Ciclesonide

For research use only.

Catalog No.S4646 Synonyms: Ciclesonide, Alvesco, Omnaris, RPR251526, Zetonna

Ciclesonide Chemical Structure

CAS No. 126544-47-6

Ciclesonide is a glucocorticoid used to treat obstructive airway diseases.

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Purity & Quality Control

Choose Selective Glucocorticoid Receptor Inhibitors

Biological Activity

Description Ciclesonide is a glucocorticoid used to treat obstructive airway diseases.
In vitro

Ciclesonide is effectively taken up into human alveolar type II epithelial (A549) cells and metabolized to its pharmacologically active metabolite des-CIC and fatty acid conjugates of desCIC[2].

Protocol

Cell Research:[2]
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  • Cell lines: Human alveolar type II epithelial cells (A549).
  • Concentrations: 0.02 μM
  • Incubation Time: 1 h
  • Method: Metabolism of ciclesonide: After initial cultivation, A549 cells are washed five times with 10 ml/dish sterile PBS. An ethanolic stock solution of ciclesonide is diluted 1000-fold with assay medium to generate the initial ciclesonide concentration. The cells are incubated for 1 h in DMEM/0.1% (w/v) BSA (5 ml/dish) containing 0.02μM ciclesonide as described above in a CO2 incubator. At the end of the incubation period, dishes are washed five times with PBS and incubated for 3, 6, or 24 h at the same conditions in 5 ml/dish fresh medium (DMEM/0.1% (w/v) BSA). At each indicated time point, the medium is removed by aspiration, 5 mM EDTA-4Na/PBS added and dishes are incubated for further 5 min. The cells are detached from the dishes and harvested. Each dish is washed five times with icechilled PBS.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Wistar rats
  • Dosages: 0.5 mg/kg
  • Administration: i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (184.94 mM)
Water Insoluble
Ethanol '100 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 540.69
Formula

C32H44O7

CAS No. 126544-47-6
Storage powder
in solvent
Synonyms Ciclesonide, Alvesco, Omnaris, RPR251526, Zetonna
Smiles CC(C)C(=O)OCC(=O)C12C(CC3C1(CC(C4C3CCC5=CC(=O)C=CC45C)O)C)OC(O2)C6CCCCC6

In vivo Formulation Calculator (Clear solution)

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01147224 Completed Drug: Alvesco Asthma|Allergy AstraZeneca March 2010 --
NCT00793858 Withdrawn Drug: placebo isotonic ciclesonide hypotonic ciclesonide Allergic Rhinitis University of Chicago|Sunovion February 2009 Phase 4
NCT00826969 Completed Drug: Ciclesonide|Drug: Placebo Asthma AstraZeneca September 2008 Phase 4
NCT00458835 Completed Drug: Ciclesonide Allergic Rhinitis AstraZeneca April 2007 Phase 4
NCT00367263 Completed Drug: Alvesco (Ciclesonide) 160 ug/day Asthma Allergy & Asthma Medical Group & Research Center October 2006 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID