Molecular Weight(MW): 515.86
Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator.
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|Description||Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator.|
Chloroquine is a chemotherapeutic agent for the clinical treatment of malaria. Chloroquine is able to bind to DNA, and inhibit DNA replication and RNA synthesis which in turn results in cell death. The effect of Chloroquine may also be related to the formation of a toxic heme-Chloroquine complex. Chloroquine inhibits trophozoite hemoglobin degradation through increasing vacuolar pH and inhibiting the activity of vacuolar phospholipase, vacuolar proteases, and heme polymerase. Chloroquine possesses definite antirheumatic properties. Chloroquine has immuno-modulatory effects, suppressing the production/release of tumour necrosis factor and interleukin 6. Moreover, Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best-studied effects are those against HIV replication. Chloroquine can accumulate inside the macrophage phagolysosome by ion trapping where it exerts potent antifungal activity against Histoplasma capsulatum and Cryptococcus neoformans by distinct mechanisms. Chloroquine inhibits growth of H. capsulatum by pH-dependent iron deprivation, whereas it is directly toxic to C. neoformans.
|In vitro||Water||100 mg/mL (193.85 mM)|
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02378532||Recruiting||Drug: Chloroquine|Radiation: Radiotherapy|Drug: Temozolomide||Glioblastoma Multiforme||Maastricht Radiation Oncology||August 2016||Phase 1|
|NCT02496741||Unknown status||Drug: Metformin and chloroquine combination||Glioma|Cholangiocarcinoma|Chondrosarcoma||Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)||November 2015||Phase 1|Phase 2|
|NCT02610686||Unknown status||Drug: Chloroquine||Plasmodium Vivax||National Institute of Malariology Parasitology and Entomology Vietnam|Institute of Tropical Medicine Belgium||March 2015||Phase 4|
|NCT02698748||Completed||Drug: Chloroquine|Drug: Placebo||Malaria||Centro de Investigacao em Saude de Manhica||January 2015||Phase 2|Phase 3|
|NCT02071537||Unknown status||Drug: Chloroquine|Drug: Carboplatin|Drug: Gemcitabine||Malignant Neoplasm|Solid Tumors||University of Cincinnati||May 2014||Phase 1|
|NCT00969306||Terminated||Drug: Chloroquine A-CQ 100||Small Cell Lung Cancer||Maastricht Radiation Oncology|Maastricht University Medical Center|National Cancer Institute (NCI)||September 2013||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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