CID 2011756

For research use only.

Catalog No.S5792

CID 2011756 Chemical Structure

CAS No. 638156-11-3

CID 2011756 is an inhibitor of protein kinase D (PKD) with IC50 values of 3.2, 0.6, and 0.7 μM for PKD1, PKD2, and PKD3, respectively.

Purity & Quality Control

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Biological Activity

Description CID 2011756 is an inhibitor of protein kinase D (PKD) with IC50 values of 3.2, 0.6, and 0.7 μM for PKD1, PKD2, and PKD3, respectively.
Targets
PKD2 [1]
()
PKD3 [1]
()
PKD1 [1]
()
0.6 μM 0.7 μM 3.2 μM

Protocol

Cell Research:

[1]

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  • Cell lines: LNCaP cells
  • Concentrations: 50 µM
  • Incubation Time: 45 min
  • Method:

    LNCaP cells were pretreated with a single concentration (i.e., 50 µM) of test compound for 45 min, followed by PMA stimulation at 10 nM for 20 min. Whole cell lysates were immunoblotted for phosphorylated Ser916-PKD1 with GAPDH serving as a loading control.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (75.59 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 396.87
Formula

C22H21ClN2O3

CAS No. 638156-11-3
Storage powder
in solvent
Synonyms N/A
Smiles C1COCCN1CC2=CC=C(C=C2)NC(=O)C3=CC=C(O3)C4=CC(=CC=C4)Cl

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID