For research use only.

Catalog No.S2027 Synonyms: Bay o 9867

1 publication

Ciprofloxacin Chemical Structure

CAS No. 85721-33-1

Ciprofloxacin (Bay o 9867) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.

Selleck's Ciprofloxacin has been cited by 1 publication

1 Customer Review

  • Ciprofoxacin (Cipro) reduces cancer cell survival in combination with chemotherapy. A and B, colony formation was conducted with A549 and SW48 cells treated with the clinically relevant chemotherapeutics cisplatin or 5-FU in the presence or absence of 2 μmol/L cipro floxacin. C, cipro fl oxacin at 2 μmol/L decreased proliferation of KG-1 cells and slightly enhanced the effect of etoposide (Etop). *, P < 0.05; **, P < 0.01 ( t tests).

    Cancer Res 2012 72(23), 6200-8. Ciprofloxacin purchased from Selleck.

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Biological Activity

Description Ciprofloxacin (Bay o 9867) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.
Topoisomerase IV [2]
In vitro

Ciprofloxacin is a fluoroquinolone antibiotic, shows MIC90 (minimal inhibitory concentrations for 90%) of between 0.008 and 2 μg/ml for Enterobacteriaceae, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, streptococci, Staphylococcus aureus, and Bacteroidesfragilis strains. [1] Ciprofloxacin inhibits topoisomerase IV as a primary topoisomerase target and gyrase as a secondary target. [2] Ciprofloxacin shows an AUC (area under the curve) of 24 μg×h/ml[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human erythrocytes NVriOpdNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2rG[|UxKGh? M3K2NGFvfGmvYXzhdolidCCjY4Tpeol1gSCjZ3HpcpN1KGOqbH;yc5F2cW6nLYLld4l{fGGwdDDQcIF{dW:maYXtJIZidGOrcHHyeY0hTGR{IHnu[oVkfGWmIHnuJIh2dWGwIHXyfZRpem:leYTld{Bie3Onc4Pl[EBieyCyYYLhd4l1\SCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA2OCCqcoOgZpkhW1mEUjDHdoVmdjFiZInlMYJie2WmIH\seY9z\XOlZX7j[UBie3OjeTygTWM2OD1|Mz65JO69VQ>? MnjJNlQ3PTB5MUW=
5637 cells M{jWW2Z2dmO2aX;uJIF{e2G7 NGD5[o8yOiCq MVrBcpRq[mGldHXybYFtKGGldHn2bZR6KGGpYXnud5QhfXKxcHH0bI9o\W6rYzDFd4Np\XKrY3jpZUBkd2yrIGXUTVg6KGmwZnXjeIVlKGmwIHj1cYFvKDV4M{egZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hcW62cnHj[YxtfWyjcjDiZYN1\XKrYXygcIV3\WxiYYSgNkB1dyB|IIXnM41tKGGodHXyJFEzKGi{czDifUB{\XKrYXyg[IltfXSrb36gcYV1cG:m M3XpN|IxOjNzM{mw
CCRF-CEM cells NUj1R4g2WHKxbHnm[ZJifGmxbjDhd5NigQ>? MXy1NEDPxE1? NVvuTJM6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDDR3JHNUOHTTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjdDC1NEB2VSCkeTDD[YxtXGm2ZYKgZZN{[XlicnXsZZRqfmVidH:gSG1UVyClb370do9t NX\KOJJ[OjRzM{i5OFE>
Caco-2 cells NVrZZnFGTnWwY4Tpc44h[XO|YYm= M2qxS|MxKG2rboO= NUe2V2ZVSW62aXLhZ5RmemmjbDDhZ5Rqfmm2eTDh[4FqdnO2IIfpcIQhfHmyZTDTZYxud26nbHzhJIVvfGW{aYTp[Il{KDV2MEigbIFz[m:{aX7nJId6ekFiREi3XUBufXSjboSg[4Vv\SCrbn\lZ5Rm\CCrbjDoeY1idiCFYXPvMVIh[2WubIOgZZN{\XO|ZXSgZZMh\W[oZXP0JI9vKGKjY4TldolidCClZXzsJIFlcGW{ZX7j[UBi\nSncjCzNEBucW6| MXyxPVkyPzd3Mh?=

... Click to View More Cell Line Experimental Data


Solubility (25°C)

In vitro DMSO Insoluble
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 331.34


CAS No. 85721-33-1
Storage powder
in solvent
Synonyms Bay o 9867
Smiles C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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% DMSO % % Tween 80 % ddH2O

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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04775238 Recruiting Other: Silver nanoparticles|Other: Copper nanoparticles Nosocomial Infections Sohag University February 27 2021 Not Applicable
NCT04513548 Recruiting Drug: Ligelizumab|Drug: Placebo Chronic Spontaneous Urticaria|Cholinergic Urticaria|Cold Urticaria Novartis Pharmaceuticals|Novartis August 5 2020 Phase 1
NCT04621253 Completed Drug: Novalgin Drug-drug Interaction University Hospital Basel Switzerland April 29 2020 Phase 1
NCT04319328 Recruiting Drug: Cefazolin|Drug: Ceftazidime|Drug: Ciprofloxacin Hemodialysis Complication|Infectious Disease|End Stage Renal Disease University of Manitoba|The Kidney Foundation of Canada October 18 2019 --
NCT04374188 Recruiting Drug: Ciprofloxacin|Drug: Levofloxacin Nephrolithiasis Diaa Eldin Taha Ramadan Mohamed|Kafrelsheikh University September 1 2019 Not Applicable

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Topoisomerase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID