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Chlorpromazine Dopamine Receptor antagonist

Name: Chlorpromazine
Brand: Selleck Chemicals
SKU: S5749
Availability: InStock
Rating: 5 (49 reviews)

Cat.No.S5749

Chlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. This compound inhibits 5-HT(2A) receptor and dopamine D2 in vitro. It also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM.

Chemical Structure

Molecular Weight: 318.86

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Quality Control

Batch: Purity: 99.12%

99.12

Related Targets	Adrenergic Receptor AChR 5-HT Receptor COX Calcium Channel Histamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE) GluR
Other Dopamine Receptor Inhibitors	MPTP Hydrochloride Trifluoperazine Trifluoperazine 2HCl Penfluridol SCH-23390 hydrochloride Domperidone SKF38393 HCl Sulpiride Azaperone C-DIM12

Solubility

In vitro
Batch:

DMSO : 64 mg/mL (200.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 64 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.250mg/ml (10.19mM)
	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.250mg/ml (10.19mM)
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	318.86	Formula	C₁₇H₁₉ClN₂S	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	50-53-3	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	CPZ			Smiles	CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl

Mechanism of Action

In vitro	Chlorpromazine exerts a mild decrease in sEV uptake in only one MM cell line, indicating that the uptake of BMSC-derived sEVs by suspension MM cells may not rely on this compound-targeted receptors.
In vivo	Chlorpromazine suppresses the growth of endometrial cancer (EC) tumors in vivo at a low dose with no signs of toxicity.
References	[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797667/ [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087176/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06238089	Recruiting	Intellectual Disability	University of Plymouth\|Peninsula Clinical Trials Unit	December 19 2023	--
NCT05206747	Recruiting	Mania\|Sleep\|Bipolar Disorder	Ottawa Hospital Research Institute	September 7 2022	Not Applicable
NCT03548714	Completed	Alcohol Dependence\|Alcohol Interaction	Pop Test Oncology LLC\|Pharmacotherapies for Alcohol and Substance Use Disorders Alliance\|Congressionally Directed Medical Research Programs\|Michael E. DeBakey VA Medical Center\|Baylor College of Medicine\|University of California San Diego	September 1 2018	Phase 1

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