For research use only.

Catalog No.S4646 Synonyms: Alvesco, Omnaris, RPR251526, Zetonna

1 publication

Ciclesonide Chemical Structure

CAS No. 126544-47-6

Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases.

Selleck's Ciclesonide has been cited by 1 publication

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Biological Activity

Description Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases.
In vitro

Ciclesonide is effectively taken up into human alveolar type II epithelial (A549) cells and metabolized to its pharmacologically active metabolite des-CIC and fatty acid conjugates of desCIC[2].


Cell Research:[2]
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  • Cell lines: Human alveolar type II epithelial cells (A549).
  • Concentrations: 0.02 μM
  • Incubation Time: 1 h
  • Method: Metabolism of ciclesonide: After initial cultivation, A549 cells are washed five times with 10 ml/dish sterile PBS. An ethanolic stock solution of ciclesonide is diluted 1000-fold with assay medium to generate the initial ciclesonide concentration. The cells are incubated for 1 h in DMEM/0.1% (w/v) BSA (5 ml/dish) containing 0.02μM ciclesonide as described above in a CO2 incubator. At the end of the incubation period, dishes are washed five times with PBS and incubated for 3, 6, or 24 h at the same conditions in 5 ml/dish fresh medium (DMEM/0.1% (w/v) BSA). At each indicated time point, the medium is removed by aspiration, 5 mM EDTA-4Na/PBS added and dishes are incubated for further 5 min. The cells are detached from the dishes and harvested. Each dish is washed five times with icechilled PBS.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Wistar rats
  • Dosages: 0.5 mg/kg
  • Administration: i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (184.94 mM)
Water Insoluble
Ethanol ''100 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 540.69


CAS No. 126544-47-6
Storage powder
in solvent
Synonyms Alvesco, Omnaris, RPR251526, Zetonna

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01147224 Completed Drug: Alvesco Asthma|Allergy AstraZeneca March 2010 --
NCT00793858 Withdrawn Drug: placebo isotonic ciclesonide hypotonic ciclesonide Allergic Rhinitis University of Chicago|Sunovion February 2009 Phase 4
NCT00826969 Completed Drug: Ciclesonide|Drug: Placebo Asthma AstraZeneca September 2008 Phase 4
NCT00458835 Completed Drug: Ciclesonide Allergic Rhinitis AstraZeneca April 2007 Phase 4
NCT00367263 Completed Drug: Alvesco (Ciclesonide) 160 ug/day Asthma Allergy & Asthma Medical Group & Research Center October 2006 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID