Home Endocrinology & Hormones Estrogen/progestogen Receptor modulator Chlorotrianisene

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Chlorotrianisene Estrogen/progestogen Receptor modulator

Cat.No.S4629

Chlorotrianisene (tri-p-anisylchloroethylene, TACE, CTA) is a synthetic, non-steroidal estrogen. It is a selective estrogen receptor modulator.
Chlorotrianisene Estrogen/progestogen Receptor modulator Chemical Structure

Chemical Structure

Molecular Weight: 380.86

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S462901 DMSO]76 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.47%
99.47

Chemical Information, Storage & Stability

Molecular Weight 380.86 Formula

C23H21ClO3

 Storage (From the date of receipt)
CAS No. 569-57-3 Download SDF Storage of Stock Solutions

Synonyms tri-p-anisylchloroethylene, tris(p-methoxyphenyl)chloroethylene, TACE, CTA Smiles COC1=CC=C(C=C1)C(=C(C2=CC=C(C=C2)OC)Cl)C3=CC=C(C=C3)OC

Solubility

In vitro
Batch:

DMSO : 76 mg/mL (199.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
Estrogen receptor [1]
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06353126 Not yet recruiting
Liver Cancer
RenJi Hospital|Boston Scientific Corporation
 June 1 2024 Phase 2
NCT06106269 Recruiting
Internal Hemorrhoid
Mayo Clinic|Terumo Corporation
 June 2024 --
NCT06041594 Not yet recruiting
Pulmonary Embolism
Innova Vascular Inc.
 May 2024 Not Applicable
NCT06272656 Recruiting
Hepatocellular Carcinoma
Hebei Medical University Third Hospital
 April 1 2024 --
NCT06068595 Not yet recruiting
Musculoskeletal; Anomaly
Central Hospital Nancy France|University of Lorraine
 April 2024 Not Applicable

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