Catalog No.S2027 Synonyms: Bay o 9867

For research use only.

Ciprofloxacin (Bay o 9867) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.

Ciprofloxacin Chemical Structure

CAS No. 85721-33-1

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Biological Activity

Description Ciprofloxacin (Bay o 9867) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.
Topoisomerase IV [2]
In vitro

Ciprofloxacin is a fluoroquinolone antibiotic, shows MIC90 (minimal inhibitory concentrations for 90%) of between 0.008 and 2 μg/ml for Enterobacteriaceae, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, streptococci, Staphylococcus aureus, and Bacteroidesfragilis strains. [1] Ciprofloxacin inhibits topoisomerase IV as a primary topoisomerase target and gyrase as a secondary target. [2] Ciprofloxacin shows an AUC (area under the curve) of 24 μg×h/ml[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human erythrocytes M4XjeGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NELQSoQ2OCCq M1PQVWFvfGmvYXzhdolidCCjY4Tpeol1gSCjZ3HpcpN1KGOqbH;yc5F2cW6nLYLld4l{fGGwdDDQcIF{dW:maYXtJIZidGOrcHHyeY0hTGR{IHnu[oVkfGWmIHnuJIh2dWGwIHXyfZRpem:leYTld{Bie3Onc4Pl[EBieyCyYYLhd4l1\SCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA2OCCqcoOgZpkhW1mEUjDHdoVmdjFiZInlMYJie2WmIH\seY9z\XOlZX7j[UBie3OjeTygTWM2OD1|Mz65JO69VQ>? M{jVVVI1PjVyN{G1
5637 cells MlS1SpVv[3Srb36gZZN{[Xl? NGj5NFYyOiCq MWPBcpRq[mGldHXybYFtKGGldHn2bZR6KGGpYXnud5QhfXKxcHH0bI9o\W6rYzDFd4Np\XKrY3jpZUBkd2yrIGXUTVg6KGmwZnXjeIVlKGmwIHj1cYFvKDV4M{egZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hcW62cnHj[YxtfWyjcjDiZYN1\XKrYXygcIV3\WxiYYSgNkB1dyB|IIXnM41tKGGodHXyJFEzKGi{czDifUB{\XKrYXyg[IltfXSrb36gcYV1cG:m MX2yNFI{OTN7MB?=
CCRF-CEM cells Mom2VJJwdGmoZYLheIlwdiCjc4PhfS=> MV21NEDPxE1? NF7UZ2FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPDVmYuS0WPIHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGG2IEWwJJVOKGK7IFPlcIxVcXSncjDhd5NigSC{ZXzheIl3\SC2bzDEUXNQKGOxboTyc4w> M{LUcVI1OTN6OUSx
Caco-2 cells MluySpVv[3Srb36gZZN{[Xl? MWizNEBucW6| MnTQRY51cWKjY4TldolidCCjY4Tpeol1gSCjZ3HpcpN1KHerbHSgeJlx\SCVYXztc45mdGyjIHXueIVzcXSrZHnzJFU1ODhiaHHyZo9zcW6pIHf5dmEhTDh5WTDteZRidnRiZ3Xu[UBqdm[nY4Tl[EBqdiCqdX3hckBE[WOxLUKgZ4VtdHNiYYPz[ZN{\WRiYYOg[YZn\WO2IH;uJIJi[3SncnnhcEBk\WyuIHHkbIVz\W6lZTDh[pRmeiB|MDDtbY5{ NE\MSWcyQTlzN{e1Ni=>

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 331.34


CAS No. 85721-33-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05133258 Not yet recruiting Drug: ciprofloxacin and dexamethasone suspension Chronic Suppurative Otitis Media Dartmouth-Hitchcock Medical Center December 15 2021 Not Applicable
NCT04775238 Recruiting Other: Silver nanoparticles|Other: Copper nanoparticles Nosocomial Infections Sohag University February 27 2021 Not Applicable
NCT04513548 Recruiting Drug: Ligelizumab|Drug: Placebo Chronic Spontaneous Urticaria|Cholinergic Urticaria|Cold Urticaria Novartis Pharmaceuticals|Novartis August 5 2020 Phase 1
NCT04621253 Completed Drug: Novalgin Drug-drug Interaction University Hospital Basel Switzerland April 29 2020 Phase 1
NCT04319328 Recruiting Drug: Cefazolin|Drug: Ceftazidime|Drug: Ciprofloxacin Hemodialysis Complication|Infectious Disease|End Stage Renal Disease University of Manitoba|The Kidney Foundation of Canada October 18 2019 --
NCT04374188 Recruiting Drug: Ciprofloxacin|Drug: Levofloxacin Nephrolithiasis Diaa Eldin Taha Ramadan Mohamed|Kafrelsheikh University September 1 2019 Not Applicable

(data from, updated on 2022-01-17)

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