For research use only.

Catalog No.S7711

26 publications

CH-223191 Chemical Structure

CAS No. 301326-22-7

CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist with IC50 of 30 nM.

Selleck's CH-223191 has been cited by 26 publications

Purity & Quality Control

Choose Selective AhR Inhibitors

Biological Activity

Description CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist with IC50 of 30 nM.
AhR [1]
(in HepG2 cells)
30 nM
In vitro

CH-223191 blocks TCDD-mediated nuclear translocation and DNA binding of AhR, and also causes the inhibition of TCDD-induced cytochrome P450 enzyme activity. [1] In human glioblastoma cells, CH-223191downregulates the TGF-beta/Smad pathway, and reduces clonogenic survival and invasiveness. [2] In SK-N-SH human-derived neuronal cells, CH223191 counteracts the TCDD-induced suppression of neuronal acetylcholinesterase expression. [3] In endothelial cells, CH-223191 potentiates ICAM-1 expression and prevents RelB nuclear translocation. [4]

Methods Test Index PMID
Western blot
hpol κ / γH2AX ; 

PubMed: 26651356     

Expression of hpol κ and γH2AX in T98G glioblastoma cells treated with the AhR inhibitor CH-223191 (10 μM and 100 μM, 24 hrs) were determined by immunoblotting. Expression of both hpol κ and γH2AX decrease in cells treated with 100 μM CH-223191.

In vivo CH-223191 (10 mg/kg/day, p.o.) potently prevents TCDD-caused cytochrome P450 induction, liver toxicity, and wasting syndrome in mice. [1]


Animal Research:[1]
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  • Animal Models: Male ICR mice
  • Dosages: 10 mg/kg/day
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 66 mg/mL (197.96 mM)
Ethanol 4 mg/mL warmed (11.99 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 333.39


CAS No. 301326-22-7
Storage powder
in solvent
Synonyms N/A
Smiles CC1=CC=CC=C1N=NC2=CC(=C(C=C2)NC(=O)C3=CC=NN3C)C

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID