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Cyclen

Name: Cyclen
Brand: Selleck Chemicals
SKU: S4927
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S4927

Cyclen (1,4,7,10-tetraazacyclododecane) is a macrocycle capable of selectively binding cations that used as a ligand in chemistry for instance with chemicals used in MRI contrast agents.

Chemical Structure

Molecular Weight: 172.27

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S492701 DMSO]34 mg/mL]false]Water]34 mg/mL]false]Ethanol]34 mg/mL]false Purity: 99.97%

99.97

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Chemical Information, Storage & Stability

Molecular Weight	172.27	Formula	C₈H₂₀N₄	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	294-90-6	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	1,4,7,10-tetraazacyclododecane			Smiles	C1CNCCNCCNCCN1

Solubility

In vitro
Batch:

DMSO : 34 mg/mL (197.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 34 mg/mL

Ethanol : 34 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01498861	Completed	Infection Human Immunodeficiency Virus	ViiV Healthcare\|Shionogi\|GlaxoSmithKline	December 2011	Phase 1
NCT01458210	Completed	Diabetes Mellitus Type 2	Eli Lilly and Company	October 2011	Phase 1
NCT01063023	Completed	Hepatitis C Virus	Bristol-Myers Squibb	January 2010	Phase 1
NCT01243580	Completed	Healthy	Agile Therapeutics	August 2009	Phase 1
NCT00901290	Suspended	Pharmacokinetics	AstraZeneca	May 2009	Phase 1

Tech Support

Handling Instructions

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