Name: Curcumin analog C1
Brand: Selleck Chemicals
SKU: S6769
Availability: InStock
Rating: 5 (4 reviews)

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Quality Control

Batch: Purity: 99.74%

99.74

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Solubility

In vitro
Batch:

DMSO : 30 mg/mL (101.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 2 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	1.500mg/ml (5.10mM)	Taking the 1 mL working solution as an example, add 50 μL of 30 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	294.34	Formula	C₁₉H₁₈O₃	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	39777-61-2	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Curcumin analog Compound C1, TFEB activator 1			Smiles	COC1=CC=CC=C1C=CC(=O)C=CC2=CC=CC=C2OC

Mechanism of Action

Targets/IC₅₀/Ki	TFEB
In vitro	Curcumin analog C1 specifically binds to TFEB at the N terminus and promotes TFEB nuclear translocation without inhibiting MTOR activity. By activating TFEB, this compound enhances autophagy and lysosome biogenesis in N2a cells. It (0.2-1 μM) dose-dependently increases the levels of LC3-II and SQSTM1/p62 in N2a cells.
In vivo	The LD⁵⁰ value of Curcumin analog C1 is 175 mg/kg in the acute toxicity assay. Short-term oral administration of this compound (low dosage 10 mg/kg and high dosage 25 mg/kg; for 24 h) dose-dependently increases the expression of LC3B-II and TFEB in the liver, frontal cortex and striatum of the brain. Chronic administration of this chemical (10 mg/kg; daily; for 21 days) activates TFEB and enhances autophagy in rat brains.
References	[1] https://www.ncbi.nlm.nih.gov/pubmed/?term=31858697 [2] https://pubmed.ncbi.nlm.nih.gov/27172265/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06371417	Not yet recruiting	Antiphospholipid Syndrome (APS)\|Bullous Pemphigoid (BP)\|Behçet''s Syndrome (BS)\|Dermatomyositis (DM)\|Immune-mediated Necrotizing Myopathy (IMNM)\|Immune Thrombocytopenia (ITP)	Chugai Pharmaceutical	May 31 2024	Phase 1
NCT06361238	Not yet recruiting	Delirium Postoperative	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School	April 30 2024	Phase 3
NCT06178120	Recruiting	X-linked Adrenoleukodystrophy	Minoryx Therapeutics S.L.	January 2 2024	--
NCT06317467	Recruiting	Pre-Eclampsia	IRCCS Burlo Garofolo	September 13 2023	--
NCT05578417	Recruiting	Hereditary Angioedema (HAE)\|Angioedema	Takeda	June 15 2023	--
NCT05833620	Not yet recruiting	Hereditary Angioedema With C1 Esterase Inhibitor Deficiency	Hospital Universitari Vall d''Hebron Research Institute\|Hospital Universitario La Paz	May 2023	--

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Curcumin analog C1

Chemical Structure

Molecular Weight: 294.34