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Carbenicillin disodium

Name: Carbenicillin disodium
Brand: Selleck Chemicals
SKU: S3179
Rating: 5 (0 reviews)

Catalog No.S3179 Synonyms: BRL-2064

For research use only.

Carbenicillin (BRL-2064) is a semi-synthetic penicillin antibiotic which interferes with cell wall synthesis of gram-negative bacteria while displaying low toxicity.

Carbenicillin disodium Chemical Structure

CAS No. 4800-94-6

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Biological Activity

Description	Carbenicillin (BRL-2064) is a semi-synthetic penicillin antibiotic which interferes with cell wall synthesis of gram-negative bacteria while displaying low toxicity.
In vitro	Carbenicillin (125 mg/L) completely suppresses the proliferation of Agrobacterium. Carbenicillin (250 mg/L-500 mg/L) enhances Callus fresh weight increase. Carbenicillin (125 mg/L) results in higher percentages of somatic embryos and larger numbers of somatic embryos from the individual callus. ^[1] Carbenicillin (1g/L) influences shoot formation negatively as the shooting frequency for leaf disc explants is reduced to 56% and for cotyledons to 51% after 2 months of culture of Nicotiana tabacum Petit Havana. ^[2] Carbenicillin prevents the development of mature somatic embryos, reduces early stage embryos by >90% and tissue growth by 50% of Sitka spruce. ^[3] The leukocytes of the patients does not release histamine on in vitro provocation with Carbenicillin (0.1 g/mL). ^[4]
In vivo	Carbenicillin (0.1 g/mL) does not show any allergic drug reactions in cystic fibrosis patients, as evident by no significant levels of antibodies of IgE, IgG or IgM classes. ^[4] Carbenicillin (50 μg/mL) results in phytotoxicity in chrysanthemum and TOB, with an increase in the concentration, and with a parallel shift in the morphogenic capacity (SRC) of threshold survival levels (TSLs). Carbenicillin results in 100% acclimatization with no different morphological flowering characteristics following subculture in vitro three times in Chrysanthemum plantlets. ^[5]

Protocol (from reference)

References

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Solubility (25°C)

In vitro	Water	84 mg/mL (198.88 mM)
	DMSO	5 mg/mL (11.83 mM)
	Ethanol	Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight	422.36
Formula	C₁₇H₁₆N₂Na₂O₆S
CAS No.	4800-94-6
Storage	3 years	-20°C	powder
Storage	2 years	-80°C	in solvent
Smiles	CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)C(=O)[O-])C(=O)[O-])C.[Na+].[Na+]

Download Carbenicillin disodium SDF

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

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% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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