Cetrimonium Bromide (CTAB)

For research use only.

Catalog No.S4242

2 publications

Cetrimonium Bromide (CTAB) Chemical Structure

CAS No. 57-09-0

Cetrimonium Bromide (CTAB) is a known component of the broad-spectrum antiseptic cetrimide, which is a mixture of different quaternary ammonium salts.

Selleck's Cetrimonium Bromide (CTAB) has been cited by 2 publications

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Biological Activity

Description Cetrimonium Bromide (CTAB) is a known component of the broad-spectrum antiseptic cetrimide, which is a mixture of different quaternary ammonium salts.
In vitro

Cetrimonium Bromide reduces cell viability of FaDu, C666-1, UTSCC-8A, UTSCC-42A, MRC5 cells and GM05757 fibroblasts with EC50 of 2 μM, 3.8 μM, 3.5 μM, 4.2 μM, 11 μM and 18 μM, respectively. Cetrimonium Bromide reduces cell viability of A549 lung and MCF7 breast cancer cells with EC50 of 17 μM and 12 μM. Cetrimonium Bromide (0.5 μM) interacts additively with radiation in a dose-dependent manner to exhibits inhibition effect on the clonogenic survival of FaDu cells. Cetrimonium Bromide results in nuclear condensation and blebbing in FaDu cells, consistent with apoptotic nuclear morphology, which is not observed in CTAB-treated GM05757 fibroblasts. Cetrimonium Bromide reproducibly decreases ATPase activity in a dose-dependent manner in FaDu cells, achieving ∼90% inhibition at 50 μM. Cetrimonium Bromide (5 μM) causes a modest (∼10%), but statistically significant decreases in ATP content in FaDu cells. Cetrimonium Bromide (5 μM) induced apoptosis is significantly suppressed by >50% when CCCP (5 μM) is used to effectively uncouple ΔΨM before Cetrimonium Bromide treatment in FaDu cells. [1]

In vivo Cetrimonium Bromide (5 μM) effectively eliminates the tumor-forming potential of FaDu cells in SCID mice. Cetrimonium Bromide (daily 5 mg/kg i.p. for 5 days) induces a modest reduction in tumor development compared with the vehicle-treatment arm in established FaDu xenograft tumors in SCID mice. [1]

Protocol

Solubility (25°C)

In vitro Water 100 mg/mL (274.38 mM)
Ethanol 100 mg/mL (274.38 mM)
DMSO 5 mg/mL (13.71 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 364.45
Formula

C19H42N.Br

CAS No. 57-09-0
Storage powder
in solvent
Synonyms N/A
Smiles CCCCCCCCCCCCCCCC[N+](C)(C)C.[Br-]

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID