Chloroquine diphosphate

Name: Chloroquine diphosphate
Brand: Selleck Chemicals
SKU: S4157
Rating: 5 (139 reviews)

For research use only.

Catalog No.S4157

139 publications

Chloroquine diphosphate Chemical Structure

CAS No. 50-63-5

Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).

Selleck's Chloroquine diphosphate has been cited by 139 publications

Theranostics, 2021, 11(2):700-714

PubMed: 33391500 ( click the link to review the publication )

Cell Death Dis, 2021, 12(1):65

PubMed: 33431801 ( click the link to review the publication )

PLoS Genet, 2021, 17(3):e1009383

PubMed: 33657091 ( click the link to review the publication )

Cancer Discov, 2021, 11(2):362-383

PubMed: 33158842 ( click the link to review the publication )

Mol Oncol, 2021, 15(4):1203-1216

PubMed: 33638615 ( click the link to review the publication )

Virulence, 2021, 12(1):509-519

PubMed: 33509041 ( click the link to review the publication )

Antiviral Res, 2021, 185:104996

PubMed: 33309540 ( click the link to review the publication )

Antiviral Res, 2021, 187:105015

PubMed: 33444702 ( click the link to review the publication )

Biochem Pharmacol, 2021, 186:114475

PubMed: 33609560 ( click the link to review the publication )

Life Sci, 2021, 275:119355

PubMed: 33744326 ( click the link to review the publication )

Planta Med, 2021, 10.1055/a-1348-1634

PubMed: 33477173 ( click the link to review the publication )

J Transl Med, 2021, 19(1):62

PubMed: 33568202 ( click the link to review the publication )

Cancer Med, 2021, 10.1002/cam4.3739

PubMed: 33626233 ( click the link to review the publication )

Autophagy, 2020, 10.1080/15548627.2020.1740529

PubMed: 32164484 ( click the link to review the publication )

Autophagy, 2020, 22:1-10

PubMed: 32286915 ( click the link to review the publication )

EMBO Rep, 2020, 6;21(5):e49232

PubMed: 32239622 ( click the link to review the publication )

Aging Cell, 2020, 19(6):e13163

PubMed: 32475059 ( click the link to review the publication )

Cell Death Dis, 2020, 8;11(6):427

PubMed: 32513919 ( click the link to review the publication )

Cell Death Dis, 2020, 11(8):712

PubMed: 32873786 ( click the link to review the publication )

Cell Death Dis, 2020, 21;11(2):141

PubMed: 32081881 ( click the link to review the publication )

Cell Death Dis, 2020, 7;11(5):337

PubMed: 32382017 ( click the link to review the publication )

Cell Death Dis, 2020, 11(2):103

PubMed: 32029706 ( click the link to review the publication )

FASEB J, 2020, 10.1096/fj.202001295R

PubMed: 33103304 ( click the link to review the publication )

FASEB J, 2020, 10.1096/fj.202001413R

PubMed: 32860638 ( click the link to review the publication )
Cell Chem Biol, 2020, 19 pii: S2451-9456(20)30078-7

PubMed: 32243810 ( click the link to review the publication )

J Mol Med (Berl), 2020, 10.1007/s00109-020-01971-2

PubMed: 32897390 ( click the link to review the publication )

Oxid Med Cell Longev, 2020, 2020:2015920

PubMed: 32908624 ( click the link to review the publication )

Oxid Med Cell Longev, 2020, 2020:1232816

PubMed: 33062133 ( click the link to review the publication )

Oxid Med Cell Longev, 2020, 2020:8345246

PubMed: 33123317 ( click the link to review the publication )

J Cell Physiol, 2020, 24

PubMed: 32329068 ( click the link to review the publication )

J Cell Mol Med, 2020, 10.1111/jcmm.15813

PubMed: 33150736 ( click the link to review the publication )

Neuropharmacology, 2020, 168:108028

PubMed: 32151646 ( click the link to review the publication )

Biochem Pharmacol, 2020, 12:114023

PubMed: 32413426 ( click the link to review the publication )

Sci Rep, 2020, 10(1):614

PubMed: 31953486 ( click the link to review the publication )

Phytomedicine, 2020, 80:153394

PubMed: 33130472 ( click the link to review the publication )

J Biomed Sci, 2020, 27(1):42

PubMed: 32169072 ( click the link to review the publication )

Exp Cell Res, 2020, 10.1016/j.yexcr.2020.111981

PubMed: 32234375 ( click the link to review the publication )

J Cardiovasc Transl Res, 2020, 10.1007/s12265-020-10075-8

PubMed: 33025271 ( click the link to review the publication )

Exp Eye Res, 2020, S0014-4835(20)30624-2

PubMed: 33227296 ( click the link to review the publication )

Toxicol In Vitro, 2020, 27;66:104837

PubMed: 32229166 ( click the link to review the publication )

Onco Targets Ther, 2020, 13:9235-9244

PubMed: 32982310 ( click the link to review the publication )

G3 (Bethesda), 2020, 4;10(5):1585-1597

PubMed: 32265286 ( click the link to review the publication )

Acta Biochim Biophys Sin (Shanghai), 2020, gmaa097

PubMed: 33085742 ( click the link to review the publication )

Oncol Lett, 2020, 20(1):551-560

PubMed: 32537026 ( click the link to review the publication )

Anticancer Drugs, 2020, 31(6):601-608

PubMed: 32011366 ( click the link to review the publication )

Pharmazie, 2020, 75(6):255-260

PubMed: 32539921 ( click the link to review the publication )

Environ Toxicol, 2020, 10.1002

PubMed: 32061152 ( click the link to review the publication )

bioRxiv, 2020, 2020/9/20.4.7.30734

PubMed: 32511305 ( click the link to review the publication )
Viruses, 2020, 12(7):E756

PubMed: 32674313 ( click the link to review the publication )

Theranostics, 2020, 10(5):1981-1996

PubMed: 32104496 ( click the link to review the publication )

BMC Complement Med Ther, 2020, 20(1):194

PubMed: 32576183 ( click the link to review the publication )

bioRxiv, 2020, 2020.10.02.324228

PubMed: 33024968 ( click the link to review the publication )

Vet Microbiol, 2020, 250:108860

PubMed: 33045632 ( click the link to review the publication )

Virol Sin, 2020, 10.1007/s12250-020-00320-4

PubMed: 33237393 ( click the link to review the publication )

Commun Biol, 2020, 13;3(1):25

PubMed: 31932716 ( click the link to review the publication )

Aging (Albany NY), 2020, 12(3):2084-2100

PubMed: 32017705 ( click the link to review the publication )

Antiviral Res, 2020, 183:104933

PubMed: 32949635 ( click the link to review the publication )

Cell Death Dis, 2020, 11(7):539

PubMed: 32681018 ( click the link to review the publication )

mBio, 2020, 11(4):e01833-20

PubMed: 32820005 ( click the link to review the publication )

Adv Ther (Weinh), 2020, 2000034

PubMed: 32838027 ( click the link to review the publication )

Sci Adv, 2019, 5(10):eaax7142

PubMed: 31681849 ( click the link to review the publication )

EMBO Mol Med, 2019, 11(10):e9930

PubMed: 31476112 ( click the link to review the publication )

Theranostics, 2019, 9(26):8392-8408

PubMed: 31754404 ( click the link to review the publication )

Cell Mol Immunol, 2019, 10.1038/s41423-019-0236-y

PubMed: 31076723 ( click the link to review the publication )

Int J Cancer, 2019, 10.1002/ijc.32395

PubMed: 31081930 ( click the link to review the publication )

Oncogene, 2019, 38(47):7249-7265

PubMed: 31420604 ( click the link to review the publication )

Cancer Lett, 2019, 456:49-58

PubMed: 31004702 ( click the link to review the publication )

Cell Death Dis, 2019,

PubMed: 30886151 ( click the link to review the publication )

Mol Cancer Ther, 2019, 18(3):718-725

PubMed: 30755456 ( click the link to review the publication )

Aging (Albany NY), 2019, 11(15):5769-5785

PubMed: 31409760 ( click the link to review the publication )

Stem Cell Res Ther, 2019, 10(1):118

PubMed: 30987681 ( click the link to review the publication )

Ecotoxicol Environ Saf, 2019, 169:266-272

PubMed: 30453174 ( click the link to review the publication )
Front Oncol, 2019, 9:436

PubMed: 31192135 ( click the link to review the publication )

Food Chem Toxicol, 2019, 131:110537

PubMed: 31150782 ( click the link to review the publication )

Cancer Cell Int, 2019, 19:179

PubMed: 31337986 ( click the link to review the publication )

Front Pharmacol, 2019, 10:1460

PubMed: 31920653 ( click the link to review the publication )

Toxicol Appl Pharmacol, 2019, 383:114781

PubMed: 31618659 ( click the link to review the publication )

Int J Oncol, 2019, 54(5):1625-1638

PubMed: 30896863 ( click the link to review the publication )

J Cell Biochem, 2019, 120(1):756-767

PubMed: 30145802 ( click the link to review the publication )

Am J Transl Res, 2019, 11(2):931-941

PubMed: 30899392 ( click the link to review the publication )

Oncol Rep, 2019, 41(5):2803-2817

PubMed: 30864717 ( click the link to review the publication )

Biochem Biophys Res Commun, 2019, 510(2):278-283

PubMed: 30686534 ( click the link to review the publication )

Biochem Biophys Res Commun, 2019, 514(4):1270-1277

PubMed: 31113618 ( click the link to review the publication )

AMB Express, 2019, 9(1):108

PubMed: 31309361 ( click the link to review the publication )

Clin Exp Pharmacol Physiol, 2019, 46(11):1053-1060

PubMed: 31407376 ( click the link to review the publication )

Breast Cancer (Dove Med Press), 2019, 11:231-241

PubMed: 31839713 ( click the link to review the publication )

Molecules, 2019, 24(15)

PubMed: 31357480 ( click the link to review the publication )

Nat Commun, 2018, 9(1):4295

PubMed: 30327467 ( click the link to review the publication )

Clin Cancer Res, 2018, 24(23):6066-6077

PubMed: 30061362 ( click the link to review the publication )

Int J Cancer, 2018,

PubMed: 29363109 ( click the link to review the publication )

J Exp Clin Cancer Res, 2018, 37(1):215

PubMed: 30180906 ( click the link to review the publication )

Cell Death Dis, 2018, 9(6):702

PubMed: 29899555 ( click the link to review the publication )

Cell Death Dis, 2018,

PubMed: 29568063 ( click the link to review the publication )

Cell Death Dis, 2018, 9(5):556

PubMed: 29748581 ( click the link to review the publication )

Oncoimmunology, 2018, 7(6):e1431086

PubMed: 29872558 ( click the link to review the publication )

Sci Rep, 2018, 8(1):10923

PubMed: 30026540 ( click the link to review the publication )
Cancer Manag Res, 2018, 10:887-897

PubMed: 29740218 ( click the link to review the publication )

Int J Oncol, 2018, 53(1):215-224

PubMed: 29693166 ( click the link to review the publication )

Int J Oncol, 2018, 53(5):2200-2212

PubMed: 30106132 ( click the link to review the publication )

Toxicology, 2018, 406-407:114-122

PubMed: 30053495 ( click the link to review the publication )

Am J Transl Res, 2018, 10(4):1229-1236

PubMed: 29736216 ( click the link to review the publication )

Oncol Rep, 2018, 40(4):2206-2214

PubMed: 30066934 ( click the link to review the publication )

Drug Des Devel Ther, 2018, 12:2413-2421

PubMed: 30122899 ( click the link to review the publication )

Med Sci Monit, 2018, 24:2339-2349

PubMed: 29667627 ( click the link to review the publication )

Cancer Lett, 2018, 436:129-138

PubMed: 30118840 ( click the link to review the publication )

J Exp Clin Cancer Res, 2018, 37(1):221

PubMed: 30200999 ( click the link to review the publication )

Front Immunol, 2018, 9:1245

PubMed: 29922290 ( click the link to review the publication )

Mol Immunol, 2018, 99:115-123

PubMed: 29763880 ( click the link to review the publication )

J Cell Biochem, 2018, 10.1002/jcb.27788

PubMed: 30320898 ( click the link to review the publication )

Platelets, 2018, 29(7):695-701

PubMed: 28984160 ( click the link to review the publication )

Arch Virol, 2018, 163(3):623-632

PubMed: 29177545 ( click the link to review the publication )

Oncotarget, 2018, 9(12):10483-10496

PubMed: 29535821 ( click the link to review the publication )

Oncotarget, 2018, 9(15):12020-12034

PubMed: 29552290 ( click the link to review the publication )

Leukemia, 2017, 10.1038/leu.2016.325

PubMed: 27857131 ( click the link to review the publication )

J Exp Clin Cancer Res, 2017, 36(1):162

PubMed: 29145888 ( click the link to review the publication )

PLoS Pathog, 2017, 13(4):e1006321

PubMed: 28394926 ( click the link to review the publication )

Cell Death Dis, 2017, 8(8):e3015

PubMed: 28837148 ( click the link to review the publication )

Br J Cancer, 2017, 117(8):1139-1153

PubMed: 29017179 ( click the link to review the publication )

Sci Rep, 2017, 7:42748

PubMed: 28209994 ( click the link to review the publication )

Biomed Pharmacother, 2017, 89:973-982

PubMed: 28292026 ( click the link to review the publication )
Front Cell Infect Microbiol, 2017, 7:400

PubMed: 28932708 ( click the link to review the publication )

Int J Mol Med, 2017, 10.3892/ijmm.2017.3008

PubMed: 28560385 ( click the link to review the publication )

Int J Clin Exp Pathol, 2017, 10(7):7603-7615

PubMed: 31966605 ( click the link to review the publication )

J Exp Clin Cancer Res, 2017, 36(1):122

PubMed: 28882160 ( click the link to review the publication )

Cell Physiol Biochem, 2017, 42(5):1812-1821

PubMed: 28750364 ( click the link to review the publication )

Biomed Res Int, 2017, 2017:7097580

PubMed: 28706950 ( click the link to review the publication )

Biochem Biophys Res Commun, 2017, 486(2):492-498

PubMed: 28320515 ( click the link to review the publication )

Oncotarget, 2017, 8(42):71642-71656

PubMed: 29069735 ( click the link to review the publication )

Cell Death Dis, 2016, 7(12):e2527

PubMed: 28005078 ( click the link to review the publication )

Cell Signal, 2016, 28(8):1086-98

PubMed: 27185187 ( click the link to review the publication )

J Mol Neurosci, 2016, 60(2):205-13

PubMed: 27498200 ( click the link to review the publication )

J Mol Neurosci, 2016, 58(4):401-10

PubMed: 26635026 ( click the link to review the publication )

Arch Biochem Biophys, 2016, 590:37-47

PubMed: 26562437 ( click the link to review the publication )

F1000Res, 2016, 5:150

PubMed: 27134728 ( click the link to review the publication )

Sci Rep, 2016, 10.1038/srep23056.

PubMed: 26976322 ( click the link to review the publication )

Oncotarget, 2016, 7(41):66360-66385

PubMed: 27626179 ( click the link to review the publication )

J Gen Virol, 2015, 96(12):3484-3492

PubMed: 26459826 ( click the link to review the publication )

Oncotarget, 2015,

PubMed: 26109433 ( click the link to review the publication )

Cancer Biol Ther, 2014, 15(3):305-16

PubMed: 24351423 ( click the link to review the publication )

Purity & Quality Control

Choose Selective ATM/ATR Inhibitors

Biological Activity

Description

Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).

Targets

TLR3 ^[4]
()

TLR7 ^[4]
()

TLR8 ^[4]
()

TLR9 ^[4]
()

ATM ^[1]
(Cell-free assay)

In vitro

Chloroquine is a chemotherapeutic agent for the clinical treatment of malaria. Chloroquine is able to bind to DNA, and inhibit DNA replication and RNA synthesis which in turn results in cell death. The effect of Chloroquine may also be related to the formation of a toxic heme-Chloroquine complex. Chloroquine inhibits trophozoite hemoglobin degradation through increasing vacuolar pH and inhibiting the activity of vacuolar phospholipase, vacuolar proteases, and heme polymerase^[1]. Chloroquine possesses definite antirheumatic properties. Chloroquine has immuno-modulatory effects, suppressing the production/release of tumour necrosis factor and interleukin 6. Moreover, Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best-studied effects are those against HIV replication^[2]. Chloroquine can accumulate inside the macrophage phagolysosome by ion trapping where it exerts potent antifungal activity against Histoplasma capsulatum and Cryptococcus neoformans by distinct mechanisms. Chloroquine inhibits growth of H. capsulatum by pH-dependent iron deprivation, whereas it is directly toxic to C. neoformans^[3].

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
human K562 cells	NIXQUXFEgXSxdH;4bYPDqGG\|c3H5			M2PvOWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[nliTWTUJIF{e2G7LDDJR\|UxRTNzLkizJI5O	NFLrW2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEWzPFU3Pyd-MUi1N\|g2Pjd:L3G+
human KB cells	MV\DfZRwfG:6aXRCpIF{e2G7			MoDYR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2Ih[2WubIOgZpkhdWmlcn;wcIF1\SCvZYToc4QtKEmFNUC9NE43KM7:TR?=	NHuzUpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNE[0NFUzPCd-MUS2OFA2OjR:L3G+
human MDA-MB-468 cells	NYfW[ZZXS3m2b4TvfIlkyqCjc4PhfS=>		NGXkfoE1QCCq	MYrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNE[4JINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XliaX6gdJJme2WwY3Wgc4YhOy53IIXNJFQuMDJvY3jsc5JwNTFySD3wbIVvd3ijennuMVExNXmuKT3OMG4u\GmndHj5cIJ2fGGwLUGtZY1qdmViaInkdo9kcGyxcnnk[UwhT0l3ME2yMlgyKM7:TR?=	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl2NUG5O{c,OTl7NEWxPVc9N2F-
human MCF7 cells	MVXDfZRwfG:6aXRCpIF{e2G7		NITWNm41QCCq	NVjpdWh[S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6KGmwIIDy[ZNmdmOnIH;mJFAvPCC3TTCxMUgyNSh2LTi3MZBp\W67bD2xTE1qdWmmYYrvX\|QtPS2pXYH1bY5wgGGuaX6tOk16dCmkZX76fYwqeGmyZYLp[IlvNTRveXypMVFJNWKnborvX4RecW2rZHH6c4wuOih\|SDmtc45mNCCJSUWwQVUvPTFizszN	NGDRdIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm0OVE6Pyd-MUm5OFUyQTd:L3G+
human MDA-MB-231 cells	NHqxVHlEgXSxdH;4bYPDqGG\|c3H5		NVX5XZd5PDhiaB?=	MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XliaX6gdJJme2WwY3Wgc4YhOy53IIXNJFQuMDJvY3jsc5JwNTFySD3wbIVvd3ijennuMVExNXmuKT3OMG4u\GmndHj5cIJ2fGGwLUGtZY1qdmViaInkdo9kcGyxcnnk[UwhT0l3ME22MlA5KM7:TR?=	NUXEXnU1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5OFUyQTdpPkG5PVQ2OTl5PD;hQi=>
human HeLa cells	NYnCZpJrS3m2b4TvfIlkyqCjc4PhfS=>			M1XKWWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYomgUXRVKGG\|c3H5MEBKSzVyPUOwJO69VQ>?	M{\mVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{W0N\|IzLz5{NEO1OFMzOjxxYU6=
human HepG2 cells	M4XJUGN6fG:2b4jpZ:Kh[XO\|YYm=		NXu3cnhwPDhiaB?=	M2j3U2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9N\|cvPjhizszN	NUfwd\|RJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NVUyQDZpPkKzPFE2OTh4PD;hQi=>
mammary tumor FM3A	NXPRNHJkS3m2b4TvfIlkcXS7IHHzd4F6			M17iVmN6fG:2b4jpZ4l1gSCxZjDjc41xd3WwZDD3ZZMhfGW\|dHXkJIFo[Wmwc4SgcY92e2VibXHtcYFzgSC2dX3vdkBHVTODIHPlcIx{NCCHQ{WwJF0hOC5yMECwNFA{KM7:TT6=	M4ToWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NUewN\|g2Lz5zMkW3NFM5PTxxYU6=
red blood cells	M36wbWFvfGmybHHzcY9lcWGuIHHzd4F6		NV:3b4tEPDhiaILz	NITNWVRCdnSrcHzhd41w\GmjbDDhZ5Rqfmm2eTDh[4FqdnO2IGDsZZNud2SrdX2g[oFt[2myYYL1cUBH[0JzL1PvcJVu[mmjIHnu[oVkfGWmIHnuJIh2dWGwIILl[EBjdG:xZDDj[YxteyCjc4Pld5Nm\CCjczDwZZJie2m2ZTDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliW{PIYU1pgXCxeHHueIhqdmViaX7jc5Jxd3KjdHnvckBie3OjeTygTWM2OCB;IECuNFAxOTFizszNMi=>	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ3OUe3NEc,OjV4NUm3O\|A9N2F-
red blood cells	MUfBcpRqeGyjc33v[IlidCCjc4PhfS=>		NHfiTZM1QCCqcoO=	NFnnfldCdnSrcHzhd41w\GmjbDDhZ5Rqfmm2eTDh[4FqdnO2IHPocI9zd3G3aX7lJIFv\CCyeYLpcYV1cGGvaX7lMZJme2m\|dHHueEBzcW6pIIP0ZYdmKFCuYYPtc4RqfW1iZnHsZ4lx[XK3bTDWNU9UKGmwZnXjeIVlKGmwIHj1cYFvKHKnZDDicI9w\CClZXzsd{Bi\nSncjC0PEBpenNuIFnDOVAhRSByLkCwOVUh\|ryPLh?=	NF65WJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUKwO\|k{Pyd-MkGyNFc6Ozd:L3G+
red blood cells	MV7BcpRqdWGuYYLpZYwh[XO\|YYm=			M1\aUGFvfGmvYXzhdolidCCjY4Tpeol1gSCjZ3HpcpN1KFCuYYPtc4RqfW1ib4\hcIUhemmwZzDzeIFo\SCrbn\lZ5Rm\CCrbjDy[YQh[myxb3SgZ4VtdHNiaX6gdJJme2WwY3Wgc4YhSUJtIHj1cYFvKHOncoXtJIJ6KGS{dXegd5V{[2WydHnibYxqfHliYYPzZZktKEmFNUCgQUAxNjByN{ig{txONg>?	NEDVSJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEmzO\|c4QSd-MkC5N\|c4Pzl:L3G+
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HepG2	NGLO[2dEgXSxdH;4bYNqfHliYYPzZZk>		M2fiUVczKGi{cx?=	Ml3kR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh\XiycnXzd4lv\yCFREixJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKt[4xwKGG\|c3H5MEBESzVyIE2gNU43KM7:TT6=	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd7MU[3OUc,OjV5OUG2O\|U9N2F-
HepG2	NV7pcolFSW62aYDsZZNud2SrYXygZZN{[Xl?		M{Pq[lQ5KGi{cx?=	NELSTW9CdnSrcHzhd41w\GmjbDDhZ5Rqfmm2eTDh[4FqdnO2IHzpeoVzKHO2YXflJI9nKFCuYYPtc4RqfW1ieX;lcIlqKDF5WDDOUEB{eG:{b4rvbZRmeyCrbn\lZ5Rm\CCrbjDoeY1idiCKZYDHNkBk\WyuczDlfJBz\XO\|aX7nJGNFQDFiYX\0[ZIhPDhiaILzJIJ6KESDUFmgd5RicW6rbnetZoF{\WRiaX3teY5w\my3b4Lld4NmdmOnIHHuZYx6e2m\|LDDJR\|UxKD1iMT62OUDPxE1w	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd7MU[3OUc,OjV5OUG2O\|U9N2F-
WI38	MnnURY51cX[rcnHsJIF{e2G7		MYGyJIhzew>?	MXzBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDCT3YhT2G{ZH7ldkBCXEOFIG\SPFM4KGmwZnXjeIVlKGmwIHj1cYFvKFeLM{igZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKH[rcnHsJGRPSSCuZY\lcEBxemWrbnP1ZoF1\WRiZn;yJFIhcHK\|IHLl[o9z\SC4aYLhcEBqdm[nY4Tpc44hdWWjc4Xy[YQh[W[2ZYKgO{Bl[Xm\|IHL5JJJm[WxidHnt[UBRS1JiYYPzZZktKEWFNUCgQUAyNjdizszNMi=>	MlLoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd6OUOxOVgoRjF5OEmzNVU5RC:jPh?=
HeLa	NIr2RXpIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MVO0PEBpenN?	NV[0dFNFT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6KGmwIIDy[ZNmdmOnIH;mJFExOCC3TTDacmNtOixiR1m1NEA:KDJwMTFOwG0v	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd2OEe4Okc,OTl5NEi3PFY9N2F-
SMB	NFzqVVhCdnSrcILpc44h[XO\|YYm=			MnHiRY51cXC{aX;uJIFkfGm4aYT5JIFo[Wmwc4SgR4hidmSuZYKgd5Rz[WmwIH;mJJNp\WWyIIPjdoFxcWVicILpc44heHKxdHXpckBqdm[nY4Tl[EBqdiCvb4Xz[UBUVUJiY3XscJMh[XO\|ZYPz[YQh[XNiY3zlZZJidmOnIH;mJIRqe2Wjc3WtZZN{d2OrYYTl[EB{[3KjcHnlJJBzcW:wIIDyc5RmcW5uIFXDOVAhRSB{LkOg{txONg>?	MkGzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3N{C4N\|coRjJzNUewPFM4RC:jPh?=
HEK293	M37pd2Z2dmO2aX;uJIF{e2G7			MofHTY5pcWKrdHnvckBw\iCqdX3hckBGWkdiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfGGrbDDjeZJz\W62IHH0JI1mdWK{YX7lJJBwfGWwdHnhcEBw\iBtMkCgcXYtKEmFNUCgQUAzNjVizszNMi=>	Mo[1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5NE[4NVYoRjJ3N{S2PFE3RC:jPh?=
red blood cells	MkXnRY51cW2jbHHybYFtKGG\|c3H5		M4TQS\|I1KGi{cx?=	M1WxXmFvfGmvYXzhdolidCCjY4Tpeol1gSCjZ3HpcpN1KGOqbH;yc5F2cW6nLYPlcpNqfGm4ZTDQcIF{dW:maYXtJIZidGOrcHHyeY0hO0R5IHnu[oVkfGWmIHnuJJJm\CCkbH;v[EBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5ibXH0eZJmKHOlaHn6c451eyCob4LtZZRqd25iYX\0[ZIhOjRiaILzJIJ6KEerZX3zZU1{fGGrbnnu[{Bj[XOnZDDhd5NigSxiRVO1NEA:KDJwOUeg{txONg>?	MlzlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2OUm0PFYoRjJ7NEm5OFg3RC:jPh?=
HEK293	MV;GeY5kfGmxbjDhd5NigQ>?			NVXsZZF7cEWURzDibY5lcW6pIHHzd4F6ezpiRHnzdIxi[2WvZX70JI9nKFt\|SG2tSI9n\XSrbHnk[UApPSCwTTDmbY5idCliZoLvcUBpTVKJIH3lcYJz[W6nczDvZpRicW6nZDDmdo9uKEiHS{K5N{Bk\WyuczygT4khRSB\|LkG2NlI5KM7:TT6=	NUDKNFk6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{KzOVM5PTlpPkOyN\|U{QDV7PD;hQi=>
1205 Lu	NFXD[HdEgXSxdH;4bYNqfHliYYPzZZk>		MXW3NkBpenN?	M2\Y[WN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJFEzODViTIWgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNwNjFOwG0v	M2TLN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nkm5NVU4Lz5{NU[5PVE2PzxxYU6=
LN229	MVTDfZRwfG:6aXPpeJkh[XO\|YYm=		MUK3NkBpenN?	NIXRbYFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNVjJ{OTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOy54IN88UU4>	NFfwdWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[5PVE2Pyd-MkW2PVkyPTd:L3G+
C8161	MXjDfZRwfG:6aXPpeJkh[XO\|YYm=		MXq3NkBpenN?	MoO1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR\|gyPjFiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFMvPiEQvF2u	NI\odlI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[5PVE2Pyd-MkW2PVkyPTd:L3G+
HT-29	M1PT[WN6fG:2b4jpZ4l1gSCjc4PhfS=>		MUC3NkBpenN?	NX\H[5dMS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRvMkmgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNwNjFOwG0v	M4S2ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nkm5NVU4Lz5{NU[5PVE2PzxxYU6=
WI38	M3u0UGN6fG:2b4jpZ4l1gSCjc4PhfS=>		NFS1R2szPCCqcoO=	NHnDOIVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBYUTN6IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YheHKxbHnm[ZJifGmxbjDh[pRmeiB{NDDodpMh[nliU2LCJIF{e2G7LDDJR\|UxKD1iMz62N{DPxE1w	M1raRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NE[xN\|A6Lz5{NUS2NVMxQTxxYU6=
ScN2a	M2rWTmZ2dmO2aX;uJIF{e2G7			MUPIZYxnKG2jeHntZYwhcW6qaXLpeIlwdiCxZjDQdolwdiCycn;0[YlvKFC{UIPjJIZwem2jdHnvckB4[XNiYYPzZZlm\CCrbjDTZ24z[SClZXzsd{whTUN3MDC9JFQh\|ryPLh?=	NX3BPFJNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK5NFQxPTlpPkGyPVA1ODV7PD;hQi=>
HepG2	MlfTR5l1d3SxeHnjbZR6KGG\|c3H5		MXeyOEBpenN?	NYPjTGdIS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KG6ndYTyZYwhemWmIHT5[UB2eHSja3WgZZN{[XluIGTDOVAhRSB2LkOg{txONg>?	Mk\NQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5OEO5PFQoRjJ{N{izPVg1RC:jPh?=
HeLa	MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NHfNOFg1QCCqcoO=	MVvHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmgbY4heHKnc3XuZ4Uhd2ZiNUCgeW0hS3WFbEKsJGdKPTBiPTC0MlQh\|ryPLh?=	NHXTXIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUe0PFc5Pid-MUm3OFg4QDZ:L3G+
HeLa	M2D0VGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NX3VOZZSPDhiaILz	NXLReVlxT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6KGmwIIDy[ZNmdmOnIH;mJFExKHWPIFP1R4wzNCCJSUWwJF0hPS5\|IN88UU4>	M4KwUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{S4O\|g3Lz5zOUe0PFc5PjxxYU6=
HeLa	NGHt[mtIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		M1f1dFQ5KGi{cx?=	MXHHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmgbY4heHKnc3XuZ4Uhd2ZiNUCgeW0hYm6FbEKsJGdKPTBiPTC1MlYh\|ryPLh?=	NX\LTGdwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3OFg4QDZpPkG5O\|Q5Pzh4PD;hQi=>
HeLa	MnjuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		NV;QZnpqPDhiaILz	NG\jVI1Iem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJ\UyjIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZkhcW5icILld4Vv[2Vib3[gNUB2VSCFdVPsNkwhT0l3MDC9JFYvOSEQvF2u	MojZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5NEi3PFYoRjF7N{S4O\|g3RC:jPh?=
SH-SY5Y	MVHGeY5kfGmxbjDhd5NigQ>?		NH24eoozPCCqcoO=	MoPCUY9lfWyjdHnvckBw\iCqdX3hckB4cWymLYT5dIUhSVCSNkm1JIV5eHKnc4Pl[EBqdiCVSD3TXVV[KGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gZY16dG:rZDDi[ZRiKChzIITvJFQxKHKnc3nkeYV{MSCycn;keYN1cW:wIH3lZZN2emWmIHHmeIVzKDJ2IHjyd{whUUN3MDC9JFch\|ryPLh?=	NW\nO4M{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OVkyQThpPkK5OVU6OTl6PD;hQi=>
SH-SY5Y	M2DNeWZ2dmO2aX;uJIF{e2G7		NVK5eGhyOjRiaILz	NWrMeXh1UW6qaXLpeIlwdiCxZjDCRWNGOSCrbjDoeY1idiCVSD3TXVV[KGOnbHzzJIhiemKxcnnu[{B4cWymIIT5dIUhSVCSNkm1JIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDhcZltd2mmIHLleIEhMDFidH:gOFAqKGyndnXsJIFnfGW{IEK0JIhzeyCkeTDFUGlUSSCvZYToc4QtKEmFNUCgQUA4KM7:TT6=	NXf4TZMzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyOlg5OjJpPkOwNlY5QDJ{PD;hQi=>
CHO	MX\GeY5kfGmxbjDhd5NigQ>?			NILRb4VKdmirYnn0bY9vKG:oIHj1cYFvKEWURzDlfJBz\XO\|ZXSgbY4hS0iRIHPlcIx{NCCNaTC9JFcvPSEQvF2u	NHrSZpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwNFYxOyd-MkS5NFA3ODN:L3G+
L6	NG\nN3JEgXSxdH;4bYNqfHliYYPzZZk>			NUPx[XJUS3m2b4TvfIlkcXS7IHHnZYlve3RiTE[gZ4VtdHNuIFnDOVAhRSB5Lkeg{txONg>?	NH\U[FI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{K4NFg{PSd-MUeyPFA5OzV:L3G+
HepG2	MljDR5l1d3SxeHnjbZR6KGG\|c3H5		Mmf0O\|IhcHK\|	NHzDeGpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyJIJtfWViYYPzZZktKEmFNUCgQUA5NjNizszNMi=>	MmD6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzNUW1PVMoRjJzMUW1OVk{RC:jPh?=
WI38	NYC1[Wh{S3m2b4TvfIlkcXS7IHHzd4F6		MVqyJIhzew>?	Mo\FR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gW2k{QCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdHWuYYKgSG5CKGyndnXsJJBz\WmwY4XiZZRm\CCob4KgNkBpenNiYnXmc5JmKH[rcnHsJIlv\mWldHnvckBu\WG\|dYLl[EBi\nSncjC3JIRigXNiYomgdoVidCC2aX3lJHBEWiCjc4PhfUwhS0N3MDC9JFgvPSEQvF2u	NGrnelc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{i5N\|E2QCd-MUe4PVMyPTh:L3G+
HepG2	MnG1RY51cW2jbHHybYFtKGG\|c3H5			NFTOfohCdnSrbXHsZZJq[WxiYXP0bZZqfHliYXfhbY5{fCC\|cH;yc5pwcXSnIIP0ZYdmKG:oIGDsZZNud2SrdX2gZoVz\2inaTD5c4VtcWliaX7m[YN1\WRiaX6gbJVu[W5iSHXwS\|Ih[2WubIOsJGlEPTBiPTC5JO69VS5?	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjZ2MEm4NUc,OjZ4NEC5PFE9N2F-
SKHep	NWXlU2wxT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		M4DtbVQ5KGi{cx?=	NFjYU4NIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBUU0incDDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6KGmwIIDy[ZNmdmOnIH;mJFExLSCIQmOgd5VxeGynbXXueIVlKESPRV2gcYVlcXWvLDDHTVUxKD1iOT61JO69VS5?	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd2OEe4Okc,OTl5NEi3PFY9N2F-
HeLa	NXHRe2o{S3m2b4TvfIlkcXS7IHHzd4F6		M1nYflchcHK\|	NXHGXJZrS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKHO3co\peoFtKGGodHXyJFchcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFkvPjZ3IN88UU4>	NEjpXnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{e2PFA2Oid-MUe3OlgxPTJ:L3G+
HeLa	M{nxWGN6fG:2b4jpZ4l1gSCjc4PhfS=>		M3PudFch\GG7cx?=	M3LkdmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMh[W[2ZYKgO{Bl[Xm\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFkvPjdizszNMi=>	MnfNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2OEm3PFkoRjJzNEi5O\|g6RC:jPh?=
K562	M4\WbmN6fG:2b4jpZ4l1gSCjc4PhfS=>		Ml\ONlQhcHK\|	MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W\|c3XkJIF{KHKjZHnvZYN1cX[nIITofY1q\GmwZTDpcoNwenCxcnH0bY9vKGGodHXyJFI1KGi{czygR2M2OCB;IEmuO{DPxE1w	MmjoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh4OECyO\|goRjF6NkiwNlc5RC:jPh?=
Vero	NFjBXo5CdnSrdnnyZYwh[XO\|YYm=		MY[2JJRwKDdiZHH5dy=>	MUDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDjbIlsfW6pdX75ZUB3cXK3czDJcoRq[W5ib3PlZY4he3S{YXnuJFg6QSCrbn\lZ5Rm\CCrbjDW[ZJwKGOnbHzzJIF{e2W\|c3XkJIF{KH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjpZ{Bm\m[nY4SgZYZ1\XJiNjD0c{A4KGSjeYOsJGVEPTBiPTCxNEDPxE1w	M1SxOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUewOVYyLz5{NUm3NFU3OTxxYU6=
PDAC	Mnq0SpVv[3Srb36gZZN{[Xl?			M{S2WWlvcGmkaYTpc44hd2ZiY3XscEBxem:uaX\ldoF1cW:wIH;mJHBFSUNiY3XscJMhMHWwa37ve44hd3KrZ3nuLUwhUUN3MDC9JFExKM7:TT6=	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF\|NUS3NUc,OjZzM{W0O\|E9N2F-
Vero	Mk\0RY51cX[rcnHsJIF{e2G7		NIT0Umo3KHSxIEeg[IF6ew>?	M3jJd2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGNpcWu3bnf1cpliKH[rcoXzJFg6QSCrbn\lZ5Rm\CCrbjDB[pJq[2GwIHfy[YVvKG2xbnvlfUBX\XKxIHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDj[YxtKGSnYYToJIFnfGW{IE[geI8hPyCmYYnzJIJ6KE2WUzDhd5NigSxiRVO1NEA:KDFyIN88UU4>	NH\3[oY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmyOlgxPyd-MkS5NlY5ODd:L3G+
HepG2	M4HPS2N6fG:2b4jpZ4l1gSCjc4PhfS=>		MX20PEBpenN?	NYnOTWh2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KEOnbHzUbZRmei2JbH:gZZN{[XluIFXDOVAhRSBzMD6xJO69VS5?	NEjk[no9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUiwNFgzPyd-Mkm4NFA5Ojd:L3G+
BT-483	MnfNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		M1\xelQ5KGi{cx?=	M2Lkfmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGJVNTR6MzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6KGmwIIDy[ZNmdmOnIH;mJFExLSCIQmOgd5VxeGynbXXueIVlKESPRV2gcYVlcXWvLDDHTVUxKD1iMUCuNkDPxE1w	NGXUfVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUe0PFc5Pid-MUm3OFg4QDZ:L3G+
Vero	NU\2TYFRSW62aY\pdoFtKGG\|c3H5		NGnWVlQ2KGSjeYO=	NGDjdnJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEcGmtdX7neY56[SC4aYL1d{BKdmSrYX6gU4Nm[W5iOEi5JIlv\mWldHXkJIlvKEGocnnjZY4h\3KnZX6gcY9vc2W7IG\ldo8h[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFUh\GG7czDifUBOXFNxUF3TJI1mfGixZDygSWM2OCB;IEGxJO69VS5?	M4nrb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7M{O2PVUyLz5{OUOzOlk2OTxxYU6=
Vero A	MWXBcpRqfmm{YXygZZN{[Xl?		MoDhOkB1dyB5IHThfZM>	Mki3RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR4hqc3WwZ4XufYEhfmm{dYOgTY5lcWGwIH;j[YFvKHO2cnHpckA5QTliaX7m[YN1\WRiaX6gRYZzcWOjbjDndoVmdiCvb37r[ZkhXmW{bzDBJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYLhcE1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JIFnfGW{IE[geI8hPyCmYYnzJIJ6KE2WUz;QUXMh[XO\|YYmsJGVEPTBiPTCxNUDPxE1w	NHHleGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[3NVg{Oid-Mki2O\|E5OzJ:L3G+
Vero	MYnBcpRqfmm{YXygZZN{[Xl?		NV7KZYc6PSCmYYnz	NELafVRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEcGmtdX7neY56[SC4aYL1d{BKdmSrYX6gU4Nm[W5ic4TyZYlvKDh7OTDpcoZm[3SnZDDpckBC\nKrY3HuJIdz\WWwIH3vcotmgSCYZYLvJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBu\WG\|dYLl[EBwdiCmYYmgOUBxd3O2IHnu[oVkfGmxbjDifUBOXFNxUF3TJIF{e2G7LDDFR\|UxKD1iMUGg{txONg>?	NFu3Nlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUS5PVQ5Pyd-Mkm0PVk1QDd:L3G+
Vero	NWrxXY9RSW62aY\pdoFtKGG\|c3H5		NGjCbWk4KGSjeYO=	MYPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDDbIlsfW6pdX75ZUB3cXK3czDJcoRq[W5iT3PlZY4he3S{YXnuJFg6QSCrbn\lZ5Rm\CCrbjDB[pJq[2GwIHfy[YVvKG2xbnvlfUBX\XKxIHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB5IHThfZMh[nliTWTTM3BOWyCvZYToc4QtKEWFNUCgQUAyOSEQvF2u	NXPVZYNtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4NFA3OjZpPkK0PFAxPjJ4PD;hQi=>
Vero	Mm\JRY51cX[rcnHsJIF{e2G7		NUTn[WhtPyCmYYnz	M2DsdGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JHNqdmSkaYOgeolzfXNic4TyZYlvKEiUc4CgbY5n\WO2ZXSgbY4h[W[{aXPhckBoemWnbjDtc45s\XliVnXyc{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{KGmwZIXj[YQh[2WubDDk[YF1cCCvZXHzeZJm\CCjZoTldkA4KGSjeYOsJGVEPTBiPTCxNUDPxE1w	M1X0N\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUS2NVE3Lz5{NUm0OlEyPjxxYU6=
Vero	NFnKT2pCdnSrdnnyZYwh[XO\|YYm=		MXu3JIRigXN?	NI\VNINCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEcGmtdX7neY56[SC4aYL1d{B{fHKjaX6gPFk6KGmwZnXjeIVlKGmwIHHmdolk[W5iZ4Ll[Y4hdW:wa3X5JHZmem9iY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3czDpcoR2[2WmIHPlcIwh\GWjdHigcYVie3W{ZXSgZYZ1\XJiNzDkZZl{NCCHQ{WwJF0hOTFizszNMi=>	Ml3uQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7NE[xNVYoRjJ3OUS2NVE3RC:jPh?=
Vero	M4jXTWFvfGm4aYLhcEBie3OjeR?=		NF\ldnQ3KHSxIEeg[IF6ew>?	MmPPRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgV4lv\GKrczD2bZJ2eyCKUoPwJIlv\mWldHXkJIlvKEGocnnjZY4h\3KnZX6gcY9vc2W7IG\ldo8h[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGOnbHyg[IVifGhiYX\0[ZIhPiC2bzC3JIRigXNiYomgUXRUKGG\|c3H5MEBGSzVyIE2gNVEh\|ryPLh?=	NWr5S3FMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NlY5ODdpPkK0PVI3QDB5PD;hQi=>
Vero	NF[4eoFCdnSrdnnyZYwh[XO\|YYm=		MnTlOkB1dyB5IHThfZM>	M2\MV2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JHNqdmSkaYOgeolzfXNiSGLzdEBqdm[nY4Tl[EBqdiCjZoLpZ4FvKGe{ZXXuJI1wdmuneTDW[ZJwKGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCrbnP1ZoF1\WRiZn;yJFYhfG9iNzDkZZl{KGK7IF3UV{Bie3OjeTygSWM2OCB;IEGxJO69VS5?	MmC1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{MUW0OlAoRjJ\|MkG1OFYxRC:jPh?=
Vero	MnPIRY51cX[rcnHsJIF{e2G7		NUG4W\|k6PiC2bzC3JIRigXN?	M1jLXGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGNpcWu3bnf1cpliKH[rcoXzJFg6QSCrbn\lZ5Rm\CCrbjDh[pJq[2GwIHfy[YVvKG2xbnvlfUBX\XKxIHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDpcoN2[mG2ZXSg[o9zKDZidH:gO{Bl[Xm\|IHL5JG1VWyCjc4PhfUwhTUN3MDC9JFEyKM7:TT6=	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJzNUS2NEc,OjN{MUW0OlA9N2F-
red blood cells	MmHFRY51cW2jbHHybYFtKGG\|c3H5		MXG0PEBpenN?	MVLBcpRqdWGuYYLpZYwh[WO2aY\peJkh[WejaX7zeEBkcGyxcn;xeYlv\S2{ZYPpd5RidnRiUHzhd41w\Gm3bTDmZYxkcXCjcoXtJGsyPCCrbn\lZ5Rm\CCrbjDoeY1idiC{ZXSgZoxwd2RiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JHs{UF2qeYDvfIFvfGirbnWgbY5kd3Kyb4LheIlwdiCjc4PhfUwhUUN3MDC9JFEyKM7:TT6=	NH7QW3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK4NlI3OCd-MkWyPFIzPjB:L3G+
red blood cells	M4C3WWFvfGmvYXzhdolidCCjc4PhfS=>		MnLDNlQhcHK\|	MojZRY51cW2jbHHybYFtKGGldHn2bZR6KGGpYXnud5Qh[2iub4LvdZVqdmVvcnXzbZN1[W62IGDsZZNud2SrdX2g[oFt[2myYYL1cUBTU0x7IHnu[oVkfGWmIHnuJJJm\CCkbH;v[EBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5ibXH0eZJmKHOlaHn6c451eyCob4LtZZRqd25iYX\0[ZIhOjRiaILzJIJ6KEerZX3zZU1{fGGrbnnu[{Bj[XOnZDDhd5NigSxiRVO1NEA:KDFzLkK1JO69VS5?	NWPweHh3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0PVk1QDZpPkK5OFk6PDh4PD;hQi=>
MCF7	NXvGO3B2S3m2b4TvfIlkcXS7IHHzd4F6			MnOyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyCdM1jdbJlxd3ijboTobY5mKGmwY3;ydI9z[XSrb36sJGlEPTBiPTCxNkDPxE1w	NYrYeXlLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1NVI6QDdpPkG4OVEzQTh5PD;hQi=>
HEK293	NXewPHh4S3m2b4TvfIlkcXS7IHHzd4F6		MVO3NkBpenN?	M2jEcWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhGUzJ7MzDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyJIJtfWViYYPzZZktKEmFNUCgQUAyOiEQvF2u	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF3NUW5N{c,OjFzNUW1PVM9N2F-
Vero	MmrQRY51cX[rcnHsJIF{e2G7		Ml[zNlQhcHK\|	MXrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDabYtiKH[rcoXzJIlv\mWldHXkJIlvKEGocnnjZY4h\3KnZX6gcY9vc2W7IG\ldo8h[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCCUTlGgdoVxdGmlYYTpc44h[W[2ZYKgNlQhcHK\|IHL5JHJVNVCFUjDt[ZRpd2RuIFXDOVAhRSBzMjFOwG0v	NIPzUnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC2PFYxPCd-MkiwOlg3ODR:L3G+
Vero	MXzBcpRqfmm{YXygZZN{[Xl?		NH2ybIwzPCCqcoO=	M{jYOWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JHpqc2FidnnyeZMhcW6oZXP0[YQhcW5iQX\ybYNidiCpcnXlckBud26tZYmgWoVzdyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIGLORUBz\XCuaXPheIlwdiCjZoTldkAzPCCqcoOgZpkhWlRvUFPSJI1mfGixZDygSWM2OCB;IEGyJO69VS5?	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB7Mki1PUc,OjhyOUK4OVk9N2F-
HeLa	NIDBVXFCdnSrdnnyZYwh[XO\|YYm=		NGjnUWU1QCCqcoO=	NXTjdJpDSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhXlOYLVegdJNmfWSxdInw[YQhUEmYMTDs[Y51cX[rcnHsJJBienSrY3zld{Bqdm[nY4Tl[EBqdiCqdX3hckBJ\UyjIHPlcIx{KGmwY4XiZZRm\CCob4KgOFghcHK\|IHL5JJNx\WO2cn;mcJVwem:vZYTyfUwhUUN3MDC9JFEzNjR6IN88UU4>	Mnj2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6NUizNFAoRjJ{OEW4N\|AxRC:jPh?=
SH-SY5Y	NGO5O3pHfW6ldHnvckBie3OjeR?=		MkC0NlQhcHK\|	MUPJcohq[mm2aX;uJI9nKEKDQ1WxJIlvKGi3bXHuJHNJNVO\NWmgZ4VtdHNiaHHyZo9zcW6pIIfpcIQhfHmyZTDBVHA3QTViYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGGveXzvbYQh[mW2YTCoNUB1dyB2MjmgcIV3\WxiYX\0[ZIhOjRiaILzJIJ6KEWOSWPBJI1mfGixZDygTWM2OCB;IEGyMlch\|ryPLh?=	M2\ESlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMk[4PFIzLz5\|MEK2PFgzOjxxYU6=
SH-SY5Y	NFvad\|NHfW6ldHnvckBie3OjeR?=		NH:wW2MzPCCqcoO=	M2\nfm1w\HWuYYTpc44hd2ZiaIXtZY4hf2muZD30fZBmKEGSUE[5OUBmgHC{ZYPz[YQhcW5iU1itV3k2YSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJIFugWyxaXSgZoV1[SBqMTD0c{A1OiC{ZYPp[JVmeylicILv[JVkfGmxbjDt[YF{fXKnZDDh[pRmeiB{NDDodpMh[nliRVzJV2EtKEmFNUCgQUAyOi56IN88UU4>	NVu2R2tXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OVkyQThpPkK5OVU6OTl6PD;hQi=>
HepG2	NH7EW5REgXSxdH;4bYNqfHliYYPzZZk>		NI[xVHA4OiCqcoO=	MnLRR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JGFt[W2jcjDCcJVmKGG\|c3H5MEBKSzVyIE2gNVIvQSEQvF2u	M2TiTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUmwPFU4Lz5{MUG5NFg2PzxxYU6=
Vero	M{WwNWFvfGm4aYLhcEBie3OjeR?=		Ml\YOkB1dyB5IHThfZM>	NFLCZ4xCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBU\W2uaXvpJIZwemW\|dDD2bZJ2eyCYaXX0coFuKGmwZnXjeIVlKGmwIFHmdolk[W5iZ4Ll[Y4hdW:wa3X5JHZmem9iY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHPlcIwh\GWjdHigZYZ1\XJiNjD0c{A4KGSjeYOgZpkhVVSVIHHzd4F6NCCHQ{WwJF0hOTNwODFOwG0v	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl{NkiwO{c,OjR7Mk[4NFc9N2F-
Vero	MV7BcpRqfmm{YXygZZN{[Xl?		NWnqTVBYPyCmYYnz	MWrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDT[Y1tcWurIH\vdoV{fCC4aYL1d{B{fHKjaX6gWolmfG6jbTDpcoZm[3SnZDDpckBi\nKrY3HuJIdz\WWwIH3vcotmgSCYZYLvJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMhcW6mdXPl[EBk\WyuIHTlZZRpKG2nYYP1doVlKGGodHXyJFch\GG7czygSWM2OCB;IEG0JO69VS5?	M4DERVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUS2NVE3Lz5{NUm0OlEyPjxxYU6=
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NSO	NHnHcWZEgXSxdH;4bYNqfHliYYPzZZk>			M3\6SmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJG5UVyClZXzsd{BjgSCPVGSgZZN{[XluIGTDOVAhRSBzND65JO69VS5?	MoXiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlzMUO5OVUoRjF7MUGzPVU2RC:jPh?=
L1210	NUfOeGxlS3m2b4TvfIlkcXS7IHHzd4F6			MVzDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W\|ZTDMNVIyOCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxicILvcIln\XKjdHnvckBjgSCFb4XseIVzKGOxdX70[ZIh[W6jbInzbZMtKEmFNUCgQUAyPSEQvF2u	M{jhTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUG0PFEyLz5{NkGxOFgyOTxxYU6=
Huh-7	MlHMRY51cXCuYYPtc4Rq[WxiYYPzZZk>		M{[1fVQ5KGi{cx?=	MX3BcpRqeGyjc33v[IlidCCjY4Tpeol1gSCjZ3HpcpN1KFCuYYPtc4RqfW1iYnXy[4hmcSCuaY\ldkB{fGGpZTDmc5JuKHS{YX7z[oVkfGWmIHnuJIh2dWGwIFj1bE04KGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUCgQUAyPS57IN88UU4>	M3XP[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MkezNFM5Lz5{M{K3N\|A{QDxxYU6=
Daudi	MXjDfZRwfG:6aXPpeJkh[XO\|YYm=			NFrtcVJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBF[XWmaTDj[YxteyCkeTDNWHQh[XO\|YYmsJHREPTBiPTCxOk44KM7:TT6=	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTFzM{m1OUc,OTlzMUO5OVU9N2F-
HeLa	M4PYeGN6fG:2b4jpZ4l1gSCjc4PhfS=>			MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCCycn;sbYZmemG2aX;uJIJ6KEOxdXz0[ZIh[2:3boTldkBidmGueYPpd{whUUN3MDC9JFE5KM7:TT6=	NEK3Olc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGxOFgyOSd-Mk[xNVQ5OTF:L3G+
J774.1	M{CxT2N6fG:2b4jpZ4l1gSCjc4PhfS=>		MnzrNlQhcHK\|	MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBud3W\|ZTDKO\|c1NjFiY3XscJMh[W[2ZYKgNlQhcHK\|IHL5JGFt[W2jclLseYUh[mG\|ZXSgZ5l1d3SxeHnjbZR6KGG\|c3H5MEBKSzVyIE2gNVgvPCEQvF2u	M1zHeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5M{G2OVQzLz5{N{OxOlU1OjxxYU6=
HeLa	NXSxeXd7T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NIH2N5o1QCCqcoO=	M{j6NWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhmVGFiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JG1VXCCjc4PhfUBqdiCycnXz[Y5k\SCxZjCxNEUhTkKVIIP1dJBt\W2nboTl[EBFVUWPIH3l[Il2dSxiR1m1NEA:KDF6Lk[g{txONg>?	MoDsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5NEi3PFYoRjF7N{S4O\|g3RC:jPh?=
MCF7	M3;0eWN6fG:2b4jpZ4l1gSCjc4PhfS=>		M3GwSFQ5KGi{cx?=	MUPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGNEPTBiPTCxPU41KM7:TT6=	MnHqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjByMUS4OVcoRjJyMEG0PFU4RC:jPh?=
MCF7	MWTDfZRwfG:6aXPpeJkh[XO\|YYm=		NYfld3RrPDhiaILz	MYrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDYWHQhemWmdXP0bY9vKGG\|c3H5MEBESzVyIE2gNVkvPCEQvF2u	M2npW\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Nki2NFE{Lz5{NE[4OlAyOzxxYU6=
MCF7	NWj5NJR5S3m2b4TvfIlkcXS7IHHzd4F6		MWm0PEBpenN?	MUnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W\|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBZXFRiYYPzZZktKEOFNUCgQUAyQS52IN88UU4>	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV7NEWyOEc,OjR3OUS1NlQ9N2F-
MDA-MB-468	M{P2RmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MYK3NkBpenN?	MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk01PjhiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFE6Njh4IN88UU4>	NVnFXY1FRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2NFI5OjdpPkK2OlAzQDJ5PD;hQi=>
KB	NHz1blJEgXSxdH;4bYNqfHliYYPzZZk>		MYO0PEBpenN?	MmLuR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2Ih[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKwMlQh\|ryPLh?=	NHO5O\|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUiwPVA4PSd-MUG4NFkxPzV:L3G+
Vero	NUnkZ\|ZlSW62aY\pdoFtKGG\|c3H5		M1LJUFUh\GG7cx?=	M2LVUmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGNpcWu3bnf1cpliKH[rcoXzJGlv\GmjbjDPZ4VidiB6OEmgbY5n\WO2ZXSgbY4hSW[{aXPhckBoemWnbjDtc45s\XliVnXyc{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgOUBl[Xm\|IHL5JG1VWy:STWOgcYV1cG:mLDDFR\|kxKD1iMkGg{txONg>?	NHi0T209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUOzOlk2OSd-MkmzN\|Y6PTF:L3G+
Vero	NVG2bZRiSW62aY\pdoFtKGG\|c3H5			NHHWdYhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBEcGmtdX7neY56[SC4aYL1d{BKdmSrYX6gU4Nm[W5ic4TyZYlvKDh7OTDpcoZm[3SnZDDpckBC\nKrY3HuJIdz\WWwIH3vcotmgSCYZYLvJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBu\WG\|dYLl[EBwdiCmYYmgOUBxd3O2IHnu[oVkfGmxbjDifUBOXFNxUF3TJIF{e2G7LDDFR\|kxKD1iMkGg{txONg>?	M{C1e\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEm5OFg4Lz5{OUS5PVQ5PzxxYU6=
Vero	MoOwRY51cX[rcnHsJIF{e2G7		NYj4eopIPyCmYYnz	M4jLOWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGNpcWu3bnf1cpliKH[rcoXzJGlv\GmjbjDPZ4VidiC\|dILhbY4hQDl7IHnu[oVkfGWmIHnuJGFnemmlYX6g[5Jm\W5ibX;ub4V6KF[ncn:gZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JIFnfGW{IEeg[IF6eyCkeTDNWHMwWE2VIH3leIhw\CxiRVO5NEA:KDJzIN88UU4>	NIm0eHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEiwNFYzPid-MkS4NFA3OjZ:L3G+
Vero	MlHER5l1d3SxeHnjbZR6KGG\|c3H5		MXO3NkBpenN?	NVLadY1GS3m2b4TvfIlkcXS7IHHnZYlve3RiYX\ybYNidiCpcnXlckBud26tZYmgWoVzdyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwJF0hOjFizszNMi=>	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd{N{WzPEc,OjN5Mke1N\|g9N2F-
HepG2	NI\HeG5EgXSxdH;4bYNqfHliYYPzZZk>		MYK0PEBpenN?	MnrJR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JIxi[3SjdHWg[IVpgWS{b3flcoF{\SCjc4PhfUwhT0l3MDC9JFIzNjF4IN88UU4>	NHPkZXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUi4Nlg{OSd-MkG4PFI5OzF:L3G+
KB	NUDOXIMzS3m2b4TvfIlkcXS7IHHzd4F6		NFfuUIM4OiCqcoO=	MWHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTTJIF{e2G7LDDJR\|UxKD1iMkKuOUDPxE1w	NF\HNo89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUi3PVE2OCd-MUm4O\|kyPTB:L3G+
MDA-MB-231	NH;WNZlEgXSxdH;4bYNqfHliYYPzZZk>		NYfVXmpmPDhiaILz	MlXjR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMkKuOVIh\|ryPLh?=	NWrwTW9{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4NFQ6PzlpPkG5PFA1QTd7PD;hQi=>
MDA-MB-231	NV;Iem1WSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M2jsZlQ5KGi{cx?=	NWXlUVhiSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDwOVMtKHCUQjDteZRidnRiYX7kJIV{fHKxZ3XuJJJm[2WydH;yJIRm\mmlaXXueEBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO\|YYmsJGdKPTBiPTCyNk42OiEQvF2u	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODV4MUeyNEc,OjB3NkG3NlA9N2F-
MDA-MB-231	MlfzR5l1d3SxeHnjbZR6KGG\|c3H5		M2\4OlQ5KGi{cx?=	M2\hcWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN\|Eh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgOFghcHK\|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFIzNjV{IN88UU4>	M3PLflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUi2O\|E3Lz5{OEW4OlcyPjxxYU6=
CEM	NE\nXJBEgXSxdH;4bYNqfHliYYPzZZk>			Mn64R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR2VOKGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCCycn;sbYZmemG2aX;uJIJ6KEOxdXz0[ZIh[2:3boTldkBidmGueYPpd{whUUN3MDC9JFI{KM7:TT6=	M{nQeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUG0PFEyLz5{NkGxOFgyOTxxYU6=
CE81T	MkfYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		MlzmOFghcHK\|	M33MZ2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGNGQDGWIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZkhcW5icILld4Vv[2Vib3[gNVAmKE[EUzDzeZBxdGWvZX70[YQhTE2HTTDt[YRqfW1uIFfJOVAhRSB{Mz60JO69VS5?	M{O1TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{S4O\|g3Lz5zOUe0PFc5PjxxYU6=
MCF7	MUDDfZRwfG:6aXPpeJkh[XO\|YYm=		NUPPUFc3PzJiaILz	MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKG63bXLldkBqdmO3YnH0[YQh\m:{IEeyJIhzeyxiSVO1NEA:KDJ\|LkSzJO69VS5?	NEXieoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGzOVQ4OSd-Mk[xN\|U1PzF:L3G+
HepG2	NFfLS25EgXSxdH;4bYNqfHliYYPzZZk>		MoPOO\|IhcHK\|	MUPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyCrboTyZYNmdGy3bHHyJGFVWCCuZY\lcEBi\nSncjC3NkBpenNiYomgR4VtdHSrdHXyMWdtdyCudX3pcoV{[2WwdDDhd5NigSxiRVO1NEA:KDJ3IN88UU4>	MlizQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7MUC0OlYoRjJzOUGwOFY3RC:jPh?=
HepG2	M1flZWN6fG:2b4jpZ4l1gSCjc4PhfS=>		M{Xwd\|czKGi{cx?=	NF\LfY9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDDueY1j\XJiaX7jeYJifGWmIH\vdkA4OiCqcoOsJGlEPTBiPTCyOUDPxE1w	NF7Kbm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGzOVQ4OSd-Mk[xN\|U1PzF:L3G+
BxPC3	MlHpRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NEfGN3g4OiCqcoO=	MlLERY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCEeGDDN{Bk\WyuczDh[pRmeiB5MjDodpMh[nliU2LCJI1mfGixZDygTWM2OCB;IEK1JO69VS5?	M1TxU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nkm5NVU4Lz5{NU[5PVE2PzxxYU6=
MDA-MB-468	MV;DfZRwfG:6aXPpeJkh[XO\|YYm=		M3fqdlQ5KGi{cx?=	NVXZe3BuS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ3QCClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG\|c3H5MEBIUTVyIE2gNlgvPThizszNMi=>	M{H5NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OEC0PVc6Lz5zOUiwOFk4QTxxYU6=
MDA-MB-468	M1n4SWN6fG:2b4jpZ4l1gSCjc4PhfS=>		Mn\GOFghcHK\|	M2raVmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20Olgh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygS2k2OCB;IEK4MlU5KM7:TT6=	M3nsO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUC2OlY5Lz5{MEGwOlY3QDxxYU6=
MDA-MB-468	Mn\TR5l1d3SxeHnjbZR6KGG\|c3H5		NVrWdWdsPDhiaILz	NGK3[FJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtOFY5KGOnbHzzJIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEmFNUCgQUAzQC53ODFOwG0v	MnzQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3OE[3NVYoRjJ6NUi2O\|E3RC:jPh?=
K562	M3jqOWN6fG:2b4jpZ4l1gSCjc4PhfS=>			NITFe2lEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEK5MlA{KM7:TT6=	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV4MkKwNkc,OTh3NkKyNFI9N2F-
HeLa	M2\XeGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NGnNZpU4OiCqcoO=	MWnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEinTHGgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDJ7Lkm2JO69VS5?	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjZyMkiyO{c,OjZ4MEK4Nlc9N2F-
HepG2	MULDfZRwfG:6aXPpeJkh[XO\|YYm=		NXzNVVRkPzJiaILz	M2G5cmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA{OCEQvF2u	NEjTUY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUS4NlQ4Pid-MUm0PFI1PzZ:L3G+
HepG2	Ml3rR5l1d3SxeHnjbZR6KGG\|c3H5		MmHsO\|IhcHK\|	NFzIeYJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOzBizszNMi=>	M2DmfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUK2NVc{Lz5zOUmyOlE4OzxxYU6=
HepG2	MoDFR5l1d3SxeHnjbZR6KGG\|c3H5			M3\SSmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOwJO69VS5?	M1G4NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUixOFYzLz5zN{m4NVQ3OjxxYU6=
HepG2	M1XmZmN6fG:2b4jpZ4l1gSCjc4PhfS=>		NGHlXGo4OiCqcoO=	M2m5PGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEOFNUCgQUA{OCEQvF2u	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTd2MUGzNUc,OjF5NEGxN\|E9N2F-
HepG2	M2TwdWN6fG:2b4jpZ4l1gSCjc4PhfS=>		MYm3NkBpenN?	NYXkUVB5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiQ1O1NEA:KDNyIN88UU4>	M1e3NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEi5OVU6Lz5{Mki4PVU2QTxxYU6=
HepG2	MYnDfZRwfG:6aXPpeJkh[XO\|YYm=		MkfBO\|IhcHK\|	MoixR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhS0N3MDC9JFMxKM7:TT6=	NYLZW3hjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OFYzOTZpPkK0PVQ3OjF4PD;hQi=>
SH-SY5Y	M4XJVmN6fG:2b4jpZ4l1gSCjc4PhfS=>		NVf5R2g6PzJiaILz	M3nPT2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNJNVO\NWmgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiQ1O1NEA:KDNyIN88UU4>	M1X5OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUW5NVk5Lz5{OUW1PVE6QDxxYU6=
HepG2	NFe3dm1EgXSxdH;4bYNqfHliYYPzZZk>		MWW3NkBpenN?	MYTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBESzVyIE2gN\|Ah\|ryPLh?=	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh3OEW0N{c,OjR6NUi1OFM9N2F-
HepG2	NWWyR\|IzS3m2b4TvfIlkcXS7IHHzd4F6		M4nYcVczKGi{cx?=	NFfJZ25EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCFQ{WwJF0hOzBizszNMi=>	M3LKNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUW1OFY{Lz5{N{G1OVQ3OzxxYU6=
HepG2	MYrDfZRwfG:6aXPpeJkh[XO\|YYm=		NF3zelY4OiCqcoO=	MmHqR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhS0N3MDC9JFMxKM7:TT6=	M{TkW\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{mxOlc2Lz5{NUe5NVY4PTxxYU6=
HepG2	NFzKeG1EgXSxdH;4bYNqfHliYYPzZZk>		NEXMVpc4OiCqcoO=	MYTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{BqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGNEPTBiPTCzNEDPxE1w	Mk\qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{OEKyOlcoRjJ3MkiyNlY4RC:jPh?=
HepG2	NIDGZ4tEgXSxdH;4bYNqfHliYYPzZZk>		NYLTXI9CPzJiaILz	MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBESzVyIE2gN\|Ah\|ryPLh?=	M1XWUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEWyNVMzLz5{MUi1NlE{OjxxYU6=
HepG2	MkHnR5l1d3SxeHnjbZR6KGG\|c3H5		MVO3NkBpenN?	NGLzTo5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCFQ{WwJF0hOzBizszNMi=>	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZyOE[3OUc,OjJ4MEi2O\|U9N2F-
HepG2	MkfYR5l1d3SxeHnjbZR6KGG\|c3H5		MoXJO\|IhcHK\|	Mm\hR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFPDOVAhRSB\|MDFOwG0v	M3jp[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NkW0N\|k2Lz5{N{[1OFM6PTxxYU6=
KB	NWXZSHBTS3m2b4TvfIlkcXS7IHHzd4F6			NUTHVWtzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hU0JiY3XscJMh[nliU2LCJIF{e2G7LDDFSFUxKD1iM{CuPEDPxE1w	M17CdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NU[yPFMzLz5zNkW2Nlg{OjxxYU6=
HepG2	M3S2R2N6fG:2b4jpZ4l1gSCjc4PhfS=>		NUj4NZVLOjRiaILz	MWjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjCyOEBpenNiYomgcoV2fHKjbDDy[YQhfXC2YXvlJIF{e2G7LDDUR\|UxKD1iM{Gg{txONg>?	NGfkdZQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G0OVgyPid-MkOxOFU5OTZ:L3G+
K562	M4\HS2N6fG:2b4jpZ4l1gSCjc4PhfS=>		M1LVS\|czKGi{cx?=	MoPyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{Bi\nSncjC3NkBpenNiYomg[oxwfyCleYTvcYV1enluIFnDOVAhRSB\|MjFOwG0v	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTR6MkS3Okc,OTl2OEK0O\|Y9N2F-
K562	M1nmbGN6fG:2b4jpZ4l1gSCjc4PhfS=>		M1;Cb\|czKGi{cx?=	MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDmcI94KGO7dH;t[ZRzgSxiSVO1NEA:KDN{IN88UU4>	M4CwTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUK2NVc{Lz5zOUmyOlE4OzxxYU6=
FM3A	M3rRdmFvfGmycn;sbYZmemG2aY\lJIF{e2G7			M{TVUGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgUY92e2VibXHtcYFzgSC2dX3vdkBHVTODIHPlcIx{NCCHQ{WwJF0hOzJizszNMi=>	M3jkU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOU[2O\|Q3Lz5zMEm2Olc1PjxxYU6=
FM3A	MWPDfZRwfG:6aXPpeJkh[XO\|YYm=			NYO4eY9RUW5idnn0do8h[3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhdWGvbXHyfUBHVTODIHPlcIx{NCCHQ{WwJF0hOzJizszNMi=>	NV3pWGRzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUKwN\|Y{PjVpPkGyNFM3OzZ3PD;hQi=>
FM3A	MnPiR5l1d3SxeHnjbZR6KGG\|c3H5			M2\qVGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJI1idW2jcomgeJVud3JiRl2zRUBk\WyuczDy[ZBz\XOnboTpcoch[SCvb3TlcEBw\iCqb4P0MEBGSzVyIE2gN\|Ih\|ryPLh?=	NHTk[Fg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUi1OVk4QCd-MUG4OVU6Pzh:L3G+
FM3A	M4rmdGN6fG:2b4jpZ4l1gSCjc4PhfS=>			MYfDfZRwfG:6aXPpeJkh[WejaX7zeEBHVTODIH3veZNmKG2jbX3hdpkh[2WubIOsJGVEPTBiPTCzNkDPxE1w	NFH4fIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zM{[3PFQyOyd-MUO2O\|g1OTN:L3G+
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LNCAP	MlK0R5l1d3SxeHnjbZR6KGG\|c3H5		MYO3NkBpenN?	M4L1dmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGxPS0GSIHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBk\WyuIH71cYJmeiCrbnP1ZoF1\WRiZn;yJFczKGi{czygTWM2OCB;IEOyMlg4KM7:TT6=	NGLGVVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGzOVQ4OSd-Mk[xN\|U1PzF:L3G+
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NCH-89	M2m5XWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		Mk\DOFghcHK\|	NVvHb4Y2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDjZZJufXO2aX7lMZJme2m\|dHHueEBPS0hvOEmgZ4VtdHNiYYPz[ZN{\WRiYYOgRpJlXSCrbnPvdpBwemG2aX;uJIFnfGW{IES4JIhzeyxiSVO1NEA:KDRzLkKg{txONg>?	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN{OUezN{c,OjB\|Mkm3N\|M9N2F-
HepG2	MknxR5l1d3SxeHnjbZR6KGG\|c3H5		M3fWXlQ5KGi{cx?=	NGX6TnNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHHmeIVzKDR6IHjyd{BjgSCORFigZZN{[XluIFfJOVAhRSB2Mz6wPUDPxE1w	MkDIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OES0NlIoRjJ3Nki0OFIzRC:jPh?=
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MKN28	M3rIZWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MWiyJIRigXN?	MVrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2NTkK4JINmdGy\|IHHmeIVzKDJiZHH5d{BjgSC\|dXzmc5Jpd2SjbXnu[UBDKGG\|c3H5MEBIUTVyIE2gOFQvPDRizszNMi=>	NYT0O2g2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxPFQxPzZpPkK0NVg1ODd4PD;hQi=>
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MRC5	NH7tdodEgXSxdH;4bYNqfHliYYPzZZk>			NFfBNJlEgXSxdH;4bYNqfHliYXfhbY5{fCCPUlO1JINmdGy\|	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF4NkexPEc,OTdzNk[3NVg9N2F-
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BT-37	Mn3HdWhVWyCjc4PhfS=>			MULxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhSlRvM{egZ4VtdHN?	NFS5c\|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
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MG 63 (6-TG R)	MVPxTHRUKGG\|c3H5			MXvxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVUdiNkOgLFYuXEdiUjmgZ4VtdHN?	NIHuTmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
NB1643	NILQWFJyUFSVIHHzd4F6			MW\xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVkJzNkSzJINmdGy\|	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
OHS-50	Mm\hdWhVWyCjc4PhfS=>			NYP3UXhbeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IF;IV{02OCClZXzsdy=>	M1fHTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-MC	NX;SN3VYeUiWUzDhd5NigQ>?			NHHxd5RyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1utUk1OSyClZXzsdy=>	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
LAN-5	MYjxTHRUKGG\|c3H5			NYfMZ212eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IFzBUk02KGOnbHzz	Mo\zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
HEK293	M3;Vd2F2fG:yaHHnfUBie3OjeR?=	M4L4dVExKHWP	MmDIPEBpenN?	MV\JcoR2[3Srb36gc4Yh[XW2b4DoZYd6KGmwIFjFT\|I6OyClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDwOlIhdGW4ZXygZZQhOTBidV2gZYZ1\XJiODDodpMh[nliaX3teY5w[myxdDDhcoFtgXOrcx?=	Ml\JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2OEG1N\|YoRjJ6NEixOVM3RC:jPh?=
HEK293	NGLH[nBCfXSxcHjh[5kh[XO\|YYm=	MUSxNEB2VQ>?	MYG4JIhzew>?	NFznbpRKdmS3Y4Tpc44hd2ZiYYX0c5Bp[We7IHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG\|ZTDpckBNSzNvMjDs[ZZmdCCjdDCxNEB2VSCjZoTldkA5KGi{czDifUBqdW23bn;icI91KGGwYXz5d4l{	Mk\CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2OEG1N\|YoRjJ6NEixOVM3RC:jPh?=
LNCAP	NYrQbHZTTnWwY4Tpc44h[XO\|YYm=			NHTrfIVT\WS3Y4Tpc44hcW5iR1\QJIV5eHKnc4Ppc44hcW5iaIXtZY4hVE6FQWCgZ4VtdHNidILhcpNn\WO2ZXSge4l1cCCybHHzcYlleyClbz3lfJBz\XO\|aX7nJGdHWCCjbnSgd4hTVkG\|IHHnZYlve3RiUlXWMWVTSmKndHGg[o9tdG:5ZXSgZpkh[2:vcH;1coQhfHKnYYTt[Y51KDJ2IHjyd{Bxd3O2LYTyZY5{\mWldHnvckBidmRibXXhd5Vz\WRiNEigbJJ{KHCxc4Sg[I9{\Q>?	NGK4T4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGzOVQ4OSd-Mk[xN\|U1PzF:L3G+
SKBR3	MYnGeY5kfGmxbjDhd5NigQ>?			NWPi[ooyWmWmdXP0bY9vKGmwIFfGVEBmgHC{ZYPzbY9vKGmwIHj1cYFvKFONQmKzJINmdGy\|IITyZY5{\mWldHXkJJdqfGhicHzhd41q\HNiY3:t[ZhxemW\|c3nu[{BITlBiYX7kJJNpWk6DczDh[4FqdnO2IGLFWk1GWkKkZYThJIZwdGyxd3XkJIJ6KGOxbYDveY5lKHS{ZXH0cYVvfCB{NDDodpMheG:\|dD30doFve2[nY4Tpc44h[W6mIH3lZZN2emWmIES4JIhzeyCyb4P0JIRwe2V?	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF\|NUS3NUc,OjZzM{W0O\|E9N2F-
HepG2	NH\NbJZHfW6ldHnvckBie3OjeR?=			NX7PdFZGWmWmdXP0bY9vKGmwIFfGVEBmgHC{ZYPzbY9vKGmwIHj1cYFvKEincFeyJINmdGy\|IITyZY5{\mWldHXkJJdqfGhicHzhd41q\HNiY3:t[ZhxemW\|c3nu[{BITlBiYX7kJJNpWk6DczDh[4FqdnO2IGLFWk1GWkKkZYThJIZwdGyxd3XkJIJ6KGOxbYDveY5lKHS{ZXH0cYVvfCB{NDDodpMheG:\|dD30doFve2[nY4Tpc44h[W6mIH3lZZN2emWmIES4JIhzeyCyb4P0JIRwe2V?	M3nVdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUO1OFcyLz5{NkGzOVQ4OTxxYU6=
H460	MkDpRZBweHSxc3nzJIF{e2G7	M{SwTlI2KHSxIEe1JJVO	NVfNT45kOjRiaILz	NV[xZnBCUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDIOFYxKGOnbHzzJIF1KDJ3IITvJFc2KHWPIHHmeIVzKDJ2IHjyd{BjgSCjbn7lfIlvNVZic4ThbY5qdmdvYnHz[YQh\myxdzDjfZRwdWW2com=	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ7OUG1O{c,OjV4OUmxOVc9N2F-
HepG2	MVLGeY5kfGmxbjDhd5NigQ>?	NVW1[Vg{PTBidV2=	MWG2JIhzew>?	NULzUHFYWmWmdXP0bY9vKGmwIHz5d49{d22jbDDhZ4llcW[rY3H0bY9vKGmwIHj1cYFvKEincFeyJINmdGy\|IHH0JFUxKHWPIHHmeIVzKDZiaILzJIJ6KESDUFmvcJl{dyC2cnHjb4VzKHKnZD3kc5VjdGVic4ThbY5qdmdiYnHz[YQh[2:wZn;jZYwhdWmlcn;zZ49xcWNiYX7hcJl{cXNicnXsZZRqfmVidH:gZ49vfHKxbB?=	MkDHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzOUezNlAoRjJ6MUm3N\|IxRC:jPh?=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	ZEBRA / p-S824 KAP1 ; PubMed: 28249048 PLoS Pathog HH514-16 BL cells were treated with chloroquine and harvested at different times post-treatment for immunoblotting with antibodies as indicated. p62 / LC3 ; PubMed: 26677873 Proc Natl Acad Sci U S A Antiautophagic activity of Lys01. Panc 10.05 cells were treated for 24 h with the indicated doses of chloroquine or Lys01 and were probed by Western blot.	28249048 26677873
Immunofluorescence	p-S824 KAP1 / ZEBRA ; PubMed: 28249048 PLoS Pathog HH514-16 BL cells were treated with chloroquine (CQ) or chloroquine plus KU-55933 (CQ+KU) and harvested at 24 hours followed by staining with anti-phospho KAP1 (S824) plus anti-ZEBRA antibodies and visualized at 1000X magnification. CD1d-β2m / LAMP1 ; PubMed: 20368272 J Immunol HEK293-CD1d WT cells were treated overnight with 20 μM of chloroquine (or vehicle). The cells were then fixed, permeabilized and stained with the anti-CD1d-β2m mAb (red), anti-LAMP-1 (green) and Hoechst (blue). The stained cells were then analyzed by confocal microscopy. SQSTM1 / MAP1LC3B ; PubMed: 29872540 Cell Discov Immunofluorescent images of astrocytoma SNB-19 cells treated with DMSO, emetine or chloroquine for 24 h, then stained with SQSTM1 protein (green), MAP1LC3B protein (red) and nuclei (blue).	28249048 20368272 29872540
Growth inhibition assay	Cell viability ; PubMed: 25521075 Br J Pharmacol A549 cells were treated with serial concentrations of chloroquine for 72 h, and Huh7 cells were treated with the same concentrations for 48 h. Tumour cell viability was determined by cell viability assay. Data represent means from at least three independent experiments ± SD.	25521075

Protocol

References

[4] Hideo Yasuda, et al. Am J Physiol Renal Physiol . 2008 May;294(5):F1050-8.

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Solubility (25°C)

In vitro	Water	100 mg/mL (193.85 mM)
	DMSO	Insoluble
	Ethanol	Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Chloroquine diphosphate SDF

Molecular Weight	515.86
Formula	C₁₈H₂₆ClN₃.2H₃O₄P
CAS No.	50-63-5
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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mg/kg

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Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)

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Calculation results:

Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-01-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04443270	Not yet recruiting	Drug: Chloroquine phosphate	COVID-19	CMN 20 de Noviembre	July 27 2020	Phase 1
NCT04462367	Not yet recruiting	--	COVID19\|Coronavirus Infection\|Pregnancy Disease\|Severe Acute Respiratory Syndrome	Instituto Materno Infantil Prof. Fernando Figueira	July 1 2020	--
NCT04340544	Terminated	Drug: Hydroxychloroquine\|Drug: Placebo	COVID-19	University Hospital Tuebingen\|Robert Bosch Medical Center\|Universitätsklinikum Hamburg-Eppendorf\|Bernhard Nocht Institute for Tropical Medicine	April 22 2020	Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Chloroquine diphosphate