CH-223191

Catalog No.S7711

For research use only.

CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist with IC50 of 30 nM.

CH-223191 Chemical Structure

CAS No. 301326-22-7

Selleck's CH-223191 has been cited by 33 publications

Purity & Quality Control

Choose Selective AhR Inhibitors

Biological Activity

Description CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist with IC50 of 30 nM.
Targets
AhR [1]
(in HepG2 cells)
30 nM
In vitro

CH-223191 blocks TCDD-mediated nuclear translocation and DNA binding of AhR, and also causes the inhibition of TCDD-induced cytochrome P450 enzyme activity. [1] In human glioblastoma cells, CH-223191downregulates the TGF-beta/Smad pathway, and reduces clonogenic survival and invasiveness. [2] In SK-N-SH human-derived neuronal cells, CH223191 counteracts the TCDD-induced suppression of neuronal acetylcholinesterase expression. [3] In endothelial cells, CH-223191 potentiates ICAM-1 expression and prevents RelB nuclear translocation. [4]

Assay
Methods Test Index PMID
Western blot hpol κ / γH2AX 26651356
In vivo CH-223191 (10 mg/kg/day, p.o.) potently prevents TCDD-caused cytochrome P450 induction, liver toxicity, and wasting syndrome in mice. [1]

Protocol (from reference)

Animal Research:[1]
  • Animal Models: Male ICR mice
  • Dosages: 10 mg/kg/day
  • Administration: p.o.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 333.39
Formula

C19H19N5O

CAS No. 301326-22-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CC=CC=C1N=NC2=CC(=C(C=C2)NC(=O)C3=CC=NN3C)C

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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