Home DNA Damage/DNA Repair Topoisomerase inhibitor Ciprofloxacin For research use only.

Ciprofloxacin

Synonyms: Bay o 9867,Bay q 3939

Ciprofloxacin (Bay o 9867,Bay q 3939) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.

Ciprofloxacin Chemical Structure

Ciprofloxacin Chemical Structure

CAS: 85721-33-1

Selleck's Ciprofloxacin has been cited by 2 Publications

1 Customer Review

Purity & Quality Control

Batch: S202701 0.5MNAOH] 3 mg/mL] false] DMSO] Insoluble] false] Water] Insoluble] false Purity: 99.97%
99.97

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Signaling Pathway

Topoisomerase Signaling Pathways

Topoisomerase Signaling Pathway

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Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human erythrocytes Growth inhibition assay 50 h Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay, IC50=33.9 μM 24650715
5637 cells Function assay 12 h Antibacterial activity against uropathogenic Escherichia coli UTI89 infected in human 5637 cells assessed as decrease in intracellular bacterial level at 2 to 3 ug/ml after 12 hrs by serial dilution method 20231390
CCRF-CEM cells Proliferation assay 50 μM Antiproliferative activity against human CCRF-CEM cells assessed as cell viability at 50 uM by CellTiter assay relative to DMSO control 24138941
Caco-2 cells Function assay 30 mins Antibacterial activity against wild type Salmonella enteritidis 5408 harboring gyrA D87Y mutant gene infected in human Caco-2 cells assessed as effect on bacterial cell adherence after 30 mins 19917752
Click to View More Cell Line Experimental Data

Biological Activity

Description Ciprofloxacin (Bay o 9867,Bay q 3939) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.
Targets
Topoisomerase IV [2]
In vitro
In vitro

Ciprofloxacin is a fluoroquinolone antibiotic, shows MIC90 (minimal inhibitory concentrations for 90%) of between 0.008 and 2 μg/ml for Enterobacteriaceae, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, streptococci, Staphylococcus aureus, and Bacteroidesfragilis strains. [1] Ciprofloxacin inhibits topoisomerase IV as a primary topoisomerase target and gyrase as a secondary target. [2] Ciprofloxacin shows an AUC (area under the curve) of 24 μg×h/ml[3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05828550 Not yet recruiting
Patients withInfections Caused by S.Aureus Like Skin Infections Chest Infections Surgical Site Infections and Urinary Tract Infections
Sohag University
 May 2023 Not Applicable
NCT05286931 Recruiting
Neisseria Gonorrhoeae Infection
University of Washington
 March 3 2022 Not Applicable

Chemical Information & Solubility

Molecular Weight 331.34 Formula

C17H18FN3O3
CAS No. 85721-33-1 SDF Download Ciprofloxacin SDF
Smiles C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O
Storage (From the date of receipt)

In vitro
Batch:

0.5MNAOH : 3 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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