Home Apoptosis TNF-alpha inhibitor CPI-1189

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CPI-1189 TNF-alpha inhibitor

Cat.No.S2465

CPI-1189 (REN 1654, REN 1189) is the proapoptotic cytokine tumor necrosis factor (TNF) alpha inhibitor. This compound intracellularly inhibits the p38 mitogen-activated protein kinase phosphoactivation and shows neuroprotective effects.
CPI-1189 TNF-alpha inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 234.29

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S246501 DMSO]47 mg/mL]false]Ethanol]15 mg/mL]false]Water]Insoluble]false Purity: 99.45%
99.45

Chemical Information, Storage & Stability

Molecular Weight 234.29 Formula

C13H18N2O2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 183619-38-7 -- Storage of Stock Solutions

Synonyms REN 1654, REN 1189 Smiles CC(=O)NC1=CC=C(C=C1)C(=O)NC(C)(C)C

Solubility

In vitro
Batch:

DMSO : 47 mg/mL (200.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 15 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
TNF-alpha [1]
References

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