Clopidogrel (SR-25990C) Bisulfate

Catalog No.S1415 Synonyms: Clopidogrel hydrogen sulfate, Iscover, Plavix

For research use only.

Clopidogrel Bisulfate (SR-25990C, Clopidogrel hydrogen sulfate, Iscover, Plavix) is an oral, thienopyridine class antiplatelet agent.

Clopidogrel (SR-25990C) Bisulfate Chemical Structure

CAS No. 120202-66-6

Selleck's Clopidogrel (SR-25990C) Bisulfate has been cited by 6 Publications

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Purity & Quality Control

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Biological Activity

Description Clopidogrel Bisulfate (SR-25990C, Clopidogrel hydrogen sulfate, Iscover, Plavix) is an oral, thienopyridine class antiplatelet agent.
Targets
P2Y12 [1]
In vitro

Clopidogrel is converted to its active metabolite by cytochrome P450 (CYP) enzymes. [1] Clopidogrel (1 μM) also inhibits EGF-stimulated EGF receptor, PERK expression, and cell proliferation in RGM-1 cells (P<0.05), and causes much less inhibition of EGF-stimulated cell proliferation in EGF receptor over-expressed RGM-1 cells than in RGM-1 cells (22% vs. 32% reduction). [2] Clopidogrel increases blood vessel number, reduces polymorphonuclear count and decreases attachment and bone loss, also decreases osteoclast number in rats submitted or not to periodontal repair. Clopidogrel decreases CXCL4, CXCL12 and PDGF content compared with saline-treated rats, without affecting CXCL5. [3]

Assay
Methods Test Index PMID
Western blot ATF2 / ATF3 / ATF4 / ATF6 ; TRIB3 / CHOP 24058556
In vivo Clopidogrel (2mg and 10mg/kg/day) significantly decreases ulcer-induced gastric epithelial cell proliferation and ulcer-stimulated expressions of EGF receptor and phosphorylated extracellular signal-regulated kinase (PERK) at the ulcer margin of rats. [2] Clopidogrel improves endothelial function and NO bioavailability in rats with congestive heart failure. Clopidogrel-treated Congestive heart failure (CHF) rat displays enhances phosphorylation of AKT and eNOS. [4] The clopidogrel/aspirin combination shows only additive-type effects on bleeding time prolongation induced by ear transection in the rabbit, therefore showing that combined inhibition of cyclooxygenase and ADP's effects provide a marked enhanced antithrombotic efficacy. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 83 mg/mL
(197.66 mM)
Water 78 mg/mL warmed
(185.75 mM)
Ethanol '''46 mg/mL

Chemical Information

Molecular Weight 419.9
Formula

C16H16ClNO2S.H2SO4

CAS No. 120202-66-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3.OS(=O)(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05166538 Not yet recruiting Drug: Ticagrelor|Drug: Clopidogrel Multi Vessel Coronary Artery Disease Yonsei University February 1 2022 Phase 4
NCT05122455 Recruiting Drug: ASA|Drug: Clopidogrel|Drug: Edoxaban SCAD|AMI University of Sao Paulo|Daiichi Sankyo Inc. September 14 2021 Phase 2|Phase 3
NCT05053828 Enrolling by invitation Drug: Antiplatelet Drug Type2 Diabetes|Antiplatelet Drugs|Myocardial Infarction|Heart Failure Tabula Rasa HealthCare September 20 2021 --
NCT04990596 Recruiting Biological: additional blood sample Drug Resistance Rennes University Hospital July 12 2021 --

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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