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CEBPα inducer 1

C/EBPα inducer 1 (compound 78) is a potent inducer of CCAAT enhancer-binding protein α (C/EBPα) and myeloid differentiation.

CEBPα inducer 1 Chemical Structure

CEBPα inducer 1 Chemical Structure

CAS: 2374285-52-4

Purity & Quality Control

Batch: S353801 DMSO] 9 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.79%
99.79

CEBPα inducer 1 Related Products

Biological Activity

Description C/EBPα inducer 1 (compound 78) is a potent inducer of CCAAT enhancer-binding protein α (C/EBPα) and myeloid differentiation.
Targets
C/EBPα [1]
In vitro
In vitro

C/EBPα inducer 1 (compound 78) causes differentiation at 3 μM concentration, increases the expression of neutrophil differentiation marker CD11b, and upregulates both the C/EBPα and C/EBPε levels.[1]
Cell Research Cell lines HL-60 cells
Concentrations 3 μM
Incubation Time 7 days
Method

HL-60 cells were treated with 0.1% DMSO and 3 µM of C/EBPα inducer 1 (compound 78) for 7 days and stained with Wright-Giemsa. Maximum cell concentrations were adjusted lower than 100,000 /mL. These treated HL-60 cells were incubated with 1.0 mg/mL nitroblue tetrazolium/PBS, and 0.36 µM Phorbol-12-myristate-13-acetate (PMA) at 37 °C for 30–40 min and stained with safranin O. Morphological differentiation and apoptosis were evaluated as − (0–5%), + (5–30%), and ++ (more than 30%).

Chemical Information & Solubility

Molecular Weight 377.33 Formula

C20H12FN3O4
CAS No. 2374285-52-4 SDF --
Smiles [O-][N+](=O)C1=CC=C(O1)/C=C/C2=NC3=C(C=C(F)C=C3)C(=O)N2C4=CC=CC=C4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 9 mg/mL ( (23.85 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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