Cytarabine (U-19920A)

For research use only.

Catalog No.S1648 Synonyms: Cytarabin, Ara-C, Arabinofuranosyl Cytidine, Cytosine β-D-arabinofuranoside, Cytosine arabinoside, NSC 63878, NSC 287459

57 publications

Cytarabine (U-19920A) Chemical Structure

CAS No. 147-94-4

Cytarabine (U-19920A, Cytarabin, Ara-C, Arabinofuranosyl Cytidine, Cytosine β-D-arabinofuranoside, Cytosine arabinoside, NSC 63878, NSC 287459) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis.

Selleck's Cytarabine (U-19920A) has been cited by 57 publications

Purity & Quality Control

Choose Selective DNA/RNA Synthesis Inhibitors

Biological Activity

Description Cytarabine (U-19920A, Cytarabin, Ara-C, Arabinofuranosyl Cytidine, Cytosine β-D-arabinofuranoside, Cytosine arabinoside, NSC 63878, NSC 287459) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis.
Features The 1st of a series of cancer drugs that alters the sugar component of nucleosides.
Targets
DNA synthesis [1]
(CCRF-CEM cells)
16 nM
In vitro

Cytarabine (AraC) is phosphorylated into a triphosphate form (Ara-CTP) involving deoxycytidine kinase (dCK), which competes with dCTP for incorporation into DNA, and then blocks DNA synthesis by inhibiting the function of DNA and RNA polymerases. Cytarabine displays a higher growth inhibitory activity towards wild-type CCRF-CEM cells compared to other acute myelogenous leukemia (AML) cells with IC50 of 16 nM. [1] Increasing concentrations of Cytarabine (IC50 of 0.69 μM) results in decreased metabolic activity of sensitive rat leukemic cell line RO/1, and the cell toxity can be highly enhanced by transfection with human wt dCK (IC50 of 0.037 μM) but not the inactive, alternatively spliced dCK forms. [2] Cytarabine apparently induces apoptosis of rat sympathetic neurons at 10 μM, of which 100 μM shows the highest toxicity and kills over 80% of the neurons by 84 hours, involving the release of mitochondrial cytochrome-c and the activation of caspase-3, and the toxicity can be attenuated by p53 knockdown and delayed by bax deletion. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
murine leukemia P388 Mn[ySpVv[3Srb36gZZN{[Xl? MojXRY51cWOjbnPldkBi[3Srdnn0fUBk[XK{aXXkJI92fCCrbjD2bZRzdyCjZ3HpcpN1KG23cnnu[UBt\XWtZX3pZUBROzh6LDDJR|UxRTBwMUSg{txO NHrzWlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUO1OlEyOCd-MUGzOVYyOTB:L3G+
L1210 cell lines NUXSeVNKTnWwY4Tpc44h[XO|YYm= MVvDc45k\W62cnH0bY9vKHKncYXpdoVlKHSxIHnubIljcXRicnXwcIlk[XSrb36gc4YhVDF{MUCgZ4VtdCCuaX7ld{BjgSB3MDWgZYZ1\XJiN{KgbJIhcW6ldXLheIlwdixiRVS1NF0xNjB3IN88UU4> MnT5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3MkCyOEc,OTZ3MkCyOFww[T5?
CCRF-CEM cell lines NXSzcXMyTnWwY4Tpc44h[XO|YYm= MUi3NkBp MkHCR49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDpcohq[mm2IILldIxq[2G2aX;uJI9nKEOFUl[tR2VOKGOnbHygcIlv\XNiYomgOVAmKGGodHXyJFczKGi{IHnuZ5Vj[XSrb36sJGVFPTB;NjDuUU4> M4jCfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NUKwNlQoRjF4NUKwNlQ9N2F-
CCRF-CEM cell line NVi1bXQ1TnWwY4Tpc44h[XO|YYm= NVj5UmhxUW6qaXLpeEB1cGVicnXwcIlk[XSrb36gc4YhS0OURj3DSW0h[2WubDDsbY5mKGmwII\peJJwNCCHREWwQVUhdk1w MmLoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7NUi5OEc,OTl7NUi5OFww[T5?
HeLa human cell lines M133VWZ2dmO2aX;uJIF{e2G7 MmPINVQ1KGh? Mnv3WIhmKGOxbYDveY5lKHejczD0[ZN1\WRiaX6geol1em9iZn;yJIFvfGm2dX3vdkBi[3Srdnn0fUg2OCViaX7obYJqfGmxbjDv[kB1fW2xcjDj[YxtKGe{b4f0bEkh[WejaX7zeEBJ\UyjIHj1cYFvKGOnbHygcIlv\XNiYX\0[ZIhOTR2IHjyMEBKTDVyPUCuNUDPxE1? NH[zVYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|NkK1O|E1Lz5|NkK1O|E1RC:jPh?=
L1210 murine cell lines NIXZRVdHfW6ldHnvckBie3OjeR?= NH;5NWE4OiCq M{W0U3Rp\SClb33wc5Vv\CC5YYOgeIV{fGWmIHnuJJZqfHKxIH\vdkBidnSrdIXtc5Ih[WO2aY\peJkpPTBnIHnubIljcXSrb36gc4YhfHWvb4KgZ4VtdCCpcn;3eIgqKGGpYXnud5QhfGinIFyxNlExKG23cnnu[UBk\WyuIHzpcoV{KGGodHXyJFczKGixdYLzMEBKTDVyPUKwJI5ONg>? MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{PjJ3N{G0K|4{PjJ3N{G0QE9iRg>?
P388 murine cell lines M3XyWWZ2dmO2aX;uJIF{e2G7 MnPaO|IhcA>? NFryc4hVcGViY3;tdI92dmRid3HzJJRme3SnZDDpckB3cXS{bzDmc5Ih[W62aYT1cY9zKGGldHn2bZR6MDVyJTDpcohq[mm2aX;uJI9nKHS3bX;yJINmdGxiZ4Lve5RpMSCjZ3HpcpN1KHSqZTDQN|g5KG23cnnu[UBk\WyuIHzpcoV{KGGodHXyJFczKGixdYLzMEBKTDVyPUKwJI5ONg>? M1ro[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzN4MkW3NVQoRjN4MkW3NVQ9N2F-
RPMI-6410 human leukemic lymphoblastoid cell lines M{nsT2N6fG:2b4jpZ:Kh[XO|YYm= MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBTWE2LLU[0NVAhcHWvYX6gcIV2c2WvaXOgcJlueGixYnzhd5RwcWRiY3XscEBtcW6nczygTWM2OD1yLkC2JO69VQ>? NU\2PW9[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxNkiyO|U1Pid-NkiyO|U1PjxxYU6=
CCRF-CEM human leukemic lymphoblastoid cell lines M4\MPWN6fG:2b4jpZ:Kh[XO|YYm= NFzxe3REgXSxdH;4bYNqfHliYXfhbY5{fCCFQ2LGMWNGVSCqdX3hckBt\XWtZX3pZ{BtgW2yaH;icIF{fG:rZDDj[YxtKGyrbnXzMEBKSzVyPUKwJI5ONg>? NW\oeYVkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxNkiyO|U1Pid-NkiyO|U1PjxxYU6=
MOLT-4 human leukemic lymphoblastoid cell lines NYjTenJyS3m2b4TvfIlkyqCjc4PhfS=> NWXnO5ZmS3m2b4TvfIlkcXS7IHHnZYlve3RiTV;MWE01KGi3bXHuJIxmfWunbXnjJIx6dXCqb3LsZZN1d2mmIHPlcIwhdGmwZYOsJGlEPTB;MUCgcm0v MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek83QDJ5NUS2K|43QDJ5NUS2QE9iRg>?
human leukemia cell line(CCRF-CEM) MlHXR5l1d3SxeHnjxsBie3OjeR?= NYP2TY9QUW5idnn0do8h[3m2b4TvfIlkcXS7IH;mJINwdXCxdX7kd{B4\XKnIHTleIVzdWmwZXSgc44hUW6qaXLpeIlwdiCxZjDoeY1idiCuZYXr[Y1q[SClZXzsJIxqdmVqQ1PSSk1ETU1rLDDJR|UxRTBwMEmg{txONg>? NFvHc|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96OUG3OlQ2Lz56OUG3OlQ2RC:jPh?=
HL60 NHfxcnpHfW6ldHnvckBie3OjeR?= M1z1cGlvKH[rdILvJINwdmOnboTyZZRqd25icnXxeYlz\WRidH:gbY5lfWOnIHHwc5B1d3OrczDpckBJVDZyIHPlcIx{NCCDQ{WwJF0hOC5zNTFOwG0v MofKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ6N{e1PVMoRjF{OEe3OVk{RC:jPh?=
HL60R M2XIPWZ2dmO2aX;uJIF{e2G7 M1vPWWlvKH[rdILvJINwdmOnboTyZZRqd25icnXxeYlz\WRidH:gbY5lfWOnIHHwc5B1d3OrczDpckBJVDZyUjDj[YxteyxiQVO1NEA:KDhizszNMi=> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjh5N{W5N{c,OTJ6N{e1PVM9N2F-
CCRF-CEM MmXWR5l1d3SxeHnjbZR6KGG|c3H5 M1ntWFQ5KGi{cx?= NXfNOo02S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0OURj3DSW0h[2WubIOgZYZ1\XJiNEigbJJ{KGK7IHPlcIwhfGm2ZYKtZox2\SCjc4PhfUwhTUN3MDC9JFAvODB3NkG0JO69VS5? NX;FUHo3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3OFM5PThpPkG5O|Q{QDV6PD;hQi=>
CCRF-CEM/C2 M1fZXWN6fG:2b4jpZ4l1gSCjc4PhfS=> NUT6S2J1PDhiaILz M2q0SWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNEWkZvQ1XNM2MzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDj[YxtKHSrdHXyMYJtfWViYYPzZZktKEWFNUCgQUAxNjB{Mkig{txONg>? MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd2M{i1PEc,OTl5NEO4OVg9N2F-
HL60/MX2 NF;0XGxEgXSxdH;4bYNqfHliYYPzZZk> NITOfJc1QCCqcoO= NH3PRXREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJVDZyL13YNkBk\WyuczDh[pRmeiB2ODDodpMh[nliY3XscEB1cXSncj3icJVmKGG|c3H5MEBGSzVyIE2gNE4zPjF{IN88UU4> MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd2M{i1PEc,OTl5NEO4OVg9N2F-
HL60 MVLDfZRwfG:6aXPpeJkh[XO|YYm= MWe0PEBpenN? M4[0OmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhNPjBiY3XscJMh[W[2ZYKgOFghcHK|IHL5JINmdGxidHn0[ZIu[my3ZTDhd5NigSxiRVO1NEA:KDBwNkW3NkDPxE1w NFyzNI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUe0N|g2QCd-MUm3OFM5PTh:L3G+
L1210 MlPQR5l1d3SxeHnjbZR6KGG|c3H5 NVraO2pyPzJiaILz M3fCZ2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGwyOjFyIHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIH3lZZN2emWmIHH0JFczKGi{czDifUB1enmyYX6gZox2\SCneHPseZNqd25iYYPzZZktKEWGNUCgQUAxNjFizszNMi=> M{OxPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzOEK1PEc,OTF6MkW4QE9iRg>?
BGM MWTBcpRqfmm{YXygZZN{[Xl? Mn;pOUBl[Xm| M1HsSWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JHZi[2OrbnnhJJZqenW|IFnISEBqdm[nY4Tl[EBqdiCDZoLpZ4FvKGe{ZXXuJI1wdmuneTDCS20h[2WubIOgZZN{\XO|ZXSgZZMheGyjcYXlJJJm\HWldHnvckBu\WG|dYLl[EBwdiCmYYmgOUBjgSCmaYPrJIRq\m[3c3nvckBie3OjeTygSWQ2OCB;IECuNFch|ryPLh?= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzh6N{OnQlE4QDh5M{yvZV4>
BGM NWflc2tuSW62aY\pdoFtKGG|c3H5 NH3JZno2KGSjeYO= M3fVTmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmenCnczDTbY1xdGW6II\pdpV{KEiIIHnu[oVkfGWmIHnuJGFnemmlYX6g[5Jm\W5ibX;ub4V6KEKJTTDj[YxteyCjc4Pld5Nm\CCjczDwcIFyfWVicnXkeYN1cW:wIH3lZZN2emWmIH;uJIRigSB3IHL5JIRqe2tiZHnm[pV{cW:wIHHzd4F6NCCHREWwJF0hOC5zNjFOwG0v MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzh6N{OnQlE4QDh5M{yvZV4>
L1210 NWrTeYpJTnWwY4Tpc44h[XO|YYm= MY\Jcohq[mm2aX;uJI9nKHSqeX3p[Jlt[XSnIIP5cpRp[XOnIHnuJGwyOjFyIHPlcIx{NCCHREWwJF0hOC5yMzFOwG0v MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJ5M{K5K|4{ODJ5M{K5QE9iRg>?
BALL-1 M{i0OWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFjK[W0zPCCqcoO= M3;4XGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGJCVExvMTDj[YxteyCjZoTldkAzPCCqcoOgZpkhX1OWLUGgZZN{[XluIFfJOVAhRSByLkC4JO69VS5? MnrsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{NkSxO|AoRjJ{Mk[0NVcxRC:jPh?=
HCT116 MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVuyOEBpenN? M4jqcmdzd3e2aDDpcohq[mm2aX;uJI9nKGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGGodHXyJFI1KGi{czDifUBYW1RvMTDhd5NigSxiR1m1NEA:KDBwMUKg{txONg>? MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ4NEG3NEc,OjJ{NkSxO|A9N2F-
HeLa MmrES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYKyOEBpenN? NVH3foFLT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUGWOYTDj[YxteyCjZoTldkAzPCCqcoOgZpkhX1OWLUGgZZN{[XluIFfJOVAhRSByLkG4JO69VS5? M2rqZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{Mk[0NVcxLz5{MkK2OFE4ODxxYU6=
A549 Ml\PS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYXWcXE5OjRiaILz MVTHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDXV3QuOSCjc4PhfUwhT0l3MDC9JFAvOiEQvF2u M1HidFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{Mk[0NVcxLz5{MkK2OFE4ODxxYU6=
HUVEC NH;vfFFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH3QcmU4OiCqcoO= NEfoS3NIem:5dHigbY5pcWKrdHnvckBw\iCKVW\FR{Bk\WyuczDh[pRmeiB5MjDodpMh[nliV2PUMVEh[XO|YYmsJGdKPTBiPTCwMlI{KM7:TT6= NYTvZm1ZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyOlQyPzBpPkKyNlY1OTdyPD;hQi=>
NUGC3 NIDlcZRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIDxNpEzPCCqcoO= Mkn2S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUnVISzNiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JHdUXC1zIHHzd4F6NCCJSUWwJF0hOC5{NTFOwG0v MoqyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{NkSxO|AoRjJ{Mk[0NVcxRC:jPh?=
HDF MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIrqbXU4OiCqcoO= NYnhPVZST3Kxd4ToJIlvcGmkaYTpc44hd2ZiSFTGJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCZU2StNUBie3OjeTygS2k2OCB;IECuNlUh|ryPLh?= NUfhRYZkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyOlQyPzBpPkKyNlY1OTdyPD;hQi=>
leukemia L1210 NH7CRlVHfW6ldHnvckBie3OjeR?= MWTJcohq[mm2aX;uJI9nKExzMkGwJIx6dXCqb3nkJIxmfWunbXnhJINmdGy|IES4JIhzKGGodHXyJIFldWmwaYP0doF1cW:wIDjs[Y5ofGhib3[gdJJmcW6ldXLheIlwdj1yIHjyLUwhUUN3MDC9JFAvODFizszNMi=> M3zQSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3Mke3PFMoRjF3Mke3PFM9N2F-
leukemia L1210 NHK2dIVHfW6ldHnvckBie3OjeR?= NILUflhKdmirYnn0bY9vKG:oIFyxNlExKGy7bYDoc4llKGyndXvlcYliKGOnbHzzJFczKGi{IHHmeIVzKGGmbXnubZN1emG2aX;uJEht\W6pdHigc4YheHKnaX7jeYJifGmxbk2wJIhzMSxiSVO1NEA:KDBwMEGg{txONg>? NUXXTnplRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWyO|c5Oyd-MUWyO|c5OzxxYU6=
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697 NVm2bZBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJcohq[mm2aX;uJI9nKGi3bXHuJFY6PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMD6wNVA3KM7:TT6= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1pZXLpMoFkNnWtL3Po[Y1jdC:lb33wc5Vv\F:{ZYDvdpRg[2G{ZD;DTGVOSkx6MEOvK|5USU6JRWK8M4E,
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HEL NHfFWXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJcohq[mm2aX;uJI9nKGi3bXHuJGhGVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMD6wNlA2OiEQvF2u MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1pZXLpMoFkNnWtL3Po[Y1jdC:lb33wc5Vv\F:{ZYDvdpRg[2G{ZD;DTGVOSkx6MEOvK|5USU6JRWK8M4E,
