For research use only.

Catalog No.S8605

16 publications

C188-9 Chemical Structure

CAS No. 432001-19-9

C188-9 is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors.

Size Price Stock Quantity  
USD 127 In stock
USD 390 In stock
USD 890 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's C188-9 has been cited by 16 publications

1 Customer Review

  • (E) Hep3B cells were pre-infected with flag-CEP55 for 24 h and were then infected with 10 nM JAK2 inhibitor XL019 or 10 nM STAT3 inhibitor C188-9 for 48 h. Cells’ invasion ability was determined by trans-well assays. Representative microscope images are plotted. Bars, 50 μm;

    Cells, 2018, 7(8). C188-9 purchased from Selleck.

Purity & Quality Control

Choose Selective STAT Inhibitors

Biological Activity

Description C188-9 is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors.
STAT3 [1]
4.7 nM(Kd)
In vitro

C188-9 is a small-molecule inhibitor of Stat3 that targets the phosphotyrosyl peptide binding site within the Stat3 Src homology 2 (SH2) domain with Ki 136 nM. It does not inhibit upstream Jak or Src kinases[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Y79 NHH6PVVHfW6ldHnvckBie3OjeR?= NXHyTmtvOTBizszN MlX6Nlg3QDR2MUm=
SK-N-DZ NEfDeYdHfW6ldHnvckBie3OjeR?= MnTmNVAh|ryP NEPV[4EzQDZ6NESxPS=>
PLC/PRF/5 NYewWZpLS2WubDD2bYFjcWyrdImgZZN{[Xl? MnPYOFghcA>? MkXmTWM2OD1zMT64N{DPxE1? NWnOZo4yOjh3M{OyNlU>
SCC-35 NWS0cHhtS2WubDDndo94fGhiYYPzZZk> NHz4WXIxNzBwMT:wMlMwOS9|L{GwM|ExOCEQvF2= NYm3bHIxOzZiaB?= NEDhNG9KSzVyPUGwMlghyrFiMD6wJO69VQ>? NIXhSY8zPzB{N{S0OS=>
SCC-61 NXn5fZA1S2WubDDndo94fGhiYYPzZZk> MlHENE8xNjFxMD6zM|EwOy9zMD:xNFAh|ryP NYi5THdLOzZiaB?= MmrFTWM2OD1zND64JOKyOi57IN88US=> MkfBNlcxOjd2NEW=
UM-SCC-17B NHLUZVBE\WyuIHfyc5d1cCCjc4PhfS=> NULnc4o{OC9yLkGvNE4{NzFxMz:xNE8yODBizszN NVy4dmtrOzZiaB?= MVLJR|UxRTBwNzFCtUAxNjZizszN Mo[wNlcxOjd2NEW=
A549 MWXGeY5kfGmxbjDhd5NigQ>? MmnpNk42KGh? M2LV[oRm[3KnYYPl[EBxW1SDVEOgcIV3\Wy|IHnuJIEh[2:wY3XueJJifGmxbj3k[ZBmdmSnboSgcYFvdmW{IIP0ZZJ1cW6pIHH0JINwdmOnboTyZZRqd26|IHHzJIxwfyCjczCzJI5O M{nO[VI3PDFyMUe3
Kasumi-1 MWDGeY5kfGmxbjDhd5NigQ>? M376T2lEPTB;ND61JO69VQ>? MUWyNVQ1Pzh|MB?=
THP-1 MkLPSpVv[3Srb36gZZN{[Xl? MlnjTWM2OD12Lkig{txO MmXXNlE1PDd6M{C=
GDM-1 MX7GeY5kfGmxbjDhd5NigQ>? MVXJR|UxRTVwMDFOwG0> NHjSW|czOTR2N{izNC=>
NB-1 M4jIWWZ2dmO2aX;uJIF{e2G7 NWrmXow6UUN3ME24MlMh|ryP NWi5b4NTOjF2NEe4N|A>
KG-1 MoflSpVv[3Srb36gZZN{[Xl? MV3JR|UxRTRwMTFOwG0> NXP6Z5QyOjF2NEe4N|A>
K562 NXrTSZE2SXCxcITvd4l{KGG|c3H5 MYTpcoR2[3Srb36gc4Yh[XCxcITvd4l{KHerdHigZY4hTUN3MDDv[kA1Oy54IN88US=> MV:yNVQ1Pzh|MB?=

... Click to View More Cell Line Experimental Data

Methods Test Index PMID
Western blot
p-STAT3 / STAT3 / CEBPδ / Myostatin / p-Akt / Akt ; 

PubMed: 24011072     

C2C12 myotubes were treated with or without C188-9 for 2 h before adding IL-6 (100 ng/ml) for 24 h. A representative western blot for the indicated proteins is shown.

VE-cadherin / β-catenin; 

PubMed: 26948077     

Confocal microscopy of VE-cadherin (green), total β-catenin (red), and DAPI (blue) in DMSO and C188–9(1µM) pre-treated HUVECs then subsequently exposed to histamine (100 µM). 

non-phosphorylated β-Catenin; 

PubMed: 26948077     

Confocal microscopy of active (non-phosphorylated) β-Catenin (green) and DAPI (blue) in DMSO and C188–9 (1 µM) pre-treated HUVECs then subsequently exposed to histamine (100 µM). 

In vivo Treatment of nude mice bearing xenografts of UM-SCC-17B, a radioresistant HNSCC line, with C188-9, but not C188, prevented tumor xenograft growth. C188-9 was well tolerated in mice, showed good oral bioavailability, and was concentrated in tumors[2].


Cell Research:


- Collapse
  • Cell lines: HNSCC cell line, UM-SCC-17B
  • Concentrations: 0, 0.1, 0.3, 1, 3, 10, 30 μM
  • Incubation Time: 24 h
  • Method:

    UM-SCC-17B cells were incubated with various doses (0/0.1/0.3/1/3/10/30μM) of C188 or C188-9 for 24 hrs.

    (Only for Reference)
Animal Research:


- Collapse
  • Animal Models: CD2F1 female mice received isogenic C26 tumor cell via s.c injection
  • Dosages: 12.5 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 94 mg/mL (199.35 mM)
Ethanol 6 mg/mL (12.72 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 471.52


CAS No. 432001-19-9
Storage powder
in solvent
Synonyms N/A
Smiles COC1=CC=C(C=C1)S(=O)(=O)NC2=CC(=C(C3=CC=CC=C32)O)C4=C(C=CC5=CC=CC=C54)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

STAT Signaling Pathway Map

Related STAT Products

Tags: buy C188-9|C188-9 ic50|C188-9 price|C188-9 cost|C188-9 solubility dmso|C188-9 purchase|C188-9 manufacturer|C188-9 research buy|C188-9 order|C188-9 mouse|C188-9 chemical structure|C188-9 mw|C188-9 molecular weight|C188-9 datasheet|C188-9 supplier|C188-9 in vitro|C188-9 cell line|C188-9 concentration|C188-9 nmr|C188-9 in vivo|C188-9 clinical trial|C188-9 inhibitor|C188-9 JAK/STAT inhibitor
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID