Chloroquine diphosphate

Catalog No.S4157

Chloroquine diphosphate Chemical Structure

Molecular Weight(MW): 515.86

Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator.

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Biological Activity

Description Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator.
Targets
ATM [1]
(Cell-free assay)
In vitro

Chloroquine is a chemotherapeutic agent for the clinical treatment of malaria. Chloroquine is able to bind to DNA, and inhibit DNA replication and RNA synthesis which in turn results in cell death. The effect of Chloroquine may also be related to the formation of a toxic heme-Chloroquine complex. Chloroquine inhibits trophozoite hemoglobin degradation through increasing vacuolar pH and inhibiting the activity of vacuolar phospholipase, vacuolar proteases, and heme polymerase[1]. Chloroquine possesses definite antirheumatic properties. Chloroquine has immuno-modulatory effects, suppressing the production/release of tumour necrosis factor and interleukin 6. Moreover, Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best-studied effects are those against HIV replication[2]. Chloroquine can accumulate inside the macrophage phagolysosome by ion trapping where it exerts potent antifungal activity against Histoplasma capsulatum and Cryptococcus neoformans by distinct mechanisms. Chloroquine inhibits growth of H. capsulatum by pH-dependent iron deprivation, whereas it is directly toxic to C. neoformans[3].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human K562 cells NYO5XZNlS3m2b4TvfIlkyqCjc4PhfS=> MWTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NF0{OS56MzDuUS=> M4\ObVE5PTN6NU[3
human KB cells MVjDfZRwfG:6aXRCpIF{e2G7 MkOwR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2Ih[2WubIOgZpkhdWmlcn;wcIF1\SCvZYToc4QtKEmFNUC9NE43KM7:TR?= NXvjN5UzOTR4NEC1NlQ>
human MDA-MB-468 cells MljCR5l1d3SxeHnjxsBie3OjeR?= M2nzTVQ5KGh? M4HMOGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20Olgh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTDpckBxemW|ZX7j[UBw\iB|LkWgeW0hPC1qMj3jbIxwem9vMUDIMZBp\W6xeHH6bY4uOTBveXypMW4tVi2maXX0bJlt[nW2YX6tNU1idWmwZTDofYRzd2OqbH;ybYRmNCCJSUWwQVIvQDFizszN NFH3eXkyQTl2NUG5Oy=>
human MCF7 cells NYPscGt4S3m2b4TvfIlkyqCjc4PhfS=> NWLTU3V3PDhiaB?= NHz4RXREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZkhcW5icILld4Vv[2Vib3[gNE41KHWPIEGtLFEuMDRvKEetdIhmdnmuLUHIMYlucWSjen;bOEw2NWefcYXpco95[Wyrbj22MZltMWKnbor5cElxcXCncnnkbY4uPC27bDmtNWgu[mWwen;b[H1qdWmmYYrvcE0zMDOKKT3vcoUtKEeLNUC9OU42OSEQvF2= MYmxPVk1PTF7Nx?=
human MDA-MB-231 cells MVLDfZRwfG:6aXRCpIF{e2G7 NV\4Z5hXPDhiaB?= MoPoR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7IHnuJJBz\XOnbnPlJI9nKDNwNTD1UUA1NSh{LXPocI9zdy1zMFitdIhmdm:6YYrpck0yOC27bDmtUkxPNWSrZYTofYxjfXSjbj2xMYFucW6nIHj5[JJw[2iub4Lp[IUtKEeLNUC9Ok4xQCEQvF2= MX2xPVk1PTF7Nx?=
human HeLa cells M4TPXmN6fG:2b4jpZ:Kh[XO|YYm= MVfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGK7IF3UWEBie3OjeTygTWM2OD1|MDFOwG0> NG\ifY0zPDN3NEOyNi=>
human HepG2 cells MVvDfZRwfG:6aXRCpIF{e2G7 M4LVTVQ5KGh? NFeyPVhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVM4NjZ6IN88US=> MWmyN|gyPTF6Nh?=

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Protocol

Solubility (25°C)

In vitro Water 100 mg/mL (193.85 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 515.86
Formula

C18H26ClN3.2H3O4P

CAS No. 50-63-5
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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    C2=C1/X C2: LOG(C2):
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    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02432417 Not yet recruiting Glioblastoma|Astrocytoma Grade IV Maastricht Radiation Oncology January 2020 Phase 2
NCT02432417 Not yet recruiting Glioblastoma|Astrocytoma Grade IV Maastricht Radiation Oncology January 2020 Phase 2
NCT03503058 Not yet recruiting Malaria Sanaria Inc.|Eijkman Oxford Clinical Research Unit Eijkman Institute|Indonesia University|Congressionally Directed Medical Research Programs March 2019 Phase 2
NCT03503058 Not yet recruiting Malaria Sanaria Inc.|Eijkman Oxford Clinical Research Unit Eijkman Institute|Indonesia University|Congressionally Directed Medical Research Programs March 2019 Phase 2
NCT03636152 Recruiting Chronic Kidney Disease|Cardiovascular Disease|Inflammation|Atherosclerosis|Aortic Stiffness VA Office of Research and Development December 14 2018 Phase 2
NCT03636152 Recruiting Chronic Kidney Disease|Cardiovascular Disease|Inflammation|Atherosclerosis|Aortic Stiffness VA Office of Research and Development December 14 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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ATM/ATR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID