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Cimetidine Histamine Receptor antagonist

Name: Cimetidine
SKU: S1845
Availability: InStock
Rating: 5 (4 reviews)

Cat.No.S1845

Cimetidine (SKF-92334), a histamine congener, competitively inhibits histamine binding to histamine H2 receptors.

Chemical Structure

Molecular Weight: 252.34

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S184501 DMSO]51 mg/mL]false]Ethanol]4 mg/mL]false]Water]Insoluble]false Purity: 99.88%

99.88

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Chemical Information, Storage & Stability

Molecular Weight	252.34	Formula	C₁₀H₁₆N₆S	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	51481-61-9	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	SKF-92334			Smiles	CC1=C(N=CN1)CSCCNC(=NC)NC#N

Solubility

In vitro
Batch:

DMSO : 51 mg/mL (202.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 4 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.55mg/ml (10.11mM)	Taking the 1 mL working solution as an example, add 50 μL of 51 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	4.25mg/ml (16.84mM)	Taking the 1 mL working solution as an example, add 50 μL of 85 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	Histamine H2 receptor ^[1]

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06056583	Recruiting	Lactation	University of Washington\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	December 4 2023	Phase 4
NCT01536249	Completed	Amyotrophic Lateral Sclerosis	Knopp Biosciences	March 2012	Phase 1
NCT01169012	Completed	Myelodysplastic Syndrome\|Acute Myeloid Leukemia\|Acute Lymphoblastic Leukemia\|Chronic Myelomonocytic Leukemia	UNC Lineberger Comprehensive Cancer Center\|Genzyme a Sanofi Company	September 2010	Phase 1
NCT00475059	Completed	Kidney Transplantation	Centre Hospitalier Universitaire de Saint Etienne	March 2007	Not Applicable

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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