Cangrelor Tetrasodium

Catalog No.S3737 Synonyms: AR-C69931MX

For research use only.

Cangrelor (AR-C69931MX) is a potent, competitive P2Y12 receptor inhibitor that is administered by intravenous infusion and rapidly achieves near complete inhibition of ADP-induced platelet aggregation.

Cangrelor Tetrasodium Chemical Structure

CAS No. 163706-36-3

Selleck's Cangrelor Tetrasodium has been cited by 2 Publications

Purity & Quality Control

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Biological Activity

Description Cangrelor (AR-C69931MX) is a potent, competitive P2Y12 receptor inhibitor that is administered by intravenous infusion and rapidly achieves near complete inhibition of ADP-induced platelet aggregation.
Targets
P2Y12 receptor [1]
In vitro

Cangrelor is an intravenous ATP analog that directly inhibits, without the need for being metabolized, the P2Y12 receptor in a reversible manner. Cangrelor has a rapid-onset and -offset mechanism of action and achieves significantly greater degrees of platelet inhibition compared with clopidogrel[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
1321N1 MnHnSpVv[3Srb36gZZN{[Xl? MYSzNEBucW6| M2XNXWFvfGGpb37pd5Qh[WO2aY\peJkh[XRiaIXtZY4hT1CUMUegVlI2PUlibYX0ZY51KGW6cILld5Nm\CCrbjDoeY1idiBzM{KxUlEh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDVSHAu\2y3Y3;z[U1qdmS3Y3XkJHs{PVOfR2TQ[4FudWGVIHLpcoRqdmdiYX\0[ZIhOzBibXnud{BjgSC{YYDp[EBncWy2cnH0bY9vKGG|c3H5MEBKSzVyPUCuNFAxOTYQvF2= NYfsToVQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzPVQ{PzdpPkKwN|k1Ozd5PD;hQi=>
1321N1 M2TTPWZ2dmO2aX;uJIF{e2G7 NGjtTXU{OCCvaX7z M3XmeWFvfGGpb37pd5Qh[WO2aY\peJkh[XRiaIXtZY4hT1CUMUeg[ZhxemW|c3XkJIlvKGi3bXHuJFE{OjGQMTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKFWGUD3ncJVkd3OnLXnu[JVk\WRiW{O1V31IXFCpYX3tZXMh[mmwZHnu[{Bi\nSncjCzNEBucW6|IHL5JJJieGmmIH\pcJRz[XSrb36gZZN{[XluIFnDOVA:OC5yMEC3{txO MlHIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|OUSzO|coRjJyM{m0N|c4RC:jPh?=
In vivo Cangrelor is rapidly deactivated by plasmatic ectonucleotidases and, thus, has an extrmely short half-life (2-5 min). Preclinical studies performed in animal models in the early stages of cangrelor development show efficacy in inhibiting thrombus formation and ADP-induced platelet aggregation, as well as a lower increase of bleeding times when compared with IIb/IIIa antagonist[1].

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 864.29
Formula

21Cl2F3N5O12P3S2.4Na

CAS No. 163706-36-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CSCCNC1=C2C(=NC(=N1)SCCC(F)(F)F)N(C=N2)C3C(C(C(O3)COP(=O)([O-])OP(=O)(C(P(=O)([O-])[O-])(Cl)Cl)[O-])O)O.[Na+].[Na+].[Na+].[Na+]

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

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