CS-2660 (JNJ-38158471)

Catalog No.S0377

For research use only.

CS-2660 (JNJ-38158471) is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50 of 40 nM. CS-2660 (JNJ-38158471) also inhibits closely related tyrosine kinases such as RET (c-RET) and Kit (c-Kit) with IC50 of 180 nM and 500 nM,while it has no significant activity (>1 microM) against VEGFR-1 and VEGFR-3.

CS-2660 (JNJ-38158471) Chemical Structure

CAS No. 951151-97-6

Purity & Quality Control

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Biological Activity

Description CS-2660 (JNJ-38158471) is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50 of 40 nM. CS-2660 (JNJ-38158471) also inhibits closely related tyrosine kinases such as RET (c-RET) and Kit (c-Kit) with IC50 of 180 nM and 500 nM,while it has no significant activity (>1 microM) against VEGFR-1 and VEGFR-3.
Targets
VEGFR2 [1]
(Cell-free assay)
RET [1]
(Cell-free assay)
Kit [1]
(Cell-free assay)
40 nM 180 nM 500 nM

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 364.79
Formula

C15H17ClN6O3

CAS No. 951151-97-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCNC(=O)NC1=C(C=C(C=C1)OC2=NC=NC(=C2C=NOC)N)Cl

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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