Chloroquine diphosphate

For research use only.

Catalog No.S4157

157 publications

Chloroquine diphosphate Chemical Structure

CAS No. 50-63-5

Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).

Selleck's Chloroquine diphosphate has been cited by 157 publications

Purity & Quality Control

Choose Selective ATM/ATR Inhibitors

Biological Activity

Description Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).
Targets
TLR3 [4]
()
TLR7 [4]
()
TLR8 [4]
()
TLR9 [4]
()
ATM [1]
(Cell-free assay)
In vitro

Chloroquine is a chemotherapeutic agent for the clinical treatment of malaria. Chloroquine is able to bind to DNA, and inhibit DNA replication and RNA synthesis which in turn results in cell death. The effect of Chloroquine may also be related to the formation of a toxic heme-Chloroquine complex. Chloroquine inhibits trophozoite hemoglobin degradation through increasing vacuolar pH and inhibiting the activity of vacuolar phospholipase, vacuolar proteases, and heme polymerase[1]. Chloroquine possesses definite antirheumatic properties. Chloroquine has immuno-modulatory effects, suppressing the production/release of tumour necrosis factor and interleukin 6. Moreover, Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best-studied effects are those against HIV replication[2]. Chloroquine can accumulate inside the macrophage phagolysosome by ion trapping where it exerts potent antifungal activity against Histoplasma capsulatum and Cryptococcus neoformans by distinct mechanisms. Chloroquine inhibits growth of H. capsulatum by pH-dependent iron deprivation, whereas it is directly toxic to C. neoformans[3].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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HepG2 M3m2eGN6fG:2b4jpZ4l1gSCjc4PhfS=> MX23NkBpenN? MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|Ah|ryPLh?= NXjnR4tYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0PFI1PzZpPkG5OFgzPDd4PD;hQi=>
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HepG2 MnHxR5l1d3SxeHnjbZR6KGG|c3H5 M4nUOFczKGi{cx?= NWfnUZV2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiQ1O1NEA:KDNyIN88UU4> NXXvVYVMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG3OFEyOzFpPkKxO|QyOTNzPD;hQi=>
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HepG2 NVXEU3F2S3m2b4TvfIlkcXS7IHHzd4F6 Ml;IO|IhcHK| M{X4PWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEOFNUCgQUA{OCEQvF2u NED6XHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUi1NlE{Oid-MkG4OVIyOzJ:L3G+
HepG2 MYXDfZRwfG:6aXPpeJkh[XO|YYm= NFnheII4OiCqcoO= M1q5[WN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEOFNUCgQUA{OCEQvF2u NWG1SWE{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2NFg3PzVpPkKyOlA5Pjd3PD;hQi=>
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OHS-50 NU\ROpN7eUiWUzDhd5NigQ>? NEXNSlRyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiT1jTMVUxKGOnbHzz MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
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LAN-5 MlHkdWhVWyCjc4PhfS=> NIO4ZVlyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTFHOMVUh[2WubIO= MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
HEK293 M3XtPGF2fG:yaHHnfUBie3OjeR?= MX[xNEB2VQ>? NEK2fW85KGi{cx?= M134[mlv\HWldHnvckBw\iCjdYTvdIhi\3liaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJJA3OiCuZY\lcEBifCBzMDD1UUBi\nSncjC4JIhzeyCkeTDpcY12dm:kbH;0JIFv[Wy7c3nz MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR6MUWzOkc,Ojh2OEG1N|Y9N2F-
HEK293 NGD4XodCfXSxcHjh[5kh[XO|YYm= Mlm5NVAhfU1? NH34Omk5KGi{cx?= NYn0SYk3UW6mdXP0bY9vKG:oIHH1eI9xcGGpeTDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hVEN|LUKgcIV3\WxiYYSgNVAhfU1iYX\0[ZIhQCCqcoOgZpkhcW2vdX7vZoxwfCCjbnHsfZNqew>? NUXrWGNORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0PFE2OzZpPkK4OFgyPTN4PD;hQi=>
LNCAP M3rTTWZ2dmO2aX;uJIF{e2G7 MWjS[YR2[3Srb36gbY4hT0[SIHX4dJJme3Orb36gbY4hcHWvYX6gUG5ESVBiY3XscJMhfHKjboPm[YN1\WRid3n0bEBxdGG|bXnkd{Bkdy2neIDy[ZN{cW6pIFfGVEBidmRic3jSUmF{KGGpYXnud5QhWkWYLVXSRoJmfGFiZn;scI94\WRiYomgZ49ueG:3bnSgeJJm[XSvZX70JFI1KGi{czDwc5N1NXS{YX7z[oVkfGmxbjDhcoQhdWWjc4Xy[YQhPDhiaILzJJBwe3RiZH;z[S=> MmrSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzM{W0O|EoRjJ4MUO1OFcyRC:jPh?=
SKBR3 NEflWHFHfW6ldHnvckBie3OjeR?= NF\ZR|lT\WS3Y4Tpc44hcW5iR1\QJIV5eHKnc4Ppc44hcW5iaIXtZY4hW0uEUkOgZ4VtdHNidILhcpNn\WO2ZXSge4l1cCCybHHzcYlleyClbz3lfJBz\XO|aX7nJGdHWCCjbnSgd4hTVkG|IHHnZYlve3RiUlXWMWVTSmKndHGg[o9tdG:5ZXSgZpkh[2:vcH;1coQhfHKnYYTt[Y51KDJ2IHjyd{Bxd3O2LYTyZY5{\mWldHnvckBidmRibXXhd5Vz\WRiNEigbJJ{KHCxc4Sg[I9{\Q>? M1fxNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUO1OFcyLz5{NkGzOVQ4OTxxYU6=
HepG2 NF3oTWVHfW6ldHnvckBie3OjeR?= Ml\FVoVlfWO2aX;uJIlvKEeIUDDlfJBz\XO|aX;uJIlvKGi3bXHuJGhmeEd{IHPlcIx{KHS{YX7z[oVkfGWmIIfpeIgheGyjc33p[JMh[29vZYjwdoV{e2mwZzDHSnAh[W6mIIPoVm5CeyCjZ3HpcpN1KFKHVj3FVmJj\XSjIH\vcIxwf2WmIHL5JINwdXCxdX7kJJRz\WG2bXXueEAzPCCqcoOgdI9{fC22cnHud4Zm[3Srb36gZY5lKG2nYYP1doVlKDR6IHjyd{Bxd3O2IHTvd4U> NFHVXFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGzOVQ4OSd-Mk[xN|U1PzF:L3G+
H460 MXjBdI9xfG:|aYOgZZN{[Xl? NIK4U4czPSC2bzC3OUB2VQ>? NYfDd4RyOjRiaILz MXXJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKEh2NkCgZ4VtdHNiYYSgNlUhfG9iN{WgeW0h[W[2ZYKgNlQhcHK|IHL5JIFvdmW6aX6tWkB{fGGrbnnu[{1j[XOnZDDmcI94KGO7dH;t[ZRzgQ>? NUCyeI9rRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PVkyPTdpPkK1Olk6OTV5PD;hQi=>
HepG2 M3Tle2Z2dmO2aX;uJIF{e2G7 Mmj0OVAhfU1? NF:xU|M3KGi{cx?= NYHTZWhwWmWmdXP0bY9vKGmwIHz5d49{d22jbDDhZ4llcW[rY3H0bY9vKGmwIHj1cYFvKEincFeyJINmdGy|IHH0JFUxKHWPIHHmeIVzKDZiaILzJIJ6KESDUFmvcJl{dyC2cnHjb4VzKHKnZD3kc5VjdGVic4ThbY5qdmdiYnHz[YQh[2:wZn;jZYwhdWmlcn;zZ49xcWNiYX7hcJl{cXNicnXsZZRqfmVidH:gZ49vfHKxbB?= MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF7N{OyNEc,OjhzOUezNlA9N2F-

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
ZEBRA / p-S824 KAP1 ; 

PubMed: 28249048     


HH514-16 BL cells were treated with chloroquine and harvested at different times post-treatment for immunoblotting with antibodies as indicated. 

p62 / LC3 ; 

PubMed: 26677873     


Antiautophagic activity of Lys01. Panc 10.05 cells were treated for 24 h with the indicated doses of chloroquine or Lys01 and were probed by Western blot.

28249048 26677873
Immunofluorescence
p-S824 KAP1 / ZEBRA ; 

PubMed: 28249048     


HH514-16 BL cells were treated with chloroquine (CQ) or chloroquine plus KU-55933 (CQ+KU) and harvested at 24 hours followed by staining with anti-phospho KAP1 (S824) plus anti-ZEBRA antibodies and visualized at 1000X magnification.

CD1d-β2m / LAMP1 ; 

PubMed: 20368272     


HEK293-CD1d WT cells were treated overnight with 20 μM of chloroquine (or vehicle). The cells were then fixed, permeabilized and stained with the anti-CD1d-β2m mAb (red), anti-LAMP-1 (green) and Hoechst (blue). The stained cells were then analyzed by confocal microscopy. 

SQSTM1 / MAP1LC3B ; 

PubMed: 29872540     


Immunofluorescent images of astrocytoma SNB-19 cells treated with DMSO, emetine or chloroquine for 24 h, then stained with SQSTM1 protein (green), MAP1LC3B protein (red) and nuclei (blue). 

28249048 20368272 29872540
Growth inhibition assay
Cell viability ; 

PubMed: 25521075     


A549 cells were treated with serial concentrations of chloroquine for 72 h, and Huh7 cells were treated with the same concentrations for 48 h. Tumour cell viability was determined by cell viability assay. Data represent means from at least three independent experiments ± SD. 

25521075

Protocol

Solubility (25°C)

In vitro Water 100 mg/mL (193.85 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 515.86
Formula

C18H26ClN3.2H3O4P

CAS No. 50-63-5
Storage powder
in solvent
Synonyms N/A
Smiles CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04443270 Not yet recruiting Drug: Chloroquine phosphate COVID-19 CMN 20 de Noviembre July 27 2020 Phase 1
NCT04462367 Recruiting -- COVID19|Coronavirus Infection|Pregnancy Disease|Severe Acute Respiratory Syndrome Instituto Materno Infantil Prof. Fernando Figueira July 1 2020 --
NCT04340544 Terminated Drug: Hydroxychloroquine|Drug: Placebo COVID-19 University Hospital Tuebingen|Robert Bosch Medical Center|Universitätsklinikum Hamburg-Eppendorf|Bernhard Nocht Institute for Tropical Medicine April 22 2020 Phase 2
NCT02378532 Completed Drug: Chloroquine|Radiation: Radiotherapy|Drug: Temozolomide Glioblastoma Multiforme Maastricht Radiation Oncology August 2016 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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ATM/ATR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID