Ciprofloxacin

For research use only.

Catalog No.S2027 Synonyms: Bay o 9867

1 publication

Ciprofloxacin Chemical Structure

Molecular Weight(MW): 331.34

Ciprofloxacin (Bay o 9867) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.

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EUR 95 In stock
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Selleck's Ciprofloxacin has been cited by 1 publication

1 Customer Review

  • Ciprofoxacin (Cipro) reduces cancer cell survival in combination with chemotherapy. A and B, colony formation was conducted with A549 and SW48 cells treated with the clinically relevant chemotherapeutics cisplatin or 5-FU in the presence or absence of 2 μmol/L cipro floxacin. C, cipro fl oxacin at 2 μmol/L decreased proliferation of KG-1 cells and slightly enhanced the effect of etoposide (Etop). *, P < 0.05; **, P < 0.01 ( t tests).

    Cancer Res 2012 72(23), 6200-8. Ciprofloxacin purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Ciprofloxacin (Bay o 9867) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.
Targets
Topoisomerase IV [2]
In vitro

Ciprofloxacin is a fluoroquinolone antibiotic, shows MIC90 (minimal inhibitory concentrations for 90%) of between 0.008 and 2 μg/ml for Enterobacteriaceae, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, streptococci, Staphylococcus aureus, and Bacteroidesfragilis strains. [1] Ciprofloxacin inhibits topoisomerase IV as a primary topoisomerase target and gyrase as a secondary target. [2] Ciprofloxacin shows an AUC (area under the curve) of 24 μg×h/ml[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human erythrocytes NFXkWmJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVu1NEBp M17LbWFvfGmvYXzhdolidCCjY4Tpeol1gSCjZ3HpcpN1KGOqbH;yc5F2cW6nLYLld4l{fGGwdDDQcIF{dW:maYXtJIZidGOrcHHyeY0hTGR{IHnu[oVkfGWmIHnuJIh2dWGwIHXyfZRpem:leYTld{Bie3Onc4Pl[EBieyCyYYLhd4l1\SCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA2OCCqcoOgZpkhW1mEUjDHdoVmdjFiZInlMYJie2WmIH\seY9z\XOlZX7j[UBie3OjeTygTWM2OD1|Mz65JO69VQ>? NInac2IzPDZ3MEexOS=>
5637 cells Mn;hSpVv[3Srb36gZZN{[Xl? MkG1NVIhcA>? Mn3URY51cWKjY4TldolidCCjY4Tpeol1gSCjZ3HpcpN1KHW{b4DheIhw\2WwaXOgSZNkcGW{aXPobYEh[2:uaTDVWGk5QSCrbn\lZ5Rm\CCrbjDoeY1idiB3NkO3JINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGmwdILhZ4VtdHWuYYKgZoFkfGW{aXHsJIxmfmWuIHH0JFIhfG9iMzD1[{9udCCjZoTldkAyOiCqcoOgZpkhe2W{aXHsJIRqdHW2aX;uJI1mfGixZB?= NXjTdpVLOjB{M{GzPVA>
CCRF-CEM cells NIjRfItRem:uaX\ldoF1cW:wIHHzd4F6 Mn30OVAh|ryP M2XhUmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ1PSSk1ETU1iY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[XRiNUCgeW0h[nliQ3XscHRqfGW{IHHzd4F6KHKnbHH0bZZmKHSxIFTNV28h[2:wdILvcC=> NV30elc6OjRzM{i5OFE>
Caco-2 cells NX\oXW9FTnWwY4Tpc44h[XO|YYm= M4i4c|MxKG2rboO= NHfUfVJCdnSrYnHjeIVzcWGuIHHjeIl3cXS7IHHnZYlve3Rid3ns[EB1gXCnIGPhcI1wdmWubHGg[Y51\XKrdHnkbZMhPTRyODDoZZJjd3Krbneg[5lzSSCGOEfZJI12fGGwdDDn[Y5mKGmwZnXjeIVlKGmwIHj1cYFvKEOjY3:tNkBk\WyuczDhd5Nme3OnZDDhd{Bm\m[nY4Sgc44h[mGldHXybYFtKGOnbHygZYRp\XKnbnPlJIFnfGW{IEOwJI1qdnN? NFXkWI0yQTlzN{e1Ni=>

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO Insoluble
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 331.34
Formula

C17H18FN3O3

CAS No. 85721-33-1
Storage powder
in solvent
Synonyms Bay o 9867
Smiles C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
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    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04513548 Recruiting Drug: Ligelizumab|Drug: Palcebo Chronic Spontaneous Urticaria|Cholinergic Urticaria|Cold Urticaria Novartis Pharmaceuticals|Novartis August 5 2020 Phase 1
NCT04319328 Enrolling by invitation Drug: Cefazolin|Drug: Ceftazidime|Drug: Ciprofloxacin Hemodialysis Complication|Infectious Disease|End Stage Renal Disease University of Manitoba|The Kidney Foundation of Canada October 18 2019 --
NCT04374188 Recruiting Drug: Ciprofloxacin|Drug: Levofloxacin Nephrolithiasis Diaa Eldin Taha Ramadan Mohamed|Kafrelsheikh University September 1 2019 Not Applicable
NCT03969758 Not yet recruiting Drug: Ciprofloxacin|Drug: Cefixime Liver Abscess Postgraduate Institute of Medical Education and Research July 2019 Phase 3
NCT03431675 Withdrawn Drug: Ciprofloxacin Meningitis Meningococcal Epicentre|Medecins Sans Frontieres Netherlands March 1 2019 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Topoisomerase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID