Cyclen

Synonyms: 1,4,7,10-tetraazacyclododecane

Cyclen (1,4,7,10-tetraazacyclododecane) is a macrocycle capable of selectively binding cations that used as a ligand in chemistry for instance with chemicals used in MRI contrast agents.

Cyclen Chemical Structure

Cyclen Chemical Structure

CAS: 294-90-6

Purity & Quality Control

Batch: S492701 DMSO] 34 mg/mL] false] Water] 34 mg/mL] false] Ethanol] 34 mg/mL] false Purity: 99.97%
99.97

Cyclen Related Products

Biological Activity

Description Cyclen (1,4,7,10-tetraazacyclododecane) is a macrocycle capable of selectively binding cations that used as a ligand in chemistry for instance with chemicals used in MRI contrast agents.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01498861 Completed
Infection Human Immunodeficiency Virus
ViiV Healthcare|Shionogi|GlaxoSmithKline
December 2011 Phase 1
NCT01458210 Completed
Diabetes Mellitus Type 2
Eli Lilly and Company
October 2011 Phase 1
NCT01063023 Completed
Hepatitis C Virus
Bristol-Myers Squibb
January 2010 Phase 1
NCT01243580 Completed
Healthy
Agile Therapeutics
August 2009 Phase 1
NCT00901290 Suspended
Pharmacokinetics
AstraZeneca
May 2009 Phase 1

Chemical Information & Solubility

Molecular Weight 172.27 Formula

C8H20N4

CAS No. 294-90-6 SDF --
Smiles C1CNCCNCCNCCN1
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 34 mg/mL ( (197.36 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 34 mg/mL

Ethanol : 34 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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