Ciclesonide

Synonyms: Alvesco, Omnaris, RPR251526, Zetonna

Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases.

Ciclesonide Chemical Structure

Ciclesonide Chemical Structure

CAS No. 126544-47-6

Purity & Quality Control

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Biological Activity

Description Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases.
In vitro
In vitro Ciclesonide is effectively taken up into human alveolar type II epithelial (A549) cells and metabolized to its pharmacologically active metabolite des-CIC and fatty acid conjugates of desCIC[2].
Cell Research Cell lines Human alveolar type II epithelial cells (A549).
Concentrations 0.02 μM
Incubation Time 1 h
Method Metabolism of ciclesonide: After initial cultivation, A549 cells are washed five times with 10 ml/dish sterile PBS. An ethanolic stock solution of ciclesonide is diluted 1000-fold with assay medium to generate the initial ciclesonide concentration. The cells are incubated for 1 h in DMEM/0.1% (w/v) BSA (5 ml/dish) containing 0.02μM ciclesonide as described above in a CO2 incubator. At the end of the incubation period, dishes are washed five times with PBS and incubated for 3, 6, or 24 h at the same conditions in 5 ml/dish fresh medium (DMEM/0.1% (w/v) BSA). At each indicated time point, the medium is removed by aspiration, 5 mM EDTA-4Na/PBS added and dishes are incubated for further 5 min. The cells are detached from the dishes and harvested. Each dish is washed five times with icechilled PBS.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01147224 Completed
Asthma|Allergy
AstraZeneca
March 2010 --
NCT00793858 Withdrawn
Allergic Rhinitis
University of Chicago|Sumitomo Pharma America Inc.
February 2009 Phase 4
NCT00826969 Completed
Asthma
AstraZeneca
September 2008 Phase 4
NCT00458835 Completed
Allergic Rhinitis
Covis Pharma S.à.r.l.
April 2007 Phase 4
NCT00367263 Completed
Asthma
Allergy & Asthma Medical Group & Research Center
October 2006 Not Applicable

Chemical Information & Solubility

Molecular Weight 540.69 Formula

C32H44O7

CAS No. 126544-47-6 SDF Download Ciclesonide SDF
Smiles CC(C)C(=O)OCC(=O)C12C(CC3C1(CC(C4C3CCC5=CC(=O)C=CC45C)O)C)OC(O2)C6CCCCC6
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (184.94 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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