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Catalog No.S2528

4 publications

Ciclopirox  Chemical Structure

CAS No. 29342-05-0

Ciclopirox is a broad-spectrum antifungal agent working as an iron chelator.

Selleck's Ciclopirox has been cited by 4 publications

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Biological Activity

Description Ciclopirox is a broad-spectrum antifungal agent working as an iron chelator.
ATPase [6]
In vitro

Ciclopirox olamine (CPX) is a lipophilic bidentate iron chelator that stabilizes HIF-1alpha under normoxic conditions at lower concentrations than other iron chelators, probably by inhibiting HIF-1alpha hydroxylation. Ciclopirox olamine (CPX)-induced HIF-1 mediates reporter gene activity and endogenous HIF-1 target gene expression, including elevation of transcription, mRNA, and protein levels of the vascular endothelial growth factor (VEGF).[1] Ciclopirox inhibits growth of C. albicans yeast and hyphal cells in a dose-dependent manner. [2] Ciclopirox blocks H2O2-induced mitochondrial injury by maintaining mitochondrial transmembrane potential (Deltapsim). Ciclopirox completely blocks H2O2-stimulated release of lactate dehydrogenase (a marker of cell death) and decreases in MTT reduction (a marker of mitochondrial function) in adenocarcinoma SK-HEP-1 cells. Ciclopirox effectively inhibits H2O2-induced mitochondrial permeability transition pore (MPTP) opening. [3] Ciclopirox increases the MTP, maintained it high, and blocks the ATP depletion in glucose-deprived SIN-1-treated astrocytes. Ciclopirox protects astrocytes from peroxynitritecytotoxicity by attenuating peroxynitrite-induced mitochondrial dysfunction. [4] Ciclopirox is a substituted pyridone antimycotic drug, unrelated to the imidazole derivatives and its topical application ensures maximum local bioavailability. Ciclopirox acts on fungi by inhibiting the intracellular uptake of essential substrates and ions and this probably acts on the Candida ability to express its adherence mechanisms. [5]


Solubility (25°C)

In vitro DMSO 42 mg/mL (202.63 mM)
Water Insoluble
Ethanol '42 mg/mL

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Chemical Information

Molecular Weight 207.27


CAS No. 29342-05-0
Storage powder
in solvent
Synonyms N/A
Smiles CC1=CC(=O)N(C(=C1)C2CCCCC2)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00990587 Completed Drug: Ciclopirox Olamine Hematologic Malignancy|Acute Lymphocytic Leukemia|Chronic Lymphocytic Leukemia|Myelodysplasia|Acute Myeloid Leukemia|Chronic Myelogenous Leukemia|Hodgkin''s Disease University Health Network Toronto|The Leukemia and Lymphoma Society October 2009 Phase 1
NCT01646580 Terminated Drug: ciclopirox Dermatomycoses Ferrer Internacional S.A. October 2008 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID