Cremophor EL

Name: Cremophor EL
Brand: Selleck Chemicals
SKU: S6828
Rating: 5 (1 reviews)

Synonyms: CrEL

Catalog No.S6828 Purity: 99%

Cremophor EL, a polyethoxylated surfactant, is a formulation vehicle used for various poorly-water soluble drugs, including the anticancer agent paclitaxel (Taxol). Cremophor EL is used in severe anaphylactoid hypersensitivity reactions, hyperlipidaemia, abnormal lipoprotein patterns, aggregation of erythrocytes and peripheral neuropathy.

Cremophor EL Chemical Structure

CAS: 61791-12-6

Selleck's Cremophor EL has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99%

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Biological Activity

Description	Cremophor EL, a polyethoxylated surfactant, is a formulation vehicle used for various poorly-water soluble drugs, including the anticancer agent paclitaxel (Taxol). Cremophor EL is used in severe anaphylactoid hypersensitivity reactions, hyperlipidaemia, abnormal lipoprotein patterns, aggregation of erythrocytes and peripheral neuropathy.

In vitro
In vitro	Cremophor EL is a widely used excipient. In the first 10 h, Cremophor EL at 5 mg/mL increases the impedance, then decreases it, and after 20 h of treatment, epithelial cell death is detected. Cremophor EL in concentrations corresponding to clinical doses causes endothelial and epithelial toxicity. Both epithelial viability and monolayer integrity are seriously impaired at 10 to 50 mg/mL concentrations of Cremophor EL at 24-h treatment. Cremophor EL also enhances cell detachment.^[1]
Cell Research	Cell lines	Human cell lines brain microvascular endothelial, Caco-2 cells
	Concentrations	0.1-50 mg/ml
	Incubation Time	24 h
	Method	Cell lines are seeded in culture dishes at a density of 5 × 10₄ cells/cm₂, and the medium is changed every 2 days. Cremophor EL are tested at 0.1–50 mg/mL concentrations. Triton X-100 detergent (10 mg/mL) is used in toxicity assays as a reference compound to cause cell death.

In Vivo
In vivo	Cremophor EL-BB4 formulation-mediated photodynamic therapy (PDT) disseminated cancer in CT26-Luc mouse colon carcinoma model of intraperitoneal (IP) and significantly prolonged survival in mice when used along with white light.

References

Chemical Information & Solubility

Molecular Weight		Formula
CAS No.	61791-12-6	SDF	--
Density	1.05 g/mL at 20 °C
Smiles	C(C(CCl)OC(=O)N)Cl
Storage (From the date of receipt)	2 years -20°C(in the dark) liquid	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	2 years -20°C(in the dark) liquid		1 month-20°Cin solvent

In vitro
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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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