Celecoxib (SC 58635)

Licensed by Pfizer Catalog No.S1261

For research use only.

Celecoxib (SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.

Celecoxib (SC 58635) Chemical Structure

CAS No. 169590-42-5

Selleck's Celecoxib (SC 58635) has been cited by 79 publications

Purity & Quality Control

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Biological Activity

Description Celecoxib (SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.
Targets
COX-2 [1]
(Sf9 cells)
40 nM
In vitro

Celecoxib shows low sensitivity against COX-1 with IC50 of 15 μM. [1] Celecoxib shows an anti-proliferative effect on nasopharyngeal carcinoma (NPC) cell lines including HNE1 and CNE1-LMP1 with IC50 of 32.86 μM and 61.31 μM, respectively. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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H460 MVfGeY5kfGmxbjDBd5NigQ>? NGTxXmwxNjFvM{Cg{txO MVu0PEBp NHL0WYxqdmS3Y3XzJGlESU1vMTDlfJBz\XO|aX;uJI9vKGKxdHigdJJwfGWrbjDhcoQhdVKQQTDs[ZZmdA>? NG\tb3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkWxN|E4Oid-Mk[1NVMyPzJ:L3G+
HKESC-2 NEn1OY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3LdJVlOjEEoN88US=> NWqyTm5wPDkEoHlCpC=> MlfDd4lodmmoaXPhcpRtgSCrbnPy[YF{\XNidHjlJGlEPTEEoI\hcJVmeyCxZjDvfIFtcXCuYYTpcuKh MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjR5NE[5N{c,OjZ2N{S2PVM9N2F-
CaES-17 NEO3RlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jvdVIxyqEQvF2= MXy0POKhcMLi M{DrWZNq\26rZnnjZY51dHliaX7jdoVie2W|IITo[UBKSzVywrD2ZYx2\XNib3[gc5hidGmybHH0bY7DqA>? MkXIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2N{S2PVMoRjJ4NEe0Olk{RC:jPh?=
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CaES-17 NHTYZlNCeG:ydH;zbZMhSXO|YYm= M1m0eFIxyqEQvF2= M2qwelQ5yqCqwrC= NWjRXVJSemWmdXPld{BwgGGuaYDsZZRqdi2rbnT1Z4VlKGGyb4D0c5Nqew>? NGHObWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS3OFY6Oyd-Mk[0O|Q3QTN:L3G+
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SGC-7901 Mon1SpVv[3Srb36gRZN{[Xl? M1HSPFc2NzFyMD:xNlUh|ryP NF64S4EzPC92OD:3NkBp Mo\ObY5kemWjc3XzJINie3Cjc3WtPEBidmRiLUmgcXJPSSCneIDy[ZN{cW:wIHnuJIJwfGhidHnt[UBidmRiZH;z[UBu[W6wZYK= M{jtfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Nke2N|k1Lz5{NE[3OlM6PDxxYU6=
LMeC  NFjxN3RHfW6ldHnvckBCe3OjeR?= MlnRNlAwPTBizszN MmHhOFghcA>? NVzvOGtH\GWlcnXhd4V{KHSqZTDlfJBz\XO|aX;uJI9nKEORWD2yJJBzd3SnaX6= NWC1T2szRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OVY4PDZpPkK0OlU3PzR4PD;hQi=>
CMeC-1 NFfpS2hE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M2fTNlIxNzVyIN88US=> NHPGPJo1QCCq NHXkZmdqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= MkfhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O|Q3RC:jPh?=
LMeC MnX2R4VtdCCYaXHibYxqfHliQYPzZZk> NEnQfmUzOC93MDFOwG0> MnW4OFghcA>? NVy2UWFtcW6qaXLpeJMh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlJIRmeGWwZHXueEBu[W6wZYK= Mn3SQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O|Q3RC:jPh?=
CMeC-1 NHG3dZlHfW6ldHnvckBCe3OjeR?= NV;udIlMOjBxNUCg{txO M{DKUVQ5KGh? MVTpcoR2[2W|IFexMXMh[XK{ZYP0 MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ3Nke0Okc,OjR4NU[3OFY9N2F-
LMeC NV\yUXpTTnWwY4Tpc44hSXO|YYm= M1f6O|IxNzVyIN88US=> NFzFNFY1QCCq MnTvbY5lfWOnczDHNU1UKGG{cnXzeC=> MlLaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O|Q3RC:jPh?=
CMeC-1 M3npdGZ2dmO2aX;uJGF{e2G7 MUKyNE82OCEQvF2= NXP4SJlEPDhiaB?= MmGz[IVkemWjc3XzJJRp\SCuZY\lcJMhd2ZiY4njcIlvKERzIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ NF[xU4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[1Olc1Pid-MkS2OVY4PDZ:L3G+
LMeC NX;5OZViTnWwY4Tpc44hSXO|YYm= NVrMVXdjOjBxNUCg{txO NYHuSHREPDhiaB?= NWH1XlR5\GWlcnXhd4V{KHSqZTDs[ZZmdHNib3[gZ5lkdGmwIFSxJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy Ml3hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O|Q3RC:jPh?=
CMeC-1 NXXmeWV[TnWwY4Tpc44hSXO|YYm= Mnq1NlAwPTBizszN MVi0PEBp NYH3UnlIcW6mdXPld{Bk[XOyYYPlMVMh[WO2aY\heIlwdg>? MkDKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O|Q3RC:jPh?=
LMeC Ml23SpVv[3Srb36gRZN{[Xl? MnT0NlAwPTBizszN MkjROFghcA>? NELtcGtqdmS3Y3XzJINie3Cjc3WtN{Bi[3SrdnH0bY9v NVrPeIMzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OVY4PDZpPkK0OlU3PzR4PD;hQi=>
OVCAR-3 MlznR4VtdCCYaXHibYxqfHliQYPzZZk> NVGzVItuOTBiwsXN NVyydGxoOSCq MYHlcohidmOnczDwZYNtcXSjeHXsMYlv\HWlZXSgc5ZiemmjbjDjZY5k\XJiY3XscEBl\WG2aNMg MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV{MEKyO{c,OjR3MkCyNlc9N2F-
OVCAR-3 NYTQVHRsSXCxcITvd4l{KEG|c3H5 NHqwVowyOCEEtV2= NXHrUmVkOSCq NELRWG9xem:vb4Tld{Bx[WOuaYThfIVtNWmwZIXj[YQh[XCxcITvd4l{yqB? NWDGfmFDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NlAzOjdpPkK0OVIxOjJ5PD;hQi=>
OVCAR-3 NVWwSJJuTnWwY4Tpc44hSXO|YYm= NF7P[oEyOCEEtV2= NHjpXGUyKGh? MY\lcohidmOnczDwZYNtcXSjeHXsMYlv\HWlZXSgZYN1cX[jdHnvckBw\iClYYPwZZNmNToEoB?= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV{MEKyO{c,OjR3MkCyNlc9N2F-
OVCAR-3 MXzGeY5kfGmxbjDBd5NigQ>? NH\iUJoyOCEEtV2= NGPNXYIyKGh? M1;kWoRwf25vcnXneYxifGW|IF7GMe67SiCjY4TpeoF1cW:wIHnu[JVk\WRiYomgdIFkdGm2YYjlcC=> MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV{MEKyO{c,OjR3MkCyNlc9N2F-
OVCAR-3 MWXGeY5kfGmxbjDBd5NigQ>? M1PUOFExKML3TR?= NXzXTlRUOSCq NYTKWm1bcW6qaXLpeJMheGGlbHn0ZZhmdC2rbnT1Z4VlKEGtdDDwbI9{eGixconsZZRqd25? NWDHRXJJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NlAzOjdpPkK0OVIxOjJ5PD;hQi=>
CF33 MkHjSpVv[3Srb36gRZN{[Xl? MVexNFAh|ryP NIfIc2wzPCCq NIXkeopqdmS3Y3XzJIRwf26{ZXf1cIF1cW:wIH;mJGNQYC1{IIDyc5RmcW5iZYjwdoV{e2mxbh?= MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVyM{e4Nkc,OjR3MEO3PFI9N2F-
CF33 MlPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPDflkxOTBvMUCwJO69VQ>? MWGwMVQh\A>? M1WyZYlvcGmkaYTzJINmdGxicILvcIln\XKjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> M161cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUCzO|gzLz5{NEWwN|c5OjxxYU6=
CF33 NYrtbpBDTnWwY4Tpc44hSXO|YYm= NUO3fVZDOTBvMUCwJO69VQ>? NXeyXJdxPC1{NDDo NVThW2xs\GWlcnXhd4V{KGOnbHzzJIlvKHSqZTDTJJBp[XOnIHHu[EBqdmO{ZXHz[ZMh[2WubIOgbY4hTzBxR{GgZZJz\XO2 NUPCO|BMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NFM4QDJpPkK0OVA{Pzh{PD;hQi=>
LNCaP NV65WmZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoqyNk82NzFyIN88US=> MXe5OkBp NXvCZYtDcW6qaXLpeJMh[2WubDDndo94fGhic3nncolncWOjboTsfUBkd22kaX7l[EB4cXSqIHH0c5J3[XO2YYTpci=> MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ7Nkm3PEc,OjR{OU[5O|g9N2F-
LNCaP NHnoc4tCeG:ydH;zbZMhSXO|YYm= MWiyM|UwOTBizszN NX[we5JzQTZiaB?= MnTobY5lfWOnczDhdI9xfG:|aYOgZ49u[mmwZXSge4l1cCCjdH;yeoF{fGG2aX6= NXezdJJ[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyPVY6PzhpPkK0Nlk3QTd6PD;hQi=>
PC-3  NWGxbHVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHTXWNuOC13MDFOwG0> NIHwNYw1QOLCiXi= NYXpd4xzcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? M3TjeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUK3PFgzLz5{NEGyO|g5OjxxYU6=
PC-3  NF32U2RE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NF;0V40xNTFyMDFOwG0> M3zrO|czKGh? MojP[IVkemWjc3XzJINmdGxidnnhZoltcXS7IHnuJIEh\G:|ZTDk[ZBmdmSnboSgcYFvdmW{ NGTUcZQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGyO|g5Oid-MkSxNlc5QDJ:L3G+
HCA-7 M4jKSmZ2dmO2aX;uJIF{e2G7 MXS3NkBpenN? M{PmZWlvcGmkaYTpc44hd2ZiSVytNYJmfGFvaX7keYNm\CCSR1WyJJBzd2S3Y4Tpc44hcW5iaIXtZY4hUEODLUegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEWLQTygSWM2OCB;IECuNFAyOTVizszNMi=> NH\kfnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkWxOlI5Oid-MkK1NVYzQDJ:L3G+
CHO M2fUcmZ2dmO2aX;uJIF{e2G7 M4HkemlvKH[rdILvJIlvcGmkaYTvdpkheG:2ZX7jfUBi\2GrboP0JIh2dWGwIFPPXE0zKGmwIIP0ZYJtgSC2cnHud4Zm[3SnZDDjbIlv\XOnIHjhcZN1\XJib4\hdpkhMEOKTzmgZ4VtdHNuIFnDOVAhRSByLkCwNkDPxE1w MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODV5Nk[4OEc,OTB3N{[2PFQ9N2F-
CHO MofiSpVv[3Srb36gZZN{[Xl? MkTtTY5pcWKrdHnvckBw\iCSR1WtNkBxem:mdXP0bY9vKGmwIFPIU{Bk\WyuczDlfJBz\XO|aX7nJIh2dWGwIFPPXE0zNCCLQ{WwJF0hOC5yMEKg{txONg>? MkPKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB3N{[2PFUoRjFyNUe2Olg2RC:jPh?=
CHO NHn5SWVHfW6ldHnvckBie3OjeR?= NXPlXZpUUW5idnn0do8heG:2ZX7jfUBi\2GrboP0JIh2dWGwIGDyc5N1[WeuYX7kbY4hTy:KIIP5cpRp[XOnIEKgbY4hfHKjboPm[YN1\WRiQ1jPJINmdGy|LDDJR|UxKD1iMD6wNFIh|ryPLh?= NWO5[|JQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUCxPVc6PzBpPkGwNVk4QTdyPD;hQi=>
CHO NI\1TVFHfW6ldHnvckBie3OjeR?= NIXocGtKdmirYnn0c5J6KG:oIHj1cYFvKFC{b4P0ZYdt[W6maX6gS{9JKHO7boToZZNmKDJiZYjwdoV{e2WmIHnuJGNJVyClZXzsd{whUUN3MDC9JFAvODB{IN88UU4> Mme3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4NEO5OFIoRjF{NkSzPVQzRC:jPh?=
synovial cells MnPmSpVv[3Srb36gZZN{[Xl? MWfJcohq[mm2b4L5JIVn\mWldDDvckBxem:mdXP0bY9vKG:oIHP5Z4xwd3i7Z3XuZZNmNTJiKFPPXE0zMSCycn;zeIFodGGwZHnuJGUzKCiSR1WyLUBqdiCqdX3hckBKVDFvYnX0ZUB{fGmvdXzheIVlKHO7bn;2bYFtKGOnbHzzMEBKSzVyIE2gNE4xODd7IN88UU4> Mk\JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB6MkG3NVYoRjFyOEKxO|E3RC:jPh?=
RAW264.7 NG\KfItHfW6ldHnvckBie3OjeR?= NYm2XlM{UW6qaXLpeIlwdiCxZjDDU3guOiCrbjDtc5V{\SCUQWeyOlQvPyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDMVHMucW6mdXPl[EBRT0V{IIDyc4R2[3Srb36geJJm[XSnZDDwdolweiC2bzDMVHMh[2ijbHzlcodmKGK7IHXufplu\SCrbX31co9ie3OjeTygTWM2OCB;IECuNFA5PyEQvF2u MoLJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[2OlIoRjJ2NkW2OlYzRC:jPh?=
HEK293 MoXaSpVv[3Srb36gZZN{[Xl? MkDuTY5pcWKrdHnvckBw\iClbH;u[YQhW3S7bH;wbI9z[SCyaYP0bYxt[XSjIHHsdIhiNUODIHX4dJJme3OnZDDpckBpfW2jbjDISWszQTNiY3XscJMh[nlic4TvdJBm\C2obH;3JGNQOiCjc4PhfUwhU2liPTCwMlA{PDJizszNMi=> MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTV{MEW3O{c,OTl3MkC1O|c9N2F-
SF9 M1TVVmZ2dmO2aX;uJIF{e2G7 M3PCeWlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQdo9{fGGpbHHu[IlvKEdxSDDzfY51cGG|ZTCyJIV5eHKnc4Pl[EBqdiC|Zj25JINmdGy|IHnu[oVkfGWmIIfpeIgh[mGldXzveolzfXNuIFnDOVAhRSByLkCzOkDPxE1w NGnFNpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNE[5PFE6OCd-MUS2PVgyQTB:L3G+
SF9 M2Tkb2Z2dmO2aX;uJIF{e2G7 NF\memxKdiC4aYTyc{BqdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhcHWvYX6gdoVkd22kaX7hcpQheHKxc4Th[4xidmSrbjDHM2ghe3mwdHjhd4UhOiCneIDy[ZN{\WRiaX6gd4YuQSClZXzsd{Bqdm[nY4Tl[EB4cXSqIHLhZ5Vtd3[rcoXzMEBKSzVyIE2gNE4xOzZizszNMi=> M2\aXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MEK2NFUxLz5zNUCyOlA2ODxxYU6=
CHO NH;2fpVHfW6ldHnvckBie3OjeR?= NFzUOoNKdmirYnn0bY9vKG:oIFPPXFIh\XiycnXzd4VlKGmwIFPIU{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHHyZYNpcWSxbnnjJIFkcWRvc4TpcZVt[XSnZDDQS2UzKHC{b3T1Z5Rqd25iYomg[Y57gW2nIHntcZVvd2G|c3H5MEBKSzVyIE2gNE4xOzZizszNMi=> NVHIfo1IRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW1OlYzQTBpPkG1OVY3OjlyPD;hQi=>
insect cells MWHGeY5kfGmxbjDhd5NigQ>? MkG1NUBucW5? M3;zSWlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiQ1;YNkBmgHC{ZYPz[YQhcW5iaX7z[YN1KGOnbHzzJJV{cW6pIHHyZYNpcWSxbnnjJIFkcWRiYYOgd5Vje3S{YYTlJIlv[3WkYYTl[EBnd3JiMTDtbY4heHKrb4KgeI8he3Wkc4TyZZRmKGGmZHn0bY9vKG2nYYP1doVlKG[xcjCyOUB{\WO|IHL5JHROWERvYnHz[YQh[2i{b33v[4VvcWNiYYPzZZktKEmFNUCgQUAxNjB2MjFOwG0v NWLxdYZGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNVAzPzBpPkKzNFExOjdyPD;hQi=>
HNSCC 1483 MXHGeY5kfGmxbjDhd5NigQ>? M3zEZ|MxKG2rboO= NUDmVppnUW6qaXLpeIlwdiCxZjDDU3guOiCrbjDoeY1idiCKTmPDR{AyPDh|IHPlcIx{KHW|aX7nJHsyPEOfIHHyZYNpcWSxbnnjJIFkcWRiYYOgd5Vje3S{YYTlJJBz\WmwY4XiZZRm\CCob4KgN|AhdWmwczDi[YZwemVic4Xid5Rz[XSnIHHk[Il1cW:wIH3lZZN2emWmIHHmeIVzKDNyIH3pcpMtKEmFNUCgQUAxNjB3NDFOwG0v NW\yfXRlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyOlM5QTRpPkKyNlY{QDl2PD;hQi=>
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J774 NYDuUpJnTnWwY4Tpc44h[XO|YYm= MnnWNVUhdWmwcx?= MUPJcohq[mm2aX;uJI9nKEORWEKgbY4hVFCVLYP0bY12dGG2ZXSgcY92e2ViSke3OEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIGDHSVIheHKxZIXjeIlwdiCjZoTldkAyPSCvaX7zJIJ6KHKjZHnvbY1ufW6xYYPzZZktKEmFNUCgQUAxNjB4IN88UU4> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDd3Mkm1O{c,OTh5NUK5OVc9N2F-
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Assay
Methods Test Index PMID
Western blot Fibronectin / Vimentin / N-cadherin / E-cadherin ; COX-2 ; pAKT / AKT / PPARγ / PTEN 28978083 29515134 24721996
Immunofluorescence PPARγ / PTEN 24721996
Growth inhibition assay Cell viability 28521485
In vivo Celecoxib exhibits a potent, oral anti-inflammatory activity. Celecoxib reduces acute inflammation in the carrageenan edema assay and chronic inflammation in the adjuvant arthritis model with ED50 of 7.1 mg/kg and 0.37 mg/kg/day, respectively. In addition, Celecoxib also exhibits analgesic activity in the Hargreaves hyperalgesia model with ED50 of 34.5 mg/kg. Besides, Celecoxib produces no acute GI toxicity in rats at doses up to 200 mg/kg and no chronic GI toxicity in rats at doses up to 600 mg/kg/day over 10 days. [1] In a C3Hf/KamLaw female mouse model, Celecoxib increases median survival time of 105 days (range, 79-145 days) after 13.5 Gy local thoracic irradiation (LTI) alone to 142 days (range, 94-155 days). [3]

Protocol (from reference)

Kinase Assay:[1]
  • COX enzyme assay in vitro:

    Expression of COX protein in insect cells is determined by assessing PG-synthetic capability in homogenates from cells incubated for 3 days with COX-1 or COX-2 baculovirus. Cells expressing COX-1 or COX-2 are homogenized and incubated with arachidonic acid (10 μM). COX activity is determined by monitoring PG production. No COX activity is detected in mock-infected Sf9 cells. Celecoxib are preincubated with crude 1% CHAPS homogenates (2-10 μg of protein) for 10 minutes before addition of arachidonic acid. PGE2 formed is detected by ELISA after 10 minute incubation.

Cell Research:[2]
  • Cell lines: HNE1 and CNE1-LMP1
  • Concentrations: 0-75 μM
  • Incubation Time: 48 hours
  • Method: The antiproliferative effect of Celecoxib on NPC cells is assessed using an MTT assay. Cells are seeded into 96-well plates and allowed to attach for 24 hours. The cells are then treated with increasing concentrations of Celecoxib (0 to 75 μM) dissolved in DMSO (final concentration ≤0.1%) and incubated for up to 48 hours. After the incubation, 20 μL of MTT dye (5 mg/mL) are added to each well and cells are incubated at 37 °C for 4 hours. After removing the supernatants, the crystals are dissolved in DMSO and the absorbance is measured at 490 nm. The half-maximal inhibitory concentration (IC50) values and the 95% confidence intervals are calculated using probit regression using SPSS 15.0 software. The experiment is performed in triplicate and repeated at least three times.
  • (Only for Reference)
Animal Research:[1]
  • Animal Models: A 0.1 mL aliquot of a 1% solution of carrageenan in 0.9% sterile saline or 1 mg of Mycobacterium butyricum in 50 μL of mineral oil is administered to the right hind foot pad of male Sprague−Dawley rats.
  • Dosages: ≤200 mg/kg
  • Administration: Administered via p.o.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 76 mg/mL
(199.28 mM)
Water Insoluble
Ethanol '33 mg/mL

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.

5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 381.37
Formula

C17H14F3N3O2S

CAS No. 169590-42-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01344200 Not yet recruiting Drug: Celecoxib|Drug: Placebo Pharmacokinetics of Celecoxib in Children Children''s Hospital of Eastern Ontario January 2022 Phase 2
NCT04526197 Completed Drug: ALXN1840|Drug: Celecoxib Wilson Disease Alexion Pharmaceuticals July 8 2020 Phase 1
NCT04447261 Completed Drug: BI 1356225|Drug: Placebo Obesity Boehringer Ingelheim June 30 2020 Phase 1
NCT03896113 Recruiting Drug: Celecoxib 200mg capsule Endometrium Cancer Cliniques universitaires Saint-Luc- Université Catholique de Louvain November 13 2019 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
I am doing an animal experiment with mice and planning to administrate S1261 via oral gavage. what are your recommendations for diluting the compound?

Answer:
For oral administration, Celecoxib can be dissolved in vehicle one: "0.5% methyl cellulose and 0.025% Tween-20", or the vehicle 2 "2% DMSO/30% PEG 300/5% Tween 80/ ddH2O".

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