tE> NY\J[JliRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3NlQ5QTlpPkK1O|I1QDl7PD;hQi=>
HLCZ01 MnHsSpVv[3Srb36gRZN{[Xl? NX[4dWRpPDEEoN88US=> NXzZUppbOjRiaB?= NIPwcWhFVVOR M1j2Zolv[3KnYYPld{BVWkGLTDDlfJBz\XO|aX;uJINwdWKrbnXkJJdqfGhiSX70[ZJn\XKxbj5OtS=> NETvVYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUeyOFg6QSd-MkW3NlQ5QTl:L3G+
MGC803 NVXsSlQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDpUG0xNTZyIN88US=> M2TzfFczKGh? NHLYOZhKSzVyPUS3MlI26oDLwsJihKk3NjR|IN88US=> NIXEZ4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUewNVM4QCd-MkW3NFE{Pzh:L3G+
SGC7901 MoT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUiwMVYxKM7:TR?= MmnqO|IhcA>? M1\YOGlEPTB;NEOuOVPjiIoEsfMAjVUvOTJizszN NYLsWo17RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3NFE{PzhpPkK1O|AyOzd6PD;hQi=>
MGC803 M2\meGZ2dmO2aX;uJGF{e2G7 MV20NOKh|ryP MmrmPE8yPi9{NDDo Ml;YeZBz\We3bHH0d{BE[mxvYjDlfJBz\XO|aX;u M13rO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{CxN|c5Lz5{NUewNVM4QDxxYU6=
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SGC-7901 MWPGeY5kfGmxbjDBd5NigQ>? NHi5PXA4PS9zMECvNVI2KM7:TR?= NGn2dJAzPC92OD:3NkBp NHnsO4ZqdmO{ZXHz[ZMh[2G|cHHz[U05KGGwZDCtPUBuWk6DIHX4dJJme3Orb36gbY4h[m:2aDD0bY1mKGGwZDDkc5NmKG2jbn7ldi=> NF31b|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[3OlM6PCd-MkS2O|Y{QTR:L3G+
LMeC  NGn6UoRHfW6ldHnvckBCe3OjeR?= M{LHSVIxNzVyIN88US=> NVHiZ3llPDhiaB?= MVvk[YNz\WG|ZYOgeIhmKGW6cILld5Nqd25ib3[gR29ZNTJicILveIVqdg>? NV70XZpYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OVY4PDZpPkK0OlU3PzR4PD;hQi=>
CMeC-1 MmftR4VtdCCYaXHibYxqfHliQYPzZZk> M1L4PFIxNzVyIN88US=> MkDFOFghcA>? MknnbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHliaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? MlLoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O|Q3RC:jPh?=
LMeC NVrzPWl5S2WubDDWbYFjcWyrdImgRZN{[Xl? MV:yNE82OCEQvF2= MX20PEBp NHv4[IpqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ3Nke0Okc,OjR4NU[3OFY9N2F-
CMeC-1 MUHGeY5kfGmxbjDBd5NigQ>? MVKyNE82OCEQvF2= NWHQRoVrPDhiaB?= MorBbY5lfWOnczDHNU1UKGG{cnXzeC=> MlPzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O|Q3RC:jPh?=
LMeC MoXiSpVv[3Srb36gRZN{[Xl? Ml;HNlAwPTBizszN M3Hh[|Q5KGh? NFjOU5VqdmS3Y3XzJGcyNVNiYYLy[ZN1 NXHuc4Z1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OVY4PDZpPkK0OlU3PzR4PD;hQi=>
CMeC-1 NWHHS5N3TnWwY4Tpc44hSXO|YYm= NVXmR25SOjBxNUCg{txO NYrOXJpVPDhiaB?= NHrZXGtl\WO{ZXHz[ZMhfGinIHzleoVteyCxZjDjfYNtcW5iREGgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NYi3[2R7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OVY4PDZpPkK0OlU3PzR4PD;hQi=>
LMeC M{Tt[WZ2dmO2aX;uJGF{e2G7 M3;tZVIxNzVyIN88US=> M4D6T|Q5KGh? NF;kXldl\WO{ZXHz[ZMhfGinIHzleoVteyCxZjDjfYNtcW5iREGgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ3Nke0Okc,OjR4NU[3OFY9N2F-
CMeC-1 M1;OVGZ2dmO2aX;uJGF{e2G7 NYLweFYzOjBxNUCg{txO NIKwPFY1QCCq M2T1T4lv\HWlZYOgZ4F{eGG|ZT2zJIFkfGm4YYTpc44> MmfPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O|Q3RC:jPh?=
LMeC NUT4[pNzTnWwY4Tpc44hSXO|YYm= MVmyNE82OCEQvF2= M1Sz[VQ5KGh? NYnMWm01cW6mdXPld{Bk[XOyYYPlMVMh[WO2aY\heIlwdg>? MkfWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O|Q3RC:jPh?=
OVCAR-3 NFXCT4VE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NXnvc|VtOTBiwsXN M3T2cFEhcA>? Mn;Z[Y5p[W6lZYOgdIFkdGm2YYjlcE1qdmS3Y3XkJI93[XKrYX6gZ4Fv[2W{IHPlcIwh\GWjdHlCpC=> NEPrWHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWyNFIzPyd-MkS1NlAzOjd:L3G+
OVCAR-3 M1fURmFxd3C2b4Ppd{BCe3OjeR?= MUSxNEDDvU1? MU[xJIg> MoPDdJJwdW:2ZYOgdIFkdGm2YYjlcE1qdmS3Y3XkJIFxd3C2b4Ppd:Kh NETPXlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWyNFIzPyd-MkS1NlAzOjd:L3G+
OVCAR-3 MWnGeY5kfGmxbjDBd5NigQ>? NX3I[o1rOTBiwsXN M2DmZVEhcA>? M1juWoVvcGGwY3XzJJBi[2yrdHH4[YwucW6mdXPl[EBi[3SrdnH0bY9vKG:oIHPhd5Bie2VvOdMg Mo\5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MkCyNlcoRjJ2NUKwNlI4RC:jPh?=
OVCAR-3 NEey[mFHfW6ldHnvckBCe3OjeR?= MVmxNEDDvU1? NXHaSohVOSCq M2[3UIRwf25vcnXneYxifGW|IF7GMe67SiCjY4TpeoF1cW:wIHnu[JVk\WRiYomgdIFkdGm2YYjlcC=> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV{MEKyO{c,OjR3MkCyNlc9N2F-
OVCAR-3 NYWzfJN[TnWwY4Tpc44hSXO|YYm= MoXsNVAhyrWP NUDHU5ZZOSCq M4nJZYlvcGmkaYTzJJBi[2yrdHH4[YwucW6mdXPl[EBCc3RicHjvd5Bpd3K7bHH0bY9v M2K2RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUKwNlI4Lz5{NEWyNFIzPzxxYU6=
CF33 NXjmd3RjTnWwY4Tpc44hSXO|YYm= NVnPRmtbOTByIN88US=> Mof0NlQhcA>? M2nFN4lv\HWlZYOg[I94dnKnZ4XsZZRqd25ib3[gR29ZNTJicILveIVqdiCneIDy[ZN{cW:w MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVyM{e4Nkc,OjR3MEO3PFI9N2F-
CF33 NFrNRWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWGx[YlJOTBvMUCwJO69VQ>? M4n6[VAuPCCm NVHoXm9ycW6qaXLpeJMh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz MljCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MEO3PFIoRjJ2NUCzO|gzRC:jPh?=
CF33 NX7uUFdZTnWwY4Tpc44hSXO|YYm= MmDRNVAuOTByIN88US=> NInVS4k1NTJ2IHi= MmKx[IVkemWjc3XzJINmdGy|IHnuJJRp\SCVIIDoZZNmKGGwZDDpcoNz\WG|ZYOgZ4VtdHNiaX6gS|AwTzFiYYLy[ZN1 MkDFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MEO3PFIoRjJ2NUCzO|gzRC:jPh?=
LNCaP NITVO4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkKyNk82NzFyIN88US=> NFXhSFc6PiCq NV7y[5ZocW6qaXLpeJMh[2WubDDndo94fGhic3nncolncWOjboTsfUBkd22kaX7l[EB4cXSqIHH0c5J3[XO2YYTpci=> MlnlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{OU[5O|goRjJ2Mkm2PVc5RC:jPh?=
LNCaP M4rRRWFxd3C2b4Ppd{BCe3OjeR?= MUmyM|UwOTBizszN M1K4UVk3KGh? MXLpcoR2[2W|IHHwc5B1d3OrczDjc41jcW6nZDD3bZRpKGG2b4L2ZZN1[XSrbh?= NHXMfWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK5Olk4QCd-MkSyPVY6Pzh:L3G+
PC-3  MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXewMVUxKM7:TR?= MlTZOFjjiImq NVrCTIdbcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF{N{i4Nkc,OjRzMke4PFI9N2F-
PC-3  NXHZRXl6S2WubDDWbYFjcWyrdImgRZN{[Xl? M3PlRVAuOTByIN88US=> M4nJb|czKGh? Mk\M[IVkemWjc3XzJINmdGxidnnhZoltcXS7IHnuJIEh\G:|ZTDk[ZBmdmSnboSgcYFvdmW{ MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF{N{i4Nkc,OjRzMke4PFI9N2F-
HCA-7 MVHGeY5kfGmxbjDhd5NigQ>? M{PhXVczKGi{cx?= NXH4eVJKUW6qaXLpeIlwdiCxZjDJUE0y[mW2YT3pcoR2[2WmIGDHSVIheHKxZIXjeIlwdiCrbjDoeY1idiCKQ1GtO{Bk\WyuczDh[pRmeiB5MjDodpMh[nliRVnBMEBGSzVyIE2gNE4xODFzNTFOwG0v MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjVzNkK4Nkc,OjJ3MU[yPFI9N2F-
CHO MnrvSpVv[3Srb36gZZN{[Xl? NG\BRYpKdiC4aYTyc{BqdmirYnn0c5J6KHCxdHXuZ5kh[WejaX7zeEBpfW2jbjDDU3guOiCrbjDzeIFjdHlidILhcpNn\WO2ZXSgZ4hqdmW|ZTDoZY1{fGW{IH;2ZZJ6KCiFSF:pJINmdGy|LDDJR|UxKD1iMD6wNFIh|ryPLh?= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODV5Nk[4OEc,OTB3N{[2PFQ9N2F-
CHO NVW1ZY9pTnWwY4Tpc44h[XO|YYm= MonmTY5pcWKrdHnvckBw\iCSR1WtNkBxem:mdXP0bY9vKGmwIFPIU{Bk\WyuczDlfJBz\XO|aX7nJIh2dWGwIFPPXE0zNCCLQ{WwJF0hOC5yMEKg{txONg>? NYT4XFN7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC1O|Y3QDVpPkGwOVc3Pjh3PD;hQi=>
CHO MXLGeY5kfGmxbjDhd5NigQ>? M4nBXWlvKH[rdILvJJBwfGWwY4mgZYdicW6|dDDoeY1idiCScn;zeIFodGGwZHnuJGcwUCC|eX70bIF{\SB{IHnuJJRz[W6|ZnXjeIVlKEOKTzDj[YxteyxiSVO1NEA:KDBwMECyJO69VS5? M1\PNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyMUm3PVcxLz5zMEG5O|k4ODxxYU6=
CHO MWnGeY5kfGmxbjDhd5NigQ>? M{jFUGlvcGmkaYTvdpkhd2ZiaIXtZY4hWHKxc4Th[4xidmSrbjDHM2ghe3mwdHjhd4UhOiCneIDy[ZN{\WRiaX6gR2hQKGOnbHzzMEBKSzVyIE2gNE4xODJizszNMi=> MkXoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4NEO5OFIoRjF{NkSzPVQzRC:jPh?=
synovial cells MXfGeY5kfGmxbjDhd5NigQ>? MXvJcohq[mm2b4L5JIVn\mWldDDvckBxem:mdXP0bY9vKG:oIHP5Z4xwd3i7Z3XuZZNmNTJiKFPPXE0zMSCycn;zeIFodGGwZHnuJGUzKCiSR1WyLUBqdiCqdX3hckBKVDFvYnX0ZUB{fGmvdXzheIVlKHO7bn;2bYFtKGOnbHzzMEBKSzVyIE2gNE4xODd7IN88UU4> MoD5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB6MkG3NVYoRjFyOEKxO|E3RC:jPh?=
RAW264.7 MXrGeY5kfGmxbjDhd5NigQ>? MWfJcohq[mm2aX;uJI9nKEORWD2yJIlvKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKEySUz3pcoR2[2WmIGDHSVIheHKxZIXjeIlwdiC2cnXheIVlKHC{aX;yJJRwKEySUzDjbIFtdGWwZ3WgZpkh\W68eX3lJIludXWwb3Hzd4F6NCCLQ{WwJF0hOC5yMEi3JO69VS5? M3jGb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkW2OlYzLz5{NE[1OlY3OjxxYU6=
HEK293 M1;vTWZ2dmO2aX;uJIF{e2G7 MnLJTY5pcWKrdHnvckBw\iClbH;u[YQhW3S7bH;wbI9z[SCyaYP0bYxt[XSjIHHsdIhiNUODIHX4dJJme3OnZDDpckBpfW2jbjDISWszQTNiY3XscJMh[nlic4TvdJBm\C2obH;3JGNQOiCjc4PhfUwhU2liPTCwMlA{PDJizszNMi=> M1G2TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NUKwOVc4Lz5zOUWyNFU4PzxxYU6=
SF9 NYSz[3R6TnWwY4Tpc44h[XO|YYm= MVnJcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUILvd5Ri\2yjbnTpckBIN0hic4nueIhie2ViMjDlfJBz\XO|ZXSgbY4he2ZvOTDj[YxteyCrbn\lZ5Rm\CC5aYToJIJi[3Wub4\pdpV{NCCLQ{WwJF0hOC5yM{[g{txONg>? MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDZ7OEG5NEc,OTR4OUixPVA9N2F-
SF9 NX6xSnhTTnWwY4Tpc44h[XO|YYm= M4\WUmlvKH[rdILvJIlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDy[YNwdWKrbnHueEBxem:|dHHncIFv\GmwIFevTEB{gW62aHHz[UAzKGW6cILld5Nm\CCrbjDz[k06KGOnbHzzJIlv\mWldHXkJJdqfGhiYnHjeYxwfmm{dYOsJGlEPTBiPTCwMlA{PiEQvF2u NH\tWoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUCyOlA2OCd-MUWwNlYxPTB:L3G+
CHO MonWSpVv[3Srb36gZZN{[Xl? M1TZOWlvcGmkaYTpc44hd2ZiQ1;YNkBmgHC{ZYPz[YQhcW5iQ1jPJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiYYLhZ4hq\G:waXOgZYNq\C2|dHnteYxifGWmIGDHSVIheHKxZIXjeIlwdiCkeTDlcpp6dWViaX3teY5w[XO|YYmsJGlEPTBiPTCwMlA{PiEQvF2u MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTV4NkK5NEc,OTV3Nk[yPVA9N2F-
insect cells MX;GeY5kfGmxbjDhd5NigQ>? MUCxJI1qdg>? Mmf1TY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCFT2iyJIV5eHKnc4Pl[EBqdiCrboPlZ5Qh[2WubIOgeZNqdmdiYYLhZ4hq\G:waXOgZYNq\CCjczDzeYJ{fHKjdHWgbY5kfWKjdHXkJIZweiBzIH3pckBxemmxcjD0c{B{fWK|dILheIUh[WSmaYTpc44hdWWjc4Xy[YQh\m:{IEK1JJNm[3NiYomgWG1RTC2kYYPl[EBkcHKxbX;n[Y5q[yCjc4PhfUwhUUN3MDC9JFAvODR{IN88UU4> NX\6bHMzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNVAzPzBpPkKzNFExOjdyPD;hQi=>
HNSCC 1483 NVXzV5B5TnWwY4Tpc44h[XO|YYm= M2\KOlMxKG2rboO= MUfJcohq[mm2aX;uJI9nKEORWD2yJIlvKGi3bXHuJGhPW0OFIEG0PFMh[2WubIOgeZNqdmdiW{G0R30h[XKjY3jp[I9vcWNiYXPp[EBieyC|dXLzeJJifGVicILlbY5kfWKjdHXkJIZweiB|MDDtbY5{KGKnZn;y[UB{fWK|dILheIUh[WSmaYTpc44hdWWjc4Xy[YQh[W[2ZYKgN|AhdWmwczygTWM2OCB;IECuNFU1KM7:TT6= MorhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{NkO4PVQoRjJ{Mk[zPFk1RC:jPh?=
J774 M4PT[2Z2dmO2aX;uJIF{e2G7 NX6xeno5UW6qaXLpeIlwdiCxZjDDU3gzKGmwIFzQV{1{fGmvdXzheIVlKEp5N{SgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCSR1WyJIxmfmWuczDifUBz[WSrb3ntcZVvd2G|c3H5MEBKSzVyIE2gNE4xPiEQvF2u MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzlzNUi1OEc,OTd7MUW4OVQ9N2F-
J774 NUTZVW1CTnWwY4Tpc44h[XO|YYm= M4jhR|E2KG2rboO= MlL4TY5pcWKrdHnvckBw\iCFT2iyJIlvKEySUz3zeIlufWyjdHXkJI1wfXOnIFq3O|Qh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDQS2UzKHC{b3T1Z5Rqd25iYX\0[ZIhOTVibXnud{BjgSC{YXTpc4ludXWwb3Hzd4F6NCCLQ{WwJF0hOC5yNjFOwG0v MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDd3Mkm1O{c,OTh5NUK5OVc9N2F-
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Saos-2 MX3xTHRUKGG|c3H5 NYP3XlNVeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGPhc5MuOiClZXzsdy=> NF32PWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
RAW264.7 Mn;ORY51cWmwZnzhcY1ifG:{eTDhd5NigQ>? NXr1enZ[OjBidV2= NGDxdHkzKGi{cx?= NG[xOXhCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViUlHXNlY1NjdiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBNWFNiaX7keYNm\CClb4itNkBmgHC{ZYPzbY9vKGG2IEKwJJVOKHC{ZXnuZ5Vj[XSnZDDmc5IhOiCqcoOg[o9tdG:5ZXSgZpkhVFCVIHPoZYxt\W6pZTDt[YF{fXKnZDDh[pRmeiB{NDDodpMh[nliV3XzeIVzdiCkbH;0JI1mfGixZB?= NXKxNnh4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxNFA4QTlpPkK5NVAxPzl7PD;hQi=>
RAW264.7 NInVRY1CdnSraX7mcIFudWG2b4L5JIF{e2G7 NGKycm8zOCC3TR?= M1;wXVIhcHK| MUfBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHHnZYlve3RibX;1d4UhWkGZMk[0Mlch[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDMVHMhcW6mdXPl[EBqVk:VIHX4dJJme3Orb36gZZQhOjBidV2gdJJmcW6ldXLheIVlKG[xcjCyJIhzeyCob3zsc5dm\CCkeTDMVHMh[2ijbHzlcodmKG2nYYP1doVlKGGodHXyJFI1KGi{czDifUBY\XO2ZYLuJIJtd3RibXX0bI9l NVHvOGFyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxNFA4QTlpPkK5NVAxPzl7PD;hQi=>
Assay
Methods Test Index PMID
Western blot Fibronectin / Vimentin / N-cadherin / E-cadherin ; COX-2 ; pAKT / AKT / PPARγ / PTEN 28978083 29515134 24721996
Immunofluorescence PPARγ / PTEN 24721996
Growth inhibition assay Cell viability 28521485
In vivo Celecoxib exhibits a potent, oral anti-inflammatory activity. Celecoxib reduces acute inflammation in the carrageenan edema assay and chronic inflammation in the adjuvant arthritis model with ED50 of 7.1 mg/kg and 0.37 mg/kg/day, respectively. In addition, Celecoxib also exhibits analgesic activity in the Hargreaves hyperalgesia model with ED50 of 34.5 mg/kg. Besides, Celecoxib produces no acute GI toxicity in rats at doses up to 200 mg/kg and no chronic GI toxicity in rats at doses up to 600 mg/kg/day over 10 days. [1] In a C3Hf/KamLaw female mouse model, Celecoxib increases median survival time of 105 days (range, 79-145 days) after 13.5 Gy local thoracic irradiation (LTI) alone to 142 days (range, 94-155 days). [3]

Protocol (from reference)

Kinase Assay:[1]
  • COX enzyme assay in vitro:

    Expression of COX protein in insect cells is determined by assessing PG-synthetic capability in homogenates from cells incubated for 3 days with COX-1 or COX-2 baculovirus. Cells expressing COX-1 or COX-2 are homogenized and incubated with arachidonic acid (10 μM). COX activity is determined by monitoring PG production. No COX activity is detected in mock-infected Sf9 cells. Celecoxib are preincubated with crude 1% CHAPS homogenates (2-10 μg of protein) for 10 minutes before addition of arachidonic acid. PGE2 formed is detected by ELISA after 10 minute incubation.

Cell Research:[2]
  • Cell lines: HNE1 and CNE1-LMP1
  • Concentrations: 0-75 μM
  • Incubation Time: 48 hours
  • Method: The antiproliferative effect of Celecoxib on NPC cells is assessed using an MTT assay. Cells are seeded into 96-well plates and allowed to attach for 24 hours. The cells are then treated with increasing concentrations of Celecoxib (0 to 75 μM) dissolved in DMSO (final concentration ≤0.1%) and incubated for up to 48 hours. After the incubation, 20 μL of MTT dye (5 mg/mL) are added to each well and cells are incubated at 37 °C for 4 hours. After removing the supernatants, the crystals are dissolved in DMSO and the absorbance is measured at 490 nm. The half-maximal inhibitory concentration (IC50) values and the 95% confidence intervals are calculated using probit regression using SPSS 15.0 software. The experiment is performed in triplicate and repeated at least three times.
Animal Research:[1]
  • Animal Models: A 0.1 mL aliquot of a 1% solution of carrageenan in 0.9% sterile saline or 1 mg of Mycobacterium butyricum in 50 μL of mineral oil is administered to the right hind foot pad of male Sprague−Dawley rats.
  • Dosages: ≤200 mg/kg
  • Administration: Administered via p.o.

Solubility (25°C)

In vitro

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.

5mg/mL

Chemical Information

Molecular Weight 381.37
Formula

C17H14F3N3O2S

CAS No. 169590-42-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01344200 Not yet recruiting Drug: Celecoxib|Drug: Placebo Pharmacokinetics of Celecoxib in Children Children''s Hospital of Eastern Ontario January 2022 Phase 2
NCT04526197 Completed Drug: ALXN1840|Drug: Celecoxib Wilson Disease Alexion Pharmaceuticals July 8 2020 Phase 1
NCT04447261 Completed Drug: BI 1356225|Drug: Placebo Obesity Boehringer Ingelheim June 30 2020 Phase 1
NCT03896113 Recruiting Drug: Celecoxib 200mg capsule Endometrium Cancer Cliniques universitaires Saint-Luc- Université Catholique de Louvain November 13 2019 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
I am doing an animal experiment with mice and planning to administrate S1261 via oral gavage. what are your recommendations for diluting the compound?

Answer:
For oral administration, Celecoxib can be dissolved in vehicle one: "0.5% methyl cellulose and 0.025% Tween-20", or the vehicle 2 "2% DMSO/30% PEG 300/5% Tween 80/ ddH2O".

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