Cambinol

Catalog No.S5913

Cambinol Chemical Structure

Molecular Weight(MW): 360.43

Cambinol is a novel uncompetitive nSMase2 inhibitor with a K i value of 7 μM (IC50 = 5 ± 1 μM).

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Biological Activity

Description Cambinol is a novel uncompetitive nSMase2 inhibitor with a K i value of 7 μM (IC50 = 5 ± 1 μM).
Targets
nSMase2 [1]
(Cell-free assay)
7 μM(Ki)
In vitro

Cambinol decreases tumor necrosis factor-α or interleukin-1 β-induced increases of ceramide and cell death in primary neurons. Cambinol is an inhibitor of the NAD-dependent deacetylase activity of sirtuin, human silent information regulator type 1/2 (SIRT1/2), with IC50 values of 56 μM and 59 μM for SIRT1 and SIRT2, respectively. Cambinol induces apoptosis in BCL6-expressing Burkitt lymphoma cell lines. Cambinol is approximately a 10-fold more potent human nSMase2 inhibitor compared to SIRT1/2[1]. Cambinol is a potent inhibitor of acidic pHe-mediated anterograde lysosome trafficking[2].

In vivo Cambinol is well tolerated in mice and has potent antitumor activity in vivo[2].

Protocol

Cell Research:

[2]

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  • Cell lines: DU145 cells
  • Concentrations: 50 μM
  • Incubation Time: 2 h
  • Method:

    --


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 21 mg/mL (58.26 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 360.43
Formula

C21H16N2O2S

CAS No. 14513-15-6
Storage powder
in solvent
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID