Chlorpromazine

Catalog No.S5749 Synonyms: CPZ

For research use only.

Chlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. Chlorpromazine (CPZ) inhibits 5-HT(2A) receptor and dopamine D2 in vitro. Chlorpromazine (CPZ) also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM.

Chlorpromazine Chemical Structure

CAS No. 50-53-3

Selleck's Chlorpromazine has been cited by 19 publications

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Biological Activity

Description Chlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. Chlorpromazine (CPZ) inhibits 5-HT(2A) receptor and dopamine D2 in vitro. Chlorpromazine (CPZ) also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 64 mg/mL
(200.71 mM)


Chemical Information

Molecular Weight 318.86
Formula

C17H19ClN2S

CAS No. 50-53-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03548714 Completed Drug: PT150|Other: Beverage Alcohol Dependence|Alcohol Interaction Pop Test Oncology LLC|Pharmacotherapies for Alcohol and Substance Abuse Consortium|Congressionally Directed Medical Research Programs|Michael E. DeBakey VA Medical Center|Baylor College of Medicine|University of California San Diego September 1 2018 Phase 1
NCT02943213 Completed Drug: Chlorpromazine Hydrochloride Anti-Psychotic|Management of Manifestations of Psychotic Disorders|Treatment of Schizophrenia|Control Nausea and Vomiting|Relief of Restlessness and Apprehension Before Surgery|Acute Intermittent Porphyria|Adjunct in the Treatment of Tetanus|Control Manifestations of the Manic Type of Mani-depressive Illness|Relief of Intractable Hiccups Cycle Pharmaceuticals Ltd.|Parexel November 2016 Phase 1
NCT02295462 Completed Other: Person-centered Care|Other: Optimised Treatment Dementia Martin-Luther-Universität Halle-Wittenberg|University of Luebeck|University of Witten/Herdecke December 2014 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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