Clopidogrel Bisulfate

Catalog No.S1415 Synonyms: SR-25990C

Clopidogrel Bisulfate Chemical Structure

Molecular Weight(MW): 419.9

Clopidogrel is an oral, thienopyridine class antiplatelet agent.

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Cited by 2 Publications

2 Customer Reviews

  • (A) HPLC glycan traces of IgG recovered from joint after K/BxN and PBS or B4ST6Fc treatment with or without clopidogrel. (B) Ratios of monosialylated and agalactosylated glycans (S1/G0) from IgG described in (A).

    Cell, 2018, 172(3):564-577.e13. Clopidogrel Bisulfate purchased from Selleck.

    C, The expression of EGFR in the clopidogrel‐ treated cells was analyzed by immunoblot analysis. The clopidogrel‐treated cells (HSC3 and SAS) show down‐regulation of FBLIM1 and EGFR compared with the control cells. D, The images of expression of EGFR after treatment with clopidogrel for 48 h analyzed by IF. Most EGFR is localized at the cellular membrane; in contrast, treatment with clopidogrel caused internalization of EGFR. Clop, clopidogrel.

    Mol Carcinog, 2018, 57(12):1690-1697. Clopidogrel Bisulfate purchased from Selleck.

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Biological Activity

Description Clopidogrel is an oral, thienopyridine class antiplatelet agent.
P2Y12 [1]
In vitro

Clopidogrel is converted to its active metabolite by cytochrome P450 (CYP) enzymes. [1] Clopidogrel (1 μM) also inhibits EGF-stimulated EGF receptor, PERK expression, and cell proliferation in RGM-1 cells (P<0.05), and causes much less inhibition of EGF-stimulated cell proliferation in EGF receptor over-expressed RGM-1 cells than in RGM-1 cells (22% vs. 32% reduction). [2] Clopidogrel increases blood vessel number, reduces polymorphonuclear count and decreases attachment and bone loss, also decreases osteoclast number in rats submitted or not to periodontal repair. Clopidogrel decreases CXCL4, CXCL12 and PDGF content compared with saline-treated rats, without affecting CXCL5. [3]

Methods Test Index PMID
Western blot
ATF2 / ATF3 / ATF4 / ATF6 ; 

PubMed: 24058556     

GES-1 cells were treated with clopidogrel 1.5 mM for 24 h. Data are expressed as mean ± SD, representative of three independent experiments. *P<0.05 vs control.


PubMed: 24058556     

The protein expression levels of both CHOP and TRIB3 were up-regulated in the GES-1 cells in a concentration- dependent manner. Consistent with their mRNA expression profiles as measured by real-time PCR. 

In vivo Clopidogrel (2mg and 10mg/kg/day) significantly decreases ulcer-induced gastric epithelial cell proliferation and ulcer-stimulated expressions of EGF receptor and phosphorylated extracellular signal-regulated kinase (PERK) at the ulcer margin of rats. [2] Clopidogrel improves endothelial function and NO bioavailability in rats with congestive heart failure. Clopidogrel-treated Congestive heart failure (CHF) rat displays enhances phosphorylation of AKT and eNOS. [4] The clopidogrel/aspirin combination shows only additive-type effects on bleeding time prolongation induced by ear transection in the rabbit, therefore showing that combined inhibition of cyclooxygenase and ADP's effects provide a marked enhanced antithrombotic efficacy. [5]


Solubility (25°C)

In vitro DMSO 83 mg/mL (197.66 mM)
Water 78 mg/mL (185.75 mM)
Ethanol 46 mg/mL (109.54 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 419.9


CAS No. 120202-66-6
Storage powder
in solvent
Synonyms SR-25990C

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03806894 Not yet recruiting Diagnostic Test: Quantification of platelet aggregation Clopidogrel Poor Metabolism of|Ischemic Stroke Ziv Hospital October 2019 --
NCT03188705 Not yet recruiting Drug: Clopidogrel|Drug: Aspirin Heart Diseases|Coronary Disease|Coronary Artery Disease|Cardiovascular Diseases|Myocardial Ischemia|Artery Occlusion|Aspirin Sensitivity|Clopidogrel Poor Metabolism of|Platelet Dysfunction|Platelet Thrombus University of Maryland Baltimore September 1 2019 Phase 4
NCT02302508 Withdrawn Drug: Clopidogrel Prasugrel Ticagrelor Diabetes Centre hospitalier de l''Université de Montréal (CHUM)|Centre de Recherche du Centre Hospitalier de l''Université de Montréal September 1 2019 Phase 4
NCT03774394 Recruiting Drug: Clopidogrel|Drug: Clopidogrel active metabolite Chronic Kidney Disease (CKD)|Type 2 Diabetes Mellitus (T2DM)|Coronary Artery Disease (CAD) University of Florida August 22 2019 Phase 4
NCT04088682 Recruiting Behavioral: Quality improvement strategies and tools ST Elevation Myocardial Infarction China National Center for Cardiovascular Diseases July 15 2018 --

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID