Celecoxib

For research use only.

Licensed by Pfizer Catalog No.S1261 Synonyms: SC 58635

66 publications

Celecoxib Chemical Structure

CAS No. 169590-42-5

Celecoxib (SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.

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Selleck's Celecoxib has been cited by 66 publications

Purity & Quality Control

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Biological Activity

Description Celecoxib (SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.
Targets
COX-2 [1]
(Sf9 cells)
40 nM
In vitro

Celecoxib shows low sensitivity against COX-1 with IC50 of 15 μM. [1] Celecoxib shows an anti-proliferative effect on nasopharyngeal carcinoma (NPC) cell lines including HNE1 and CNE1-LMP1 with IC50 of 32.86 μM and 61.31 μM, respectively. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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H460 MVzGeY5kfGmxbjDBd5NigQ>? M3\oTlAvOS1|MDFOwG0> MUS0PEBp MV;pcoR2[2W|IFnDRW0uOSCneIDy[ZN{cW:wIH;uJIJwfGhicILveIVqdiCjbnSgcXJPSSCuZY\lcC=> NF\qfpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkWxN|E4Oid-Mk[1NVMyPzJ:L3G+
HKESC-2 M1\qXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWKyNOKh|ryP M2Hsb|Q5yqCqwrC= M{n4TJNq\26rZnnjZY51dHliaX7jdoVie2W|IITo[UBKSzVywrD2ZYx2\XNib3[gc5hidGmybHH0bY7DqA>? NVjCZZJXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0O|Q3QTNpPkK2OFc1Pjl|PD;hQi=>
CaES-17 M{fRcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkOyNlDDqM7:TR?= MYi0POKhcMLi Mknnd4lodmmoaXPhcpRtgSCrbnPy[YF{\XNidHjlJGlEPTEEoI\hcJVmeyCxZjDvfIFtcXCuYYTpcuKh NUPRdpM{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0O|Q3QTNpPkK2OFc1Pjl|PD;hQi=>
HKESC-2 M3XuSGFxd3C2b4Ppd{BCe3OjeR?= MknQNlDDqM7:TR?= NUDYWFJLPDkEoHlCpC=> NXLTVXZ3emWmdXPld{BwgGGuaYDsZZRqdi2rbnT1Z4VlKGGyb4D0c5Nqew>? MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjR5NE[5N{c,OjZ2N{S2PVM9N2F-
CaES-17 M1;URmFxd3C2b4Ppd{BCe3OjeR?= NX3DeIlUOjEEoN88US=> NF7XXHY1QMLiaNMg MX3y[YR2[2W|IH;4ZYxqeGyjdHnuMYlv\HWlZXSgZZBweHSxc3nz Mk[0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2N{S2PVMoRjJ4NEe0Olk{RC:jPh?=
A549 MnPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPjOU0yPjBizszN M4\rdVQ5yqCqwrC= NF6yd2FFVVOR MkC0TWM2OD1zNkOuOEDPxE1? MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjR4NE[0N{c,OjZ2NkS2OFM9N2F-
