Catalog No.S1371 Synonyms: FK 037 Sulfate
Molecular Weight(MW): 620.64
Cefoselis is a widely used beta-lactam antibiotic.
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|Description||Cefoselis is a widely used beta-lactam antibiotic.|
Cefoselis inhibits GABA-induced currents in a concentration-dependent manner with IC50 of 185 mM.  Cefoselis possesses a superior antistaphylococcal activity on MSSA isolates to both other compounds being however equal active to Cefepime and Cefpirome on multiresistant enterobacteriaceae.  Cefoselis is dose-dependently appeared in brain extracellular fluid in proportion to its blood level.  Cefoselis, a new parenteral cephalosporin, is active against clinical isolates of both gram-positive and gram-negative aerobic bacteria. 
|In vivo||Cefoselis elicits a massive elevation of extracellular glutamate concentration in normal rats.  Cefoselis (50 mg/animal)-induced convulsions are prevented by pretreatment with 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801), diazepam and phenobarbital (ED(50) values (mg/kg) of 0.78, 1.59 and 33.0, respectively), but not by carbamazepine or phenytoin. |
-  Sugimoto M, et al. Br J Pharmacol, 2002, 135(2), 427-432.
-  Giamarellos-Bourboulis EJ, et al. Diagn Microbiol Infect Dis, 2000, 36(3), 185-191.
-  Ohtaki K, et al. J Neural Transm, 2004, 111(12), 1523-1535.
|In vitro||Water||5 mg/mL (8.05 mM)|
|DMSO||3 mg/mL (4.83 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||FK 037 Sulfate|
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