Ciprofloxacin

Catalog No.S2027 Synonyms: Bay o 9867

For research use only.

Ciprofloxacin (Bay o 9867) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.

Ciprofloxacin Chemical Structure

CAS No. 85721-33-1

Selleck's Ciprofloxacin has been cited by 1 Publication

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Biological Activity

Description Ciprofloxacin (Bay o 9867) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.
Targets
Topoisomerase IV [2]
In vitro

Ciprofloxacin is a fluoroquinolone antibiotic, shows MIC90 (minimal inhibitory concentrations for 90%) of between 0.008 and 2 μg/ml for Enterobacteriaceae, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, streptococci, Staphylococcus aureus, and Bacteroidesfragilis strains. [1] Ciprofloxacin inhibits topoisomerase IV as a primary topoisomerase target and gyrase as a secondary target. [2] Ciprofloxacin shows an AUC (area under the curve) of 24 μg×h/ml[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human erythrocytes M4XjeGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NELQSoQ2OCCq M1PQVWFvfGmvYXzhdolidCCjY4Tpeol1gSCjZ3HpcpN1KGOqbH;yc5F2cW6nLYLld4l{fGGwdDDQcIF{dW:maYXtJIZidGOrcHHyeY0hTGR{IHnu[oVkfGWmIHnuJIh2dWGwIHXyfZRpem:leYTld{Bie3Onc4Pl[EBieyCyYYLhd4l1\SCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA2OCCqcoOgZpkhW1mEUjDHdoVmdjFiZInlMYJie2WmIH\seY9z\XOlZX7j[UBie3OjeTygTWM2OD1|Mz65JO69VQ>? M{jVVVI1PjVyN{G1
5637 cells MlS1SpVv[3Srb36gZZN{[Xl? NGj5NFYyOiCq MWPBcpRq[mGldHXybYFtKGGldHn2bZR6KGGpYXnud5QhfXKxcHH0bI9o\W6rYzDFd4Np\XKrY3jpZUBkd2yrIGXUTVg6KGmwZnXjeIVlKGmwIHj1cYFvKDV4M{egZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hcW62cnHj[YxtfWyjcjDiZYN1\XKrYXygcIV3\WxiYYSgNkB1dyB|IIXnM41tKGGodHXyJFEzKGi{czDifUB{\XKrYXyg[IltfXSrb36gcYV1cG:m MX2yNFI{OTN7MB?=
CCRF-CEM cells Mom2VJJwdGmoZYLheIlwdiCjc4PhfS=> MV21NEDPxE1? NF7UZ2FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPDVmYuS0WPIHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGG2IEWwJJVOKGK7IFPlcIxVcXSncjDhd5NigSC{ZXzheIl3\SC2bzDEUXNQKGOxboTyc4w> M{LUcVI1OTN6OUSx
Caco-2 cells MluySpVv[3Srb36gZZN{[Xl? MWizNEBucW6| MnTQRY51cWKjY4TldolidCCjY4Tpeol1gSCjZ3HpcpN1KHerbHSgeJlx\SCVYXztc45mdGyjIHXueIVzcXSrZHnzJFU1ODhiaHHyZo9zcW6pIHf5dmEhTDh5WTDteZRidnRiZ3Xu[UBqdm[nY4Tl[EBqdiCqdX3hckBE[WOxLUKgZ4VtdHNiYYPz[ZN{\WRiYYOg[YZn\WO2IH;uJIJi[3SncnnhcEBk\WyuIHHkbIVz\W6lZTDh[pRmeiB|MDDtbY5{ NE\MSWcyQTlzN{e1Ni=>

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 331.34
Formula

C17H18FN3O3

CAS No. 85721-33-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05133258 Not yet recruiting Drug: ciprofloxacin and dexamethasone suspension Chronic Suppurative Otitis Media Dartmouth-Hitchcock Medical Center December 15 2021 Not Applicable
NCT04775238 Recruiting Other: Silver nanoparticles|Other: Copper nanoparticles Nosocomial Infections Sohag University February 27 2021 Not Applicable
NCT04513548 Recruiting Drug: Ligelizumab|Drug: Placebo Chronic Spontaneous Urticaria|Cholinergic Urticaria|Cold Urticaria Novartis Pharmaceuticals|Novartis August 5 2020 Phase 1
NCT04621253 Completed Drug: Novalgin Drug-drug Interaction University Hospital Basel Switzerland April 29 2020 Phase 1
NCT04319328 Recruiting Drug: Cefazolin|Drug: Ceftazidime|Drug: Ciprofloxacin Hemodialysis Complication|Infectious Disease|End Stage Renal Disease University of Manitoba|The Kidney Foundation of Canada October 18 2019 --
NCT04374188 Recruiting Drug: Ciprofloxacin|Drug: Levofloxacin Nephrolithiasis Diaa Eldin Taha Ramadan Mohamed|Kafrelsheikh University September 1 2019 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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