CA77.1

Synonyms: CA

CA77.1 (CA) is a potent, brain-penetrant and orally active activator of chaperone-mediated autophagy (CMA) for the treament of Alzheimer's disease (AD).

CA77.1 Chemical Structure

CA77.1 Chemical Structure

CAS: 2412270-22-3

Selleck's CA77.1 has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.93%
99.93

CA77.1 Related Products

Choose Selective Autophagy Inhibitors

Biological Activity

Description CA77.1 (CA) is a potent, brain-penetrant and orally active activator of chaperone-mediated autophagy (CMA) for the treament of Alzheimer's disease (AD).
Targets
CMA [1]
In Vivo
In vivo

CA77.1 activates CMA in vitro in dose- and time-dependent manner without affecting macroautophagy and when administering in vivo demonstrate brain penetrance with favorable pharmacokinetics, activation of CMA in brain of KFERQ-Dendra mice, and absence of blood or major organs toxicity after 3 months of daily treatment.[2]

Animal Research Animal Models Male wild-type mice (C57BL/6J)
Dosages 10 mg/Kg or 1mg/Kg
Administration i.v.&p.o.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01199250 Not yet recruiting
Lynch Syndrome|Recurrent Uterine Corpus Carcinoma|Stage I Uterine Corpus Cancer|Stage II Uterine Corpus Cancer|Stage III Uterine Corpus Cancer|Stage IV Uterine Corpus Cancer
Gynecologic Oncology Group|National Cancer Institute (NCI)|GOG Foundation
January 2100 --
NCT01164735 Not yet recruiting
Recurrent Uterine Corpus Carcinoma|Stage III Uterine Corpus Cancer|Stage IV Uterine Corpus Cancer
Gynecologic Oncology Group|National Cancer Institute (NCI)|GOG Foundation
January 2100 --

Chemical Information & Solubility

Molecular Weight 297.74 Formula

C16H12ClN3O

CAS No. 2412270-22-3 SDF --
Smiles CC(=O)NC1=CC=C(C=C1)C2=NC3=CC=C(Cl)C=C3N=C2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 30 mg/mL ( (100.75 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy CA77.1 | CA77.1 supplier | purchase CA77.1 | CA77.1 cost | CA77.1 manufacturer | order CA77.1 | CA77.1 distributor