CH-223191

For research use only.

Catalog No.S7711

26 publications

CH-223191 Chemical Structure

CAS No. 301326-22-7

CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist with IC50 of 30 nM.

Selleck's CH-223191 has been cited by 26 publications

Purity & Quality Control

Choose Selective AhR Inhibitors

Biological Activity

Description CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist with IC50 of 30 nM.
Targets
AhR [1]
(in HepG2 cells)
30 nM
In vitro

CH-223191 blocks TCDD-mediated nuclear translocation and DNA binding of AhR, and also causes the inhibition of TCDD-induced cytochrome P450 enzyme activity. [1] In human glioblastoma cells, CH-223191downregulates the TGF-beta/Smad pathway, and reduces clonogenic survival and invasiveness. [2] In SK-N-SH human-derived neuronal cells, CH223191 counteracts the TCDD-induced suppression of neuronal acetylcholinesterase expression. [3] In endothelial cells, CH-223191 potentiates ICAM-1 expression and prevents RelB nuclear translocation. [4]

Assay
Methods Test Index PMID
Western blot
hpol κ / γH2AX ; 

PubMed: 26651356     


Expression of hpol κ and γH2AX in T98G glioblastoma cells treated with the AhR inhibitor CH-223191 (10 μM and 100 μM, 24 hrs) were determined by immunoblotting. Expression of both hpol κ and γH2AX decrease in cells treated with 100 μM CH-223191.

26651356
In vivo CH-223191 (10 mg/kg/day, p.o.) potently prevents TCDD-caused cytochrome P450 induction, liver toxicity, and wasting syndrome in mice. [1]

Protocol

Animal Research:[1]
- Collapse
  • Animal Models: Male ICR mice
  • Dosages: 10 mg/kg/day
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 66 mg/mL (197.96 mM)
Ethanol 4 mg/mL warmed (11.99 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 333.39
Formula

C19H19N5O

CAS No. 301326-22-7
Storage powder
in solvent
Synonyms N/A
Smiles CC1=CC=CC=C1N=NC2=CC(=C(C=C2)NC(=O)C3=CC=NN3C)C

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID