Home Endocrinology & Hormones Glucocorticoid Receptor agonist Cortisone acetate

research use only

Cortisone acetate Glucocorticoid Receptor agonist

Cat.No.S2559

Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.
Cortisone acetate Glucocorticoid Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 402.48

Jump to

Quality Control

Batch: Purity: 99.56%
99.56

Solubility

In vitro
Batch:

DMSO : 7 mg/mL (17.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 402.48 Formula

C23H30O6

 Storage (From the date of receipt)
CAS No. 50-04-4 Download SDF Storage of Stock Solutions

Synonyms Cortone,NSC 49420 Smiles CC(=O)OCC(=O)C1(CCC2C1(CC(=O)C3C2CCC4=CC(=O)CCC34C)C)O

Mechanism of Action

Targets/IC50/Ki
Glucocorticoid receptor

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04855630 Recruiting
Alzheimer Disease|Dementia
University of Miami|Shipley Foundation|Dreem
 March 1 2023 Not Applicable
NCT05790083 Active not recruiting
Atopic Dermatitis|Eczema-Prone Skin
Bionorica SE
 January 3 2023 Not Applicable
NCT05336968 Recruiting
Osteoarthritis Knee
United Health Services Hospitals Inc.
 September 15 2022 Phase 4
NCT05435781 Recruiting
Adrenal Insufficiency|Polymyalgia Rheumatica|Giant Cell Arteritis
Ulla Feldt-Rasmussen|Aarhus University Hospital|Odense University Hospital|Rigshospitalet Denmark
 June 7 2022 Phase 4
NCT05237440 Recruiting
Obesity
University Hospital Limoges
 April 13 2022 Not Applicable
NCT05222152 Active not recruiting
Primary Adrenal Insufficiency
Diurnal Limited
 November 23 2021 Phase 2

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.