Ciprofloxacin

Catalog No.S2027 Synonyms: Bay o 9867

Ciprofloxacin Chemical Structure

Molecular Weight(MW): 331.34

Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.

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Cited by 1 Publication

1 Customer Review

  • Ciprofoxacin (Cipro) reduces cancer cell survival in combination with chemotherapy. A and B, colony formation was conducted with A549 and SW48 cells treated with the clinically relevant chemotherapeutics cisplatin or 5-FU in the presence or absence of 2 μmol/L cipro floxacin. C, cipro fl oxacin at 2 μmol/L decreased proliferation of KG-1 cells and slightly enhanced the effect of etoposide (Etop). *, P < 0.05; **, P < 0.01 ( t tests).

    Cancer Res 2012 72(23), 6200-8. Ciprofloxacin purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.
Targets
Topoisomerase IV [2]
In vitro

Ciprofloxacin is a fluoroquinolone antibiotic, shows MIC90 (minimal inhibitory concentrations for 90%) of between 0.008 and 2 μg/ml for Enterobacteriaceae, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, streptococci, Staphylococcus aureus, and Bacteroidesfragilis strains. [1] Ciprofloxacin inhibits topoisomerase IV as a primary topoisomerase target and gyrase as a secondary target. [2] Ciprofloxacin shows an AUC (area under the curve) of 24 μg×h/ml[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human erythrocytes MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWjjUXdFPTBiaB?= NIXKdIZCdnSrbXHsZZJq[WxiYXP0bZZqfHliYXfhbY5{fCClaHzvdo9yfWmwZT3y[ZNqe3SjboSgVIxie22xZHn1cUBn[WylaYDhdpVuKESmMjDpcoZm[3SnZDDpckBpfW2jbjDldpl1cHKxY4n0[ZMh[XO|ZYPz[YQh[XNicHHyZZNqfGViZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPTBiaILzJIJ6KFO\QmKgS5Jm\W5zIHT5[U1j[XOnZDDmcJVwemW|Y3XuZ4Uh[XO|YYmsJGlEPTB;M{OuPUDPxE1? M1;kNFI1PjVyN{G1
5637 cells NI\qXIRHfW6ldHnvckBie3OjeR?= M{fUSVEzKGh? MY\BcpRq[mGldHXybYFtKGGldHn2bZR6KGGpYXnud5QhfXKxcHH0bI9o\W6rYzDFd4Np\XKrY3jpZUBkd2yrIGXUTVg6KGmwZnXjeIVlKGmwIHj1cYFvKDV4M{egZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hcW62cnHj[YxtfWyjcjDiZYN1\XKrYXygcIV3\WxiYYSgNkB1dyB|IIXnM41tKGGodHXyJFEzKGi{czDifUB{\XKrYXyg[IltfXSrb36gcYV1cG:m M3rKN|IxOjNzM{mw
CCRF-CEM cells MX;Qdo9tcW[ncnH0bY9vKGG|c3H5 NWXjbGY{PTBizszN MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEOFUl[tR2VOKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIF1KDVyIIXNJIJ6KEOnbHzUbZRmeiCjc4PhfUBz\WyjdHn2[UB1dyCGTWPPJINwdnS{b3y= NGnFPWMzPDF|OEm0NS=>
Caco-2 cells NX63b4lpTnWwY4Tpc44h[XO|YYm= MYqzNEBucW6| MYTBcpRq[mGldHXybYFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKFOjbH3vcoVtdGFiZX70[ZJqfGmmaYOgOVQxQCCqYYLic5JqdmdiZ4nyRUBFQDe\IH31eIFvfCCpZX7lJIlv\mWldHXkJIlvKGi3bXHuJGNi[29vMjDj[YxteyCjc4Pld5Nm\CCjczDl[oZm[3Rib36gZoFkfGW{aXHsJINmdGxiYXTo[ZJmdmOnIHHmeIVzKDNyIH3pcpM> MV[xPVkyPzd3Mh?=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO Insoluble
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 331.34
Formula

C17H18FN3O3

CAS No. 85721-33-1
Storage powder
in solvent
Synonyms Bay o 9867

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03969758 Not yet recruiting Drug: Ciprofloxacin|Drug: Cefixime Liver Abscess Postgraduate Institute of Medical Education and Research July 2019 Phase 3
NCT03431675 Withdrawn Drug: Ciprofloxacin Meningitis Meningococcal Epicentre|Medecins Sans Frontieres Netherlands March 1 2019 Phase 4
NCT03150082 Completed Drug: GR37547 tablet|Drug: Ciprofloxacin reference tablet Infections Bacterial GlaxoSmithKline|Parexel August 1 2017 Phase 1
NCT02724046 Completed Drug: Ciprofloxacin Meningitis Meningococcal Epicentre|Medecins Sans Frontieres Netherlands April 22 2017 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Topoisomerase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID