Chloroquine diphosphate

Catalog No.S4157

For research use only.

Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).

Chloroquine diphosphate Chemical Structure

CAS No. 50-63-5

Selleck's Chloroquine diphosphate has been cited by 176 publications

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Biological Activity

Description Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).
Targets
TLR3 [4] TLR7 [4] TLR8 [4] TLR9 [4] ATM [1]
(Cell-free assay)
In vitro

Chloroquine is a chemotherapeutic agent for the clinical treatment of malaria. Chloroquine is able to bind to DNA, and inhibit DNA replication and RNA synthesis which in turn results in cell death. The effect of Chloroquine may also be related to the formation of a toxic heme-Chloroquine complex. Chloroquine inhibits trophozoite hemoglobin degradation through increasing vacuolar pH and inhibiting the activity of vacuolar phospholipase, vacuolar proteases, and heme polymerase[1]. Chloroquine possesses definite antirheumatic properties. Chloroquine has immuno-modulatory effects, suppressing the production/release of tumour necrosis factor and interleukin 6. Moreover, Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best-studied effects are those against HIV replication[2]. Chloroquine can accumulate inside the macrophage phagolysosome by ion trapping where it exerts potent antifungal activity against Histoplasma capsulatum and Cryptococcus neoformans by distinct mechanisms. Chloroquine inhibits growth of H. capsulatum by pH-dependent iron deprivation, whereas it is directly toxic to C. neoformans[3].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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HepG2 M1u0c2N6fG:2b4jpZ4l1gSCjc4PhfS=> MlHJO|IhcHK| M3;VdGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGG|c3Xzd4VlKGG|IHnueJJi[2WubIXsZZIhSVSSIHzleoVtKGGodHXyJFczKGi{czDifUBE\WyudHn0[ZIuT2yxIHz1cYlv\XOlZX70JIF{e2G7LDDFR|UxKD1iMkWg{txONg>? NU\EN4M5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5NVA1PjZpPkKxPVExPDZ4PD;hQi=>
HepG2 NVXmdlNjS3m2b4TvfIlkcXS7IHHzd4F6 M3XBb|czKGi{cx?= M37QV2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuIH71cYJmeiCrbnP1ZoF1\WRiZn;yJFczKGi{czygTWM2OCB;IEK1JO69VS5? NXnjZldxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xN|U1PzFpPkK2NVM2PDdzPD;hQi=>
BxPC3 NWXrS5lnSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Mo\YO|IhcHK| MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEK6UFOzJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCVUlKgcYV1cG:mLDDJR|UxKD1iMkWg{txONg>? NXzqbnM6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PVkyPTdpPkK1Olk6OTV5PD;hQi=>
MDA-MB-468 MoDER5l1d3SxeHnjbZR6KGG|c3H5 MmjzOFghcHK| MXzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNE[4JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFfJOVAhRSB{OD61PEDPxE1w MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQThyNEm3PUc,OTl6MES5O|k9N2F-
MDA-MB-468 MoXuR5l1d3SxeHnjbZR6KGG|c3H5 MmDlOFghcHK| NX7OfHFuS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ3QCClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBIUTVyIE2gNlgvPThizszNMi=> NVvh[ZE3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxNFY3PjhpPkKwNVA3PjZ6PD;hQi=>
MDA-MB-468 NYq5T3VlS3m2b4TvfIlkcXS7IHHzd4F6 M1TtZlQ5KGi{cx?= MnPxR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUS2PEBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gNlgvPThizszNMi=> NX3qNolYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1PFY4OTZpPkK4OVg3PzF4PD;hQi=>
K562 MYfDfZRwfG:6aXPpeJkh[XO|YYm= MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ7LkCzJO69VS5? M4LoZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NU[yNlAzLz5zOEW2NlIxOjxxYU6=
HeLa NEPYUIFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MkTTO|IhcHK| MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEinTHGgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDJ7Lkm2JO69VS5? M4LzU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkCyPFI4Lz5{Nk[wNlgzPzxxYU6=
HepG2 NHHhTVhEgXSxdH;4bYNqfHliYYPzZZk> M4HGOlczKGi{cx?= MlvpR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMxKM7:TT6= NEHGfIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUS4NlQ4Pid-MUm0PFI1PzZ:L3G+
HepG2 MVzDfZRwfG:6aXPpeJkh[XO|YYm= NFPqU4Y4OiCqcoO= NV3IVXNzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNyIN88UU4> M1PnNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUK2NVc{Lz5zOUmyOlE4OzxxYU6=
HepG2 NWP5SYc3S3m2b4TvfIlkcXS7IHHzd4F6 MVXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|MDFOwG0v MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl6MUS2Nkc,OTd7OEG0OlI9N2F-
HepG2 MVLDfZRwfG:6aXPpeJkh[XO|YYm= NXXTW3ZQPzJiaILz NIT0R2JEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCFQ{WwJF0hOzBizszNMi=> NGnBd5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUe0NVE{OSd-MkG3OFEyOzF:L3G+
HepG2 MoO3R5l1d3SxeHnjbZR6KGG|c3H5 NH75Spg4OiCqcoO= NEn5fmhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCFQ{WwJF0hOzBizszNMi=> M3izRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEi5OVU6Lz5{Mki4PVU2QTxxYU6=
HepG2 NEHwWo5EgXSxdH;4bYNqfHliYYPzZZk> NVLQXWN[PzJiaILz MXLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBESzVyIE2gN|Ah|ryPLh?= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl2NkKxOkc,OjR7NE[yNVY9N2F-
SH-SY5Y M{f3WWN6fG:2b4jpZ4l1gSCjc4PhfS=> MUW3NkBpenN? NFfyTG1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUUC2VWUXZJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFPDOVAhRSB|MDFOwG0v MlPnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NUmxPVgoRjJ7NUW5NVk5RC:jPh?=
HepG2 NF7GT2FEgXSxdH;4bYNqfHliYYPzZZk> M2XRPFczKGi{cx?= NUf2[YFUS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiQ1O1NEA:KDNyIN88UU4> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh3OEW0N{c,OjR6NUi1OFM9N2F-
HepG2 MWrDfZRwfG:6aXPpeJkh[XO|YYm= NHfoZms4OiCqcoO= NHT6bW9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCFQ{WwJF0hOzBizszNMi=> M3rLO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUW1OFY{Lz5{N{G1OVQ3OzxxYU6=
HepG2 MVPDfZRwfG:6aXPpeJkh[XO|YYm= M{fOXlczKGi{cx?= Ml3nR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhS0N3MDC9JFMxKM7:TT6= NELnUGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5NVY4PSd-MkW3PVE3PzV:L3G+
HepG2 M1LScmN6fG:2b4jpZ4l1gSCjc4PhfS=> NIqzZW44OiCqcoO= MYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{BqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGNEPTBiPTCzNEDPxE1w NHLqb2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK4NlI3Pyd-MkWyPFIzPjd:L3G+
HepG2 MnT4R5l1d3SxeHnjbZR6KGG|c3H5 MWW3NkBpenN? Ml3KR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhS0N3MDC9JFMxKM7:TT6= MlO3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6NUKxN|IoRjJzOEWyNVMzRC:jPh?=
HepG2 NHTmVlJEgXSxdH;4bYNqfHliYYPzZZk> NWDzNYxzPzJiaILz MmrrR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhS0N3MDC9JFMxKM7:TT6= M3PBZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NkC4Olc2Lz5{Mk[wPFY4PTxxYU6=
HepG2 NWnQNYs1S3m2b4TvfIlkcXS7IHHzd4F6 NGLne4c4OiCqcoO= M1q4fGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDDR|UxKD1iM{Cg{txONg>? NVTnN|FWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2OVQ{QTVpPkK3OlU1Ozl3PD;hQi=>
KB NEH1c5ZEgXSxdH;4bYNqfHliYYPzZZk> MUfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRkBk\WyuczDifUBUWkJiYYPzZZktKEWGNUCgQUA{OC56IN88UU4> MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV4MkizNkc,OTZ3NkK4N|I9N2F-
HepG2 M{e0ZWN6fG:2b4jpZ4l1gSCjc4PhfS=> MX6yOEBpenN? MXfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjCyOEBpenNiYomgcoV2fHKjbDDy[YQhfXC2YXvlJIF{e2G7LDDUR|UxKD1iM{Gg{txONg>? Ml\kQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNEW4NVYoRjJ|MUS1PFE3RC:jPh?=
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K562 NF;4WlREgXSxdH;4bYNqfHliYYPzZZk> NFL2N2o4OiCqcoO= MXfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDmcI94KGO7dH;t[ZRzgSxiSVO1NEA:KDN{IN88UU4> NGHQcII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUmyOlE4Oyd-MUm5NlYyPzN:L3G+
FM3A NHzVNVRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IF3veZNmKG2jbX3hdpkhfHWvb4KgSm0{SSClZXzsd{whTUN3MDC9JFMzKM7:TT6= M1LkNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOU[2O|Q3Lz5zMEm2Olc1PjxxYU6=
FM3A M3z2[2N6fG:2b4jpZ4l1gSCjc4PhfS=> NIn5NldKdiC4aYTyc{BkgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBu[W2vYYL5JGZOO0FiY3XscJMtKEWFNUCgQUA{OiEQvF2u MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjB|NkO2OUc,OTJyM{[zOlU9N2F-
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MG 63 (6-TG R) NEH1XXRyUFSVIHHzd4F6 MXzxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVUdiNkOgLFYuXEdiUjmgZ4VtdHN? M4TMNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
NB1643 M2HRc5FJXFNiYYPzZZk> NGCwVG9yUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTlKxOlQ{KGOnbHzz NGPW[lQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
OHS-50 NFnF[nlyUFSVIHHzd4F6 NF\4UINyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiT1jTMVUxKGOnbHzz MmPLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
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LAN-5 MkSzdWhVWyCjc4PhfS=> NVTkUXV3eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IFzBUk02KGOnbHzz NH\uUlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
HEK293 M3n2[2F2fG:yaHHnfUBie3OjeR?= MnfFNVAhfU1? M{fY[FghcHK| MlfETY5lfWO2aX;uJI9nKGG3dH;wbIFogSCrbjDISWszQTNiY3XscJMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gdFYzKGyndnXsJIF1KDFyIIXNJIFnfGW{IEigbJJ{KGK7IHntcZVvd2Kub4SgZY5idHm|aYO= NUDaNZRqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0PFE2OzZpPkK4OFgyPTN4PD;hQi=>
HEK293 MWLBeZRweGijZ4mgZZN{[Xl? Mon2NVAhfU1? MXi4JIhzew>? MXjJcoR2[3Srb36gc4Yh[XW2b4DoZYd6KGmwIFjFT|I6OyClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDMR|MuOiCuZY\lcEBifCBzMDD1UUBi\nSncjC4JIhzeyCkeTDpcY12dm:kbH;0JIFv[Wy7c3nz NHLvXYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OES4NVU{Pid-Mki0PFE2OzZ:L3G+
LNCAP NUTJXXAyTnWwY4Tpc44h[XO|YYm= MljjVoVlfWO2aX;uJIlvKEeIUDDlfJBz\XO|aX;uJIlvKGi3bXHuJGxPS0GSIHPlcIx{KHS{YX7z[oVkfGWmIIfpeIgheGyjc33p[JMh[29vZYjwdoV{e2mwZzDHSnAh[W6mIIPoVm5CeyCjZ3HpcpN1KFKHVj3FVmJj\XSjIH\vcIxwf2WmIHL5JINwdXCxdX7kJJRz\WG2bXXueEAzPCCqcoOgdI9{fC22cnHud4Zm[3Srb36gZY5lKG2nYYP1doVlKDR6IHjyd{Bxd3O2IHTvd4U> MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF|NUS3NUc,OjZzM{W0O|E9N2F-
SKBR3 NYT6bHZ3TnWwY4Tpc44h[XO|YYm= MXzS[YR2[3Srb36gbY4hT0[SIHX4dJJme3Orb36gbY4hcHWvYX6gV2tDWjNiY3XscJMhfHKjboPm[YN1\WRid3n0bEBxdGG|bXnkd{Bkdy2neIDy[ZN{cW6pIFfGVEBidmRic3jSUmF{KGGpYXnud5QhWkWYLVXSRoJmfGFiZn;scI94\WRiYomgZ49ueG:3bnSgeJJm[XSvZX70JFI1KGi{czDwc5N1NXS{YX7z[oVkfGmxbjDhcoQhdWWjc4Xy[YQhPDhiaILzJJBwe3RiZH;z[S=> MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF|NUS3NUc,OjZzM{W0O|E9N2F-
HepG2 M1[zb2Z2dmO2aX;uJIF{e2G7 NYr0eXQ1WmWmdXP0bY9vKGmwIFfGVEBmgHC{ZYPzbY9vKGmwIHj1cYFvKEincFeyJINmdGy|IITyZY5{\mWldHXkJJdqfGhicHzhd41q\HNiY3:t[ZhxemW|c3nu[{BITlBiYX7kJJNpWk6DczDh[4FqdnO2IGLFWk1GWkKkZYThJIZwdGyxd3XkJIJ6KGOxbYDveY5lKHS{ZXH0cYVvfCB{NDDodpMheG:|dD30doFve2[nY4Tpc44h[W6mIH3lZZN2emWmIES4JIhzeyCyb4P0JIRwe2V? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF|NUS3NUc,OjZzM{W0O|E9N2F-
H460 NWP0cItSSXCxcITvd4l{KGG|c3H5 NV\OWYxyOjVidH:gO|UhfU1? NIH0TJczPCCqcoO= MoiyTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCKNE[wJINmdGy|IHH0JFI2KHSxIEe1JJVOKGGodHXyJFI1KGi{czDifUBidm6neHnuMXYhe3SjaX7pcocu[mG|ZXSg[oxwfyCleYTvcYV1enl? NXHO[WxuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PVkyPTdpPkK1Olk6OTV5PD;hQi=>
HepG2 Mnj2SpVv[3Srb36gZZN{[Xl? M3viN|UxKHWP M{P3fVYhcHK| MmrTVoVlfWO2aX;uJIlvKGy7c3;zc41idCCjY3nkbYZq[2G2aX;uJIlvKGi3bXHuJGhmeEd{IHPlcIx{KGG2IEWwJJVOKGGodHXyJFYhcHK|IHL5JGRCWElxbInzc{B1emGla3XyJJJm\C2mb4XicIUhe3SjaX7pcoch[mG|ZXSgZ49v\m:lYXygcYlkem:|Y3;wbYMh[W6jbInzbZMhemWuYYTpeoUhfG9iY3;ueJJwdA>? M2myb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUm3N|IxLz5{OEG5O|MzODxxYU6=
Assay
Methods Test Index PMID
Western blot ZEBRA / p-S824 KAP1 ; p62 / LC3 28249048 26677873
Immunofluorescence p-S824 KAP1 / ZEBRA ; CD1d-β2m / LAMP1 ; SQSTM1 / MAP1LC3B 28249048 20368272 29872540
Growth inhibition assay Cell viability 25521075

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 515.86
Formula

C18H26ClN3.2H3O4P

CAS No. 50-63-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04443270 Not yet recruiting Drug: Chloroquine phosphate COVID-19 CMN 20 de Noviembre July 27 2020 Phase 1
NCT04462367 Recruiting -- COVID19|Coronavirus Infection|Pregnancy Disease|Severe Acute Respiratory Syndrome Instituto Materno Infantil Prof. Fernando Figueira July 1 2020 --
NCT04340544 Terminated Drug: Hydroxychloroquine|Drug: Placebo COVID-19 University Hospital Tuebingen|Robert Bosch Medical Center|Universitätsklinikum Hamburg-Eppendorf|Bernhard Nocht Institute for Tropical Medicine April 22 2020 Phase 2
NCT04334148 Completed Drug: Hydroxychloroquine|Drug: Placebo oral tablet COVID-19 Adrian Hernandez|Patient-Centered Outcomes Research Institute|Duke University April 22 2020 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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