HCC827 NEmyWnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nwOlUuOTZyIN88US=> M3TidlQ5yqCqwrC= NHrBOHZFVVOR M{DJUmlEPTB;NkmuNkDPxE1? NF24[GU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS2OFY1Oyd-Mk[0OlQ3PDN:L3G+
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SGC-7901 NInD[oxHfW6ldHnvckBCe3OjeR?= NUfN[YV7PzVxMUCwM|EzPSEQvF2= MmPGNlQwPDhxN{KgbC=> NEnsdWJqdmO{ZXHz[ZMh[2G|cHHz[U05KGGwZDCtPUBuWk6DIHX4dJJme3Orb36gbY4h[m:2aDD0bY1mKGGwZDDkc5NmKG2jbn7ldi=> NYCwXYZVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2O|Y{QTRpPkK0Olc3Ozl2PD;hQi=>
LMeC  NGnsR|hHfW6ldHnvckBCe3OjeR?= NYC1R4tsOjBxNUCg{txO NWDBT4tpPDhiaB?= NH32RWxl\WO{ZXHz[ZMhfGinIHX4dJJme3Orb36gc4YhS0:[LUKgdJJwfGWrbh?= NYjUVZM2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OVY4PDZpPkK0OlU3PzR4PD;hQi=>
CMeC-1 MYrD[YxtKF[rYXLpcIl1gSCDc4PhfS=> Mk\GNlAwPTBizszN M{jCW|Q5KGh? MoSwbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHliaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? MmfCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O|Q3RC:jPh?=
LMeC M2XBPGNmdGxiVnnhZoltcXS7IFHzd4F6 M1TvPVIxNzVyIN88US=> MWe0PEBp MVvpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ3Nke0Okc,OjR4NU[3OFY9N2F-
CMeC-1 Ml\RSpVv[3Srb36gRZN{[Xl? NG\aVY0zOC93MDFOwG0> MlTLOFghcA>? MUfpcoR2[2W|IFexMXMh[XK{ZYP0 Mo\JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O|Q3RC:jPh?=
LMeC NF7Ycm9HfW6ldHnvckBCe3OjeR?= M{DPVVIxNzVyIN88US=> MX:0PEBp MoTHbY5lfWOnczDHNU1UKGG{cnXzeC=> Mmr4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O|Q3RC:jPh?=
CMeC-1 NH3rN2dHfW6ldHnvckBCe3OjeR?= MmfuNlAwPTBizszN Mke4OFghcA>? NFXRNY5l\WO{ZXHz[ZMhfGinIHzleoVteyCxZjDjfYNtcW5iREGgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NIj5PIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[1Olc1Pid-MkS2OVY4PDZ:L3G+
LMeC M1f0UmZ2dmO2aX;uJGF{e2G7 NH7DdIUzOC93MDFOwG0> MnHxOFghcA>? M1zufYRm[3KnYYPld{B1cGVibHX2[Yx{KG:oIHP5Z4xqdiCGMTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= M1L1OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkW2O|Q3Lz5{NE[1Olc1PjxxYU6=
CMeC-1 MXfGeY5kfGmxbjDBd5NigQ>? M2D3TVIxNzVyIN88US=> NHT2PXc1QCCq MWPpcoR2[2W|IHPhd5Bie2VvMzDhZ5RqfmG2aX;u M2\nblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkW2O|Q3Lz5{NE[1Olc1PjxxYU6=
LMeC NYn4UVZkTnWwY4Tpc44hSXO|YYm= MlTVNlAwPTBizszN M3v4OFQ5KGh? MV3pcoR2[2W|IHPhd5Bie2VvMzDhZ5RqfmG2aX;u NY\vU3RxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OVY4PDZpPkK0OlU3PzR4PD;hQi=>
OVCAR-3 MUnD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M1PKSFExKML3TR?= M2L4PFEhcA>? M3;6VIVvcGGwY3XzJJBi[2yrdHH4[YwucW6mdXPl[EBwfmG{aXHuJINidmOncjDj[YxtKGSnYYToxsA> NWCyd5FoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NlAzOjdpPkK0OVIxOjJ5PD;hQi=>
OVCAR-3 MkXLRZBweHSxc3nzJGF{e2G7 M1fGVlExKML3TR?= M4PWSVEhcA>? MULwdo9ud3SnczDwZYNtcXSjeHXsMYlv\HWlZXSgZZBweHSxc3nzxsA> M{f1VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUKwNlI4Lz5{NEWyNFIzPzxxYU6=
OVCAR-3 M3Ppc2Z2dmO2aX;uJGF{e2G7 NGDEWFgyOCEEtV2= MWexJIg> MVHlcohidmOnczDwZYNtcXSjeHXsMYlv\HWlZXSgZYN1cX[jdHnvckBw\iClYYPwZZNmNToEoB?= NX3O[Gh[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NlAzOjdpPkK0OVIxOjJ5PD;hQi=>
OVCAR-3 NX7oXItwTnWwY4Tpc44hSXO|YYm= MYKxNEDDvU1? MYKxJIg> M4XycIRwf25vcnXneYxifGW|IF7GMe67SiCjY4TpeoF1cW:wIHnu[JVk\WRiYomgdIFkdGm2YYjlcC=> MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV{MEKyO{c,OjR3MkCyNlc9N2F-
OVCAR-3 NXXlXYwyTnWwY4Tpc44hSXO|YYm= NYDDbpNVOTBiwsXN NYnafmdbOSCq NYfRdGN7cW6qaXLpeJMheGGlbHn0ZZhmdC2rbnT1Z4VlKEGtdDDwbI9{eGixconsZZRqd25? NFjqVVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWyNFIzPyd-MkS1NlAzOjd:L3G+
CF33 NEHQSYdHfW6ldHnvckBCe3OjeR?= MmHNNVAxKM7:TR?= MlPsNlQhcA>? NX;UW4xwcW6mdXPld{Bld3ewcnXneYxifGmxbjDv[kBEV1hvMjDwdo91\WmwIHX4dJJme3Orb36= NHX2O|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWwN|c5Oid-MkS1NFM4QDJ:L3G+
CF33 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHv5bGgyOC1zMECg{txO NFXmPFExNTRiZB?= MUDpcohq[mm2czDj[YxtKHC{b3zp[oVz[XSrb36gbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NFu4cm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWwN|c5Oid-MkS1NFM4QDJ:L3G+
CF33 NGDlfoNHfW6ldHnvckBCe3OjeR?= MkPxNVAuOTByIN88US=> NGrGbnk1NTJ2IHi= MljU[IVkemWjc3XzJINmdGy|IHnuJJRp\SCVIIDoZZNmKGGwZDDpcoNz\WG|ZYOgZ4VtdHNiaX6gS|AwTzFiYYLy[ZN1 MljpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MEO3PFIoRjJ2NUCzO|gzRC:jPh?=
LNCaP NYnVSVh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG[4b2UzNzVxMUCg{txO NELwT2I6PiCq NV\wN|VRcW6qaXLpeJMh[2WubDDndo94fGhic3nncolncWOjboTsfUBkd22kaX7l[EB4cXSqIHH0c5J3[XO2YYTpci=> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ7Nkm3PEc,OjR{OU[5O|g9N2F-
LNCaP NWH0OosySXCxcITvd4l{KEG|c3H5 MlfaNk82NzFyIN88US=> MonQPVYhcA>? NIDXe|BqdmS3Y3XzJIFxd3C2b4Ppd{Bkd22kaX7l[EB4cXSqIHH0c5J3[XO2YYTpci=> NGHvfpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK5Olk4QCd-MkSyPVY6Pzh:L3G+
PC-3  MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17iTVAuPTBizszN MnrIOFjjiImq NUHNeWF6cW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? MnHpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzMke4PFIoRjJ2MUK3PFgzRC:jPh?=
PC-3  NWrDUGg{S2WubDDWbYFjcWyrdImgRZN{[Xl? MoKwNE0yODBizszN MkX6O|IhcA>? M3rrSoRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= NECxOYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGyO|g5Oid-MkSxNlc5QDJ:L3G+
HCA-7 MYDGeY5kfGmxbjDhd5NigQ>? MnrnO|IhcHK| NXvMU5dQUW6qaXLpeIlwdiCxZjDJUE0y[mW2YT3pcoR2[2WmIGDHSVIheHKxZIXjeIlwdiCrbjDoeY1idiCKQ1GtO{Bk\WyuczDh[pRmeiB5MjDodpMh[nliRVnBMEBGSzVyIE2gNE4xODFzNTFOwG0v NEDoe3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkWxOlI5Oid-MkK1NVYzQDJ:L3G+
CHO MVLGeY5kfGmxbjDhd5NigQ>? NX34OJV{UW5idnn0do8hcW6qaXLpeI9zgSCyb4TlcoN6KGGpYXnud5QhcHWvYX6gR29ZNTJiaX6gd5Ri[my7IITyZY5{\mWldHXkJINpcW6nc3WgbIFue3SncjDveoFzgSBqQ1jPLUBk\WyuczygTWM2OCB;IECuNFAzKM7:TT6= NETpcW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEW3OlY5PCd-MUC1O|Y3QDR:L3G+
CHO MUnGeY5kfGmxbjDhd5NigQ>? MmjETY5pcWKrdHnvckBw\iCSR1WtNkBxem:mdXP0bY9vKGmwIFPIU{Bk\WyuczDlfJBz\XO|aX7nJIh2dWGwIFPPXE0zNCCLQ{WwJF0hOC5yMEKg{txONg>? MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODV5Nk[4OUc,OTB3N{[2PFU9N2F-
CHO NFnaO5VHfW6ldHnvckBie3OjeR?= NVXUXHh1UW5idnn0do8heG:2ZX7jfUBi\2GrboP0JIh2dWGwIGDyc5N1[WeuYX7kbY4hTy:KIIP5cpRp[XOnIEKgbY4hfHKjboPm[YN1\WRiQ1jPJINmdGy|LDDJR|UxKD1iMD6wNFIh|ryPLh?= MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODF7N{m3NEc,OTBzOUe5O|A9N2F-
CHO NFT5OXBHfW6ldHnvckBie3OjeR?= MU\Jcohq[mm2b4L5JI9nKGi3bXHuJHBzd3O2YXfsZY5lcW5iRz;IJJN6dnSqYYPlJFIh\XiycnXzd4VlKGmwIFPIU{Bk\WyuczygTWM2OCB;IECuNFAzKM7:TT6= M1fETlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NkSzPVQzLz5zMk[0N|k1OjxxYU6=
synovial cells M4fxTWZ2dmO2aX;uJIF{e2G7 NGT3O3dKdmirYnn0c5J6KGWoZnXjeEBwdiCycn;keYN1cW:wIH;mJIN6[2yxb4j5[4Vv[XOnLUKgLGNQYC1{KTDwdo9{fGGpbHHu[IlvKEV{IDjQS2UzMSCrbjDoeY1idiCLTEGtZoV1[SC|dHnteYxifGWmIIP5co93cWGuIHPlcIx{NCCLQ{WwJF0hOC5yMEe5JO69VS5? NVn4bpI1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC4NlE4OTZpPkGwPFIyPzF4PD;hQi=>
RAW264.7 M4PGT2Z2dmO2aX;uJIF{e2G7 NGSyR5lKdmirYnn0bY9vKG:oIFPPXE0zKGmwIH3veZNmKFKDV{K2OE44KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIFzQV{1qdmS3Y3XkJHBITTJicILv[JVkfGmxbjD0doVifGWmIIDybY9zKHSxIFzQV{BkcGGubHXu[4Uh[nliZX76fY1mKGmvbYXuc4F{e2G7LDDJR|UxKD1iMD6wNFg4KM7:TT6= M1j2[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkW2OlYzLz5{NE[1OlY3OjxxYU6=
HEK293 M2LVWWZ2dmO2aX;uJIF{e2G7 MXPJcohq[mm2aX;uJI9nKGOub37l[EBUfHmub4Doc5JiKHCrc4TpcIxifGFiYXzwbIEuS0FiZYjwdoV{e2WmIHnuJIh2dWGwIFjFT|I6OyClZXzsd{BjgSC|dH;wdIVlNW[ub4egR28zKGG|c3H5MEBMcSB;IECuNFM1OiEQvF2u MlHXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl3MkC1O|coRjF7NUKwOVc4RC:jPh?=
SF9 NX\kbYxHTnWwY4Tpc44h[XO|YYm= M{jvS2lvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQdo9{fGGpbHHu[IlvKEdxSDDzfY51cGG|ZTCyJIV5eHKnc4Pl[EBqdiC|Zj25JINmdGy|IHnu[oVkfGWmIIfpeIgh[mGldXzveolzfXNuIFnDOVAhRSByLkCzOkDPxE1w NFHXNWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNE[5PFE6OCd-MUS2PVgyQTB:L3G+
SF9 MmHwSpVv[3Srb36gZZN{[Xl? MUPJckB3cXS{bzDpcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5icnXjc41jcW6jboSgdJJwe3SjZ3zhcoRqdiCJL1igd5lvfGijc3WgNkBmgHC{ZYPz[YQhcW5ic3[tPUBk\WyuczDpcoZm[3SnZDD3bZRpKGKjY4Xsc5ZqenW|LDDJR|UxKD1iMD6wN|Yh|ryPLh?= NYrYO|h{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWwNlYxPTBpPkG1NFI3ODVyPD;hQi=>
CHO NEHXdpVHfW6ldHnvckBie3OjeR?= NUG5SplIUW6qaXLpeIlwdiCxZjDDU3gzKGW6cILld5Nm\CCrbjDDTG8h[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDhdoFkcGmmb37pZ{Bi[2mmLYP0bY12dGG2ZXSgVGdGOiCycn;keYN1cW:wIHL5JIVvgnmvZTDpcY12dm:jc4PhfUwhUUN3MDC9JFAvODN4IN88UU4> NX3UcIs{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW1OlYzQTBpPkG1OVY3OjlyPD;hQi=>
insect cells M4rR[mZ2dmO2aX;uJIF{e2G7 M2rJb|EhdWmw MXvJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEORWEKg[ZhxemW|c3XkJIlvKGmwc3XjeEBk\WyuczD1d4lv\yCjcnHjbIlld26rYzDhZ4llKGG|IIP1ZpN1emG2ZTDpcoN2[mG2ZXSg[o9zKDFibXnuJJBzcW:{IITvJJN2[nO2cnH0[UBi\GSrdHnvckBu\WG|dYLl[EBnd3JiMkWgd4VkeyCkeTDUUXBFNWKjc3XkJINpem:vb3flcolkKGG|c3H5MEBKSzVyIE2gNE4xPDJizszNMi=> M3;NbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEGwNlcxLz5{M{CxNFI4ODxxYU6=
HNSCC 1483 MXHGeY5kfGmxbjDhd5NigQ>? NXLPNnNWOzBibXnudy=> NF;TSYFKdmirYnn0bY9vKG:oIFPPXE0zKGmwIHj1cYFvKEiQU1PDJFE1QDNiY3XscJMhfXOrbnegX|E1S11iYYLhZ4hq\G:waXOgZYNq\CCjczDzeYJ{fHKjdHWgdJJmcW6ldXLheIVlKG[xcjCzNEBucW6|IHLl[o9z\SC|dXLzeJJifGViYXTkbZRqd25ibXXhd5Vz\WRiYX\0[ZIhOzBibXnud{whUUN3MDC9JFAvODV2IN88UU4> NXLOZllURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyOlM5QTRpPkKyNlY{QDl2PD;hQi=>
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HT29 MX3GeY5kfGmxbjDhd5NigQ>? M4fSWVExKHWP MV3Jcohq[mm2aX;uJI9nKGi7YXz1do9v[W5vaX7keYNm\CCFRES0JIFvfGmpZX6geoFzcWGwdDDlfI9vKDZiYXP0bZZqfHliaX6gbJVu[W5iSGSyPUBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCFT2itNkBmgHC{ZYPzbY9vKGG2IEGwJJVO M2r0bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NUG3O|IyLz5{M{WxO|czOTxxYU6=
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HCA-7 NF;4T4VHfW6ldHnvckBie3OjeR?= MXO1JJVO NY\zVmxQOjRiaILz M4TLO2lvcGmkaYTpc44hd2ZiaInhcJVzd26jbj3pcoR2[2WmIFPEOFR3PiCrbjDoeY1idiCKQ1GtO{Bk\WyuczD0doFve2[nY4Tl[EB4cXSqIFjhd|JkTE6DIHHzd4V{e2WmIHHzJIRwf26{ZXf1cIF1cW:wIH;mJGNQYC1zIIDyc5RmcW5iZYjwdoV{e2mxbjDheEA2KHWPIHHmeIVzKDJ2IHjyd{BjgSCZZYP0[ZJvKGKub4T0bY5oKGGwYXz5d4l{ M4TKb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Mkm1O|g4Lz5{NEK5OVc5PzxxYU6=
HeLa NXjYNY9QTnWwY4Tpc44h[XO|YYm= MXuxNFAhfU1? NEK4NpQzPCCqcoO= NWHIbYs2UW6qaXLpeIlwdiCxZjDtVGdGWy1zIHnuJIh2dWGwIFjlUIEh[2WubIOgeZNqdmdiUFfINkBieyC|dXLzeJJifGViYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCLTD2xZoV1[S:WTl\hcJBp[S2|dHnteYxifGWmIGDHSVIheHKxZIXjeIlwdiCjdDCxNFAhfU1iYX\0[ZIhOjRiaILzJIJ6KEyFLV3TM21UKGGwYXz5d4l{ NV70O494RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxPFM4OzlpPkK0NVg{PzN7PD;hQi=>
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Saos-2 Ml;LdWhVWyCjc4PhfS=> MXHxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW2Gxcz2yJINmdGy| M2r0VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
RAW264.7 NFTvXGJCdnSraX7mcIFudWG2b4L5JIF{e2G7 NYnoVllJOjBidV2= M1XHeFIhcHK| M4S1dWFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCUQWeyOlQvPyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGxRWyCrbnT1Z4VlKGOxeD2yJIV5eHKnc4Ppc44h[XRiMkCgeW0heHKnaX7jeYJifGWmIH\vdkAzKGi{czDmc4xtd3enZDDifUBNWFNiY3jhcIxmdmenIH3lZZN2emWmIHHmeIVzKDJ2IHjyd{BjgSCZZYP0[ZJvKGKub4SgcYV1cG:m MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTFyMEe5PUc,OjlzMEC3PVk9N2F-
RAW264.7 NGTMcG9CdnSraX7mcIFudWG2b4L5JIF{e2G7 NVXzTXVIOjBidV2= MWSyJIhzew>? NY\aNotxSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIGLBW|I3PC55IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhVFCVIHnu[JVk\WRiaV7PV{BmgHC{ZYPzbY9vKGG2IEKwJJVOKHC{ZXnuZ5Vj[XSnZDDmc5IhOiCqcoOg[o9tdG:5ZXSgZpkhVFCVIHPoZYxt\W6pZTDt[YF{fXKnZDDh[pRmeiB{NDDodpMh[nliV3XzeIVzdiCkbH;0JI1mfGixZB?= NYjXbo5YRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxNFA4QTlpPkK5NVAxPzl7PD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Fibronectin / Vimentin / N-cadherin / E-cadherin ; 

PubMed: 28978083     


(A) Celecoxib treatment reduces the mesenchymal phenotype in SUM149 cells.

COX-2; 

PubMed: 29515134     


L02 cells exposed to PA (200 μM) with different concentrations of celecoxib (Cel, 5-40 μM) for 24 h. Celecoxib decreased protein expression of COX-2 compared with control as indicated by western blot. 

pAKT / AKT / PPARγ / PTEN ; 

PubMed: 24721996     


Immunoblots from N1-S1 cells treated with different dose celecoxib for 48 h. 

28978083 29515134 24721996
Immunofluorescence
PPARγ / PTEN ; 

PubMed: 24721996     


Immunofluorescence analysis in N1-S1 cells treated with 10 μM celecoxib for 48 h.

24721996
Growth inhibition assay
Cell viability; 

PubMed: 28521485     


Celecoxib caused the concentration-dependent inhibition of (A) GBC-SD and (B) NOZ cell growth. 

28521485
In vivo Celecoxib exhibits a potent, oral anti-inflammatory activity. Celecoxib reduces acute inflammation in the carrageenan edema assay and chronic inflammation in the adjuvant arthritis model with ED50 of 7.1 mg/kg and 0.37 mg/kg/day, respectively. In addition, Celecoxib also exhibits analgesic activity in the Hargreaves hyperalgesia model with ED50 of 34.5 mg/kg. Besides, Celecoxib produces no acute GI toxicity in rats at doses up to 200 mg/kg and no chronic GI toxicity in rats at doses up to 600 mg/kg/day over 10 days. [1] In a C3Hf/KamLaw female mouse model, Celecoxib increases median survival time of 105 days (range, 79-145 days) after 13.5 Gy local thoracic irradiation (LTI) alone to 142 days (range, 94-155 days). [3]

Protocol

Kinase Assay:[1]
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COX enzyme assay in vitro:

Expression of COX protein in insect cells is determined by assessing PG-synthetic capability in homogenates from cells incubated for 3 days with COX-1 or COX-2 baculovirus. Cells expressing COX-1 or COX-2 are homogenized and incubated with arachidonic acid (10 μM). COX activity is determined by monitoring PG production. No COX activity is detected in mock-infected Sf9 cells. Celecoxib are preincubated with crude 1% CHAPS homogenates (2-10 μg of protein) for 10 minutes before addition of arachidonic acid. PGE2 formed is detected by ELISA after 10 minute incubation.
Cell Research:[2]
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  • Cell lines: HNE1 and CNE1-LMP1
  • Concentrations: 0-75 μM
  • Incubation Time: 48 hours
  • Method: The antiproliferative effect of Celecoxib on NPC cells is assessed using an MTT assay. Cells are seeded into 96-well plates and allowed to attach for 24 hours. The cells are then treated with increasing concentrations of Celecoxib (0 to 75 μM) dissolved in DMSO (final concentration ≤0.1%) and incubated for up to 48 hours. After the incubation, 20 μL of MTT dye (5 mg/mL) are added to each well and cells are incubated at 37 °C for 4 hours. After removing the supernatants, the crystals are dissolved in DMSO and the absorbance is measured at 490 nm. The half-maximal inhibitory concentration (IC50) values and the 95% confidence intervals are calculated using probit regression using SPSS 15.0 software. The experiment is performed in triplicate and repeated at least three times.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: A 0.1 mL aliquot of a 1% solution of carrageenan in 0.9% sterile saline or 1 mg of Mycobacterium butyricum in 50 μL of mineral oil is administered to the right hind foot pad of male Sprague−Dawley rats.
  • Dosages: ≤200 mg/kg
  • Administration: Administered via p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 76 mg/mL (199.28 mM)
Ethanol 33 mg/mL (86.53 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 381.37
Formula

C17H14F3N3O2S

CAS No. 169590-42-5
Storage powder
in solvent
Synonyms SC 58635
Smiles CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04526197 Enrolling by invitation Drug: ALXN1840|Drug: Celecoxib Wilson Disease Alexion Pharmaceuticals July 8 2020 Phase 1
NCT04447261 Recruiting Drug: BI 1356225|Drug: Placebo Obesity Boehringer Ingelheim June 30 2020 Phase 1
NCT03896113 Recruiting Drug: Celecoxib 200mg capsule Endometrium Cancer Cliniques universitaires Saint-Luc- Université Catholique de Louvain November 13 2019 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    I am doing an animal experiment with mice and planning to administrate S1261 via oral gavage. what are your recommendations for diluting the compound?

  • Answer:

    For oral administration, Celecoxib can be dissolved in vehicle one: "0.5% methyl cellulose and 0.025% Tween-20", or the vehicle 2 "2% DMSO/30% PEG 300/5% Tween 80/ ddH2O".

COX Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID