Cyclandelate

Catalog No.S4189 Synonyms: BS 572

Cyclandelate Chemical Structure

Molecular Weight(MW): 276.37

Cyclandelate is an effective inhibitor of rat hepatic acycloenzyme A: cholesterol acyltransferase (ACAT) with IC50 of 80 μM.

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Biological Activity

Description Cyclandelate is an effective inhibitor of rat hepatic acycloenzyme A: cholesterol acyltransferase (ACAT) with IC50 of 80 μM.
Targets
ACAT [1]
In vitro

Cyclandelate is a direct-acting smooth muscle relaxant used to dilate blood vessels. It may cause gastrointestinal distress and tachycardia. Cyclandelate is in a class of drugs called vasodilators. Cyclandelate relaxes veins and arteries, which makes them wider and allows blood to pass through them more easily. Cyclandelate produces peripheral vasodilation by a direct effect on vascular smooth muscle. Pharmacological action may be due to calcium-channel antagonism. [1] Cyclandelate is involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Cyclandelate hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl CoA ester. [2]

Protocol

Solubility (25°C)

In vitro DMSO 55 mg/mL (199.0 mM)
Ethanol 55 mg/mL (199.0 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 276.37
Formula

C17H24O3

CAS No. 456-59-7
Storage powder
in solvent
Synonyms BS 572

Bio Calculators

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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