CHP-212 M{PUbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJcohq[mm2aX;uJI9nKGi3bXHuJGNJWC1{MUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFAvODN|NEeg{txONg>? NGjiZWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2n[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4NFMwLz6VQV7HSXI9N2F-
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MOLT-16 NEHPRpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\zTY5pcWKrdHnvckBw\iCqdX3hckBOV0yWLUG2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAxNjB|NkC3JO69VS5? MmXHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3XibU5i[y63az;jbIVu[mxxY3;tdI92dmShcnXwc5J1Z2OjcnSvR2hGVUKOOECzM{c,W0GQR1XSQE9iRg>?
MC-IXC NH\1bW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfwbnpKdmirYnn0bY9vKG:oIHj1cYFvKE2FLVnYR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOC5yNEG0NUDPxE1w MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1pZXLpMoFkNnWtL3Po[Y1jdC:lb33wc5Vv\F:{ZYDvdpRg[2G{ZD;DTGVOSkx6MEOvK|5USU6JRWK8M4E,
BHT-101 MmXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zESWlvcGmkaYTpc44hd2ZiaIXtZY4hSkiWLUGwNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOC5yNEG3OkDPxE1w NGnpbZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2n[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4NFMwLz6VQV7HSXI9N2F-
K5 MnvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTKOVZUUW6qaXLpeIlwdiCxZjDoeY1idiCNNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gNE4xPDN{IN88UU4> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1pZXLpMoFkNnWtL3Po[Y1jdC:lb33wc5Vv\F:{ZYDvdpRg[2G{ZD;DTGVOSkx6MEOvK|5USU6JRWK8M4E,
A549 NIfpOodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3frVWlvcGmkaYTpc44hd2ZiaIXtZY4hSTV2OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gNE4xPDl4NjFOwG0v NE\yWYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2n[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4NFMwLz6VQV7HSXI9N2F-
NCI-H1703 NWHhXHVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PMfmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixO|A{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSByLkC0PVgyKM7:TT6= M2\uPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTflZokv[WNwdXuvZ4hmdWKuL3PvcZBwfW6mX4LldI9zfF:lYYLkM2NJTU2ETEiwN{8oRlODTlfFVlww[T5?
LB2241-RCC M3ewWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LhXmlvcGmkaYTpc44hd2ZiaIXtZY4hVEJ{MkSxMXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMD6wOVU{PCEQvF2u M37tSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTflZokv[WNwdXuvZ4hmdWKuL3PvcZBwfW6mX4LldI9zfF:lYYLkM2NJTU2ETEiwN{8oRlODTlfFVlww[T5?
MLMA NFv5N3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJcohq[mm2aX;uJI9nKGi3bXHuJG1NVUFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IECuNFU2PTFizszNMi=> MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1pZXLpMoFkNnWtL3Po[Y1jdC:lb33wc5Vv\F:{ZYDvdpRg[2G{ZD;DTGVOSkx6MEOvK|5USU6JRWK8M4E,
P30-OHK MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXiwTY1pUW6qaXLpeIlwdiCxZjDoeY1idiCSM{CtU2hMKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSByLkC1OlUh|ryPLh?= M2D0W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTflZokv[WNwdXuvZ4hmdWKuL3PvcZBwfW6mX4LldI9zfF:lYYLkM2NJTU2ETEiwN{8oRlODTlfFVlww[T5?
NCI-H510A MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGH0bZRKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVExSSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMD6wOlgzPiEQvF2u MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1pZXLpMoFkNnWtL3Po[Y1jdC:lb33wc5Vv\F:{ZYDvdpRg[2G{ZD;DTGVOSkx6MEOvK|5USU6JRWK8M4E,
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T-24 NWLScmhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3Jcohq[mm2aX;uJI9nKGi3bXHuJHQuOjRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IECuNFc5PTZizszNMi=> MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1pZXLpMoFkNnWtL3Po[Y1jdC:lb33wc5Vv\F:{ZYDvdpRg[2G{ZD;DTGVOSkx6MEOvK|5USU6JRWK8M4E,
NB69 M363T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rnbWlvcGmkaYTpc44hd2ZiaIXtZY4hVkJ4OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gNE4xPzl2ODFOwG0v M2nxOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTflZokv[WNwdXuvZ4hmdWKuL3PvcZBwfW6mX4LldI9zfF:lYYLkM2NJTU2ETEiwN{8oRlODTlfFVlww[T5?
CTV-1 M2T3fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIns[XNKdmirYnn0bY9vKG:oIHj1cYFvKEOWVj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAxNjB6NEe0JO69VS5? MorpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3XibU5i[y63az;jbIVu[mxxY3;tdI92dmShcnXwc5J1Z2OjcnSvR2hGVUKOOECzM{c,W0GQR1XSQE9iRg>?
MEL-JUSO M4n6V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3Jcohq[mm2aX;uJI9nKGi3bXHuJG1GVC2MVWPPJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAxNjB6NUe2JO69VS5? M1fKW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTflZokv[WNwdXuvZ4hmdWKuL3PvcZBwfW6mX4LldI9zfF:lYYLkM2NJTU2ETEiwN{8oRlODTlfFVlww[T5?
MOLT-4 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjYOllKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOC5yOEm2O{DPxE1w MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1pZXLpMoFkNnWtL3Po[Y1jdC:lb33wc5Vv\F:{ZYDvdpRg[2G{ZD;DTGVOSkx6MEOvK|5USU6JRWK8M4E,
SW982 NUnQdG4yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHFTY0xUW6qaXLpeIlwdiCxZjDoeY1idiCVV{m4NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOC5yOUGyN{DPxE1w M3uwclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTflZokv[WNwdXuvZ4hmdWKuL3PvcZBwfW6mX4LldI9zfF:lYYLkM2NJTU2ETEiwN{8oRlODTlfFVlww[T5?
NCI-SNU-1 NWH4d3lyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYGy[Yo1UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtV25WNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IECuNFk3PzdizszNMi=> NIjjTo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2n[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4NFMwLz6VQV7HSXI9N2F-
GP5d MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJcohq[mm2aX;uJI9nKGi3bXHuJGdRPWRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IECuNVAzODVizszNMi=> NHXBXWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2n[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4NFMwLz6VQV7HSXI9N2F-
SAS MmHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnyTY5pcWKrdHnvckBw\iCqdX3hckBUSVNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IECuNVA4PTdizszNMi=> NYPwcHpTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4VjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFA{Nyd-U1HOS2VTRC:jPh?=
BFTC-905 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPuTY5pcWKrdHnvckBw\iCqdX3hckBDTlSFLUmwOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOC5zMEizNUDPxE1w M1\3RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTflZokv[WNwdXuvZ4hmdWKuL3PvcZBwfW6mX4LldI9zfF:lYYLkM2NJTU2ETEiwN{8oRlODTlfFVlww[T5?
LB1047-RCC NH\xNmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrl[4tSUW6qaXLpeIlwdiCxZjDoeY1idiCOQkGwOFcuWkOFIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCwMlExQDR{IN88UU4> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1pZXLpMoFkNnWtL3Po[Y1jdC:lb33wc5Vv\F:{ZYDvdpRg[2G{ZD;DTGVOSkx6MEOvK|5USU6JRWK8M4E,
BB65-RCC NWLBSWtVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fCcmlvcGmkaYTpc44hd2ZiaIXtZY4hSkJ4NT3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDBwMUGwNVkh|ryPLh?= M3TSU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTflZokv[WNwdXuvZ4hmdWKuL3PvcZBwfW6mX4LldI9zfF:lYYLkM2NJTU2ETEiwN{8oRlODTlfFVlww[T5?
KE-37 NIjWNIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIOzWXFKdmirYnn0bY9vKG:oIHj1cYFvKEuHLUO3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAxNjFzMEi1JO69VS5? NYrIfYx[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4VjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFA{Nyd-U1HOS2VTRC:jPh?=
NCI-H292 MnHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2WyVmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyPVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDBwMUG0NkDPxE1w MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1pZXLpMoFkNnWtL3Po[Y1jdC:lb33wc5Vv\F:{ZYDvdpRg[2G{ZD;DTGVOSkx6MEOvK|5USU6JRWK8M4E,
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MFM-223 MlH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJcohq[mm2aX;uJI9nKGi3bXHuJG1HVS1{MkOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFM1NjB{NEOg{txONg>? MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1pZXLpMoFkNnWtL3Po[Y1jdC:lb33wc5Vv\F:{ZYDvdpRg[2G{ZD;DTGVOSkx6MEOvK|5USU6JRWK8M4E,
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BT-474 M17ENWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIT5PY5KdmirYnn0bY9vKG:oIHj1cYFvKEKWLUS3OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPDlwNE[zNUDPxE1w MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1pZXLpMoFkNnWtL3Po[Y1jdC:lb33wc5Vv\F:{ZYDvdpRg[2G{ZD;DTGVOSkx6MEOvK|5USU6JRWK8M4E,

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-mTOR / mTOR / p-S6K / S6K / p-AMPK / AMPK / p-AKT / AKT / p-ERK / ERK ; 

PubMed: 24714637     


REH cells were incubated for the indicated time periods with cytarabine (3.2 μM) and the levels of phosphorylated/total mTOR, p70S6K, AMPK, Akt and ERK were determined by immunoblotting. The representative blots from three independent experiments are shown.

24714637
Growth inhibition assay
Cell viability; 

PubMed: 24714637     


REH cells were incubated in the presence of different concentrations of cytarabine and cell viability was determined by acid phosphatase assay after 24 h and 48 h. The data are mean ± SD values of triplicate measurements from a representative of three independent experiments (*p<0.05 compared to untreated cells). 

24714637
In vivo Cytarabine is highly effective against acute leukaemias, which causes the characteristic G1/S blockage and synchronization, and increases the survival time for leukaemic Brown Norway rats in a weak dose-related fashion indicating that the use of higher dosages of Cytarabine does not contribute to its antileukaemic effectiveness in man. [4] Cytarabine (250 mg/kg) also causes placental growth retardation and increases placental trophoblastic cells apoptosis in the placental labyrinth zone of the pregnant Slc:Wistar rats, which increases from 3 hour after the treatment and peaks at 6 hour before returning to control levels at 48 hour, with remarkably enhanced p53 protein, p53 trancriptional target genes such as p21, cyclinG1 and fas and caspase-3 activity. [5]

Protocol

Kinase Assay:[1]
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In Vitro Growth Inhibition Assay:

Stock solution of Cytarabine is prepared in absolute ethanol, and serial dilutions of Cytarabine are prepared. CCRF-CEM cells are suspended in RPMI medium supplemented with 10% FBS, 0.1% gentamicin, and 1% sodium pyruvate. The cells are suspended in their respective media to give 10 mL volumes of cell suspension at a final density of 3-6 × 104 cells/mL. Appropriate volumes of Cytarabine solution are transferred to the cell suspensions, and incubation is continued for 72 hours. The cells are spun down and resuspended in fresh Cytarabine -free medium, and final cell counts are determined. The data are analyzed by sigmoidal curve fitting of the cell count versus Cytarabine concentration, and the results are expressed as the IC50 (Cytarabine concentration that inhibits cell growth to 50% of the control value).
Cell Research:[2]
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  • Cell lines: Rat leukemic cell lines RCL/0, RO/1 and K7 and human myelomonocytic leukemic U937
  • Concentrations: ~100 μM
  • Incubation Time: 24, 48 and 72 hours
  • Method: Cells are incubated in the presence of different concentrations of Cytarabine at 37 °C for 24, 48, and 72 hours. At the time of 20-, 44-, or 68-hour incubation in the presence of Cytarabine, 10 mL of cell proliferation reagent WST-1 solution is added. After 2- and 4-hour incubation with WST-1, cell metabolic activity is assessed with colorimetric changes quantified by measuring the absorbance in a spectrophotometer at 450 nm. And cell division times are calculated from eosin counting in parallel with viability assay
    (Only for Reference)
Animal Research:[4]
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  • Animal Models: Brown Norway rat with myelocytic leukaemia
  • Dosages: 5 - 1000 mg/kg
  • Administration: Injection i.v.
    (Only for Reference)

Solubility (25°C)

In vitro Water 48 mg/mL (197.35 mM)
DMSO 1 mg/mL (4.11 mM)
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 243.22
Formula

C9H13N3O5

CAS No. 147-94-4
Storage powder
in solvent
Synonyms Cytarabin, Ara-C, Arabinofuranosyl Cytidine, Cytosine β-D-arabinofuranoside, Cytosine arabinoside, NSC 63878, NSC 287459
Smiles C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04526795 Recruiting Drug: Cytarabine|Drug: Fludarabine|Drug: Pegcrisantaspase Blast Phase Chronic Myelogenous Leukemia BCR-ABL1 Positive|Recurrent Acute Biphenotypic Leukemia|Recurrent Acute Lymphoblastic Leukemia|Recurrent Acute Myeloid Leukemia|Recurrent Chronic Myelogenous Leukemia BCR-ABL1 Positive|Recurrent T-Cell Prolymphocytic Leukemia|Refractory Acute Biphenotypic Leukemia|Refractory Acute Lymphoblastic Leukemia|Refractory Acute Myeloid Leukemia|Refractory Chronic Myelogenous Leukemia BCR-ABL1 Positive|Refractory T-Cell Prolymphocytic Leukemia M.D. Anderson Cancer Center|National Cancer Institute (NCI) April 9 2021 Phase 1
NCT04330820 Recruiting Drug: Venetoclax Oral Tablet Relapsed Adult AML Technische Universität Dresden|AbbVie April 6 2020 Phase 1|Phase 2
NCT04253314 Recruiting -- Acute Myeloid Leukemia (AML) AbbVie March 13 2020 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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DNA/RNA Synthesis Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID