Clioquinol

Catalog No.S4601 Synonyms: Iodochlorhydroxyquin, Chinoform

For research use only.

Clioquinol is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities.

Clioquinol Chemical Structure

CAS No. 130-26-7

Selleck's Clioquinol has been cited by 2 Publications

Purity & Quality Control

Choose Selective Fungal Inhibitors

Biological Activity

Description Clioquinol is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities.

Protocol (from reference)

Cell Research:

[2]

  • Cell lines: DU 145 cells
  • Concentrations: 10 μM 
  • Incubation Time: 2 h
  • Method:

    DU 145 cells are plated in a 12-well plate. After incubation for 24 h, the cells are treated with 10 μM clioquinol and 50 μM ZnCl2 for 2 h. AO is then added to each well (at a final concentration of 2.5 μg/ml). After 30 min of incubation with AO, cells are washed twice with HBSS and examined with a fluorescence microscope.

Animal Research:

[1]

  • Animal Models: Golden Syrian Hamsters
  • Dosages: 7.5 mg/kg
  • Administration: s.c.

Solubility (25°C)

In vitro

DMSO 61 mg/mL
(199.67 mM)
Water Insoluble
Ethanol '1 mg/mL

Chemical Information

Molecular Weight 305.50
Formula

C9H5ClINO

CAS No. 130-26-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC2=C(C(=C(C=C2Cl)I)O)N=C1

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00963495 Terminated Drug: Clioquinol Acute Myeloid Leukemia|Acute Lymphocytic Leukemia|Chronic Lymphocytic Leukemia|Myelodysplasia|Lymphoma Non-Hodgkin|Hodgkin''s Lymphoma|Multiple Myeloma University Health Network Toronto August 2009 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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