Cangrelor Tetrasodium

For research use only.

Catalog No.S3737 Synonyms: AR-C69931MX

2 publications

Cangrelor Tetrasodium Chemical Structure

CAS No. 163706-36-3

Cangrelor (AR-C69931MX) is a potent, competitive P2Y12 receptor inhibitor that is administered by intravenous infusion and rapidly achieves near complete inhibition of ADP-induced platelet aggregation.

Selleck's Cangrelor Tetrasodium has been cited by 2 publications

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Biological Activity

Description Cangrelor (AR-C69931MX) is a potent, competitive P2Y12 receptor inhibitor that is administered by intravenous infusion and rapidly achieves near complete inhibition of ADP-induced platelet aggregation.
Targets
P2Y12 receptor [1]
()
In vitro

Cangrelor is an intravenous ATP analog that directly inhibits, without the need for being metabolized, the P2Y12 receptor in a reversible manner. Cangrelor has a rapid-onset and -offset mechanism of action and achieves significantly greater degrees of platelet inhibition compared with clopidogrel[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
1321N1 NVPrRYpETnWwY4Tpc44h[XO|YYm= MkXoN|AhdWmwcx?= MY\BcpRi\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJGdRWjF5IGKyOVVKKG23dHHueEBmgHC{ZYPz[YQhcW5iaIXtZY4hOTN{MV6xJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiVVTQMYdtfWOxc3WtbY5lfWOnZDDbN|VUZUeWUHfhcY1iWyCkaX7kbY5oKGGodHXyJFMxKG2rboOgZpkhemGyaXSg[oltfHKjdHnvckBie3OjeTygTWM2OD1yLkCwNFE2|ryP M4jTTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{m0N|c4Lz5{MEO5OFM4PzxxYU6=
1321N1 NH;wfnNHfW6ldHnvckBie3OjeR?= MYezNEBucW6| NX3KSYYzSW62YXfvcol{fCCjY4Tpeol1gSCjdDDoeY1idiCJUGKxO{BmgHC{ZYPz[YQhcW5iaIXtZY4hOTN{MV6xJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiVVTQMYdtfWOxc3WtbY5lfWOnZDDbN|VUZUeWUHfhcY1iWyCkaX7kbY5oKGGodHXyJFMxKG2rboOgZpkhemGyaXSg[oltfHKjdHnvckBie3OjeTygTWM2OD1yLkCwNFfPxE1? M{XKdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{m0N|c4Lz5{MEO5OFM4PzxxYU6=

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In vivo Cangrelor is rapidly deactivated by plasmatic ectonucleotidases and, thus, has an extrmely short half-life (2-5 min). Preclinical studies performed in animal models in the early stages of cangrelor development show efficacy in inhibiting thrombus formation and ADP-induced platelet aggregation, as well as a lower increase of bleeding times when compared with IIb/IIIa antagonist[1].

Protocol

Solubility (25°C)

In vitro Water 100 mg/mL (115.7 mM)
DMSO 2 mg/mL (2.31 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 864.29
Formula

21Cl2F3N5O12P3S2.4Na

CAS No. 163706-36-3
Storage powder
in solvent
Synonyms AR-C69931MX
Smiles CSCCNC1=C2C(=NC(=N1)SCCC(F)(F)F)N(C=N2)C3C(C(C(O3)COP(=O)([O-])OP(=O)(C(P(=O)([O-])[O-])(Cl)Cl)[O-])O)O.[Na+].[Na+].[Na+].[Na+]

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID