Choline Chloride

For research use only.

Catalog No.S4171

Choline Chloride Chemical Structure

Molecular Weight(MW): 139.62

Choline chloride is a quaternary ammonium salt used as an additive for animal feed. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.

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Biological Activity

Description Choline chloride is a quaternary ammonium salt used as an additive for animal feed. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
In vitro

Choline is a major part of the polar head group of phosphatidylcholine and a major part of another membrane phospholipid, sphingomyelin, which are very important for maintenance of cell structure and function. Choline deficiency in cell culture causes apoptosis or programmed cell death. Betaine or trimethylglycine is derived from choline via an oxidation reaction. Acetylcholine is one of the major neurotransmitters and requires choline for its synthesis. Adequate acetylcholine levels in the brain are believed to be protective against certain types of dementia, including Alzheimer's disease. Choline is also needed for gallbladder regulation, liver function and lecithin (a key lipid) formation. Choline also aids in fat and cholesterol metabolism and prevents excessive fat build up in the liver. Choline has been used to mitigate the effects of Parkinsonism and tardive dyskinesia. Choline deficiencies may result in excessive build-up of fat in the liver, high blood pressure, gastric ulcers, kidney and liver dysfunction and stunted growth.

In vivo Choline chloride is of very low acute oral toxicity. The oral LD50 in rats is determined to be between 3150 and 5000 mg/kg bw. Clinical symptoms after application are restlessness, increased frequency of respiration, hypoactivity, convulsions, ruffled coat, staggered gait and dyspnoea. Some animals have diarrhoea and at necropsy in the high dose groups in one study 3 out of 10 rats have inflamed lungs.

Protocol

References

Solubility (25°C)

In vitro DMSO 28 mg/mL (200.54 mM)
Water 28 mg/mL (200.54 mM)
Ethanol 28 mg/mL (200.54 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 139.62
Formula

C5H14NO.Cl

CAS No. 67-48-1
Storage powder
in solvent
Synonyms N/A
Smiles [Cl-].C[N+](C)(C)CCO

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04150458 Not yet recruiting Drug: 18F-fluorocholine PET/CT. Fluorocholine PET/CT Sir Mortimer B. Davis - Jewish General Hospital June 2020 Phase 3
NCT04158024 Not yet recruiting Other: Erector Spinae Plane Block Congenital Heart Disease in Children|Neurologic Complication Stanford University May 2020 Not Applicable
NCT04192526 Active not recruiting -- Toxicity;Chemical Assiut University December 1 2019 --

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID