Colivelin

For research use only.

Catalog No.S9664 Synonyms: CLN

Colivelin Chemical Structure

CAS No. 867021-83-8

Colivelin (CLN) is a brain-penetrant neuroprotective peptide with potent long-term capacity against deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin is an activator of STAT3.

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Biological Activity

Description Colivelin (CLN) is a brain-penetrant neuroprotective peptide with potent long-term capacity against deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin is an activator of STAT3.
Targets
[1]
()
STAT3 [1]
()

Protocol

Solubility (25°C)

In vitro Water 100 mg/mL (37.8 mM)
Ethanol ''-1 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 2645.10
Formula

C119H206N32O35

CAS No. 867021-83-8
Storage powder
in solvent
Synonyms CLN
Smiles CCC(C)C(C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(C(C)O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CO)NC(=O)C(C)NC(=O)CNC(=O)C(C)NC(=O)C2CCCN2C(=O)C(C)NC(=O)C3CCCN3C(=O)C(䲧瘆Ỵ瘇㧀瘅膉疴睥ଐ঵ី'঵ð㺣疲帉疲Ѐ瑖猗﫜돸ቬ঵ð鄸ቬ

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04974307 Recruiting Device: OrCam MyEye 2 CLN3-related Disorders|Low Vision Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institutes of Health Clinical Center (CC) September 9 2021 Not Applicable
NCT04637282 Not yet recruiting Drug: PLX-200|Drug: Placebo Juvenile Neuronal Ceroid Lipofuscinosis Polaryx Therapeutics Inc. September 1 2021 Phase 3
NCT04480476 Not yet recruiting -- Late-infantile Neuronal Ceroid Lipofuscinosis Type 2 (CLN2) Regenxbio Inc. March 31 2021 --
NCT04462692 Not yet recruiting -- Neuronal Ceroid Lipofuscinosis Type 2 (CLN2) Regenxbio Inc. March 31 2021 --
NCT04098211 Active not recruiting -- Neuronal Ceroid-Lipofuscinoses|Neuronal Ceroid Lipofuscinosis CLN2|Spinocerebellar Ataxia Autosomal Recessive 7 Children''s Hospital of Orange County November 1 2019 --

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STAT Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID