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Chloroquine diphosphate

For research use only.

Catalog No.S4157

130 publications

Chloroquine diphosphate Chemical Structure

CAS No. 50-63-5

Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).

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Selleck's Chloroquine diphosphate has been cited by 130 publications

Purity & Quality Control

Choose Selective ATM/ATR Inhibitors

Biological Activity

Description Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).
Targets
TLR3 [4]
()
TLR7 [4]
()
TLR8 [4]
()
TLR9 [4]
()
ATM [1]
(Cell-free assay)
In vitro

Chloroquine is a chemotherapeutic agent for the clinical treatment of malaria. Chloroquine is able to bind to DNA, and inhibit DNA replication and RNA synthesis which in turn results in cell death. The effect of Chloroquine may also be related to the formation of a toxic heme-Chloroquine complex. Chloroquine inhibits trophozoite hemoglobin degradation through increasing vacuolar pH and inhibiting the activity of vacuolar phospholipase, vacuolar proteases, and heme polymerase[1]. Chloroquine possesses definite antirheumatic properties. Chloroquine has immuno-modulatory effects, suppressing the production/release of tumour necrosis factor and interleukin 6. Moreover, Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best-studied effects are those against HIV replication[2]. Chloroquine can accumulate inside the macrophage phagolysosome by ion trapping where it exerts potent antifungal activity against Histoplasma capsulatum and Cryptococcus neoformans by distinct mechanisms. Chloroquine inhibits growth of H. capsulatum by pH-dependent iron deprivation, whereas it is directly toxic to C. neoformans[3].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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human MCF7 cells NH;1WY9EgXSxdH;4bYPDqGG|c3H5 MWm0PEBp NH;CeWhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZkhcW5icILld4Vv[2Vib3[gNE41KHWPIEGtLFEuMDRvKEetdIhmdnmuLUHIMYlucWSjen;bOEw2NWefcYXpco95[Wyrbj22MZltMWKnbor5cElxcXCncnnkbY4uPC27bDmtNWgu[mWwen;b[H1qdWmmYYrvcE0zMDOKKT3vcoUtKEeLNUC9OU42OSEQvF2= NVfNbolDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5OFUyQTdpPkG5PVQ2OTl5PD;hQi=>
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MDA-MB-231 NIWzW|lEgXSxdH;4bYNqfHliYYPzZZk> Mnu1OFghcHK| NIHPTopEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEmFNUCgQUAzOi53MjFOwG0v MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV6NkexOkc,Ojh3OE[3NVY9N2F-
CEM NETSVlZEgXSxdH;4bYNqfHliYYPzZZk> NXvWd3Z7S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0WPIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGK7IFPveYx1\XJiY3;1cpRmeiCjbnHsfZNqeyxiSVO1NEA:KDJ|IN88UU4> MoXqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzMUS4NVEoRjJ4MUG0PFEyRC:jPh?=
CE81T NHrkdm5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoDOOFghcHK| NWTzeIM2T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hS0V6MWSgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSCrbjDwdoV{\W6lZTDv[kAyOCViRlLTJJN2eHCuZX3lcpRm\CCGTVXNJI1m\Gm3bTygS2k2OCB;IEKzMlQh|ryPLh?= NXPrS49sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3OFg4QDZpPkG5O|Q5Pzh4PD;hQi=>
MCF7 NIjVcXpEgXSxdH;4bYNqfHliYYPzZZk> MUC3NkBpenN? NV;BSINTS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDDueY1j\XJiaX7jeYJifGWmIH\vdkA4OiCqcoOsJGlEPTBiPTCyN{41OyEQvF2u NW[wcGNORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xN|U1PzFpPkK2NVM2PDdzPD;hQi=>
HepG2 NEjpOodEgXSxdH;4bYNqfHliYYPzZZk> M1i3TlczKGi{cx?= NVrhdG4xS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOgbY51emGlZXzseYxieiCDVGCgcIV3\WxiYX\0[ZIhPzJiaILzJIJ6KEOnbHz0bZRmei2JbH:gcJVucW6nc3PlcpQh[XO|YYmsJGVEPTBiPTCyOUDPxE1w MmjzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7MUC0OlYoRjJzOUGwOFY3RC:jPh?=
HepG2 MW\DfZRwfG:6aXPpeJkh[XO|YYm= MUK3NkBpenN? MlvKR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxiboXtZoVzKGmwY4XiZZRm\CCob4KgO|IhcHK|LDDJR|UxKD1iMkWg{txONg>? NYjwU5VxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xN|U1PzFpPkK2NVM2PDdzPD;hQi=>
BxPC3 MVvBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MXG3NkBpenN? MlSwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCEeGDDN{Bk\WyuczDh[pRmeiB5MjDodpMh[nliU2LCJI1mfGixZDygTWM2OCB;IEK1JO69VS5? MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ7OUG1O{c,OjV4OUmxOVc9N2F-
MDA-MB-468 MoPmR5l1d3SxeHnjbZR6KGG|c3H5 NH3QO|E1QCCqcoO= MonKR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUS2PEBk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMkiuOVgh|ryPLh?= M1rJdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OEC0PVc6Lz5zOUiwOFk4QTxxYU6=
MDA-MB-468 M3e4WGN6fG:2b4jpZ4l1gSCjc4PhfS=> MVK0PEBpenN? Mn7SR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUS2PEBk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMkiuOVgh|ryPLh?= NHjJPFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGwOlY3QCd-MkCxNFY3Pjh:L3G+
MDA-MB-468 M2HBR2N6fG:2b4jpZ4l1gSCjc4PhfS=> M2LwWlQ5KGi{cx?= M4PQT2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20Olgh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFI5NjV6IN88UU4> MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV6NkexOkc,Ojh3OE[3NVY9N2F-
K562 NXfJVHhtS3m2b4TvfIlkcXS7IHHzd4F6 MXjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDJ7LkCzJO69VS5? NYPDZXNyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1OlIzODJpPkG4OVYzOjB{PD;hQi=>
HeLa M3TP[2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NYnwNoVHPzJiaILz NWLWOVJ7SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCyPU46PiEQvF2u MlXtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4MEK4NlcoRjJ4NkCyPFI4RC:jPh?=
HepG2 NEfWd4tEgXSxdH;4bYNqfHliYYPzZZk> NH74bGE4OiCqcoO= NYPvc4E{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNyIN88UU4> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTR6MkS3Okc,OTl2OEK0O|Y9N2F-
HepG2 MYTDfZRwfG:6aXPpeJkh[XO|YYm= MXq3NkBpenN? MULDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gN|Ah|ryPLh?= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl{NkG3N{c,OTl7Mk[xO|M9N2F-
HepG2 MUXDfZRwfG:6aXPpeJkh[XO|YYm= Mn\xR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxKD1iM{Cg{txONg>? NEXTVXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m4NVQ3Oid-MUe5PFE1PjJ:L3G+
HepG2 M{O0NmN6fG:2b4jpZ4l1gSCjc4PhfS=> MlLwO|IhcHK| Mn\OR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhS0N3MDC9JFMxKM7:TT6= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTd2MUGzNUc,OjF5NEGxN|E9N2F-
HepG2 Mmj4R5l1d3SxeHnjbZR6KGG|c3H5 MXO3NkBpenN? NEX2TI5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCFQ{WwJF0hOzBizszNMi=> NGT1eok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki4PVU2QSd-MkK4PFk2PTl:L3G+
HepG2 NEfSR3dEgXSxdH;4bYNqfHliYYPzZZk> M3T1d|czKGi{cx?= MmPxR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhS0N3MDC9JFMxKM7:TT6= NUPwV5dURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OFYzOTZpPkK0PVQ3OjF4PD;hQi=>
SH-SY5Y NGfsSGhEgXSxdH;4bYNqfHliYYPzZZk> MoDPO|IhcHK| NFHvSnpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUUC2VWUXZJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFPDOVAhRSB|MDFOwG0v NYDU[GtrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OVkyQThpPkK5OVU6OTl6PD;hQi=>
HepG2 MmnOR5l1d3SxeHnjbZR6KGG|c3H5 NV[0TpVjPzJiaILz NIXLToFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCFQ{WwJF0hOzBizszNMi=> NYjNc|F4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4OVg2PDNpPkK0PFU5PTR|PD;hQi=>
HepG2 NX3WXmZbS3m2b4TvfIlkcXS7IHHzd4F6 MUK3NkBpenN? NH7BPYVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCFQ{WwJF0hOzBizszNMi=> M{nDPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUW1OFY{Lz5{N{G1OVQ3OzxxYU6=
HepG2 MX3DfZRwfG:6aXPpeJkh[XO|YYm= M3XnSlczKGi{cx?= MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBESzVyIE2gN|Ah|ryPLh?= NYPuTIViRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PVE3PzVpPkK1O|kyPjd3PD;hQi=>
HepG2 MYLDfZRwfG:6aXPpeJkh[XO|YYm= NWfzW3ZKPzJiaILz NWnwWFRbS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCFQ{WwJF0hOzBizszNMi=> MmrUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{OEKyOlcoRjJ3MkiyNlY4RC:jPh?=
HepG2 NG\zfIREgXSxdH;4bYNqfHliYYPzZZk> M12yT|czKGi{cx?= NV;4fWo3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiQ1O1NEA:KDNyIN88UU4> NYDTTpJVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4OVIyOzJpPkKxPFUzOTN{PD;hQi=>
HepG2 Ml7IR5l1d3SxeHnjbZR6KGG|c3H5 M{PJS|czKGi{cx?= NWXIPY9ZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiQ1O1NEA:KDNyIN88UU4> NHewVVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[wPFY4PSd-MkK2NFg3PzV:L3G+
HepG2 M1fsZWN6fG:2b4jpZ4l1gSCjc4PhfS=> MkL1O|IhcHK| NUDsb2loS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGNEPTBiPTCzNEDPxE1w NVTwTYdZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2OVQ{QTVpPkK3OlU1Ozl3PD;hQi=>
KB MYDDfZRwfG:6aXPpeJkh[XO|YYm= MV7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRkBk\WyuczDifUBUWkJiYYPzZZktKEWGNUCgQUA{OC56IN88UU4> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV4MkizNkc,OTZ3NkK4N|I9N2F-
HepG2 MofzR5l1d3SxeHnjbZR6KGG|c3H5 NXHTT|dPOjRiaILz Mk\nR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgNlQhcHK|IHL5JI5mfXS{YXygdoVlKHWydHHr[UBie3OjeTygWGM2OCB;IEOxJO69VS5? NEGwXXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G0OVgyPid-MkOxOFU5OTZ:L3G+
K562 MXPDfZRwfG:6aXPpeJkh[XO|YYm= NUX0dpVqPzJiaILz NHu4NHpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFczKGi{czDifUBndG:5IHP5eI9u\XS{eTygTWM2OCB;IEOyJO69VS5? NFXLbZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUS4NlQ4Pid-MUm0PFI1PzZ:L3G+
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FM3A NVTBOoJUS3m2b4TvfIlkcXS7IHHzd4F6 M{f2VWlvKH[rdILvJIN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJI1idW2jcomgSm0{SSClZXzsd{whTUN3MDC9JFMzKM7:TT6= NHfJZ249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkCzOlM3PSd-MUKwN|Y{PjV:L3G+
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OHS-50 NIjlWIxyUFSVIHHzd4F6 NUG2V|E5eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IF;IV{02OCClZXzsdy=> M1PVcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-MC MnW0dWhVWyCjc4PhfS=> NFPUR4JyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1utUk1OSyClZXzsdy=> NYjFSWtxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
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HEK293 NHPiNVRCfXSxcHjh[5kh[XO|YYm= MojxNVAhfU1? NU\mb3VXQCCqcoO= NVLNdWVyUW6mdXP0bY9vKG:oIHH1eI9xcGGpeTDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hVEN|LUKgcIV3\WxiYYSgNVAhfU1iYX\0[ZIhQCCqcoOgZpkhcW2vdX7vZoxwfCCjbnHsfZNqew>? MkK4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2OEG1N|YoRjJ6NEixOVM3RC:jPh?=
LNCAP NIPVWoxHfW6ldHnvckBie3OjeR?= M{n5c3Jm\HWldHnvckBqdiCJRmCg[ZhxemW|c3nvckBqdiCqdX3hckBNVkODUDDj[YxteyC2cnHud4Zm[3SnZDD3bZRpKHCuYYPtbYR{KGOxLXX4dJJme3OrbnegS2ZRKGGwZDDzbHJPSXNiYXfhbY5{fCCURW[tSXJD[mW2YTDmc4xtd3enZDDifUBkd22yb4Xu[EB1emWjdH3lcpQhOjRiaILzJJBwe3RvdILhcpNn\WO2aX;uJIFv\CCvZXHzeZJm\CB2ODDodpMheG:|dDDkc5Nm Ml;VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzM{W0O|EoRjJ4MUO1OFcyRC:jPh?=
SKBR3 NI\BfHJHfW6ldHnvckBie3OjeR?= MX\S[YR2[3Srb36gbY4hT0[SIHX4dJJme3Orb36gbY4hcHWvYX6gV2tDWjNiY3XscJMhfHKjboPm[YN1\WRid3n0bEBxdGG|bXnkd{Bkdy2neIDy[ZN{cW6pIFfGVEBidmRic3jSUmF{KGGpYXnud5QhWkWYLVXSRoJmfGFiZn;scI94\WRiYomgZ49ueG:3bnSgeJJm[XSvZX70JFI1KGi{czDwc5N1NXS{YX7z[oVkfGmxbjDhcoQhdWWjc4Xy[YQhPDhiaILzJJBwe3RiZH;z[S=> NUPLO4I1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xN|U1PzFpPkK2NVM2PDdzPD;hQi=>
HepG2 M3:4N2Z2dmO2aX;uJIF{e2G7 NXnjNnluWmWmdXP0bY9vKGmwIFfGVEBmgHC{ZYPzbY9vKGmwIHj1cYFvKEincFeyJINmdGy|IITyZY5{\mWldHXkJJdqfGhicHzhd41q\HNiY3:t[ZhxemW|c3nu[{BITlBiYX7kJJNpWk6DczDh[4FqdnO2IGLFWk1GWkKkZYThJIZwdGyxd3XkJIJ6KGOxbYDveY5lKHS{ZXH0cYVvfCB{NDDodpMheG:|dD30doFve2[nY4Tpc44h[W6mIH3lZZN2emWmIES4JIhzeyCyb4P0JIRwe2V? M1[zNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUO1OFcyLz5{NkGzOVQ4OTxxYU6=
H460 M1TsdWFxd3C2b4Ppd{Bie3OjeR?= M33me|I2KHSxIEe1JJVO NHjyNmgzPCCqcoO= NH;Kb2pKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIFi0OlAh[2WubIOgZZQhOjVidH:gO|UhfU1iYX\0[ZIhOjRiaILzJIJ6KGGwbnX4bY4uXiC|dHHpcolv\y2kYYPl[EBndG:5IHP5eI9u\XS{eR?= NWDkWpJERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PVkyPTdpPkK1Olk6OTV5PD;hQi=>
HepG2 NGfRfHVHfW6ldHnvckBie3OjeR?= NGP2eVk2OCC3TR?= MYq2JIhzew>? MWTS[YR2[3Srb36gbY4hdHm|b4PvcYFtKGGlaXTp[olk[XSrb36gbY4hcHWvYX6gTIVxTzJiY3XscJMh[XRiNUCgeW0h[W[2ZYKgOkBpenNiYomgSGFRUS:ueYPvJJRz[WOtZYKgdoVlNWSxdXLs[UB{fGGrbnnu[{Bj[XOnZDDjc45nd2OjbDDtbYNzd3Olb4DpZ{BidmGueYPpd{Bz\WyjdHn2[UB1dyClb370do9t NWDyWYoxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixPVc{OjBpPkK4NVk4OzJyPD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
ZEBRA / p-S824 KAP1 ; 

PubMed: 28249048     


HH514-16 BL cells were treated with chloroquine and harvested at different times post-treatment for immunoblotting with antibodies as indicated. 

p62 / LC3 ; 

PubMed: 26677873     


Antiautophagic activity of Lys01. Panc 10.05 cells were treated for 24 h with the indicated doses of chloroquine or Lys01 and were probed by Western blot.

28249048 26677873
Immunofluorescence
p-S824 KAP1 / ZEBRA ; 

PubMed: 28249048     


HH514-16 BL cells were treated with chloroquine (CQ) or chloroquine plus KU-55933 (CQ+KU) and harvested at 24 hours followed by staining with anti-phospho KAP1 (S824) plus anti-ZEBRA antibodies and visualized at 1000X magnification.

CD1d-β2m / LAMP1 ; 

PubMed: 20368272     


HEK293-CD1d WT cells were treated overnight with 20 μM of chloroquine (or vehicle). The cells were then fixed, permeabilized and stained with the anti-CD1d-β2m mAb (red), anti-LAMP-1 (green) and Hoechst (blue). The stained cells were then analyzed by confocal microscopy. 

SQSTM1 / MAP1LC3B ; 

PubMed: 29872540     


Immunofluorescent images of astrocytoma SNB-19 cells treated with DMSO, emetine or chloroquine for 24 h, then stained with SQSTM1 protein (green), MAP1LC3B protein (red) and nuclei (blue). 

28249048 20368272 29872540
Growth inhibition assay
Cell viability ; 

PubMed: 25521075     


A549 cells were treated with serial concentrations of chloroquine for 72 h, and Huh7 cells were treated with the same concentrations for 48 h. Tumour cell viability was determined by cell viability assay. Data represent means from at least three independent experiments ± SD. 

25521075

Protocol

Solubility (25°C)

In vitro Water 100 mg/mL (193.85 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 515.86
Formula

C18H26ClN3.2H3O4P

CAS No. 50-63-5
Storage powder
in solvent
Synonyms N/A
Smiles CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04443270 Not yet recruiting Drug: Chloroquine phosphate COVID-19 CMN 20 de Noviembre July 27 2020 Phase 1
NCT04462367 Not yet recruiting -- COVID19|Coronavirus Infection|Pregnancy Disease|Severe Acute Respiratory Syndrome Instituto Materno Infantil Prof. Fernando Figueira July 1 2020 --
NCT04340544 Terminated Drug: Hydroxychloroquine|Drug: Placebo COVID-19 University Hospital Tuebingen|Robert Bosch Medical Center|Universitätsklinikum Hamburg-Eppendorf|Bernhard Nocht Institute for Tropical Medicine April 22 2020 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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ATM/ATR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID